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*  Faculty Research Page | Department of Molecular & Cell Biology
... we are working with several other labs in Berkeley to systematically dissect gene expression and regulation in the early D. ... I and members of my lab are actively involved in the experimental portions of the project and are carrying out the analyses of ... We now have extensive comparative sequence data for fruitflies (12 Drosophila genomes) and yeasts (many fungal genomes), and ... Experimental characterization of gene regulation in D. melanogaster embryos. To provide a solid experimental foundation for our ...
  https://mcb.berkeley.edu/faculty/ggd/eisenm.html
*  Discovering Antibacterial and Anticancer Therapeutics in Unexpected Places | The New York Academy of Sciences
... of quorum sensing to develop anti-microbial agents and a potential therapy for human melanoma discovered in the study of fungal ... Quorum sensing in Chromobacterium violaceum: DNA recognition and gene regulation by the CviR receptor. J. Bacteriol. 2011;193( ... Quorum-sensing regulators control virulence gene expression in Vibrio cholerae. Proc. Natl. Acad. Sci. USA 2002;99(5):3129-3134 ... Toward developing a universal treatment for fungal disease using radioimmunotherapy targeting common fungal antigens. ...
  https://www.nyas.org/ebriefings/discovering-antibacterial-and-anticancer-therapeutics-in-unexpected-places/
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Moreover, inhibiting these NAc D1-MSNs during cocaine exposure reversed the down-regulation of Tiam1 gene expression and ... Here, we demonstrate that rats that actively self-administer cocaine display reduced levels of Tiam1 in the NAc. To further ... Development of an amperometric polyphenol biosensor based on fungal laccase immobilized on nitrocellulose membrane. ... Expression of skin color genes in lymphocytes of Karan Fries cattle and seasonal relationship with tyrosinase and cortisol. ...
  https://www.jove.com/visualize?author=Ramesh+Chandra
*  Predicting the Fission Yeast Protein Interaction Network | G3: Genes | Genomes | Genetics
... apart from regulation of gene expression and anti-virulence action (Babar et al. 2008). siRNAs are of immense interest as a ... other fungal species, and plants in regulation of osmotic and oxidative stress response (Desikan et al. 2008; Krell et al. 2010 ... It is therefore interesting to examine physical interactors of proteins actively involved in this process, to gain insight on ... 2008 Tuning gene expression to changing environments: from rapid responses to evolutionary adaptation. Nat. Rev. Genet. 9: 583- ...
  http://www.g3journal.org/content/2/4/453.long
*  NLM Informatics Training Conference 2008: Agenda and Abstracts
... are recognized by regulatory proteins that are involved in the proper regulation of gene expression, which is critical for the ... Additionally we show that Sono-Seq sites occur preferentially at promoters of actively transcribed genes relative to inactive ... Using a comparative genomics approach that takes advantage of the growing numbers of sequenced fungal genomes, we developed a ... Hyper- and Hypo-Dynamism in Gene Expression Across Multiple Studies Authors:. Alexander A Morgan, Atul J Butte, Stanford ...
  https://www.nlm.nih.gov/ep/trainingconf2009agenda.html
*  Identifying combinatorial regulation of transcription factors and binding motifs | Genome Biology | Full Text
Thus the number of distinct times of gene expression is greater than the number of transcription factors. We also see that some ... is important for gene regulation. Although various genomic datasets are relevant to this issue, each dataset provides ... pairwise combination of a TF for an early cell-cycle phase and a TF for a later phase is often used to control gene expression ... We reconstruct a new combinatorial regulatory map of the yeast cell cycle in which cell-cycle regulation can be drawn as a ...
  https://0-genomebiology-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/gb-2004-5-8-r56
*  IL-17 and Therapeutic Kynurenines in Pathogenic Inflammation to Fungi | The Journal of Immunology
However, Tregs may actively participate in this process (54 ). Tryptophan metabolites will induce the Foxp3-encoding gene and ... which limits fungal inflammation (2 ,3 ). Fungal persistence in this setting may further stimulate IL-23 production by both ... or functional NADPH oxidase expression (22) (e.g., in CGD mice; Table II⇓). In all of these settings, Th17 pathway expression ... Cross-regulation occurs at different levels, including IL-12 (p70) and IL-23 production by DCs. IL-23 production by murine DCs ...
  http://www.jimmunol.org/content/180/8/5157
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... regulation of gene expression and survival in toxic hydrocarbon-rich environments. A three-step pathway for alkane degradation ... Isolates were identified via analysis of ribosomal RNA gene sequences. This report describes methods for fungal isolation, but ... Misfolded proteins that are not ubiquitinated are diverted to the IPOD, where they are actively aggregated in a protective ... The expression of these genes led to an improved hydrocarbon tolerance shown by an increased growth rate (up to 50%) in the ...
  https://www.jove.com/visualize/abstract/26186340/proteasome-activity-is-affected-fluctuations-insulin-degrading-enzyme
*  Most recent papers with the keyword Dark matter | Read by QxMD
They directly modulate the gene expression of mRNA genes leading to mRNA target cleavage and degradation and translation ... Bioinformatic predictions indicate that non coding RNAs may be involved in the regulation of 60% of the coding genes and each ... and obtained 563 fungal strains via the dilution plate method. Preliminary ITS analyses of these strains suggested that they ... of our genome being actively transcribed, protein-coding mRNAs make up only 2-3 % of the total amount of the transcribed RNA. ...
  https://www.readbyqxmd.com/keyword/43477
*  FiDiPro Professors - Academy of Finland
Comparisons at genomic and gene expression levels between three contrasting plant-fungus situations will help improve our ... Particular attention is paid to gene regulations, translocation phenomena across cell membranes, and diffusion of biomolecular ... Professor Palmgren is also chair of the Swedish Research Council eScience sub-committee and works actively for the promotion of ... He combines systems biology and advanced bioinformatics methods in fungal genomics research in a unique way. Professor Lee is ...
  https://www.aka.fi/en/about-us/scientists-behind-the-research/fidipro/
*  Local and systemic changes in expression of resistance genes, nb-lrr genes and their putative microRNAs in Norway spruce after...
Expression profiling of these key genes will clarify whether transcriptional regulation of NB-LRRs or miRNAs is a key feature ... Genes regulating lignin metabolism are important for angiosperms resistance to fungal pathogens [17] as plants seem to use ... The plants were inoculated and wounded at the time when the leader shoot had extended (actively growing) and well prior to any ... Local and systemic changes in expression of resistance genes, nb-lrr genes and their putative microRNAs in Norway spruce after ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3431983/
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Neural immune gene expression variables are measured with qPCR screening, qPCR arrays, and, importantly, use of cDNA ... Using RNA-mediated Interference Feeding Strategy to Screen for Genes Involved in Body Size Regulation in the Nematode C. ... Disruption of the C. elegans Intestinal Brush Border by the Fungal Lectin CCL2 Phenocopies Dietary Lectin Toxicity in Mammals. ... M cells are atypical epithelial cells that actively phagocytose macromolecules and microbes. Unlike dendritic cells (DCs) and ...
  https://www.jove.com/visualize/abstract/26057124/disruption-c-elegans-intestinal-brush-border-fungal-lectin-ccl2
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
High-resolution, cell type-specific analysis of gene expression greatly enhances understanding of developmental regulation and ... Examination of GUS expression in transgenic Arabidopsis seedlings shows that TSO2 is expressed in actively dividing tissues. ... U. maydis is a biotrophic fungal pathogen and the causal agent of corn smut on maize. This disease is responsible for ... Gene Targeting, Eukaryota, Toxoplasma gondii, genetic manipulation, gene targeting, gene deletion, gene replacement, gene ...
  https://www.jove.com/visualize/abstract/24223858/the-maize-zea-mays-l-auxinindole-3-acetic-acid-gene-family-phylogeny
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
High-resolution, cell type-specific analysis of gene expression greatly enhances understanding of developmental regulation and ... Examination of GUS expression in transgenic Arabidopsis seedlings shows that TSO2 is expressed in actively dividing tissues. ... U. maydis is a biotrophic fungal pathogen and the causal agent of corn smut on maize. This disease is responsible for ... specific gene expression profiling through microarray analysis is being used to identify putative downstream target genes ...
  https://www.jove.com/visualize/abstract/24853557/the-phytochrome-bphytochrome-c-heterodimer-is-necessary-for
*  Homoserine dehydrogenase - Wikipedia
... there is also environmental regulation of AK-HSD gene expression. Light exposure has been demonstrated to increase expression ... Additionally, the aspartate kinase-homoserine dehydrogenase gene is primarily expressed in actively growing, young plant ... Bareich DC, Nazi I, Wright GD (October 2003). "Simultaneous In Vitro Assay of the First Four Enzymes in the Fungal Aspartate ... "Expression of an Aspartate Kinase Homoserine Dehydrogenase Gene IS Subject to Specific Spatial and Temporal Regulation in ...
  https://en.wikipedia.org/wiki/Homoserine_dehydrogenase
*  Intron - Wikipedia
While introns do not encode protein products, they are integral to gene expression regulation. Some introns themselves encode ... Actively transcribed regions of DNA frequently form R-loops that are vulnerable to DNA damage. In highly expressed yeast genes ... Stajich JE, Dietrich FS, Roy SW (2007). "Comparative genomic analysis of fungal genomes reveals intron-rich ancestors". Genome ... Some introns are known to enhance the expression of the gene that they are contained in by a process known as intron-mediated ...
  https://en.wikipedia.org/wiki/Intron
*  Research in the BMS department - by professor - Biomedical Sciences - Grand Valley State University
... the expression of the genes necessary to build the type III secretion needle structure and the effector genes. These effectors ... My research focuses on the regulation of cell shape and stress responses in the opportunistic fungal pathogen Candida albicans ... I am actively involved in both laboratory and field research. My current lab-based projects include assessing various aspects ... Profiling Changes in Gene Expression in Response to Exercise & Aging Obesity is a significant health concern as it is a major ...
  http://www.gvsu.edu/bms/research-in-the-bms-department-by-professor-138.htm
*  Construction of an improved Aspergillus niger platform for enhanced glucoamylase secretion | Microbial Cell Factories | Full...
Regulation of glaA gene expression by omitting or adding the inducer doxycycline to cultivation media allowed us to study the ... we could demonstrate that the amount of post-Golgi carriers indeed depends on and correlates with glaA gene expression. By ... First, we put the glaA gene encoding for glucoamylase (GlaA), the most abundant secreted protein of A. niger, under control of ... By inducing glaA expression in a fluorescently tagged v-SNARE reporter strain expressing GFP-SncA, ...
  https://microbialcellfactories.biomedcentral.com/articles/10.1186/s12934-018-0941-8
*  W4147: Managing Plant Microbe Interactions in Soil to Promote Sustainable Agriculture - NIMSS
Induction of plant resistance mechanisms and regulation of gene expression. *Antibiotic and toxin production. ... Inhibition of fungal and. bacterial plant pathogens by VegelysTM, an Allium-based antimicrobial formulation. J Biol Nat 8(2): ... Generally speaking, there are two approaches to actively managing crop-associated microbial communities. The first approach is ... Researchers at ARS-WA are mapping resistance genes to Fusarium crown rot and using markers to identify Cre genes for resistance ...
  https://www.nimss.org/projects/view/mrp/outline/18474
*  Characterization of a set of novel meiotically-active promoters in Arabidopsis | BMC Plant Biology | Full Text
... are prime candidates to specifically drive gene expression during meiosis in plants and can thus provide important tools for ... profile the transcriptome landscape of isolated meiocytes provided the means to discover promoters from genes that are actively ... unite optimal properties which are invaluable for meiosis-directed studies such as delivering specific gene expression in early ... Furthermore, the examination of homologs of the corresponding genes within green plants points to a great potential of applying ...
  https://bmcplantbiol.biomedcentral.com/articles/10.1186/1471-2229-12-104
*  News | Department of CELL BIOLOGY
In a recent article in Genes and Development, the Shi Lab describes a molecular program that induces the early morphology of ... In addition, they show that the poorly characterized fungal protein Arb1 is essential for loading small RNAs onto the S. pombe ... They find that ectopic expression of Unkempt confers neuronal-like morphology to cells of different nonneuronal lineages, while ... Using Aspergillus nidulans, the Reck-Peterson group found that protein aggregates are actively organized at periodic ...
  http://cellbio.med.harvard.edu/news?page=5
*  Epigenetics: How Nurture Shapes Our Nature - Footnote
While an organism's genes define its potential traits, the expression of the genes determines which traits are actively enacted ... The regulation of gene expression through epigenetic mechanisms can occur at any of these steps. Proteins and carbohydrates can ... For instance, certain human immune responses to specific viral, bacterial, or fungal pathogens are regulated by epigenetic ... If we think of the genes that make up the genome as the blueprints for an organism, gene expression is the execution of these ...
  http://footnote.co/epigenetics-reveals-how-environment-shapes-gene-expression/
*  UAB - Graduate Biomedical Sciences - Coursework
This includes new areas of epigenetic regulation of gene expression and post-translational regulation of protein function. ... All students are expected to actively participate in the discussion. The goals of this course are to enhance one's ability to ... Most of the lectures describe the unique aspects of specific bacterial (and fungal) pathogens. Although many of the most ... GBSC 707- Metabolic Regulation of Gene Expression- Natalia Kedishvili. This course will focus on the impact of various ...
  https://www.uab.edu/gbs/home/requirements/coursework
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
RNA interference (RNAi) is an intrinsic cellular mechanism for the regulation of gene expression. Harnessing the innate power ... In order to actively target pancreatic cancer cell line, EGFR specific peptide was conjugated on the particle surface through a ... The most important function of fungal fruiting bodies is the dispersal of spores. In many of the species of Ascomycota (ascus ... Functional inactivation of gene expression in mammalian cells is crucial for the study of the contribution of a protein of ...
  https://www.jove.com/visualize/abstract/20967281/novel-hts-strategy-identifies-trail-sensitizing-compounds-acting
*  Set2-dependent H3K36 methylation is required for the fu | Open-i
Gene Expression Profiling. *Gene Expression Regulation, Fungal. *Histones/metabolism. *Isoenzymes/genetics/metabolism ... DSIF and RNA polymerase II CTD phosphorylation coordinate the recruitment of Rpd3S to actively transcribed genes. ... DSIF and RNA polymerase II CTD phosphorylation coordinate the recruitment of Rpd3S to actively transcribed genes. ... While Rpd3L targets specific promoters for gene repression, Rpd3S is recruited to ORFs to deacetylate histones in the wake of ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC2965751_pgen.1001173.g003&req=4