A Study to Evaluate the Effect of Ustekinumab on Cytochrome P450 Enzyme Activities Following Induction and Maintenance Dosing...
A Study to Evaluate the Effect of Ustekinumab on Cytochrome P450 Enzyme Activities Following Induction and Maintenance Dosing ... Drug Interaction Study to Evaluate the Effect of Ustekinumab on Cytochrome P450 Enzyme Activities Following Induction and ... The purpose of this study is to evaluate the potential effects of an intravenous (IV) induction and subcutaneous (SC) ... enzymes (CYP3A4, CYP2C9, CYP2C19, CYP2D6, and CYP1A2) in participants with moderate to severe Crohn's disease (CD). ...https://clinicaltrials.gov/ct2/show/NCT03358706?term=omeprazole&
Activity of antioxidant enzymes during induction of morphogenesis of Fritillaria meleagris in bulb scale culture
Activity of antioxidant enzymes during induction of morphogenesis of Fritillaria meleagris in bulb scale culture. 2014. ... nutrient medium composition on enzyme activity. Enzyme activity was measured 7, 14, 21, and 28 days after the start of ... We investigated the activity of 3 antioxidant enzymes: superoxide dismutase, catalase, and peroxidase during morphogenesis of ... Superoxide dismutase and catalase showed the highest activity at the beginning of morphogenesis in vitro. Peroxidase activity ...http://ibiss-r.rcub.bg.ac.rs/handle/123456789/2292
Modest induction of phase 2 enzyme activity in the F-344 rat prostate | BMC Cancer | Full Text
Mean enzyme specific activities for tissues from animals in each group were calculated and the fold-induction enzyme specific ... could produce greater phase 2 enzyme induction . In addition, measurement of phase 2 enzyme activity occurred 24 hours ... Fold-induction of phase 2 enzymes NQO1, total GST and GST-mu activity in the prostate tissue of male F344 rats treated for 5 ... Fold-induction in NQO1 (A) and total GST (B) enzyme activities in the liver, kidney and bladder tissues of male F344 rats ...https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-6-62
Induction of Drug Metabolism Enzymes and MDR1 Using a Novel Human Hepatocyte Cell Line | Journal of Pharmacology and...
Measurement of induction by cytochromes 450 enzyme activity. Induction of CYP3A4, CYP2C9, and CYP1A2 enzyme activity in Fa2N-4 ... For enzyme activity, a separate well in a multiwell plate must be used for each enzyme activity endpoint, whereas a single well ... Induction in the Fa2N-4 cells is not limited to mRNA and can also be assessed at the enzyme activity level. The extent of ... In vitro induction studies traditionally use primary hepatocyte cultures and enzyme activity with selected marker compounds. We ...http://jpet.aspetjournals.org/content/309/1/303
Primary Hepatocytes | Human and Animal Hepatocytes | Corning
... metabolic activity, and CYP enzyme induction. ... and CYP enzyme induction.. *Support ADME assays such as drug ... Characterized for platability and many metabolic enzyme activities.. *Suitable for metabolic stability studies, metabolite ... Characterized for platability and many metabolic enzyme activities.. *Suitable for metabolic stability studies, metabolite ... Pre-screened and characterized for transporter-mediated uptake and biliary efflux activity, metabolic activity, ...https://www.corning.com/in/en/products/life-sciences/products/adme-tox-research/primary-hepatocytes.html
Dilantin-125 (phenytoin) dose, indications, adverse effects, interactions... from PDR.net
... one study in mice has suggested that hepatic enzyme induction antagonizes antitumor activity of altretamine. Amiodarone: (Major ... Phenytoin stimulates hepatic enzyme activity, which may cause an increased degradation of circulating concentrations of thyroid ... Slow metabolism may be due to limited enzyme availability and lack of induction; slow metabolism appears to be genetically ... It should be noted that because clobazam is metabolized by multiple enzyme systems, induction of one pathway may not ...http://www.pdr.net/drug-summary/dilantin-125?druglabelid=1843
Capiri-sutent Phase-1 in Advanced Colo-rectal Cancer - Full Text View - ClinicalTrials.gov
... use medication that may significantly affect hepatic cytochrome P450 drug metabolizing activity by way of enzyme induction or ... Enzyme Inhibitors. Angiogenesis Inhibitors. Angiogenesis Modulating Agents. Growth Substances. Physiological Effects of Drugs. ...https://www.clinicaltrials.gov/ct2/show/NCT00777478
Photosynthetic activities, C3 and C4 indicative enzymes and the role of photoperiod in dormancy induction in 'Chunjie' peach |...
Photosynthetic activities, C3 and C4 indicative enzymes and the role of photoperiod in dormancy induction in 'Chunjie' peach ...http://ps.ueb.cas.cz/contribution/photosynthetic-activities-c3-and-c4-indicative-enzymes-and-role-photoperiod-dormancy-induction
Effects of Glucosinolate-Rich Broccoli Sprouts on Urinary Levels of Aflatoxin-DNA Adducts and Phenanthrene Tetraols in a...
Bioassay of the infusions for phase 2 enzyme induction activity showed no detectable activity in either placebo or myrosinase- ... Bioassay of Phase 2 Enzyme Inducer Activity. Aliquots of the broccoli sprouts and placebo infusions were diluted 200-fold into ... Disappearance of glucosinolates, and appearance of isothiocyanates, and their induction of a marker mammalian phase 2 enzyme ... Exceptional activity of murine glutathione transferase A1-1 against (7R,8S)-dihydroxy-(9S,10R)-epoxy-7,8,9,10-tetrahydrobenzo(a ...http://cebp.aacrjournals.org/content/14/11/2605.long
Glutathione-S-transferase P protects against endothelial dysfunction induced by exposure to tobacco smoke | Heart and...
... individual differences in GSTP activity may arise also from enzyme induction. GSTP is a highly inducible enzyme. Although GSTP ... D: catalytic activity of GST in the mouse lung. Total GST and GSTP activities in lung homogenates of WT and GSTP-null mice ... Because tobacco smoke is known to induce oxidative stress, we tested whether the induction of antioxidant enzymes in the lung ... This surprising effect of GSTP deficiency on the transcriptional regulation of other antioxidant enzymes and the induction of ...http://ajpheart.physiology.org/content/296/5/H1586.long
First-Pass Elimination Basic Concepts and Clinical Consequences | SpringerLink
... in first-pass metabolism is accounted for by differences in metabolising enzyme activity produced either by enzyme induction, ... The major factors are enzyme activity, plasma protein and blood cell binding, and gastrointestinal motility. Models that ... Liver disease affects bioavailability by changing metabolising enzyme activity and plasma protein binding, and creating intra- ... model for a given change in drug-metabolising enzyme activity, blood flow, or fraction of drug unbound. ...https://link.springer.com/article/10.2165%2F00003088-198409010-00001
betA - Oxygen-dependent choline dehydrogenase - Escherichia coli (strain K12) - betA gene & protein
Cited for: FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, INDUCTION, ENZYME REGULATION, SUBCELLULAR LOCATION. ... Cited for: FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, INDUCTION, ENZYME REGULATION, SUBCELLULAR LOCATION. ... Cited for: FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, INDUCTION, ENZYME REGULATION, SUBCELLULAR LOCATION. ... Cited for: FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, INDUCTION, ENZYME REGULATION, SUBCELLULAR LOCATION. ...http://www.uniprot.org/uniprot/P17444
Gut microbiota functions: metabolism of nutrients and other food components | SpringerLink
... but complements the activity of mammalian enzymes in the liver and gut mucosa... ... to dietary exposure may be due to changes in the number of microbes possessing those activities and also enzyme induction in ... It should be noted that measurement of enzyme activities of individual strains in vitro does not necessarily reflect activity ... Enzyme Classification using ensemble approach) to model and predict enzymes from protein sequences and identify enzyme classes ...https://link.springer.com/article/10.1007/s00394-017-1445-8
Fruit and Vegetables and Health: An Overview | SpringerLink
... redox cycling in vitro and hemolytic activity and Phase 2 enzyme induction in vivo. Free Rad Biol Med 34:1200-1211PubMed ... McDougall GJ, Stewart D (2005) The inhibitory effects of berry polyphenols on digestive enzymes. BioFactors 23:189-195PubMed ... Prasad K, Laxdal VA, Yu M, Raney BL (1995) Antioxidant activity of allicin, an active principle in garlic. Mol Cell Biochem 148 ... Choi SS, Lee DH, Lee SH (2012) Blueberry protects LPS-stimulated BV-2 microglia through inhibiting activities of p38 MAPK and ...https://link.springer.com/chapter/10.1007/978-94-017-8560-0_2
A New Hope for a Devastating Disease: Hydrogen Sulfide in Parkinson's Disease | SpringerLink
... redox cycling in vitro and hemolytic activity and phase 2 enzyme induction in vivo. Free Radic Biol Med 34(9):1200-1211PubMed ... Padilla-Camberos E, Zaitseva G, Padilla C, Puebla AM (2010) Antitumoral activity of allicin in murine lymphoma L5178Y. Asian ... Kashfi K (2014) Anti-cancer activity of new designer hydrogen sulfide-donating hybrids. Antioxid Redox Signal 20(5):831-846. ... and pro-survival activity, which are also summarized in the review. Moreover, the progresses on the development of H2S donors ...https://link.springer.com/article/10.1007/s12035-017-0617-0
Induction of Aryl Hydrocarbon Hydroxylase in Ambystoma tigrinum - Digital Library
Differences in optimal temperature for enzyme induction and activity were noted in organ culture of human and Ambystoma tissues ... The half life of enzyme activity induced in vivo was related to the excretion of hydrocarbon metabolites. ... The cytochrome P-450-associated microsomal enzyme is similar to the inducible, one-gene, autosomal-dominant system typical in ... Differences in optimal temperature for enzyme induction and activity were noted in organ culture of human and Ambystoma tissues ...https://digital.library.unt.edu/ark:/67531/metadc663117/
Leicester Research Archive: On the factors influencing the individual variation in gamma glutamyltransferase induction.
However previous studies of the measurement of serum gammaGT activity as an index of microsomal enzyme induction have been ... Enzyme induction is a phenomenon that describes increased microsomal enzyme synthesis caused by the administration of enzyme ... induction it is helpful to have a simple and reliable indicator of microsomal enzyme activity in patients exposed to enzyme ... enzyme induction or protein synthesis. The process of the effects of the dietary factors on induction of gammaGT by ...https://lra.le.ac.uk/handle/2381/35290
Biotransformation | definition of biotransformation by Medical dictionary
Enzyme induction, which is involved in a drug's metabolism may reduce the drug's activity; enzyme-inducing drugs include ... Enzyme inhibition, which is involved in drug metabolism, resulting in ↑ drug activity, prolonging the action of various drugs, ... enzyme activity, density of receptors on the cell surfaces and ↓ albumin, the major drug transporting molecule ... enzyme activity resulting in a functional ↑ in drug levels, due to ↓ availability of drug-carrying proteins ...https://medical-dictionary.thefreedictionary.com/biotransformation
Griseofulvin Tablets - FDA prescribing information, side effects and uses
Whether this is due to a P-450 mediated enzyme induction effects on sulfurtransferase and/or glucotransferase activity, or some ... Activity In Vitro In vitro, griseofulvin has been shown to have activity against many dermatophytes, but the clinical ... Activity In Vivo Griseofulvin may be active against most strains of the following dermatophytes as described in the INDICATIONS ... Griseofulvin decreases the activity of warfarin-type anticoagulants, so that patients receiving these drugs concomitantly may ...https://www.drugs.com/pro/griseofulvin-tablets.html
411. Tertiary butyl hydroquinone (TBHQ) (WHO Food Additives Series 8)
In dog no induction effects were noted. In rat and dog heated oil had no effect on enzyme activities. In rat induction of pNaD ... reasonable to conclude the enzyme induction activity noted for TBHQ is freely reversible. In the seventeenth report of the ... Enzyme induction experiments were done with rat and dog. Glucose-6-phosphatase, paranitroanisole demethylase (pNaD) and aniline ... Since there was no change in enzyme induction seen in chronically exposed as opposed to acutely exposed rats, it is ...http://inchem.org/documents/jecfa/jecmono/v08je11.htm
NIOSHTIC-2 Publications Search - 00188654 - The role of enzyme induction on metabolite formation of bis(2- methoxyethyl) ether...
The effect of enzyme induction on the metabolism of bis(2- methoxyethyl)ether (111966) (diglyme) was studied in rats. Male ... NIOSH-Author; Organic-solvents; Glycols; In-vivo-studies; Laboratory-animals; Biotransformation; Enzyme-activity; Urinalysis; ... The effect of enzyme induction on the metabolism of bis(2- methoxyethyl)ether (111966) (diglyme) was studied in rats. Male ... The role of enzyme induction on metabolite formation of bis(2- methoxyethyl) ether in the rat.. ...https://www.cdc.gov/niosh/nioshtic-2/00188654.html
Allium species poisoning in dogs and cats
... activity and phase 2 enzyme induction in vivo. Free Radic Biol Med. 2003; 34(9):1200-11. [ Links ]. ... Enzyme. 1976;21(4): 379-82. [ Links ]. 57. Robertson JE, Christopher MM, Rogers QR. Heinz body formation in cats fed baby food ... Catalase antioxidant activity in dog erythrocytes is low, and normal hemoglobin in cats is about two to three times more ... Induction of emesis (e.g. apomorphine 0.08 mg/kg intramuscularly or subcutaneously, or 3% hydrogen peroxidase 2 mL/kg, no more ...http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992011000100002
Estrogenic activity of zearalenone and zearalanol in the neonatal rat uterus.
Enzyme Induction / drug effects. Female. Organ Size / drug effects. Ornithine Decarboxylase / biosynthesis, metabolism. Rats. ... Time course studies revealed that a low dose of zearalenone, but not of zearalanol, resulted in a shift in peak activity from 6 ... We conclude that the uterine growth response and ODC induction demonstrate the neonatal estrogenic action of these mycotoxins, ... Since estrogens can irreversibly alter target tissue development, we investigated the estrogenic activity of these compounds in ...http://www.biomedsearch.com/nih/Estrogenic-activity-zearalenone-zearalanol-in/6235618.html
A Clinical Overview of INCB-9471 - TheBodyPRO.com
... and CYP3A4 activity and has low potential for CYP3A4 enzyme induction.3,6 ... Potent antiretroviral activity of the once-daily CCR5 antagonist INCB009471 over 14 days of monotherapy. Abstract presented at ... Phase IIa Study Results Demonstrate that Once-Daily 200 mg Dosing of INCB9471 Provided Potent and Prolonged Antiviral Activity ... Visit the AIDSinfo website to find out more about their activities and publications. ...http://www.thebodypro.com/content/71718/a-clinical-overview-of-incb-9471.html?ic=4003
Theolair (Theophylline): Side Effects, Interactions, Warning, Dosage & Uses
Increases theophylline clearance by induction of microsomal enzyme activity.. 25% decrease. Carbamazepine. Similar to ... Phenytoin increases theophylline clearance by increasing microsomal enzyme activity.. Serum theophylline and phenytoin ... The activity of these pathways slowly increases to maximal levels by one year of age. ... Increases theophylline clearance by increasing cytochrome P-450 1A2 and 3A3 activity.. 20-40% decrease. ...https://www.rxlist.com/theolair-drug.htm