*  Antagonistic Effect of Aclarubicin on Daunorubicin-induced Cytotoxicity in Human Small Cell Lung Cancer Cells: Relationship to...
Finally, the effect of daunorubicin on the DNA cleavage activity of purified topoisomerase II in the presence and absence of ... Aclarubicin had no influence on the accumulation of daunorubicin in these cells. In contrast, the accumulation of daunorubicin ... It was found that daunorubicin stimulated DNA cleavage by topoisomerase II at specific DNA sites. The addition of aclarubicin ... The effect of combinations of the anthracyclines aclarubicin and daunorubicin was investigated in a clonogenic assay using the ...
  http://cancerres.aacrjournals.org/content/51/19/5093
*  Streptomyces isolates - Wikipedia
Daunorubicin is the precursor to idarubicin (Idamycin), epirubicin (Ellence), and zorubicin. Streptomyces is the original ... are being researched for anticancer activity. Most clinical antibiotics were found during the "golden age of antibiotics" ( ... Streptomyces, yielded the medicines doxorubicin (Doxil), daunorubicin (DaunoXome), and streptozotocin (Zanosar). Doxorubicin is ... Nucleotide sequence of three genes and analysis of transcriptional activity". Nucleic Acids Research. 15 (19): 8041-56. doi: ...
  https://en.wikipedia.org/wiki/Streptomyces_isolates
*  Marine Drugs | Free Full-Text | Marine Benthic Cyanobacteria Contain Apoptosis-Inducing Activity Synergizing with Daunorubicin...
Several strains contained activity against AML cells, but not against non-malignant cells like hepatocytes and cardiomyoblasts ... One strain (M44) was particularly promising since its activity counteracted the protective effect of LEDGF/p75 overexpressed in ... Of the 41 marine cyanobacterial strains screened, more than half contained cell death-inducing activity. ... AML cells, acted synergistically with the anthracycline anticancer drug daunorubicin in AML cells, and protected ...
  http://www.mdpi.com/1660-3397/8/10/2659
*  New daunorubicin analog exhibits anticancer activity and overcomes P-gp-mediated drug resistance. | Cancer Research
New daunorubicin analog exhibits anticancer activity and overcomes P-gp-mediated drug resistance.. Lanyan Fang, Guisheng Zhang ... New daunorubicin analog exhibits anticancer activity and overcomes P-gp-mediated drug resistance. ... New daunorubicin analog exhibits anticancer activity and overcomes P-gp-mediated drug resistance. ... New daunorubicin analog exhibits anticancer activity and overcomes P-gp-mediated drug resistance. ...
  http://cancerres.aacrjournals.org/content/66/8_Supplement/1270.1
*  Doxorubicin - Wikipedia
Doxorubicin showed better activity than daunorubicin against mouse tumors, and especially solid tumors. It also showed a higher ... including steps leading to daunorubicin. This was significant because it became clear that all daunorubicin-producing strains ... Daunorubicin is more abundantly found as a natural product because it is produced by a number of different wild type strains of ... Since daunorubicin is produced by fermentation, it would be ideal if the bacteria could complete DXR synthesis more effectively ...
  https://en.wikipedia.org/wiki/Doxorubicin
*  Casazza AM[au] - PubMed - NCBI
Synthesis and antitumour activity of new daunorubicin and adriamycin analogues.. Arcamone F, Bernardi L, Patelli B, Giardino P ... Selective proteolytic activity of the antitumor agent kedarcidin.. Zein N, Casazza AM, Doyle TW, Leet JE, Schroeder DR, Solomon ... Preclinical antitumor activity of orally administered platinum (IV) complexes.. Rose WC, Crosswell AR, Schurig JE, Casazza AM. ... Synthesis, antitumor activity, and cardiac toxicity of new 4-demethoxyanthracyclines.. Penco S, Casazza AM, Franchi G, Barbieri ...
  https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Casazza+AM%5Bau%5D&dispmax=50
*  Browsing Department of Biomedicine by Subject "cancer"
Marine Benthic Cyanobacteria Contain Apoptosis-Inducing Activity Synergizing with Daunorubicin to Kill Leukemia Cells, but not ...
  http://bora.uib.no/handle/1956/934/browse?value=cancer&type=subject
*  Plus it
Coadministration of HG-829 fully restored in vivo antitumor activity of daunorubicin in mice without added toxicity. Functional ... In ABCB1-overexpressing cell lines, HG-829 significantly enhanced cytotoxicity to daunorubicin, paclitaxel, vinblastine, ...
  http://cancerres.aacrjournals.org/content/early/2012/08/03/0008-5472.CAN-12-0743
*  CBR1 - Wikipedia
"Genomic sequence and expression of a cloned human carbonyl reductase gene with daunorubicin reductase activity". Molecular ... Finckh C, Atalla A, Nagel G, Stinner B, Maser E (Jan 2001). "Expression and NNK reducing activities of carbonyl reductase and ... Their data demonstrates that CBR1 expression level and enzyme activity are decreased in pancreatic islets isolated from db/db ... and daunorubicin. Recent studies in human liver cytosols show that an untranslated polymorphism on the 3'UTR region of the CBR1 ...
  https://en.wikipedia.org/wiki/CBR1
*  Marine Drugs | Free Full-Text | Marine Antitumor Drugs: Status, Shortfalls and Strategies | HTML
Marine Benthic Cyanobacteria Contain Apoptosis-Inducing Activity Synergizing with Daunorubicin to Kill Leukemia Cells, but not ... Aplidin, a marine organism-derived compound with potent antimyeloma activity in vitro and in vivo. Cancer Res 2008, 68, 5216- ... They studied the effect of Arenamides A and B on NF-κB activity with stably transfected 293/NF-κB-Luc human embryonic kidney ... 2006) investigated the effect of low molecular weight COS (1-3 kDa) on the activity and expression of MMP-9 in HT1080 cells and ...
  http://www.mdpi.com/1660-3397/8/10/2702/htm
*  Use of Somatic Cell Hybrids to Analyze Role of Specific Enzymes in Daunorubicin Cytotoxicity | Cancer Research
To test whether the activity of daunorubicin reductase or NADPH diaphorase independently influences in vitro daunorubicin- ... whereas daunorubicin reductase activities and NADPH diaphorase isozyme activities differed by more than 100-and 15-fold, ... The in vitro cytotoxicity of daunorubicin was compared in hybrid clones having variable enzyme activities; the concentrations ... Use of Somatic Cell Hybrids to Analyze Role of Specific Enzymes in Daunorubicin Cytotoxicity. Marshall P. Goren, Nahed K. Ahmed ...
  http://cancerres.aacrjournals.org/content/47/7/1924
*  Providers Orders for Life Sustaining Treatment
Daunorubicin exhibits cytotoxic activity through topoisomerase-mediated interaction with DNA, thereby inhibiting DNA ... DAUNORUBICIN, Daunorubicin [Chemical/Ingredient], dnm, rubidomycin, drb, rubomycin, DAUNOrubicin, daunorubicin, RUBOMYCIN C, 5, ... Ontology: Daunorubicin. (C0011015) Definition (NCI) An anthracycline antineoplastic antibiotic with therapeutic effects similar ... Not Translated[Daunorubicin] Spanish. daunorubicina, daunorrubicina (producto), daunorubicina (producto), daunorrubicina, ...
  https://fpnotebook.com/geri/Prevent/PrvdrsOrdrsFrLfSstngTrtmnt.htm
*  PEPD - Wikipedia
Muszyńska A, Pałka J, Gorodkiewicz E (May 2000). "The mechanism of daunorubicin-induced inhibition of prolidase activity in ... Şen V, Uluca Ü, Ece A, Kaplan İ, Bozkurt F, Aktar F, Bağlı S, Tekin R (Nov 2014). "Serum prolidase activity and oxidant- ... Serum prolidase enzyme activity is also currently being explored as a possible, reliable marker for diseases including chronic ... Furthermore, prolidase activity was found to be abnormal compared to healthy levels in various medical conditions including but ...
  https://en.wikipedia.org/wiki/PEPD
*  Tiludronic acid - DrugBank
Daunorubicin. Daunorubicin may increase the hypocalcemic activities of Tiludronic acid.. Approved. Deferasirox. The risk or ... Proton-transporting atpase activity, rotational mechanism. Specific Function. Catalytic subunit of the peripheral V1 complex of ... GENTAMICIN C1A may increase the hypocalcemic activities of Tiludronic acid.. Experimental. GPX-150. GPX-150 may increase the ... Zorubicin may increase the hypocalcemic activities of Tiludronic acid.. Experimental. Food Interactions. *Do not take aluminum ...
  https://www.drugbank.ca/drugs/DB01133
*  Indian Journal of Pharmaceutical Sciences | Volume 64, Issue 1 | 2002
Liposomal Daunorubicin : Reduced Cardiotoxicity In The Face Of Unaltered Antitumor Activity In Swiss Mice Bearing Fibrosarcoma ... Synthesis And Antitubercular Activity Studies Of Some Unsymmetrical 1,4-Dihydropyridines. H Gaveriya, B Desai, V Vora, A Shah ... Antitumour Activity Of Elephantopus Scaber Linn Against Dalton's Ascitic Lymphoma. B Rajkapoor, B Jayakar, R Anandan ...
  http://www.ijpsonline.com/archive/ijps-volume-64-issue-1-year-2002.html
*  Norman J. Lacayo, MD | Stanford Medicine Profiles
The purpose of this study is to provide data on the activity of a standard daunorubicin, cytarabine, and etoposide (ADE) ... Cyclosporine inhibited ATPase activity in both cell types, whereas the cyclosporin D analog valspodar (PSC 833), vinblastine, ... In addition, Phe(335) in transmembrane 6 may play a role in coupling drug binding to ATPase activity. The deletion of Phe(335) ... High-dose araC (HD-araC) was used in the second induction cycle instead of the intensification cycle, and 1 of 4 daunorubicin- ...
  https://med.stanford.edu/profiles/norman-lacayo
*  Studying Body Mass Index in Younger Patients Who Are Receiving Treatment for High-Risk Acute Lymphoblastic Leukemia - Full Text...
... daunorubicin hydrochloride, and vincristine sulfate activity levels. ... Drug: daunorubicin hydrochloride Drug: prednisolone Drug: prednisone Drug: vincristine sulfate Other: pharmacological study ... Pharmacokinetic parameters of daunorubicin hydrochloride [ Time Frame: Pre-dose, 0.5, 0.75, 1, 2, 4, 8, 12, 24 to 36 hours, and ... Daunorubicin. Anti-Inflammatory Agents. Glucocorticoids. Hormones. Hormones, Hormone Substitutes, and Hormone Antagonists. ...
  https://clinicaltrials.gov/ct2/show/NCT00900445
*  Drug Coupons - Ventolin Hfa Gluten Free
Your daunorubicin, free gluten hfa ventolin way law who used activity tempé. The copd were selected on the warning of shipping ...
  http://www.sunice.sk/catalog/product/view/id/183/category/30/
*  US5955590A - Conjugates of minor groove DNA binders with antisense oligonucleotides - Google Patents
Daunomycin (daunorubicin) and adriamycin and structural analogues: biological activity and mechanism of action. ... Compositions for inhibiting RNA activity US5519126A (en) * 1988-03-25. 1996-05-21. University Of Virginia Alumni Patents ... Sterol modified oligonucleotide duplexes having anticancer activity US5969116A (en) 1999-10-19. Nucleosides and ... Synthesis, hybridization properties and antiviral activity of lipid-oligodeoxynucleotide conjugates. US5637683A (en) 1997-06-10 ...
  https://patents.google.com/patent/US5955590
*  Plus it
A, P-gp and BCRP R482 mutant ATPase activities in the absence or presence of 200 μM daunorubicin. The basal ATPase activities ... B, the inhibitory effects of CsA on daunorubicin-stimulated P-gp and BCRP mutant ATPase activities. Daunorubicin was tested at ... The basal ATPase activities of P-gp and BCRP mutant were 3.8 and 37.4 nmol/min/mg. Daunorubicin at a concentration of 200 μM ... In the presence of 200 μM daunorubicin, the ATPase activities of P-gp and BCRP mutant were increased to 9.8 and 90.4 nmol/min/ ...
  http://dmd.aspetjournals.org/content/35/4/576
*  NYOH - Drug Dictionary
Daunorubicin exhibits cytotoxic activity through topoisomerase-mediated interaction with DNA, thereby inhibiting DNA ... This inhibits the activity of the NS5A protein and results in the disruption of the viral RNA replication complex, blockage of ... Dabrafenib selectively binds to and inhibits the activity of B-raf, which may inhibit the proliferation of tumor cells which ... A highly diluted solution of sodium hypochlorite (0.5% w/v) with topical anti-infective activity. Dakin's solution is used as ...
  http://newyorkoncology.com/disease-drug-info/drug-dictionary/D/
*  Identification of caspase 3 motifs and critical aspartate residues in human Phospholipase D1b and Phopsholipase D2a - WRAP:...
phospholipase D activity and ceramide production in daunorubicin-induced apoptosis. in A-431 cells. Biochimica et Biophysica ... 1998). Increased activity of oleate-dependent type phospholipase D during. actinomycin D-induced apoptosis in Jurkat T cells. ... 1998). Decreased phospholipase D activity in ceramide-induced apoptosis of human. keratinocyte cell line HaCaT. Journal of ... phospholipase D1 is required for its catalytic activity. Journal of Biological. Chemistry 273, pp34679-34682 ...
  http://wrap.warwick.ac.uk/106/
*  Abelcet (amphotericin B lipid complex) dose, indications, adverse effects, interactions... from PDR.net
Daunorubicin Liposomal: (Minor) Amphotericin B can reduce cell resistance to daunorubicin, thus enhancing its activity. ... Daunorubicin Liposomal; Cytarabine Liposomal: (Minor) Amphotericin B can reduce cell resistance to daunorubicin, thus enhancing ... its activity. Amphotericin B can alter cell membranes, which could otherwise impede daunorubicin's entry into the cell. How ... ABLC has demonstrated activity in animal models against Aspergillus fumigatus, Blastomyces species, Candida albicans, Candida ...
  http://m.pdr.net/drug-summary/Abelcet-amphotericin-B-lipid-complex-539
*  Activation Approaches on Delivery of Imaging and Therapeutic Agents | Springer for Research & Development
... and antitumor activity of oxime bond-linked daunorubicin-GnRH-III bioconjugates and DNA-binding properties of daunorubicin- ... Huan M, Zhang B, Teng Z, Cui H, Wang J, Liu X, Xia H, Zhou S et al (2012) In vitro and in vivo antitumor activity of a novel pH ... Lim SH, Jeong YI, Moon KS, Ryu HH, Jin YH, Jin SG, Jung TY, Kim IY et al (2010) Anticancer activity of PEGylated matrix ... Indira Chandran V, Matesic L, Locke JM, Skropeta D, Ranson M, Vine KL (2012) Anti-cancer activity of an acid-labile N- ...
  https://rd.springer.com/chapter/10.1007/978-1-4471-4372-7_26
*  Novantrone (mitoxantrone) Chemotherapy, Side Effects - Navigating Care
These tests may include an electrocardiogram (ECG; test that records the electrical activity of the heart) and an ... your doctor and pharmacist if you are taking or have ever received certain cancer chemotherapy medications such as daunorubicin ...
  https://www.navigatingcare.com/chemotherapy_drugs/mitoxantrone