A Study to Evaluate the Effect of Ustekinumab on Cytochrome P450 Enzyme Activities Following Induction and Maintenance Dosing...
A Study to Evaluate the Effect of Ustekinumab on Cytochrome P450 Enzyme Activities Following Induction and Maintenance Dosing ... Drug Interaction Study to Evaluate the Effect of Ustekinumab on Cytochrome P450 Enzyme Activities Following Induction and ... The purpose of this study is to evaluate the potential effects of an intravenous (IV) induction and subcutaneous (SC) ... enzymes (CYP3A4, CYP2C9, CYP2C19, CYP2D6, and CYP1A2) in participants with moderate to severe Crohn's disease (CD). ...https://clinicaltrials.gov/ct2/show/NCT03358706?term=omeprazole&
Activity of antioxidant enzymes during induction of morphogenesis of Fritillaria meleagris in bulb scale culture
Activity of antioxidant enzymes during induction of morphogenesis of Fritillaria meleagris in bulb scale culture. 2014. ... nutrient medium composition on enzyme activity. Enzyme activity was measured 7, 14, 21, and 28 days after the start of ... We investigated the activity of 3 antioxidant enzymes: superoxide dismutase, catalase, and peroxidase during morphogenesis of ... Superoxide dismutase and catalase showed the highest activity at the beginning of morphogenesis in vitro. Peroxidase activity ...http://ibiss-r.rcub.bg.ac.rs/handle/123456789/2292
Modest induction of phase 2 enzyme activity in the F-344 rat prostate | BMC Cancer | Full Text
Mean enzyme specific activities for tissues from animals in each group were calculated and the fold-induction enzyme specific ... could produce greater phase 2 enzyme induction . In addition, measurement of phase 2 enzyme activity occurred 24 hours ... Fold-induction of phase 2 enzymes NQO1, total GST and GST-mu activity in the prostate tissue of male F344 rats treated for 5 ... Fold-induction in NQO1 (A) and total GST (B) enzyme activities in the liver, kidney and bladder tissues of male F344 rats ...https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-6-62
Induction of Drug Metabolism Enzymes and MDR1 Using a Novel Human Hepatocyte Cell Line | Journal of Pharmacology and...
Measurement of induction by cytochromes 450 enzyme activity. Induction of CYP3A4, CYP2C9, and CYP1A2 enzyme activity in Fa2N-4 ... For enzyme activity, a separate well in a multiwell plate must be used for each enzyme activity endpoint, whereas a single well ... Induction in the Fa2N-4 cells is not limited to mRNA and can also be assessed at the enzyme activity level. The extent of ... In vitro induction studies traditionally use primary hepatocyte cultures and enzyme activity with selected marker compounds. We ...http://jpet.aspetjournals.org/content/309/1/303
Primary Hepatocytes | Human and Animal Hepatocytes | Corning
... metabolic activity, and CYP enzyme induction. ... and CYP enzyme induction.. *Support ADME assays such as drug ... Characterized for platability and many metabolic enzyme activities.. *Suitable for metabolic stability studies, metabolite ... Characterized for platability and many metabolic enzyme activities.. *Suitable for metabolic stability studies, metabolite ... Pre-screened and characterized for transporter-mediated uptake and biliary efflux activity, metabolic activity, ...https://www.corning.com/in/en/products/life-sciences/products/adme-tox-research/primary-hepatocytes.html
Dilantin-125 (phenytoin) dose, indications, adverse effects, interactions... from PDR.net
... one study in mice has suggested that hepatic enzyme induction antagonizes antitumor activity of altretamine. Amiodarone: (Major ... Phenytoin stimulates hepatic enzyme activity, which may cause an increased degradation of circulating concentrations of thyroid ... Slow metabolism may be due to limited enzyme availability and lack of induction; slow metabolism appears to be genetically ... It should be noted that because clobazam is metabolized by multiple enzyme systems, induction of one pathway may not ...http://www.pdr.net/drug-summary/dilantin-125?druglabelid=1843
Capiri-sutent Phase-1 in Advanced Colo-rectal Cancer - Full Text View - ClinicalTrials.gov
... use medication that may significantly affect hepatic cytochrome P450 drug metabolizing activity by way of enzyme induction or ... Enzyme Inhibitors. Angiogenesis Inhibitors. Angiogenesis Modulating Agents. Growth Substances. Physiological Effects of Drugs. ...https://www.clinicaltrials.gov/ct2/show/NCT00777478
Effects of Glucosinolate-Rich Broccoli Sprouts on Urinary Levels of Aflatoxin-DNA Adducts and Phenanthrene Tetraols in a...
Bioassay of the infusions for phase 2 enzyme induction activity showed no detectable activity in either placebo or myrosinase- ... Bioassay of Phase 2 Enzyme Inducer Activity. Aliquots of the broccoli sprouts and placebo infusions were diluted 200-fold into ... Disappearance of glucosinolates, and appearance of isothiocyanates, and their induction of a marker mammalian phase 2 enzyme ... Exceptional activity of murine glutathione transferase A1-1 against (7R,8S)-dihydroxy-(9S,10R)-epoxy-7,8,9,10-tetrahydrobenzo(a ...http://cebp.aacrjournals.org/content/14/11/2605.long
Glutathione-S-transferase P protects against endothelial dysfunction induced by exposure to tobacco smoke | Heart and...
... individual differences in GSTP activity may arise also from enzyme induction. GSTP is a highly inducible enzyme. Although GSTP ... D: catalytic activity of GST in the mouse lung. Total GST and GSTP activities in lung homogenates of WT and GSTP-null mice ... Because tobacco smoke is known to induce oxidative stress, we tested whether the induction of antioxidant enzymes in the lung ... This surprising effect of GSTP deficiency on the transcriptional regulation of other antioxidant enzymes and the induction of ...http://ajpheart.physiology.org/content/296/5/H1586.long
betA - Oxygen-dependent choline dehydrogenase - Escherichia coli (strain K12) - betA gene & protein
Cited for: FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, INDUCTION, ENZYME REGULATION, SUBCELLULAR LOCATION. ... Cited for: FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, INDUCTION, ENZYME REGULATION, SUBCELLULAR LOCATION. ... Cited for: FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, INDUCTION, ENZYME REGULATION, SUBCELLULAR LOCATION. ... Cited for: FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, INDUCTION, ENZYME REGULATION, SUBCELLULAR LOCATION. ...http://www.uniprot.org/uniprot/P17444
A New Hope for a Devastating Disease: Hydrogen Sulfide in Parkinson's Disease | SpringerLink
... redox cycling in vitro and hemolytic activity and phase 2 enzyme induction in vivo. Free Radic Biol Med 34(9):1200-1211PubMed ... Padilla-Camberos E, Zaitseva G, Padilla C, Puebla AM (2010) Antitumoral activity of allicin in murine lymphoma L5178Y. Asian ... Kashfi K (2014) Anti-cancer activity of new designer hydrogen sulfide-donating hybrids. Antioxid Redox Signal 20(5):831-846. ... and pro-survival activity, which are also summarized in the review. Moreover, the progresses on the development of H2S donors ...https://link.springer.com/article/10.1007/s12035-017-0617-0
Induction of Aryl Hydrocarbon Hydroxylase in Ambystoma tigrinum - Digital Library
Differences in optimal temperature for enzyme induction and activity were noted in organ culture of human and Ambystoma tissues ... The half life of enzyme activity induced in vivo was related to the excretion of hydrocarbon metabolites. ... The cytochrome P-450-associated microsomal enzyme is similar to the inducible, one-gene, autosomal-dominant system typical in ... Differences in optimal temperature for enzyme induction and activity were noted in organ culture of human and Ambystoma tissues ...https://digital.library.unt.edu/ark:/67531/metadc663117/
Biotransformation | definition of biotransformation by Medical dictionary
Enzyme induction, which is involved in a drug's metabolism may reduce the drug's activity; enzyme-inducing drugs include ... Enzyme inhibition, which is involved in drug metabolism, resulting in ↑ drug activity, prolonging the action of various drugs, ... enzyme activity, density of receptors on the cell surfaces and ↓ albumin, the major drug transporting molecule ... enzyme activity resulting in a functional ↑ in drug levels, due to ↓ availability of drug-carrying proteins ...https://medical-dictionary.thefreedictionary.com/biotransformation
Griseofulvin Tablets - FDA prescribing information, side effects and uses
Whether this is due to a P-450 mediated enzyme induction effects on sulfurtransferase and/or glucotransferase activity, or some ... Activity In Vitro In vitro, griseofulvin has been shown to have activity against many dermatophytes, but the clinical ... Activity In Vivo Griseofulvin may be active against most strains of the following dermatophytes as described in the INDICATIONS ... Griseofulvin decreases the activity of warfarin-type anticoagulants, so that patients receiving these drugs concomitantly may ...https://www.drugs.com/pro/griseofulvin-tablets.html
411. Tertiary butyl hydroquinone (TBHQ) (WHO Food Additives Series 8)
In dog no induction effects were noted. In rat and dog heated oil had no effect on enzyme activities. In rat induction of pNaD ... reasonable to conclude the enzyme induction activity noted for TBHQ is freely reversible. In the seventeenth report of the ... Enzyme induction experiments were done with rat and dog. Glucose-6-phosphatase, paranitroanisole demethylase (pNaD) and aniline ... Since there was no change in enzyme induction seen in chronically exposed as opposed to acutely exposed rats, it is ...http://inchem.org/documents/jecfa/jecmono/v08je11.htm
NIOSHTIC-2 Publications Search - 00188654 - The role of enzyme induction on metabolite formation of bis(2- methoxyethyl) ether...
The effect of enzyme induction on the metabolism of bis(2- methoxyethyl)ether (111966) (diglyme) was studied in rats. Male ... NIOSH-Author; Organic-solvents; Glycols; In-vivo-studies; Laboratory-animals; Biotransformation; Enzyme-activity; Urinalysis; ... The effect of enzyme induction on the metabolism of bis(2- methoxyethyl)ether (111966) (diglyme) was studied in rats. Male ... The role of enzyme induction on metabolite formation of bis(2- methoxyethyl) ether in the rat.. ...https://www.cdc.gov/niosh/nioshtic-2/00188654.html
Estrogenic activity of zearalenone and zearalanol in the neonatal rat uterus.
Enzyme Induction / drug effects. Female. Organ Size / drug effects. Ornithine Decarboxylase / biosynthesis, metabolism. Rats. ... Time course studies revealed that a low dose of zearalenone, but not of zearalanol, resulted in a shift in peak activity from 6 ... We conclude that the uterine growth response and ODC induction demonstrate the neonatal estrogenic action of these mycotoxins, ... Since estrogens can irreversibly alter target tissue development, we investigated the estrogenic activity of these compounds in ...http://www.biomedsearch.com/nih/Estrogenic-activity-zearalenone-zearalanol-in/6235618.html
Theolair (Theophylline): Side Effects, Interactions, Warning, Dosage & Uses
Increases theophylline clearance by induction of microsomal enzyme activity.. 25% decrease. Carbamazepine. Similar to ... Phenytoin increases theophylline clearance by increasing microsomal enzyme activity.. Serum theophylline and phenytoin ... The activity of these pathways slowly increases to maximal levels by one year of age. ... Increases theophylline clearance by increasing cytochrome P-450 1A2 and 3A3 activity.. 20-40% decrease. ...https://www.rxlist.com/theolair-drug.htm
... and toxicant exposure can considerably alter CYP3A4 and CYP2D6 expression or activities via enzyme induction and/or inhibition ... Enzyme activity was evaluated over a range of concentrations (DXM, 0-2000 μM) or at a single concentration for each probe ... were selected based on the Km value for human CYP3A4 to ensure sensitivity in measuring changes in induction of enzyme activity ... Nonetheless, sex difference was also shown in TEST 6β-hydroxylase activity after CYP3A induction in 8-week-old mice (Fig. 5B). ...http://dmd.aspetjournals.org/content/36/2/435
Vpt 311 General and Systemic Veterinary Pharamacology Tanuvas Lect Notes | Pharmacology | Cell Membrane
Significance of enzyme induction / inhibition • Inhibitors prolong the activity of co-administered drugs • It also increases ... Enzyme induction - microsomal induction by drugs - increased synthesis of proteins • Enzyme inhibition - a most common mode of ... ENZYME INDUCTION AND INHIBITION Enzyme inhibition • Some drugs on repeated administration have the ability to "inhibit" ... Increase in enzyme concentration due to induction of protein synthesis ( hence called INDUCERS) and takes long time to set in ...https://www.scribd.com/doc/105615542/Vpt-311-General-and-Systemic-Veterinary-Pharamacology-Tanuvas-Lect-Notes
PHM1000 Pharmacy Technician - Chap 11: Factors Affecting Drug Activity Walajtys Flashcards - Course Hero
Factors Affecting Drug Activity Walajtys. Find, create, and access Pharmacology, flashcards with Course Hero. ... induction a drug causes more metabolic enzymes to be produced, thus increasing metabolic activity. Ex: phenytoin + oral ... enzyme induction drug-drug interaction; increased concentration of metabolizing enzymes in the liver and results in reduction ... enzyme induction drug-drug interaction; increased concentration of metabolizing enzymes in the liver and results in reduction ...https://www.coursehero.com/flashcards/431582/PHM1000-Pharmacy-Technician-Chap-11-Factors-Affecting-Drug-Activity-Walajtys/
566. Triadimefon (Pesticide residues in food: 1981 evaluations)
... and 25 mg/kg bw caused slight induction of microsomal liver enzymes. The enzyme induction was reversible within the 4-week post ... increased enzyme activities, indicative of liver damage, was observed in the 1 800 ppm group. The incidence of liver cell ... enzyme induction was the rat, which reacted to minimum oral daily doses of 5 mg/kg bw. In the rat, the liver microsomal enzyme ... For clinical laboratory tests (haematology, clinical chemistry, urinalysis, enzyme induction assays), 10 rats were additionally ...http://www.inchem.org/documents/jmpr/jmpmono/v81pr32.htm
DailyMed - THEOPHYLLINE- theophylline, anhydrous capsule, extended release
Increases theophylline clearance by induction of microsomal enzyme activity.. 25% decrease. Carbamazepine. Similar to ... Phenytoin increases theophylline clearance by increasing microsomal enzyme activity. Theophylline decreases phenytoin ... The activity of these pathways slowly increases to maximal levels by one year of age. ... Smokers Tobacco and marijuana smoking appears to increase the clearance of theophylline by induction of metabolic pathways. ...https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=4692
Frontiers | Experimental and Metabolic Modeling Evidence for a Folate-Cleaving Side-Activity of Ketopantoate...
10-methylene-THF-dependent enzyme ketopantoate hydroxymethyltransferase, led us to infer that PanB has a side activity that ... 10-methylene-THF-dependent enzyme ketopantoate hydroxymethyltransferase, led us to infer that PanB has a side activity that ... The presence of a duplication of the gene encoding the folate biosynthesis enzyme 6-hydr¬oxymethyl-7,8-dihydropterin ... 10-methylene-THF by a side-activity of PanB, with FolK-mediated recycling of the pterin cleavage product, and with regulation ...https://www.frontiersin.org/articles/10.3389/fmicb.2016.00431/full
In Vitro Inhibition and Induction of Human Hepatic Cytochrome P450 Enzymes by Modafinil | Drug Metabolism & Disposition
Modafinil also caused an induction of cytochrome P450 activities in vitro in human hepatocytes. Three enzymes appeared to be ... To determine whether the changes in enzyme activity were due to changes in enzyme concentration, Western immunoblotting was ... only the positive controls produced detectable levels of enzyme activity. Hence, an induction of CYP2C19 to levels less than ... 40-fold interindividual variability observed for this enzyme. In the case of CYP2B6, the activity of the enzyme is extremely ...http://dmd.aspetjournals.org/content/28/6/664.long