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*  Adenylate kinase - Wikipedia
Adenylate Kinase is a signal transducing protein; thus, the balance between conformations regulates protein activity. ADK has a ... By continually monitoring and altering the levels of ATP and the other adenyl phosphates (ADP and AMP levels) adenylate kinase ... Sub-cellular localization of the ADK enzymes is done by including a targeting sequence in the protein. Each isoform also has ... Adenylate kinase, subfamily InterPro: IPR006259 UMP-CMP kinase InterPro: IPR006266 Adenylate kinase, isozyme 1 InterPro: ...
  https://en.wikipedia.org/wiki/Adenylate_kinase
*  Protein kinase A - Wikipedia
Adrenaline and glucagon affect the activity of protein kinase A by changing the levels of cAMP in a cell via the G-protein ... Turnham, Rigney E.; Scott, John D. (2016-02-15). "Protein kinase A catalytic subunit isoform PRKACA; History, function and ... mechanism, using adenylate cyclase. Protein kinase A acts to phosphorylate many enzymes important in metabolism. For example, ... The liberated catalytic subunits can then catalyze the transfer of ATP terminal phosphates to protein substrates at serine, or ...
  https://en.wikipedia.org/wiki/Protein_kinase_A
*  Proteomic Investigation of Changes in Rat Skeletal Muscle after Exercise-Induced Fatigue
2010) SIRT 1, AMP-activated protein kinase phosphorylation and downstream kinases in response to a single bout of sprint ... Creatine kinase M chain (M-CK, pI 6.58, Mr 43kD); Adenylate kinase isoenzyme 1, ATP-AMP Transphosphorylase (AK1, pI 7.71, Mr ... The cause of fatigue is probably multifactorial, but a central role is changes in high-energy phosphates (i.e. ATP and ADP). ... GOODMAN, CRAIG, HAYES, ALAN AND MCKENNA, MICHAEL J (2009) Dissociation between force and maximal Na+, K+-ATPase activity in rat ...
  https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000100010&lng=en&nrm=iso&tlng=en
*  Frontiers | Computational Modeling of the Metabolic States Regulated by the Kinase Akt | Physiology
Protein Kinase B (PKB), also known as Akt, participates in the PI3K/Akt/mTOR pathway, a master regulator of aerobic glycolysis ... two activities shown by both normal and cancer proliferating cells. Not surprisingly considering its relevance for cellular ... Protein Kinase B (PKB), also known as Akt, participates in the PI3K/Akt/mTOR pathway, a master regulator of aerobic glycolysis ... as reported in literature in relation to the activity of the PI3K/Akt/mTOR. Some steps that link glycolysis and pentose ...
  https://www.frontiersin.org/articles/10.3389/fphys.2012.00418/full
*  ADCY2 - Adenylate cyclase type 2 - Homo sapiens (Human) - ADCY2 gene & protein
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642). Down-stream ... activation of protein kinase A activity Source: Reactome. *adenylate cyclase-activating G-protein coupled receptor signaling ... "Raf kinase activation of adenylyl cyclases: isoform-selective regulation.". Ding Q., Gros R., Gray I.D., Taussig R., Ferguson S ... p>This subsection of the 'Function' section describes a region in the protein which binds nucleotide phosphates. It always ...
  http://www.uniprot.org/uniprot/Q08462
*  Mechanism of Cardiac Sarcolemmal Adenosine Triphosphate-sensitive Potassium Channel Activation by Isoflurane in a Heterologous...
Consequently, it has been demonstrated that under such conditions (pHi 7.4), activation of protein kinase C isoform PKC-ϵ is ... The phosphotransfer enzymes such as creatine kinase or adenylate kinase provide a mechanism to communicate changes in the ... 12 and this effect is mediated by protein kinase C.13,14 However, how halogenated anesthetics enhance activity of the KATP ... Schulze D, Rapedius M, Krauter T, Baukrowitz T: Long-chain acyl-CoA esters and phosphatidylinositol phosphates modulate ATP ...
  http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1931115
*  Actin - Wikipedia
... a protein similar to phosducin) inhibits its activity through the formation of a tertiary complex. Actin is an ATPase, which ... The ACTC1 gene codes for the α-actin isoform present in heart muscle. It was first sequenced by Hamada and co-workers in 1982, ... Cofilin-actin complex finally dissociate after cofilin phosphorylation by nuclear LIM kinase. Actin is SUMOylated and in this ... a process regulator related to adenylate cyclase proteins; a profilin with a molecular weight of approximately 14 kDa that is ...
  https://en.wikipedia.org/wiki/Actin
*  C-Raf - Wikipedia
... group of protein kinases. Although some features unite their catalytic domains with protein tyrosine kinases, the activity of ... The shorter, major isoform - consisting of 17 exons - encodes a protein kinase of 648 amino acids. Similarly to many other ... and the enzymes dedicated for removal of these phosphates are the protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A ... BAD (Bcl2-atagonist of cell death) is directly phosphorylated by c-Raf, along with several types of adenylate cyclases, myosin ...
  https://en.wikipedia.org/wiki/C-Raf
*  The E-NTPDase family of ectonucleotidases: Structure function relationships and pathophysiological significance | SpringerLink
... protein kinase C, ERKs, phosphatidylinositol 3-kinases (PI3K), MAP kinases (MAPK) and Rho [6, 7, 8]. The situation concerning ... adenylate kinase, nucleoside diphosphate kinase, and potentially ecto-F1-Fo ATP synthases [21, 22, 23, 24, 25] that may ... The future planned use of transgenic mice expressing fluorescent protein under the promoter of the respective NTPDase isoform ... suggest that changes in neural plasticity can be paralleled by changes in ecto-ATPase activity. Enzyme activity is reduced ...
  https://link.springer.com/article/10.1007%2Fs11302-006-9003-5
*  Enzyme assays for synthesis and degradation of 2-5As and other 2′-5′ oligonucleotides | BMC Biochemistry | Full Text
The activities measured for purified human PDE12ΔmTP-His and PDE12ΔmTP-His in HeLa cell protein extracts are listed in Table 1 ... A variety of 2′-5′ oligo(adenylate) synthetase activity assays have been devised, which generally rely on ATP as substrate [4, ... Zilberstein A, Kimchi A, Schmidt A, Revel M. Isolation of two interferon-induced translational inhibitors: a protein kinase and ... Synthesis of 2-5As was performed with a human OAS1 isoform known to produce oligomers up to 30-mers in vitro [5]. The OAS2 and ...
  https://bmcbiochem.biomedcentral.com/articles/10.1186/s12858-015-0043-8
*  Plus it
... evidence that the Ca2+ influx through this pathway may serve to regulate cellular functions such as adenylate cyclase activity ... This model suggests that there is a direct (protein-protein) interaction between the intracellular Ca2+ storage compartment and ... Irvine, R. F. "Quantal" Ca2+ release and the control of Ca2+ entry by inositol phosphates-a possible mechanism. FEBS Lett. 263 ... The activation of a tyrosine kinase is also suggested to occur in a parallel fashion with store Ca2+ depletion. Indeed, it has ...
  http://physiologyonline.physiology.org/content/13/4/157
*  CALM2 calmodulin 2 [Homo sapiens (human)] - Gene - NCBI
positive regulation of protein serine/threonine kinase activity TAS Traceable Author Statement. more info ... The encoded isoform (3) has a shorter N-terminus than isoform 1. Both variants 3 and 4 encode the same protein.. Source ... The majority of Ca2+ in many organisms is bound to phosphates which form skeletal structures and also buffer Ca2+ levels in ... organism-specific biosystemCa2+ signal generated through NMDA receptor in the post-synaptic neuron activates adenylate cyclase ...
  https://www.ncbi.nlm.nih.gov/gene/805
*  Protein kinase A - Wikipedia
Adrenaline and glucagon affect the activity of protein kinase A by changing the levels of cAMP in a cell via the G-protein ... "Protein kinase A catalytic subunit isoform PRKACA; History, function and physiology". Gene. 577 (2): 101-108. doi:10.1016/j. ... mechanism, using adenylate cyclase. Protein kinase A acts to phosphorylate many enzymes important in metabolism. For example, ... The liberated catalytic subunits can then catalyze the transfer of ATP terminal phosphates to protein substrates at serine, or ...
  https://en.m.wikipedia.org/wiki/Protein_kinase_A
*  Use it or lose it? Sablefish, Anoplopoma fimbria, a species representing a fifth teleostean group where the βNHE associated...
protein kinase A. PO2. oxygen tension. PROP. propranolol. RBC. red blood cell. RVI. regulatory volume increase. S. fractional ... 1985). Inhibition by amiloride of both adenylate cyclase activity and the Na+/H+ antiporter in fish erythrocytes. Eur. J. Pharm ... 1990). Influence of organic phosphates on the Root effect of multiple fish haemoglobins. J. Exp. Biol. 149, 425-437. ... and the NHE1 isoform is important for regulation of pHi and cell volume in nearly all eukaryotic cells (Wakabayashi, 1997; Yun ...
  http://jeb.biologists.org/content/213/9/1503
*  The Immature Heart and Anesthesia | Anesthesiology | ASA Publications
Developmental regulation of protein kinase C (PKC) isoform mRNAs; The identity of the atypical PKC (aPKC) isoform in neonatal ... The V1 isoform (two alpha chains) has the highest ATPase activity. [132 ] The V2 isoform (an alpha and a beta chain) is ... McAuliffe JJ, Hickey PR: The effect of halothane on the steady-state levels of high energy phosphates in the neonatal heart. ... Tanaka H, Shigenobu K: Role of beta-adrenoceptor-adenylate cyclase system in the developmental decrease in sensitivity to ...
  http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1948387
*  Optogenetic Reporters: Fluorescent Protein-Based Genetically-Encoded Indicators of Signaling and Metabolism in the Brain
Protein kinase activities downstream from cAMP can also be monitored with GEIs. To report the activity of the downstream cAMP- ... Phosphoinositides can be hydrolyzed to inositol phosphates and diacylglycerol (DAG) in a receptor-mediated manner, and these ... The chloride transporter Na(+)-K(+)-Cl- cotransporter isoform-1 contributes to intracellular chloride increases after in vitro ... Two major downstream pathways involve activation of phospholipase C (PLC) or activation/inhibition of adenylate cyclase. ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3494096/?lang=en-ca
*  Adenoprotection of the heart involves phospholipase C-induced activation and translocation of PKC-ε to RACK2 in adult rat and...
Steinberg SF, Goldberg M, Rybin VO. The protein kinase C isoform diversity in the heart. J Mol Cell Cardiol 27: 141-153, 1995. ... adenylyl cyclase activity (24, 36, 37), cAMP formation (7), activation of PKA (8), protein phosphorylation (13), myocardial Ca ... Romano FD, MacDonald SG, Dobson JG Jr. Adenosine receptor coupling to adenylate cyclase of rat ventricular myocyte membranes. ... and inositol phosphates, suggesting that the A1R is coupled to phospholipase C (PLC) (34). One objective of the present study ...
  http://ajpheart.physiology.org/content/297/2/H718.long
*  Actin - WOW.com
... a protein similar to phosducin) inhibits its activity through the formation of a tertiary complex.[39] ... Research concerns on nuclear actin are usually focused on isoform beta.[96][97][98][99] However the use of antibodies directed ... Cofilin-actin complex finally dissociate after cofilin phosphorylation by nuclear LIM kinase. ... phosphates. This calcium is coordinated with six water molecules that are retained by the amino acids Asp11, Asp154, and Gln137 ...
  http://www.wow.com/wiki/Actin?s_pt=aolsem&s_chn=9
*  Carbon Dioxide and the Cerebral Circulation | Anesthesiology | ASA Publications
54,61] Both cAMP and cGMP appear to activate their respective protein kinases and phosphorylate calcium channels, which reduces ... The cellular source of NO important during hypercapnia is unknown but appears to involve the neuronal isoform of NO-synthase. ... Schieve JF, Wilson WP: The influence of age, anesthesia and cerebral arteriosclerosis on cerebral vascular activity to CO2. Am ... activate adenylate cyclase and increase the cAMP concentration. [32,36] In adult rats, hypercapnia increases brain cGMP ...
  http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1947393
*  Application # 2018/0071285. SYSTEMS PHARMACOLOGY FOR TREATING OCULAR DISORDERS - Patents.com
protein kinase C.alpha.), and GFAP (glial fibrillary acidic protein) (all of which are green) was then revealed by ... Bottom: Quantification of antagonistic activity of ligands. To examine the antagonistic activity, cells were preincubated with ... TABLE-US-00003 TABLE 3 Expression of adrenergic receptors, serotonin receptors, and adenylate cyclases in the eye and retina of ... 0083] Examples of prodrugs include, but are not limited to, esters (e.g., acetate, dialkylaminoacetates, formates, phosphates, ...
  http://patents.com/us-20180071285.html
*  GNAQ - Guanine nucleotide-binding protein G(q) subunit alpha - Homo sapiens (Human) - GNAQ gene & protein
G protein-coupled receptor signaling pathway Source: Reactome. *negative regulation of protein kinase activity Source: BHF-UCL ... Guanine nucleotide binding protein (G protein), q polypeptide, isoform CRA_c. HUMAN ... adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: GO_CentralInferred from biological aspect of ... p>This subsection of the 'Function' section describes a region in the protein which binds nucleotide phosphates. It always ...
  https://www.uniprot.org/uniprot/P50148
*  Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP), a Neuron-Derived Peptide Regulating Glial Glutamate Transport and...
... but not on protein kinase A, nerve growth factor receptor tyrosine kinase, p21ras G-protein, and pp60c-src cytoplasmic tyrosine ... β-Galactosidase activity was visualized by incubating the cultures for 24 hr at 37°C with X-gal (1 mg/ml; Bachem). ... receptor isoform, respond to PACAP by proliferation, whereas cerebral neuroblasts, expressing PAC1-R s, cease to divide in the ... these splice variants induce cAMP and inositol phosphates to different levels, probably because they interact with different G- ...
  http://www.jneurosci.org/content/20/10/3596
*  Critical Appraisal of the MTT Assay in the Presence of Rottlerin and Uncouplers | Biological Procedures Online | Full Text
... it does not exhibit any reactivity toward the tetrazolium salts in vitro nor does it modulate lactate dehydrogenase activity. ... can inhibit many other PKC-unrelated kinases and has a number of biological actions, including mitochondrial uncoupling effects ... Storz P, Döppler H, Toker A: Protein kinase Cdelta selectively regulates protein kinase D-dependent activation of NF-kappaB in ... Cells were treated with 5 and 20 μM Rottlerin (R5 and R20), and high-energy phosphates (ATP, ADP, and AMP) were determined by ...
  https://biologicalproceduresonline.biomedcentral.com/articles/10.1007/s12575-009-9020-1
*  James Ferrell | Stanford Medicine Profiles
Assessing activities of blotted protein kinases In: Protein Phosphorylation, Ed. by Hunter T, Sefton BM, Academic Press, San ... Progesterone brings about inhibition of adenylate cyclase and activation of the Mos/MEK1/p42 MAP kinase cascade, which ... Selective regulation of neurite extension and synapse formation by the beta but not the of isoform of CaMKII NEURON Fink, C. C ... Remarkably, SCF(Cdc4) ubiquitin ligase binds and ubiquitinates Sic1 decorated with six, but not five, phosphates. This ...
  https://med.stanford.edu/profiles/james-ferrell
*  Download Hacking Exposed™ Web Applications 2002
... coordinates two kinase receptors that must have adenylate for linking the basolateral activation in an various deletion. The ... protein-protein from archaeal methyl, and cyclin-dependent cholesterol. highly, unclear factors can be FN1 widely to their form ... found on in acid activity, RUNX3 appears closed to Wish the PRL-binding of transport, but multiple odorants and mild diversity ... and the isoform receptor( NOP). squamous download is cleaved by SMAD4 holes. RUNX3 may structurally diminish its reversible ...
  http://familie-walther.eu/photos/books/download-Hacking-Exposed%E2%84%A2-Web-applications-2002.php