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*  Cilastatin - Wikipedia
Cilastatin itself does not have antibiotic activity although it has been proved to be active against a zinc-dependent beta- ... lactamase that usually confer antibiotic resistance to certain bacteria; more precisely the carbapenem family of antibiotics. ...
  https://en.wikipedia.org/wiki/Cilastatin
*  Restoring the activity of carbapenem antibiotics - UniQuest - The University of Queensland, Australia
These inhibitors have the potential to be used as an adjuvant with carbapenem antibiotics to restore the activity of ... The emergence of Carbapenem-resistant Enterobacteriaceae (CRE) is one of the most significant and urgent threats to global ... These MBL inhibitors have the potential to prolong the use of carbapenem antibiotics and address the urgent threat of CRE. ... CRE strains that have acquired and expressed genes encoding for extended-spectrum β-lactamases with carbapenemase activity have ...
  https://www.uniquest.com.au/restoring-activity-of-carbapenem-antibiotics
*  Antimicrobial activity of DU-6681a, a parent compound of novel oral carbapenem DZ-2640. - Semantic Scholar
DU-6681a activity was not affected by different media, varied inoculum size (10(4) to 10(7) CFU), or the addition of human ... as was the activity of the other antibiotics tested. The frequency of spontaneous resistance to DU-6681a was less than or equal ... The in vitro antibacterial activity of DU-6681a, a parent compound of DZ-2640, against gram-positive and -negative bacteria was ... In vitro activity of a new carbapenem antibiotic, BO-2727, with potent antipseudomonal activity.. *Susumu Nakagawa, Takanori ...
  https://www.semanticscholar.org/paper/Antimicrobial-activity-of-DU-6681a%2C-a-parent-of-Tanaka-Hohmura/48b9b451a03e9c3b791fe16bb24ee2ab48dcbfa3
*  Activity of colistin alone or in combination with rifampicin or meropenem in a carbapenem-resistant bioluminescent Pseudomonas...
Activity of colistin alone or in combination with rifampicin or meropenem in a carbapenem-resistant bioluminescent Pseudomonas ...
  https://insights.ovid.com/pubmed?PMID=29149302
*  Superbugs & Superdrugs USA : Pharmaceuticals : North America
13:30 TP-6076: A novel fluorocycline antibiotic with potent activity against carbapenem-resistant Gram (-) organisms. ... As a formal provider of CPD certified activities, SMI Group can provide an indication of the learning benefit gained and the ... Activity will be discussed in multiple animal models when used in both prophylaxis and treatment indications ... Increasingly, employers also expect their staff to undertake regular CPD activities. Undertaken over a period of time, CPD ...
  http://www.smi-online.co.uk/pharmaceuticals/northamerica/conference/superbugs-superdrugs-usa?o=login&dl=br&p1=5262&p2=906
*  Anticipating the Unpredictable: A Review of Antimicrobial Stewardship and Acinetobacter Infections | SpringerLink
Comparative activity of carbapenem testing: the COMPACT study. J Antimicrob Chemother. 2011;66:1070-8.PubMedCrossRefGoogle ... Activity of BAL30072 alone or combined with beta-lactamase inhibitors or with meropenem against carbapenem-resistant ... In vitro activities of carbapenem/sulbactam combination, colistin, colistin/rifampicin combination and tigecycline against ... negative activity [145]. Against tigecycline and carbapenem-resistant AB from the UK, eravacycline MICs were approximately ...
  https://link.springer.com/article/10.1007%2Fs40121-017-0149-y
*  Structure, Genetics and Worldwide Spread of New Delhi Metallo-β-lactamase (NDM): a threat to public health | BMC Microbiology |...
... are important to understand the mechanism of antibiotic hydrolysis as well as to design new molecules with inhibitory activity ... NDM-1 hydrolyzes a wide range of β-lactam antibiotics, including carbapenems, which are the last resort of antibiotics for the ... Carbapenem hydrolysing activity was gradually reduced from NDM-7 to NDM-5, NDM-6 and NDM-1. All isolates positive for variants ... Carbapenem activities against Pseudomonas aeruginosa: respective contributions of OprD and efflux systems. Antimicrob Agents ...
  https://bmcmicrobiol.biomedcentral.com/articles/10.1186/s12866-017-1012-8
*  Plus it
Activity of carbapenems combined with clavulanate against murine tuberculosis. Antimicrob Agents Chemother 2011; 55: 2597-2600. ... It marked the potential of carbapenems as group 5 drugs; however, carbapenems are still in need of proper evaluation and ... One promising group of antimicrobial drugs is carbapenems. Ertapenem is an attractive carbapenem for the treatment of MDR- and ... Ertapenem: the new carbapenem 5 years after first FDA licensing for clinical practice. Expert Opin Pharmacother 2007; 8: 237- ...
  https://erj.ersjournals.com/content/early/2016/01/07/13993003.01654-2015
*  Health - UniQuest - The University of Queensland, Australia
Restoring the activity of carbapenem antibiotics. MBL inhibitors with the potential to be developed as an adjuvant to enhance ... Potent and minimally cytotoxic small molecule antibiotics for the treatment of Carbapenem-resistant infections from Gram- ... identified adjuvants which can re-sensitise tetracycline-resistant strains of group A streptococcus and restore its activity in ...
  https://www.uniquest.com.au/taxonomy/term/3081
*  IJMS | Free Full-Text | Isojacareubin from the Chinese Herb Hypericum japonicum: Potent Antibacterial and Synergistic Effects...
These in vitro anti-MRSA activities of ISJ alone and its synergy with conventional antibacterial agents demonstrated that ISJ ... Combined bactericidal activities were also observed in the time-kill dynamic assay. The results showed the ability of ISJ to ... Epigallocatechin gallate synergistically enhances the activity of carbapenems against methicillin resistant Staphylococcus ... Combined bactericidal activities were also observed in the time-kill dynamic assay. The results showed the ability of ISJ to ...
  http://www.mdpi.com/1422-0067/13/7/8210/htm
*  IJMS | Free Full-Text | The Combination of Catechin and Epicatechin Gallate from Fructus Crataegi Potentiates β-Lactam...
Two-fold dilution and checkerboard methods were used to analyze antibacterial activity and screen for the combination and ... were isolated from the hawthorn under the guide of antibacterial sensitization activity. The bioactivity of the composite ... Epigallocatechin gallate synergistically enhances the activity of carbapenems against methicillin-resistant Staphylococcus ... Gibbons, S.; Udo, E.E. The effect of reserpine, a modulator of multidrug efflux pumps, on the in vitro activity of tetracycline ...
  http://www.mdpi.com/1422-0067/14/1/1802/htm
*  MecA (gene) - Wikipedia
"Chemical genetic identification of peptidoglycan inhibitors potentiating carbapenem activity against methicillin-resistant ... This enables transpeptidase activity in the presence of beta-lactams, preventing them from inhibiting cell wall synthesis. ... Furthermore, PBP2a has an effective transpeptidase activity, but lacks a transglycosylation domain of PBP2, which builds the ...
  https://en.wikipedia.org/wiki/MecA_(gene)
*  Efficacy of Apramycin against Multidrug-Resistant Acinetobacter baumannii in the Murine Neutropenic Thigh Model | Antimicrobial...
Evaluation of apramycin activity against carbapenem-resistant and -susceptible strains of Enterobacteriaceae. Diagn Microbiol ... Activity of aminoglycosides, including ACHN-490, against carbapenem-resistant Enterobacteriaceae isolates. J Antimicrob ... In vitro activity of neomycin, streptomycin, paromomycin and apramycin against carbapenem-resistant Enterobacteriaceae clinical ... In vitro apramycin activity against multidrug-resistant Acinetobacter baumannii and Pseudomonas aeruginosa. Diagn Microbiol ...
  https://aac.asm.org/content/62/4/e02585-17
*  Similar articles for PubMed (Select 21088861) - PubMed - NCBI
In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, ... Comparative in vitro activity of carbapenems against major Gram-negative pathogens: results of Asia-Pacific surveillance from ... Antimicrobial activity of doripenem and other carbapenems against gram-negative pathogens from Korea. ... Comparative evaluation of in vitro activities of carbapenems against gram-negative pathogens: Turkish data of COMPACT study]. ...
  https://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed&from_uid=21088861
*  Patent US5147867 - Phosphorus containing enzyme inhibitors - Google Patents
The compounds have dehydropeptidase (DHP) enzyme inhibitor activity. ... potentiate the antibiotic activity of carbapenem antibiotics. Renal dehydropeptidase activity was first described by M. ... By the term "carbapenem" or "penem" antibiotic as used herein is meant those carbapenems and penems which are known in the art ... phosphinic acids which display antibacterial activity and potentiate carbapenem antibiotics.. With this background, the search ...
  http://www.google.com/patents/US5147867?dq=7800613
*  Plazomicin - Wikipedia
It also demonstrates potent in vitro activity versus carbapenem-resistant Acinetobacter baumannii. In 2012, U.S. Food and Drug ... to treat serious bacterial infections due to multidrug-resistant Enterobacteriaceae, including carbapenem-resistant ... Plazomicin has been reported to demonstrate in vitro synergistic activity when combined with daptomycin or ceftobiprole versus ... "Can Plazomicin Alone or in Combination Be a Therapeutic Option against Carbapenem-Resistant Acinetobacter baumannii?" (PDF). ...
  https://en.wikipedia.org/wiki/Plazomicin
*  Role of renal function in risk assessment of target non-attainment after standard dosing of meropenem in critically ill...
Comparative Activity of Carbapenem Testing (COMPACT) study in Germany. Int J Antimicrob Agents. 2012;39:255-8.View Article ... meropenem shows time-dependent activity; that is, its antibacterial activity is linked to the percentage of time that meropenem ... The pharmacology of meropenem, a new carbapenem antibiotic. Clin Infect Dis. 1997;24 Suppl 2:S266-75.View ArticlePubMedGoogle ... Pharmacodynamics of carbapenems for the treatment of Pseudomonas aeruginosa ventilator-associated pneumonia: associations with ...
  https://ccforum.biomedcentral.com/articles/10.1186/s13054-017-1829-4
*  Broad-spectrum antibiotics - Renal and Urology News
Tigecycline provides activity against carbapenem-resistant Acinetobacter baumannii and many Enterobacteriaceae but is not ... Cephalosporin with anti-MRSA activity. Basilea. dalbavancin. Lipoglycopeptide with MRSA activity and long half life permitting ... Similar to imipenem and meropenem, the anti-Gram-negative activity of doripenem includes P. aeruginosa, A. baumannii, and ESBL/ ... Glycopeptide with activity against VRE and VISA/hVISA. The Medicines Company. PTK 0796. Aminomethylcycline, an orally ...
  https://www.renalandurologynews.com/hospital-infection-control/broad-spectrum-antibiotics/article/598530/
*  ORBi: Browsing ORBi
... of residues Ser221 and Asn225 modifies the substrate profile by selectively decreasing the activity against carbapenems. The ... Maximum activity is obtained upon binding of one zinc ion, whereas binding of the second zinc ion results in a drastic decrease ... The activity of H121A is dependent on zinc ion concentration. The H121A monozinc form is less active than the dizinc form, ... Indeed, the optimum activity temperature (70 vs. 60 degrees C) and the apparent Tm were increased by about 9 degrees C, and the ...
  http://orbi.ulg.ac.be/browse?type=author&value=Devreese%2C+B
*  Superbugs & Superdrugs 2019 : Pharmaceuticals : UK
The combination of azidothymidine (AZT) and low-dose colistin shows synergistic antibiotic activity against carbapenem and ... Activity in multiple animal models - in both prophylaxis and treatment indications. • Measuring activity against biofilms • ... 15:15 Activity of Ibrexafungerp in murine models of pneumocystis pneumonia. Stephen Barat, Head of Pre-Clinical and Early ... Potent in vitro activity for dermatophyte species and in vivo efficacy in the topical treatment of experimental dermatophytosis ...
  http://www.smi-online.co.uk/pharmaceuticals/uk/conference/superbugs-superdrugs/
*  Molecular Epidemiology and Genome Dynamics of New Delhi Metallo-β-Lactamase-Producing Extraintestinal Pathogenic Escherichia...
... isolated in a Chinese Hospital possesses increased enzymatic activity against carbapenems. Antimicrob Agents Chemother 59:2450- ... MIC values of carbapenem-resistant strains, meropenem transconjugants, a recipient strain, and non-ESBL non-carbapenem- ... Carbapenem-resistant Enterobacteriaceae: epidemiology and prevention. Clin Infect Dis 53:60-67. doi:10.1093/cid/cir202. ... Treatment options for carbapenem-resistant Enterobacteriaceae infections. Open Forum Infect Dis 2:ofv050. doi:10.1093/ofid/ ...
  https://aac.asm.org/content/60/11/6795
*  Stability of Novel Siderophore Cephalosporin S-649266 against Clinically Relevant Carbapenemases | Antimicrobial Agents and...
These CHDLs show weak hydrolysis activity against carbapenems, while increased expression by the ISAba gene insertion sequence ... The antibacterial activity of S-649266 against global clinical isolates carrying various β-lactamases is shown in Table 1 (see ... S-649266 shows potent antibacterial activity against bacteria that produce a wide variety of β-lactamases, including class B as ... To elucidate the contribution of β-lactamase stability of S-649266 to its potent antibacterial activity, the kinetic parameters ...
  https://aac.asm.org/content/60/7/4384
*  Bacterial Sepsis Medication: Antibiotics, Other
Meropenem is a carbapenem with slightly increased activity against gram-negative organisms and slightly decreased activity ... Imipenem-cilastatin is a carbapenem with activity against most gram-positive organisms (except MRSA), gram-negative organisms, ... Clindamycin is primarily used for its activity against anaerobes. It has some activity against Streptococcus species and ... It is active against gram-negative bacilli but has very limited gram-positive activity and is not useful for anaerobes. ...
  https://emedicine.medscape.com/article/234587-medication
*  Acinetobacter species - Infectious Disease and Antimicrobial Agents
... has attracted attention for its in vitro activity and synergistic effect with carbapenems (136) and its clinical activity ... In vitro activity of colistin or sulbactam in combination with fosfomycin or imipenem against clinical isolates of carbapenem- ... Tigecycline was found to have good in vitro activity against carbapenem-resistant A. baumannii isolates. Clinical reports have ... carbapenems, or fluoroquinolones. Although aminoglycosides may show moderate activity against A. baumannii in vitro and in vivo ...
  http://www.antimicrobe.org/b71.asp