*  Human anti-nucleolin recombinant immunoagent for cancer therapy. - Semantic Scholar
... and it abrogates the biogenesis of NCL-dependent miRNAs. Binding of 4LB5 to NCL on the cell surface of a variety of breast ... the first anti-NCL single-chain fragment variable displaying antineoplastic activity against established solid tumors, which ... This immunoagent binds NCL on the cell surface, it is translocated into the cytoplasm of target cells, ... cancer and hepatocellular carcinoma cell lines, but not to normal-like MCF-10a breast cells, dramatically reduces cancer cell ...
  https://www.semanticscholar.org/paper/Human-anti-nucleolin-recombinant-immunoagent-for-Palmieri-Richmond/3781116b28ec94f2b11a75fd11f460859e583d91
*  Heterogeneous neutralizing antibody and antibody-dependent cell cytotoxicity responses in HIV-1 elite controllers
FcγR-mediated antiviral activities, antibody-dependent cell cytotoxicity (ADCC), as well as autoantibody levels, were ... Heterogeneous neutralizing antibody and antibody-dependent cell cytotoxicity responses in HIV-1 elite controllers. ... Neutralizing Antibody (nAb) activities (neutralization assay, competition with broadly reactive monoclonal antibodies, and ... Regardless of the type of antibody tested, there was no correlation with HIV-specific CD8 T cell responses. ADCC was detectable ...
  https://insights.ovid.com/crossref?an=00002030-200905150-00004
*  The Controversial Role of Microglia in Malignant Gliomas
... antibody-dependent cell mediated cytotoxicity (ADCC) has also been shown to be involved in microglia anti-tumor activities. ... M1 cells have high anti-microbial activity, immune stimulatory functions and tumor cytotoxicity and express the signal ... W. Jia, C. Jackson-Cook, and M. R. Graf, "Tumor-infiltrating, myeloid-derived suppressor cells inhibit T cell activity by ... A. Sutter, A. Hekmat, and G. A. Luckenbach, "Antibody-mediated tumor cytotoxicity of microglia," Pathobiology, vol. 59, no. 4, ...
  https://www.hindawi.com/journals/jir/2013/285246/
*  Characterization of ASKP1240, a Fully Human Antibody Targeting Human CD40 With Potent Immunosuppressive Effects
Antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) activities of 100. µg/mL of ... antibody-dependent cell-mediated cytotoxicity. CDC. complement-dependent cytotoxicity. DCs. dendritic cells. DTH. delayed-type ... This is an IgG4 masking antibody that shows neither antibody-dependent cell-mediated cytotoxicity (ADCC) nor complement- ... µg/mL indicated antibodies: ASKP1240, human isotype antibody, mu5C8 (ATCC) or mouse isotype antibody. The antibody-treated ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC4225473/
*  Genentech: Valerie Quarmby | Staff Scientist and Director, BioAnalytical Sciences
Characterization of in vitro antibody-dependent cell-mediated cytotoxicity activity of therapeutic antibodies - Impact of ... reducing effects in a humanized antibody on Fcγ receptor binding and antibody-dependent cell-mediated cytotoxicity activities ... A host-cell protein impurity in therapeutic monoclonal antibodies derived from chinese hamster ovary cells ... Development and optimization of a cell-based neutralizing antibody assay using a sample pre-treatment step to eliminate serum ...
  https://www.gene.com/scientists/our-scientists/valerie-quarmby
*  ASCO Report (2016) - Assessing biomarker responses in Immunotherapy treatment | | Phacilitate
... of antitumor activity of cetuximab is based on antibody-dependent cell mediated cytotoxicity mediated by natural killer cells. ... Different antibodies, different staining protocols, different target cell assessment (tumour cells, tumour-infiltrating immune ... Researchers used immunohistochemistry in tumor cells alone (tumor proportions score) or with inflammatory cells (combined ... on tumor cells and inflammatory cells may predict which patients with recurrent or metastatic head and neck squamous cell ...
  https://www.phacilitate.co.uk/article/asco-report-2016-assessing-biomarker-responses-immunotherapy-treatment
*  Endocrine Immune Interactions in the Host-Parasite Relationship: Steroid Hormones as Immune Regulators in Parasite Infections ...
In monocytes, P4 inhibits NK cell activity and FcγR expression and reduces antibody-dependent cell cytotoxicity mediated by the ... Dendritic cells. Induce mature DCs. [76]. Lymphocytes. Enhance IL-2 secretion of Th1 cells and cytotoxicity function of T cells ... B cells are grouped into B1 and B2 cells and are responsible for antibody secretion [21]. T cells are categorized into four ... Estrogen induces suppression of natural killer cell cytotoxicity and augmentation of polyclonal B cell activation. Cell Immunol ...
  https://www.omicsonline.org/open-access/endocrine-immune-interactions-in-the-hostparasite-relationship-steroidhormones-as-immune-regulators-in-parasite-infections-2157-7536-1000165.php?aid=66321
*  Roche - Pipeline
Its therapeutic activity in pre-clinical models was shown to take place via antibody-dependent cell-mediated cytotoxicity (ADCC ... ERY974 is a bispecific antibody designed to elicit T cell activation and T cell-dependent cellular cytotoxicity by ... is a humanised full-length T cell-dependent bispecific antibody designed to target both CD20 on B cells and CD3 on T cells. ... The antibody induces T cell-driven tumor killing by activation of CD40 on antigen-presenting cells which in turn prime T cells ...
  https://www.roche.com/research_and_development/who_we_are_how_we_work/pipeline.htm
*  Frontiers | Intracellular Crosslinking of Filoviral Nucleoproteins with Xintrabodies Restricts Viral Packaging | Immunology
Infection of stable Vero cell lines expressing dimeric sdAb specific for either MARV or EBOV NP resulted in smaller plaques and ... Previously, we had generated sdAb (single-domain antibodies) against Filoviruses that have all targeted highly conserved C- ... Previously, we had generated sdAb (single-domain antibodies) against Filoviruses that have all targeted highly conserved C- ... reduced progeny of cognate virus relative to wild-type Vero cells. Though the impact was marginal at later time-points the ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2017.01197/full
*  51Cr Release Assay of AntibodyDependent Cell‐Mediated Cytotoxicity (ADCC) - Current Protocols
... dependent cell‐mediated cytotoxicity (ADCC) is an immunologic cytotoxic effector mechanism that is dependent on the cooperative ... ADCC against human erythrocyte target cells: Role of the anti‐target cell antibodies in determining lymphocyte killer activity ... Antibodydependent cell‐mediated cytotoxicity (ADCC) is an immunologic cytotoxic effector mechanism that is dependent on the ... 51Cr Release Assay of AntibodyDependent Cell‐Mediated Cytotoxicity (ADCC). David L. Nelson1, Carole C. Kurman1, Deborah E. ...
  http://www.currentprotocols.com/WileyCDA/CPUnit/refId-im0727.html
*  Oral lactoferrin in the treatment of respiratory disorders - Patent # 7238661 - PatentGenius
... enhance antibody-dependent cell cytotoxicity, stimulate lymphokine-activated killer (LAK) cell activity, and potentiate ... T cell E cell % Cytotoxicity* cell E cell Increased ratio mix ctrl Final mix ctrl Finalover ctrl 30:1 0.281 0.215 2.86 0.358 ... These cells are mainly involved in stimulating B cells to produce antibody and are often called helper T-cells. It is also ... Type II is described as cytotoxic which involves complement-fixing antibody with cell lysis or antibody-dependent ...
  http://www.patentgenius.com/patent/7238661.html
*  Buy Septilin '' Online Without Prescriptions. No Prescription Needed. Only $38.58. Order Septilin '' Online Without...
... natural killer cell activity and antibody-dependent cell cytotoxicity. Septilin's stimulatory effect on the humoral immunity ... increases the antibody forming cells, thereby enhancing the secretion of antibodies into the circulation. Septilin also ... Septilin stimulates phagocytosis by macrophage activation and increases the polymorphonuclear cells and helps overcome ... augments the population of erythropoietic and granulopoietic precursor cells, stab cells and primary. ...
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*  Buy Septilin () $36.91 Per bottle
... natural killer cell activity and antibody-dependent cell cytotoxicity. Septilin's stimulatory effect on the humoral immunity ... increases the antibody forming cells, thereby enhancing the secretion of antibodies into the circulation. Septilin also ... Septilin stimulates phagocytosis by macrophage activation and increases the polymorphonuclear cells and helps overcome ... augments the population of erythropoietic and granulopoietic precursor cells, stab cells and primary. ...
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*  Most recent papers with the keyword Cancer glycobiology | Read by QxMD
... for its interaction with the immune system and induction of effector activities such as antibody-dependent cell cytotoxicity, ... among which are cell adhesion and migration, cell differentiation, gene transcription and RNA splicing, cell cycle and ... Therapeutic antibodies hold great promise for the treatment of cancer and autoimmune diseases, and developments in antibody- ... Within the tumor microenvironment, the presence of immune cells, extracellular matrix proteins, cell surface receptors, and ...
  https://www.readbyqxmd.com/keyword/100700
*  ImmunoGen, Inc. Earns Milestone with Start of SAR650984 Clinical Trial. - Free Online Library
... it has been found to have potent antibody-dependent cell-mediated cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC ... and apoptotic activity (achievement of programmed cell death).1 John Lambert, PhD, Executive Vice President and Chief ... The Company's TAP technology uses antibodies to deliver one of ImmunoGen's proprietary cancer-cell killing agents specifically ... These included therapeutic antibody compounds, such as SAR650984, and Targeted Antibody Payload (TAP) compounds, in which the ...
  https://www.thefreelibrary.com/ImmunoGen%2C+Inc.+Earns+Milestone+with+Start+of+SAR650984+Clinical+Trial-a0229740490
*  Plus it
... carcinoma and may prove useful for modulating the activity of human effectors for antibody-dependent cell-mediated cytotoxicity ... Administration of C. parvum i.p. has augmented the ability of human peritoneal cells to lyse human ovarian carcinoma cell lines ...
  http://cancerres.aacrjournals.org/content/43/3/1395
*  Identification of epidermal growth factor receptor-derived peptides immunogenic for HLA-A2(+) cancer patients. - PubMed - NCBI
B) To test the antibody-dependent cell-mediated cytotoxicity of antipeptide IgG, the cytotoxicity of freshly isolated PBMCs ... which had detectable levels of antipeptide activity. The 11-18 cells at 1 × 103 cells well−1 in a 96-well microculture plate ( ... Direct inhibition and antibody-dependent cell-mediated cytotoxicity of sera possessing antipeptide IgG. (A) To test the direct ... Cytotoxicity. Peptide-stimulated PBMCs were tested for their cytotoxicity against the following cancer cell lines: 11-18 (HLA- ...
  https://www.ncbi.nlm.nih.gov/pubmed/15083186
*  A Study Evaluating Dalotuzumab (MK-0646) in Combination With Erlotinib for Participants With Non-Small Cell Lung Cancer (MK...
Antibody dependent cell-mediated cytotoxicity. In preclinical studies, dalotuzumab improved the activity of an anti-Epidermal ... Activity of dalotuzumab, a selective anti-IGF1R antibody, in combination with erlotinib in unselected patients with Non-small- ... Carcinoma, Non-small-cell Lung. Intervention ICMJE *Drug: Dalotuzumab Dalotuzumab 20 mg/mL in sterile solution. Intravenous (IV ... A Study Evaluating Dalotuzumab (MK-0646) in Combination With Erlotinib for Participants With Non-Small Cell Lung Cancer (MK- ...
  https://clinicaltrials.gov/ct2/show/record/NCT00654420
*  Improved Natural Killer cell activity and retained anti-tumor CD8+ T cell responses contribute to the induction of a...
... and with the in vitro monitoring of Trastuzumab-mediated antibody-dependent cell cytotoxicity (ADCC). CD8+ T cell responses ... regulatory T cells, T helper 17 lymphocytes, were quantified by multiparametric flow cytometry. NK cells functional activity ... After NC, HER2-positive patients showed a significant increase in the number of NK cells and regulatory T cells irrespective of ... Characterization of anti-tumor T cell responses highlighted sustained levels of CD8+ T cells specific for survivin and ...
  https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-015-0567-0
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... through a cell contact-dependent mechanism involving hydrogen peroxide or through antibody-dependent cell-mediated cytotoxicity ... anti-tumor cytotoxicity, BrdU labeling, CFSE labeling, luciferase assay, neutrophil depletion, anti-metastatic activity, lung ... While IFN-dependent-innate and cell mediated immunity is important for eventual control of infection, innate immune cells, ... Immunology, Issue 95, Endothelial cells, leukocytes, mesenchymal stromal cells, mesenchymal stem cells, co-culture, adhesion, ...
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*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... through a cell contact-dependent mechanism involving hydrogen peroxide or through antibody-dependent cell-mediated cytotoxicity ... anti-tumor cytotoxicity, BrdU labeling, CFSE labeling, luciferase assay, neutrophil depletion, anti-metastatic activity, lung ... While IFN-dependent-innate and cell mediated immunity is important for eventual control of infection, innate immune cells, ... Immunology, Issue 80, Virus Diseases, Immune System Diseases, HIV, CD4 T cell, CD8 T cell, antigen-presenting cell, Cytokines, ...
  https://www.jove.com/visualize/abstract/26066058/high-pulmonary-levels-il-6-il-1-children-with-chronic-suppurative
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... through a cell contact-dependent mechanism involving hydrogen peroxide or through antibody-dependent cell-mediated cytotoxicity ... In healthy individuals it exhibits greatest activity during periods of rest, with less activity, observed as deactivation, ... CD45RBhigh T cells into T and B cell deficient recipient mice. The CD4+CD45RBhigh T cell population that largely consists of ... blood cell aggregation, microvascular blood flow, and blood cell-endothelial cell interactions6-13.However, these microfluidic ...
  https://www.jove.com/visualize/abstract/25946088/correlation-between-lactate-dehydrogenase-levels-with-laboratory
*  Novel Toll-Like Receptor 9 Agonist Induces Epidermal Growth Factor Receptor (EGFR) Inhibition and Synergistic Antitumor...
... and the antibody-dependent cell-mediated cytotoxicity (ADCC; ref. 12). For these reasons, several early clinical studies are ... dendritic cells, and natural killer cell lytic activity (1-3), and potent induction of (a) the secretion of cytokines, such as ... Western blotting of GEO cells treated in vitro. Cell lysates of GEO cells treated in vitro on days 0 and 2 were collected on ... IMO boosted the non-EGFR-dependent cetuximab activity, causing a cooperative antitumor effect in GEO-CR cells. Finally, ...
  http://clincancerres.aacrjournals.org/content/12/2/577
*  Cell Based Neutralizing Antibody Assays
Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC), Complement-Dependent Cytotoxicity (CDC), Cytopathic Effect Inhibition ( ... CPE), Apoptosis, Ligand Stimulated Cell Signaling, Enzyme Activity, Reporter Gene Assays, Protein Secretion, Metabolic Activity ... Cell Based Neutralizing Antibody Assays. Cell-based anti-drug neutralizing antibody (NAb) assays for safety and efficacy ... Experienced cell-based neutralizing antibody assay capabilities. Our experts, based in Good Laboratory Practice (GLP) compliant ...
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*  Chiome Bioscience Selects ProBioGen for Antibody Manufacturing Program Labmate Online
... a Japanese antibody discovery and development company, have jointly announced signing a service and license agreement. Click to ... which will be optimised for enhanced antibody-dependent cell-mediated cytotoxicity (ADCC) cancer cell-killing activity. ... technology for our antibody before and saw in-vivo in animal models an obviously potentiated cancer cell-killing efficacy of ... followed by process development and GMP manufacturing of the ADCC-enhanced cancer stem cell antibody, ...
  https://www.labmate-online.com/news/news-and-views/5/chiome-bioscience-inc/chiome-bioscience-selects-probiogen-for-antibody-manufacturing-program/44343