*  Ginkgolide C 15291-76-6 Precursor & Downstream Compound Dictionary
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*  Bilobalide - Wikipedia
Bilobalide is a biologically active terpenic trilactone present in Ginkgo biloba. Bilobalide is a main constituent of the terpenoids found in Ginkgo leaves. It also exists in minor amounts in the roots. It is a sesquiterpenoid, i.e. it has a 15-carbon skeleton. Its exact synthesis pathway from farnesyl pyrophosphate is still unknown. Bilobalide and ginkgolide both have very similar biosynthesis pathway. Bilobalide is formed by partially degraded from ginkgoglide. Bilibalide is derived from geranylgeranyl pyrophosphate (GGPP), which is formed by addition of farnesyl pyrophosphate (FPP) to isopentenyl pyrophosphate (IPP) unit, to form a C15 sesquiterpene. Such formation went through the mevalonate pathway (MVA) and methylerythritol phosphate MEP pathway. In order to generate bilobalide, C20 ginkgolide 13 must form first. To transform from GGPP to abietenyl cation 5, a single bifunctional enzyme abietadiene synthase E1 is required. However, due to the complexity of ginkgolide structures for ...
*  Gentaur Molecular :Nacala \ Ginkgolide B \ 02593-74
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*  Neuroprotective Effect of Ginkgolide B on Bupivacaine-Induced Apoptosis in SH-SY5Y Cells
Oxidative Medicine and Cellular Longevity is a unique peer-reviewed, Open Access journal that publishes original research and review articles dealing with the cellular and molecular mechanisms of oxidative stress in the nervous system and related organ systems in relation to aging, immune function, vascular biology, metabolism, cellular survival and cellular longevity. Oxidative stress impacts almost all acute and chronic progressive disorders and on a cellular basis is intimately linked to aging, cardiovascular disease, cancer, immune function, metabolism and neurodegeneration. The journal fills a significant void in today's scientific literature and serves as an international forum for the scientific community worldwide to translate pioneering
EGb 761 [Ginkgo biloba extract EGb 761, Rökan, Tanakan, Tebonin] is a standardised extract of Ginkgo biloba leaves and has antioxidant properties as a free radical scavenger. A standardised extract of Ginkgo biloba leaves is a well defined product and contains approximately 24% flavone glycosides (primarily quercetin, kaempferol and isorhamnetin) and 6% terpene lactones (2.8-3.4% ginkgolides A, B and C, and 2.6-3.2% bilobalide). Ginkgolide B and bilobalide account for about 0.8% and 3% of the total extract, respectively. Other constituents include proanthocyanadins, glucose, rhamnose, organic acids, D-glucaric and ginkgolic acids. EGb 761 promotes vasodilation and improves blood flow through arteries, veins and capillaries. It inhibits platelet aggregation and prolongs bleeding time. EGb 761, which was originated by Dr Willmar Schwabe Pharmaceuticals (Dr Willmar Schwabe Group), has been available in Europe as a herbal extract since the early 1990s. However, products containing EGb 761 are ...
*  Extract Of Ginkgo Biloba Leaves, Extract Of Ginkgo Biloba Leaves Suppliers and Manufacturers at Alibaba.com
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*  29 billion/year industry thrives despite negative clinical trial outcomes - Terra Sigillata
quitter raises some very good points, namely, the one espoused by Bazell: no matter what science comes out of the best of these studies, true "believers" will continue to practice their consumerism as they might feel that they are among the few people who gain benefit from such remedies, regardless of whether the benefit is placebo or not.. btw, quitter, happy first anniversary on your blog.. Joe takes me to task on some of my previous recommendations of reference sources. My response is that I am doing the best in making fact-based recommendations driven by independent information sources. Unfortunately, these sources do not even come close to the standards of basic, translational, and clinical medicine that we associate with prescription pharmaceuticals. I also cannot speak for Purdue's Dr Varro Tyler, who left this world over five years ago.. The EGb761 discussion I have had before relates to a remedy that is indeed standardized for ginkgolide A, ginkgolide B, ginkgolide C, and bilobalide. ...
*  Wholesale Ginkgo Biloba Leaf, China Wholesale Ginkgo Biloba Leaf Manufacturers & Suppliers | Made-in-China.com
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*  Natural Factors - Ginkgo Biloba 60mg 60cap
.LongDesc { font-family: Verdana, Helvetica, Arial, sans-serif; font-size: 14px; font-style: normal; font-weight: normal; font-variant: normal; color: #666; } Natural Factors Ginkgo Biloba 60 Capsules Ginko Biloba 24% Ginkgo Flavonglycosides, 6% Terpene Lactones. 60 Capsules, 60mg Suggested Usage: 1 capsule 3 times per day preferably with meals or as directed by a health professional. Supplement Facts Serving Size 1 Capsule Ginkgo Biloba, powdered extract (leaves) 60mg** Ginkgo flavonglycosides (24%) 14.4mg** Terpene lactones (6%) 3.6mg** (includes ginkgolides A, B, C, and bilobalide) **Daily Value not established. Other Ingredients: Gelatin capsule (gelatin, purified water), rice powder, magnesium stearate (vegetable grade). Warning: Consult your healthcare professional prior to use especially if you are pregnant,nursing, under doctors care for a medical condition or scheduling a medical procedure.
*  Ginkgolide B, a compound found within Ginkgo biloba, is
Greenmedinfo.com - Natural Health Resource - The world's most widely referenced, open access, natural medicine database, with 30,000+ study abstracts and growing daily
Chemical substances known as ginkgolides and bilobalide, found in the leaves of the tree, are believed to be the most pharmacologically active compounds, say the researchers. However, they point out, as is the case with many herbal products, the active ingredients are usually present in only trace amounts along with large quantities of other compounds. Determining the amount of ginkgolides and bilobalide in Ginkgo products generally is a time-consuming and tedious process, which has added to the difficulty of establishing efficient quality control programs for the products, claim the researchers. ...
*  Ginkgo Ginkgo Biloba Supplier, Find Best Ginkgo Ginkgo Biloba Supplier on Alibaba.com
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*  Chinese herbs and their active ingredients for activating xue (blood) promote the proliferation and differentiation of neural...
Baicalin promoted the survival of NSCs in embryonic rats with an increase of 42.3% determined by MTT assay[44]. Salidroside serum significantly promoted hippocampal NSCs to differentiate into neurons in a dose-dependent manner[34]. Different concentrations of ginkgolide B (20, 40, and 60 mg/L) added to DMEM/F12 medium promoted NSC differentiation into neuron-like cells when they were cultured for 7 or 14 days[34]. The relationship between differentiation and concentration was not significant, and the concentration had little effect on the percentage of oligodendrocytes. However, the percentage of astrocyte-like cells increased with the concentration of ginkgolide B[46, 47]. Different concentrations of rose roxburghii tratt polysaccharide (RRTP) (20, 40, and 80 μmol/L) reduced the degree of injury of embryonic rat striatal neural stem cells caused by glutamate. A high concentration of RRTP (60 mg/L) significantly reduced mortality and the rate of leakage of lactate dehydrogenase from NSCs, ...
*  Natures Plus - Nature's Plus - Ginkgo Biloba 100Mg Vcaps 60
For more than 5000 years, Ginkgo Biloba leaves have been recommended by Chinese and Japanese herbalists. Nature's Plus Herbal Actives Ginkgo Biloba Leaf extract is uniformly standardized to a minimum of 24% (24 mg) ginkgo flavone-glycosides, 6% (6 mg) terpene lactones. Each capsule, providing the greatest concentration of active botanical principles, maximizes the synergistic benefits of the whole leaf which naturally contains bioflavonoids, isoginkgetin and ginkolide A,B,C,M and J.Ginkgo Biloba leaf (standardized 24% ginkgo flavone-glycosides, 6% terpene lactones)\100 mg|Gelatin, glycerin, silica and water.
*  Long-term potentiation in the hippocampus induced by platelet-activating factor. - Semantic Scholar
Platelet-activating factor (PAF) is an ether phospholipid that serves as an autacoid in a wide range of biological processes. We found that when PAF was added to hippocampal slices, it induced a stable and concentration-dependent increase in excitatory postsynaptic potential and population spike recordings (long-term potentiation [LTP]). The PAF effect was blocked by the PAF receptor antagonists BN 52021 and WEB 2086 and the N-methyl-D-aspartate receptor antagonists MK 801 and 2-amino-5-phosphonovalerate. However, these PAF receptor antagonists did not block LTP induced by high frequency stimulation. The facilitation induced by PAF could not be reversed by PAF receptor antagonists. Induction of either PAF-or tetanus-triggered facilitation occluded the subsequent expression of the other, suggesting a common pathway. LTP is a type of synaptic plasticity associated with the formation of memory, and PAF may play an important modulatory role in this process.
*  China Ginkgo Biloba Extract 24/6, China Ginkgo Biloba Extract 24/6 Manufacturers and Suppliers on Alibaba.com
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*  Ginkgo biloba extract improves neuroplasticity.
PMID: Int Psychogeriatr. 2012 Aug ;24 Suppl 1:S21-4. PMID: 22784424. Abstract Title: Effects of the standardized Ginkgo biloba extract EGb 761® on neuroplasticity. Abstract: Neuroplasticity, the ability of synapses to undergo structural adaptations in response to functional demand or dysfunctions is increasingly impaired in aging and Alzheimer's disease. EGb761® has been shown in several preclinical reports to increase nearly all aspects of impaired neuroplasticity (long-term potentiation, spine density, neuritogenesis, neurogenesis). While all three fractions of constituents (ginkgolides, flavonoids, bilobalide) seem to be active, the flavonoids and specifically the aglycone isorhamnetin seem to be most relevant.. ...
*  Ginkgo Biloba - Memory - Health Concerns - Nutrition Express
Low prices on Ginkgo Biloba! Ginkgo biloba improves mental sharpness*. Longevity is important to the ginkgo biloba tree, which can live as long as 1,000 years. From ginkgo's uniquely shaped leaves come an extract shown to support circulation to the brain as well as the extremities. Ginkgo biloba also helps maintain healthy blood vessel tone and reduce blood viscosity.* Ginkgo biloba extract is the most frequently prescribed herbal extract by both doctors and pharmacists worldwide and is the best-selling natural healthcare product in Europe.
*  Lindberg - Ginkgo Biloba Extract 120 mg 60 Capsules - Save 41%
Save 41% Lindberg - Ginkgo Biloba Extract 120 mg 60 Capsules Ginkgo Biloba Extract 120 mg Ginkgo biloba 24% Ginkgo Flavone Glycosides 6% Terpene Lactones Supports Mental Sharpness* Clinical studies on Ginkgo Biloba Extract show that it supports circulation to the brain and helps support mental sharpness. It also helps support circulation to the extremities.* Vegetarian Capsules. Vegetarian.
*  Now Foods Ginkgo Biloba em evitamins-br
Now Foods Ginkgo Biloba found in: Ginkgo Biloba - 240 VCapsules, Ginkgo Biloba - 50 VCapsules, Ginkgo Biloba - 120 VCapsules, Ginkgo Biloba - 60..
*  ORBi: Browsing ORBi
in Journal of Lipid Mediators (1989), 1(4, Jul-Aug), 201-15. Three-dimensional electrostatic maps were calculated for six potent antagonists of platelet-activating factor (PAF), the antagonists being selected for their apparent structural heterogeneity. The ... [more ▼]. Three-dimensional electrostatic maps were calculated for six potent antagonists of platelet-activating factor (PAF), the antagonists being selected for their apparent structural heterogeneity. The molecules examined were the compact Ginkgolides BN 52020, BN 52021 and BN 52022 (1, 2 and 3), the semi-rigid kadsurenone (4), a flexible synthetic dinor type C furanoid lignan L-652,731 (5a) and the triazolothienobenzodiazepine WEB 2086 (7). Calculation of the electrostatic potential generated around all the above molecules showed the existence of two wells of negative potential or 'cache-oreilles' (ear-muffs), i.e., the isocontours drawn at -10 kcal/mol, located at 180 degrees from each other and separated by a maximum distance of ...
*  Stimulation of Neurogenesis and Synaptogenesis by Bilobalide and Quercetin via Common Final Pathway in Hippocampal Neurons -...
Loss of synapses has been correlated with dementia in Alzheimer's disease (AD) as an early event during the disease progression. Hence, synaptogenesis and neurogenesis in adulthood could serve as a therapeutic target for the prevention and treatment
*  Research programme: macrophage colony stimulating factor receptor antagonists - Novartis/Celgene - AdisInsight
Novartis and Celgene Corporation were developing orally active antagonists of the macrophage colony stimulating factor receptor (colony stimulating factor-1