Cilastatin - Wikipedia
Cilastatin itself does not have antibiotic activity although it has been proved to be active against a zinc-dependent beta- ... lactamase that usually confer antibiotic resistance to certain bacteria; more precisely the carbapenem family of antibiotics. ...https://en.wikipedia.org/wiki/Cilastatin
Restoring the activity of carbapenem antibiotics - UniQuest - The University of Queensland, Australia
These inhibitors have the potential to be used as an adjuvant with carbapenem antibiotics to restore the activity of ... The emergence of Carbapenem-resistant Enterobacteriaceae (CRE) is one of the most significant and urgent threats to global ... These MBL inhibitors have the potential to prolong the use of carbapenem antibiotics and address the urgent threat of CRE. ... CRE strains that have acquired and expressed genes encoding for extended-spectrum β-lactamases with carbapenemase activity have ...https://www.uniquest.com.au/restoring-activity-of-carbapenem-antibiotics
Superbugs & Superdrugs USA : Pharmaceuticals : North America
13:30 TP-6076: A novel fluorocycline antibiotic with potent activity against carbapenem-resistant Gram (-) organisms. ... As a formal provider of CPD certified activities, SMI Group can provide an indication of the learning benefit gained and the ... Activity will be discussed in multiple animal models when used in both prophylaxis and treatment indications ... Increasingly, employers also expect their staff to undertake regular CPD activities. Undertaken over a period of time, CPD ...http://www.smi-online.co.uk/pharmaceuticals/northamerica/conference/superbugs-superdrugs-usa?o=login&dl=br&p1=5262&p2=906
Anticipating the Unpredictable: A Review of Antimicrobial Stewardship and Acinetobacter Infections | SpringerLink
Comparative activity of carbapenem testing: the COMPACT study. J Antimicrob Chemother. 2011;66:1070-8.PubMedCrossRefGoogle ... Activity of BAL30072 alone or combined with beta-lactamase inhibitors or with meropenem against carbapenem-resistant ... In vitro activities of carbapenem/sulbactam combination, colistin, colistin/rifampicin combination and tigecycline against ... negative activity . Against tigecycline and carbapenem-resistant AB from the UK, eravacycline MICs were approximately ...https://link.springer.com/article/10.1007%2Fs40121-017-0149-y
Health - UniQuest - The University of Queensland, Australia
Restoring the activity of carbapenem antibiotics. MBL inhibitors with the potential to be developed as an adjuvant to enhance ... Potent and minimally cytotoxic small molecule antibiotics for the treatment of Carbapenem-resistant infections from Gram- ... identified adjuvants which can re-sensitise tetracycline-resistant strains of group A streptococcus and restore its activity in ...https://www.uniquest.com.au/taxonomy/term/3081
IJMS | Free Full-Text | Isojacareubin from the Chinese Herb Hypericum japonicum: Potent Antibacterial and Synergistic Effects...
These in vitro anti-MRSA activities of ISJ alone and its synergy with conventional antibacterial agents demonstrated that ISJ ... Combined bactericidal activities were also observed in the time-kill dynamic assay. The results showed the ability of ISJ to ... Epigallocatechin gallate synergistically enhances the activity of carbapenems against methicillin resistant Staphylococcus ... Combined bactericidal activities were also observed in the time-kill dynamic assay. The results showed the ability of ISJ to ...http://www.mdpi.com/1422-0067/13/7/8210/htm
IJMS | Free Full-Text | The Combination of Catechin and Epicatechin Gallate from Fructus Crataegi Potentiates β-Lactam...
Two-fold dilution and checkerboard methods were used to analyze antibacterial activity and screen for the combination and ... were isolated from the hawthorn under the guide of antibacterial sensitization activity. The bioactivity of the composite ... Epigallocatechin gallate synergistically enhances the activity of carbapenems against methicillin-resistant Staphylococcus ... Gibbons, S.; Udo, E.E. The effect of reserpine, a modulator of multidrug efflux pumps, on the in vitro activity of tetracycline ...http://www.mdpi.com/1422-0067/14/1/1802/htm
Similar articles for PubMed (Select 21088861) - PubMed - NCBI
In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, ... Comparative in vitro activity of carbapenems against major Gram-negative pathogens: results of Asia-Pacific surveillance from ... Antimicrobial activity of doripenem and other carbapenems against gram-negative pathogens from Korea. ... Comparative evaluation of in vitro activities of carbapenems against gram-negative pathogens: Turkish data of COMPACT study]. ...https://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed&from_uid=21088861
MecA (gene) - Wikipedia
"Chemical genetic identification of peptidoglycan inhibitors potentiating carbapenem activity against methicillin-resistant ... This enables transpeptidase activity in the presence of beta-lactams, preventing them from inhibiting cell wall synthesis. ... Furthermore, PBP2a has an effective transpeptidase activity, but lacks a transglycosylation domain of PBP2, which builds the ...https://en.wikipedia.org/wiki/MecA_(gene)
Patent US5147867 - Phosphorus containing enzyme inhibitors - Google Patents
The compounds have dehydropeptidase (DHP) enzyme inhibitor activity. ... potentiate the antibiotic activity of carbapenem antibiotics. Renal dehydropeptidase activity was first described by M. ... By the term "carbapenem" or "penem" antibiotic as used herein is meant those carbapenems and penems which are known in the art ... phosphinic acids which display antibacterial activity and potentiate carbapenem antibiotics.. With this background, the search ...http://www.google.com/patents/US5147867?dq=7800613
Role of renal function in risk assessment of target non-attainment after standard dosing of meropenem in critically ill...
Comparative Activity of Carbapenem Testing (COMPACT) study in Germany. Int J Antimicrob Agents. 2012;39:255-8.View Article ... meropenem shows time-dependent activity; that is, its antibacterial activity is linked to the percentage of time that meropenem ... The pharmacology of meropenem, a new carbapenem antibiotic. Clin Infect Dis. 1997;24 Suppl 2:S266-75.View ArticlePubMedGoogle ... Pharmacodynamics of carbapenems for the treatment of Pseudomonas aeruginosa ventilator-associated pneumonia: associations with ...https://ccforum.biomedcentral.com/articles/10.1186/s13054-017-1829-4
Plazomicin - Wikipedia
It also demonstrates potent in vitro activity versus carbapenem-resistant Acinetobacter baumannii. In 2012, U.S. Food and Drug ... to treat serious bacterial infections due to multidrug-resistant Enterobacteriaceae, including carbapenem-resistant ... Plazomicin has been reported to demonstrate in vitro synergistic activity when combined with daptomycin or ceftobiprole versus ... "Can Plazomicin Alone or in Combination Be a Therapeutic Option against Carbapenem-Resistant Acinetobacter baumannii?" (PDF). ...https://en.wikipedia.org/wiki/Plazomicin
ORBi: Browsing ORBi
... of residues Ser221 and Asn225 modifies the substrate profile by selectively decreasing the activity against carbapenems. The ... Maximum activity is obtained upon binding of one zinc ion, whereas binding of the second zinc ion results in a drastic decrease ... The activity of H121A is dependent on zinc ion concentration. The H121A monozinc form is less active than the dizinc form, ... Indeed, the optimum activity temperature (70 vs. 60 degrees C) and the apparent Tm were increased by about 9 degrees C, and the ...http://orbi.ulg.ac.be/browse?type=author&value=Devreese%2C+B
Broad-spectrum antibiotics - The Clinical Advisor
Tigecycline provides activity against carbapenem-resistant Acinetobacter baumannii and many Enterobacteriaceae but is not ... Cephalosporin with anti-MRSA activity. Basilea. dalbavancin. Lipoglycopeptide with MRSA activity and long half life permitting ... Similar to imipenem and meropenem, the anti-Gram-negative activity of doripenem includes P. aeruginosa, A. baumannii, and ESBL/ ... Glycopeptide with activity against VRE and VISA/hVISA. The Medicines Company. PTK 0796. Aminomethylcycline, an orally ...http://www.clinicaladvisor.com/hospital-infection-control/broad-spectrum-antibiotics/article/598528/
Bacterial Sepsis Medication: Antibiotics, Other
Meropenem is a carbapenem with slightly increased activity against gram-negative organisms and slightly decreased activity ... Imipenem-cilastatin is a carbapenem with activity against most gram-positive organisms (except MRSA), gram-negative organisms, ... Clindamycin is primarily used for its activity against anaerobes. It has some activity against Streptococcus species and ... It is active against gram-negative bacilli but has very limited gram-positive activity and is not useful for anaerobes. ...https://emedicine.medscape.com/article/234587-medication
Treatment Options for Carbapenem-Resistant Gram-Negative Infections (21.05.2018)
Oliva A, Gizzi F, Mascellino MT, et al.: Bactericidal and synergistic activity of double-carbapenem regimen for infections ... Oliva A, Gizzi F, Mascellino MT, et al.: Bactericidal and synergistic activity of double-carbapenem regimen for infections ... Carbapenems. At minimum inhibitory concentration (MIC) just within the realm of resistance, a high-dose carbapenem may still ... Combination of two carbapenems. The findings of non-controlled case series suggest that combinations of two carbapenems ( ...https://www.aerzteblatt.de/int/archive/article?id=197994
Carbapenem-resistant enterobacteriaceae - Wikipedia
Carbapenem covalently binds to PBPs, which causes transpeptidases to irreversibly lose their catalytic activity. Inhibition of ... In vitro studies have shown that rifampin has synergistic activity against carbapenem-resistant E. coli and K. pneumoniae. ... Carbapenem-resistant Enterobacteriaceae (CRE) have been defined as carbapenem-nonsusceptible and extended-spectrum ... Using another antibiotic concomitantly with carbapenem can help prevent the development of carbapenem resistance. One specific ...https://en.wikipedia.org/wiki/Carbapenem-resistant_enterobacteriaceae
Epidemiology of Multi-Drug Resistant Organisms in a Teaching Hospital in Oman: A One-Year Hospital-Based Study
... also investigated the in vitro activity of carbapenems, piperacillin-tazobactam, and ciprofloxacin alone or in combination with ... A. M. Somily, "Comparison of E-test and disc diffusion methods for the in vitro evaluation of the antimicrobial activity of ... A. M. Somily, A. S. Al-Khattaf, and A. M. Kambal, "Antimicrobial activity of tigecycline against bacterial isolates from ... Centers for Disease Control and Prevention, "Vital signs: carbapenem-resistant enterobacteriaceae," Morbidity and Mortality ...https://www.hindawi.com/journals/tswj/2014/157102/
Bacterial zincophore [S,S]-ethylenediamine-N,N′-disuccinic acid is an effective inhibitor of MBLs, Journal of Antimicrobial...
... as well as carbapenem-resistant MBL-negative Enterobacteriaceae and A. baumannii. The activity (MIC) of imipenem alone and in ... c) Influence of ZnCl2 on the enzymatic activity of recombinant NDM-1, determined by a fluorescence-based activity assay. The ... c) Influence of ZnCl2 on the enzymatic activity of recombinant NDM-1, determined by a fluorescence-based activity assay. The ... c) Influence of ZnCl2 on the enzymatic activity of recombinant NDM-1, determined by a fluorescence-based activity assay. The ...https://www.deepdyve.com/lp/ou_press/bacterial-zincophore-s-s-ethylenediamine-n-n-disuccinic-acid-is-an-9pWiB8FZcS
Epidemiology of NDM-1 and its Variants in Multidrug Resistant Gram-Negative Bacilli Isolated from Infection in Cancer Patients
... and possessed increased hydrolytic activity toward carbapenems and several cephalosporins compared to that of NDM-1. This amino ... is mostly resistant to the drug of last resort the class of carbapenems. The increase in extended spectrum carbapenem ... Rampant use of antibiotics has unfortunately led to increasing resistance to the carbapenems as well, and this is generally due ... reported 24 consecutive carbapenem resistant Enterobacteriaceae isolates from patients admitted in a tertiary care hospital in ...https://www.omicsonline.org/open-access/epidemiology-of-ndm1-and-its-variants-in-multidrug-resistant-gramnegative-bacilli-isolated-from-infection-in-cancer-patients-2161-0444-1000482-97258.html
CiNii 論文 - CP6679, a new injectable cephalosporin with broad spectrum and potent activities...
Antimicrobial activity of SM-17466, a novel carbapenem antibiotic with potent activity against methicillin-resistant ... CP5068, a new carbapenem : in vitro and in vivo activities against MRSA IDA T ... In Vitro and in vivo antistaphylococcal activities of L-695256, a carbapenem with high affinity for the penicillin-binding ... In vitro activities of novel trans-3,5-disubstituted pyrrolidinylthio-1β-methylcarbapenems with potent activities against ...https://ci.nii.ac.jp/naid/10013892541
MALDI-TOF mass spectrometry technology for detecting biomarkers of antimicrobial resistance: current achievements and future...
Hrabák et al. described an innovative method that detects degradation products of carbapenems from the activity of carbapenem ... coli was carbapenem susceptible, eight were resistant or with reduced susceptibility against carbapenem, one strain of K. ... using MALDI-TOF method (69). They used 5 carbapenem susceptible isolates of K. pneumoniae and 7 carbapenem resistant in their ... Detection of carbapenemase activity using VITEK MS: interplay of carbapenemase type and period of incubation. J Med Microbiol ...http://atm.amegroups.com/article/view/19972/html
JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Background: Biapenem is a parenteral carbapenem antibiotic that has powerful antibacterial activity. The aim of this study is ... Furthermore, activity-dependent GABAergic PV FS pyramidal neuron transmission was decreased, whereas activity of pyramidal ... and nitrate reductase activity. Such similar trend between OCP biodegradation and soil-denitrifying activities suggests a close ... Moreover, the addition of nitrate and MCD also obtained the highest values of soil microbial activities, including soil ...https://www.jove.com/visualize?author=Li%20Mao%20
INVANZ is a broad-spectrum, injectable, carbapenem antibiotic with activity against gram-positive, gram-negative, and anaerobic ...http://www.lymphedemapeople.com/wiki/doku.php?id=glossary:invanz
Enterobacter Infections Medication: Antibiotics
Carbapenems continue to have the best activity against E cloacae, E aerogenes, and other Enterobacter species.  They are ... Carbapenem antibiotic. Doripenem is a new alternative choice. Has spectrum of activity similar to that of imipenem and ... Carbapenem of choice for meningitis and for patients at risk for seizures. Bactericidal broad-spectrum carbapenem antibiotic ... Fluoroquinolone with good activity against pseudomonads and most gram-negative organisms, but no activity against anaerobes. ...https://emedicine.medscape.com/article/216845-medication