Human anti-nucleolin recombinant immunoagent for cancer therapy. - Semantic Scholar
... and it abrogates the biogenesis of NCL-dependent miRNAs. Binding of 4LB5 to NCL on the cell surface of a variety of breast ... the first anti-NCL single-chain fragment variable displaying antineoplastic activity against established solid tumors, which ... This immunoagent binds NCL on the cell surface, it is translocated into the cytoplasm of target cells, ... cancer and hepatocellular carcinoma cell lines, but not to normal-like MCF-10a breast cells, dramatically reduces cancer cell ...https://www.semanticscholar.org/paper/Human-anti-nucleolin-recombinant-immunoagent-for-Palmieri-Richmond/3781116b28ec94f2b11a75fd11f460859e583d91
Heterogeneous neutralizing antibody and antibody-dependent cell cytotoxicity responses in HIV-1 elite controllers
FcγR-mediated antiviral activities, antibody-dependent cell cytotoxicity (ADCC), as well as autoantibody levels, were ... Heterogeneous neutralizing antibody and antibody-dependent cell cytotoxicity responses in HIV-1 elite controllers. ... Neutralizing Antibody (nAb) activities (neutralization assay, competition with broadly reactive monoclonal antibodies, and ... Regardless of the type of antibody tested, there was no correlation with HIV-specific CD8 T cell responses. ADCC was detectable ...https://insights.ovid.com/crossref?an=00002030-200905150-00004
Fc gamma receptors: glycobiology and therapeutic prospects | JIR
... for its interaction with the immune system and induction of effector activities such as antibody-dependent cell cytotoxicity, ... as IgG-based antibodies are currently the only therapeutic antibody-based products on the market. In addition, FcγRs as ... and developments in antibody-drug conjugates and bispecific antibodies continue to enhance treatment options for patients. ... Communication of IgG antibodies with the immune system is controlled and mediated by Fc gamma receptors (FcγRs), membrane-bound ...https://www.dovepress.com/fc-gamma-receptors-glycobiology-and-therapeutic-prospects-peer-reviewed-article-JIR
It also lowered thyroid antibody secretory levels and the antibody-dependent cell-mediated cytotoxicity activities of ... In addition, the action of moxibustion in reducing the secretion of thyroid antibodies was found to be related to its action of ... Moxibustion reduced thyroid antibodies in the blood of patients with hypothyroidism leading to improved thyroid function. ... Analytical cookies which allow anonymous analysis of the behavior of web users and allow to measure user activity and develop ...https://www.acupuncture.org.uk/a-to-z-of-conditions/a-to-z-of-conditions/thyroid-disease.html
Characterization of ASKP1240, a Fully Human Antibody Targeting Human CD40 With Potent Immunosuppressive Effects
Antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) activities of 100. µg/mL of ... antibody-dependent cell-mediated cytotoxicity. CDC. complement-dependent cytotoxicity. DCs. dendritic cells. DTH. delayed-type ... This is an IgG4 masking antibody that shows neither antibody-dependent cell-mediated cytotoxicity (ADCC) nor complement- ... µg/mL indicated antibodies: ASKP1240, human isotype antibody, mu5C8 (ATCC) or mouse isotype antibody. The antibody-treated ...http://pubmedcentralcanada.ca/pmcc/articles/PMC4225473/
The Controversial Role of Microglia in Malignant Gliomas
... antibody-dependent cell mediated cytotoxicity (ADCC) has also been shown to be involved in microglia anti-tumor activities. ... M1 cells have high anti-microbial activity, immune stimulatory functions and tumor cytotoxicity and express the signal ... W. Jia, C. Jackson-Cook, and M. R. Graf, "Tumor-infiltrating, myeloid-derived suppressor cells inhibit T cell activity by ... A. Sutter, A. Hekmat, and G. A. Luckenbach, "Antibody-mediated tumor cytotoxicity of microglia," Pathobiology, vol. 59, no. 4, ...https://www.hindawi.com/journals/jir/2013/285246/
Genentech: Valerie Quarmby | Staff Scientist and Director, BioAnalytical Sciences
Characterization of in vitro antibody-dependent cell-mediated cytotoxicity activity of therapeutic antibodies - Impact of ... reducing effects in a humanized antibody on Fcγ receptor binding and antibody-dependent cell-mediated cytotoxicity activities ... A host-cell protein impurity in therapeutic monoclonal antibodies derived from chinese hamster ovary cells ... Development and optimization of a cell-based neutralizing antibody assay using a sample pre-treatment step to eliminate serum ...https://www.gene.com/scientists/our-scientists/valerie-quarmby
ASCO Report (2016) - Assessing biomarker responses in Immunotherapy treatment | | Phacilitate
... of antitumor activity of cetuximab is based on antibody-dependent cell mediated cytotoxicity mediated by natural killer cells. ... Different antibodies, different staining protocols, different target cell assessment (tumour cells, tumour-infiltrating immune ... Researchers used immunohistochemistry in tumor cells alone (tumor proportions score) or with inflammatory cells (combined ... on tumor cells and inflammatory cells may predict which patients with recurrent or metastatic head and neck squamous cell ...https://www.phacilitate.co.uk/article/asco-report-2016-assessing-biomarker-responses-immunotherapy-treatment
Roche - Pipeline
Its therapeutic activity in pre-clinical models was shown to take place via antibody-dependent cell-mediated cytotoxicity (ADCC ... ERY974 is a bispecific antibody designed to elicit T cell activation and T cell-dependent cellular cytotoxicity by ... is a humanised full-length T cell-dependent bispecific antibody designed to target both CD20 on B cells and CD3 on T cells. ... The antibody induces T cell-driven tumor killing by activation of CD40 on antigen-presenting cells which in turn prime T cells ...https://www.roche.com/research_and_development/who_we_are_how_we_work/pipeline.htm
Endocrine Immune Interactions in the Host-Parasite Relationship: Steroid Hormones as Immune Regulators in Parasite Infections ...
In monocytes, P4 inhibits NK cell activity and FcγR expression and reduces antibody-dependent cell cytotoxicity mediated by the ... Dendritic cells. Induce mature DCs. . Lymphocytes. Enhance IL-2 secretion of Th1 cells and cytotoxicity function of T cells ... B cells are grouped into B1 and B2 cells and are responsible for antibody secretion . T cells are categorized into four ... Estrogen induces suppression of natural killer cell cytotoxicity and augmentation of polyclonal B cell activation. Cell Immunol ...https://www.omicsonline.org/open-access/endocrine-immune-interactions-in-the-hostparasite-relationship-steroidhormones-as-immune-regulators-in-parasite-infections-2157-7536-1000165.php?aid=66321
Frontiers | Intracellular Crosslinking of Filoviral Nucleoproteins with Xintrabodies Restricts Viral Packaging | Immunology
Infection of stable Vero cell lines expressing dimeric sdAb specific for either MARV or EBOV NP resulted in smaller plaques and ... Previously, we had generated sdAb (single-domain antibodies) against Filoviruses that have all targeted highly conserved C- ... Previously, we had generated sdAb (single-domain antibodies) against Filoviruses that have all targeted highly conserved C- ... reduced progeny of cognate virus relative to wild-type Vero cells. Though the impact was marginal at later time-points the ...https://www.frontiersin.org/articles/10.3389/fimmu.2017.01197/full
51Cr Release Assay of Antibody‐Dependent Cell‐Mediated Cytotoxicity (ADCC) - Current Protocols
... dependent cell‐mediated cytotoxicity (ADCC) is an immunologic cytotoxic effector mechanism that is dependent on the cooperative ... ADCC against human erythrocyte target cells: Role of the anti‐target cell antibodies in determining lymphocyte killer activity ... Antibody‐dependent cell‐mediated cytotoxicity (ADCC) is an immunologic cytotoxic effector mechanism that is dependent on the ... 51Cr Release Assay of Antibody‐Dependent Cell‐Mediated Cytotoxicity (ADCC). David L. Nelson1, Carole C. Kurman1, Deborah E. ...http://www.currentprotocols.com/WileyCDA/CPUnit/refId-im0727.html
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... natural killer cell activity and antibody-dependent cell cytotoxicity. Septilin's stimulatory effect on the humoral immunity ... increases the antibody forming cells, thereby enhancing the secretion of antibodies into the circulation. Septilin also ... Septilin stimulates phagocytosis by macrophage activation and increases the polymorphonuclear cells and helps overcome ... augments the population of erythropoietic and granulopoietic precursor cells, stab cells and primary. ...http://ushealthworks.net/catalog/Other/Buy-Cheap-Septilin-Online-No-Prescription.htm
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CBT Pharmaceuticals Receives First Australian Ethics Approval to Initiate APOLLO-1 Phase 1/2 Clinical Trial for Hepatocellular...
Receives First Australian Ethics Approval to Initiate APOLLO-1 Phase 1/2 Clinical Trial for Hepatocellular and Renal Cell ... and has a favorable profile with very low antibody-dependent cell-mediated cytotoxicity (ADCC) and complement dependent ... cytotoxicity (CDC) activity. In China, CBT-501 is referred to as GB226 where it is being developed by CBT partner Genor ... CBT-501 is a novel IgG4 humanized monoclonal antibody against the Programmable Death-1 (PD-1) membrane receptor on immune cells ...https://www.biospace.com/article/cbt-pharmaceuticals-receives-first-australian-ethics-approval-to-initiate-apollo-1-phase-1-2-clinical-trial-for-hepatocellular-and-renal-cell-carcinoma/
Most recent papers with the keyword Cancer glycobiology | Read by QxMD
... for its interaction with the immune system and induction of effector activities such as antibody-dependent cell cytotoxicity, ... among which are cell adhesion and migration, cell differentiation, gene transcription and RNA splicing, cell cycle and ... Therapeutic antibodies hold great promise for the treatment of cancer and autoimmune diseases, and developments in antibody- ... Within the tumor microenvironment, the presence of immune cells, extracellular matrix proteins, cell surface receptors, and ...https://www.readbyqxmd.com/keyword/100700
ImmunoGen, Inc. Earns Milestone with Start of SAR650984 Clinical Trial. - Free Online Library
... it has been found to have potent antibody-dependent cell-mediated cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC ... and apoptotic activity (achievement of programmed cell death).1 John Lambert, PhD, Executive Vice President and Chief ... The Company's TAP technology uses antibodies to deliver one of ImmunoGen's proprietary cancer-cell killing agents specifically ... These included therapeutic antibody compounds, such as SAR650984, and Targeted Antibody Payload (TAP) compounds, in which the ...https://www.thefreelibrary.com/ImmunoGen%2C+Inc.+Earns+Milestone+with+Start+of+SAR650984+Clinical+Trial-a0229740490
... carcinoma and may prove useful for modulating the activity of human effectors for antibody-dependent cell-mediated cytotoxicity ... Administration of C. parvum i.p. has augmented the ability of human peritoneal cells to lyse human ovarian carcinoma cell lines ...http://cancerres.aacrjournals.org/content/43/3/1395
Switchable CAR-T cells mediate remission in metastatic pancreatic ductal adenocarcinoma | Gut
... whereby the mechanism of tumour killing is through antibody-dependent cell-mediated cytotoxicity (ADCC) and the activity of the ... We developed an antibody-based switchable CAR system whose activity can be titrated in vivo.14 15 These switchable CAR-T cells ... CAR-T cells were incubated with target cells at an effector: target cell ratio of 10:1, while maintaining a total cell ... Switchable CAR-T cells whereby activity of the CAR-T cell is controlled by dosage of a tumour antigen-specific recombinant Fab- ...https://gut.bmj.com/content/early/2018/08/17/gutjnl-2018-316595
Identification of epidermal growth factor receptor-derived peptides immunogenic for HLA-A2(+) cancer patients. - PubMed - NCBI
B) To test the antibody-dependent cell-mediated cytotoxicity of antipeptide IgG, the cytotoxicity of freshly isolated PBMCs ... which had detectable levels of antipeptide activity. The 11-18 cells at 1 × 103 cells well−1 in a 96-well microculture plate ( ... Direct inhibition and antibody-dependent cell-mediated cytotoxicity of sera possessing antipeptide IgG. (A) To test the direct ... Cytotoxicity. Peptide-stimulated PBMCs were tested for their cytotoxicity against the following cancer cell lines: 11-18 (HLA- ...https://www.ncbi.nlm.nih.gov/pubmed/15083186
Emblica Uses, Benefits & Dosage - Drugs.com Herbal Database
Augmentation of murine natural killer cell and antibody dependent cellular cytotoxicity activities by Phyllanthus emblica, a ... antibody-dependent cellular cytotoxicity, and survival in response to tumor cells (lymphoma and mammary carcinoma).37, 38, 39 ... and increased cell survival.33, 34, 35, 36 Rodents fed emblica extracts showed an increase in activity of natural killer cells ... Activity appears to be stronger against gram-positive bacteria, and only limited efficacy against fungi.25, 26, 27, 28 Activity ...https://www.drugs.com/npp/emblica.html
Improved Natural Killer cell activity and retained anti-tumor CD8+ T cell responses contribute to the induction of a...
... and with the in vitro monitoring of Trastuzumab-mediated antibody-dependent cell cytotoxicity (ADCC). CD8+ T cell responses ... regulatory T cells, T helper 17 lymphocytes, were quantified by multiparametric flow cytometry. NK cells functional activity ... After NC, HER2-positive patients showed a significant increase in the number of NK cells and regulatory T cells irrespective of ... Characterization of anti-tumor T cell responses highlighted sustained levels of CD8+ T cells specific for survivin and ...https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-015-0567-0
A Study Evaluating Dalotuzumab (MK-0646) in Combination With Erlotinib for Participants With Non-Small Cell Lung Cancer (MK...
Antibody dependent cell-mediated cytotoxicity. In preclinical studies, dalotuzumab improved the activity of an anti-Epidermal ... Activity of dalotuzumab, a selective anti-IGF1R antibody, in combination with erlotinib in unselected patients with Non-small- ... Carcinoma, Non-small-cell Lung. Intervention ICMJE *Drug: Dalotuzumab Dalotuzumab 20 mg/mL in sterile solution. Intravenous (IV ... A Study Evaluating Dalotuzumab (MK-0646) in Combination With Erlotinib for Participants With Non-Small Cell Lung Cancer (MK- ...https://clinicaltrials.gov/ct2/show/record/NCT00654420
Novel Toll-Like Receptor 9 Agonist Induces Epidermal Growth Factor Receptor (EGFR) Inhibition and Synergistic Antitumor...
... and the antibody-dependent cell-mediated cytotoxicity (ADCC; ref. 12). For these reasons, several early clinical studies are ... dendritic cells, and natural killer cell lytic activity (1-3), and potent induction of (a) the secretion of cytokines, such as ... Western blotting of GEO cells treated in vitro. Cell lysates of GEO cells treated in vitro on days 0 and 2 were collected on ... IMO boosted the non-EGFR-dependent cetuximab activity, causing a cooperative antitumor effect in GEO-CR cells. Finally, ...http://clincancerres.aacrjournals.org/content/12/2/577
JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... through a cell contact-dependent mechanism involving hydrogen peroxide or through antibody-dependent cell-mediated cytotoxicity ... anti-tumor cytotoxicity, BrdU labeling, CFSE labeling, luciferase assay, neutrophil depletion, anti-metastatic activity, lung ... While IFN-dependent-innate and cell mediated immunity is important for eventual control of infection, innate immune cells, ... Immunology, Issue 95, Endothelial cells, leukocytes, mesenchymal stromal cells, mesenchymal stem cells, co-culture, adhesion, ...https://www.jove.com/visualize/abstract/25807235/effects-of-malaria-parasite-density-on-blood-cell-parameters