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*  Patent US5066789 - Targeting substance-diagnostic/therapeutic agent conjugates having Schiff ... - Google Patents
... including controlled release of the active agent at a target site. ... Targeting substance-diagnostic/therapeutic agent conjugates joined by stabilized Schiff base or hydrazone linkages are ... are treated with a reagent (for instance, iminothiolane) that adds free sulfhydryl groups to the targeting substance. The ... Ribosomal inactivating proteins (RIPs) are naturally occurring protein synthesis inhibitors that lack translocating and cell- ...
  http://www.google.com/patents/US5066789?dq=5,832,511
*  Лаборатория оксилипинов - ИБХ РАН
... the most active compound being AA-5-HT. This substance was also active on FAAH from rat basophilic leukaemia (RBL-2H3) cells ( ... Gukovskaya A.S., Trepakova E.S., Zinchenko V.P., Korystov Y.N., Bezuglov V.V. (1992). Effect of the sulfhydryl reagent ... Studies with cholinergic receptor blocking agents and protein kinase C inhibitors indicated two distinct types of effects, one ... The sulfhydryl reagent thimerosal at concentrations 5-100 microM has been found to induce a variety of changes in ion transport ...
  http://www.ibch.ru/structure/groups/oxylipin
*  Gastroprotective effect of desmosdumotin C isolated from Mitrella kentii against ethanol-induced gastric mucosal hemorrhage in...
The effects of DES on the anti-oxidant system, non-protein sulfhydryl (NP-SH) content, nitric oxide (NO)level, cyclooxygenase-2 ... The compound up regulated heat shock protein-70 (HSP-70) and down regulated Bax protein expression in the ulcerated tissue. DES ... COX-2) enzyme activity, bcl-2-associated X (Bax) protein expression and Helicabacter pylori (H pylori) were also investigated. ... activation of HSP-70 protein, intervention with COX-2 inflammatory pathway and potent anti H pylori effect. ...
  https://bmccomplementalternmed.biomedcentral.com/articles/10.1186/1472-6882-13-183
*  Patent US5200313 - Nucleic acid hybridization assay employing detectable anti-hybrid antibodies - Google Patents
Resulting hybrids are detected by binding of an antibody reagent, preferably labeled with a detectable chemical group, ... Fractions containing protein are combined into a pool. The number of moles of sulfhydryl groups per mole of enzyme is measured ... It is preferred that the antibody reagent be labeled with a detectable chemical group such as an enzymatically active group, a ... Coenzyme A disulfide reductase, and inhibitors thereof useful as antimicrobial agents. US6110676 *. 3 Nov 1997. 29 Aug 2000. ...
  http://www.google.ca/patents/US5200313
*  US4614712A - Immunoassays with luciferase labeled ligands or receptors - Google Patents
For protein or other ligand or receptor for which structure is unknown one can titrate for sulfhydryl groups to determine the ... that is located on the α subunit in or near the active center which when modified with any of a variety of reagents renders the ... the substance being measured or assayed, and receptor or receptors, i.e., the compound or substance having a binding affinity ... G01N33/535-Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme ...
  https://patents.google.com/patent/US4614712A/en
*  Application # 2017/0150922. Methods of Enhancing Homeostatic Capacity in a Subject by Increasing Homeostatic System...
... target protein itself or active fragments, as well as mimetics, thereof. [0076] In some instances, the active agent is ... Progesterone Inhibitors; Testosterone Inhibitors; Gonadotropin-releasing Hormone Inhibitors; Dipeptidyl Peptidase IV inhibitors ... 0080] In certain embodiments where targeting moieties or active agents are peptides, any convenient reagents and methods may be ... Haloacetyls react with sulfhydryl groups at physiologic pH. The reaction of the iodoacetyl group proceeds by nucleophilic ...
  http://patents.com/us-20170150922.html
*  US20080292618A1 - Intranuclear protein transduction through a nucleoside salvage pathway - Google Patents
... wherein the conjugate contains a substrate for the nucleoside transport pathway linked to an active agent. Also provided are ... Provided herein are conjugate molecules containing a substrate for a nucleoside transport pathway linked to an active agent, ... Alternatively, molecules such asamino-sulfhydryl cross-linking reagents which are cleavable under mildly acidic conditions may ... active substance can be added later by resuspending the polymerized liposomes in a solution of a biologically active substance ...
  https://patents.google.com/patent/US20080292618A1/en
*  Patent US4177253 - Magnetic particles for immunoassay - Google Patents
The active site can be protected during coupling reactions by employing a covalent blocking reagent, or by performing the ... A method of preparing composite magnetic particles as claimed in claim 19 in which the biologically active group of the protein ... the substance and the biologically active component having a specific biological affinity for each other. ... and sulfhydryl; R is a member selected from the group consisting of lower alkoxy, phenoxy, and halo; and n is an integer having ...
  http://www.google.com/patents/US4177253?dq=%22Meaning-based+advertising+and+document+relevance+determination%22
*  Patent WO1992021770A1 - Reagents and methods for performing two-step ion-capture binding assays - Google Patents
The use of a polycationic substance, having a nitrogen content of at least about two percent (excluding the counter ions), to ... In one embodiment a test sample suspected of containing the analyte of interest may be contacted with the capture reagent to ... The complex is then contacted to the oppositely charged solid phase to attract, attach, and immobilize the capture reagent/ ... and a solid phase material containing a reaction site comprising a polymeric cation substance having a nitrogen content of at ...
  http://www.google.ca/patents/WO1992021770A1?cl=en
*  Synthesis and biochemical evaluation of benzyl propargyl ethers as inhibitors of 5-lipoxygenase
Keywords: Sulfolobus acidocaldarius, E. coli, RNase A, Archaeal ribosomes, Polyamines, Sulfhydryl reagents, Structural ... Structure-function relationships of biomolecules, protein-protein and protein-DNA interactions, protein folding, mechanisms, ... Quantitative structure-activity relationship study of orally active cyclooxygenase-2 (COX-2) inhibitors of derivatives of 3- ... Molecular mass is the mass of one molecule of a substance. ... min-1 mg protein-1, respectively, whereas KM values were 33.3 m ...
  http://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijbb/ijbb2k7/ijbb_feb07.asp
*  Patent US7737252 - Peptide-based compounds - Google Patents
Device for evaporating an active fluid substance. WO1997029783A1. Feb 19, 1997. Aug 21, 1997. Nycomed Imaging A/S. Improvements ... heterobifunctional cross-linking reagents such as those listed in the Pierce Chemical Company Immunotechnology Catalog-Protein ... a group that will react directly with carboxy, aldehyde, amine (NHR), alcohols, sulfhydryl groups, activated methylenes and the ... as well as inhibitors which limit the action of these potentially harmful enzymes. The other prominent effect of angiogenic ...
  http://www.google.com/patents/US7737252?dq=7253017
*  US5434052A - Complementation assay for drug screening - Google Patents
The following reagents are prepared:. Binding Protein Reagent consists of bovine Folate Binding Protein (Biochemical Inc., ... Method for detecting protein inhibitors and ligands of medical value WO2001094612A3 (en) * 2000-06-09. 2002-09-06. Aventis ... Specific binding assay with an enzyme modulator as a labeling substance EP0042673A1 (en) * 1980-06-20. 1981-12-30. The Regents ... Method for identifying medically valuable active substances US20020048778A1 (en) * 1997-04-02. 2002-04-25. Blau Helen M.. ...
  https://patents.google.com/patent/US5434052?oq=flatulence
*  Application # 2016/0194410. BINDING AGENT - Patents.com
An exemplary effector group is a therapeutically active substance. [0130] Therapeutically active substances have different ways ... bifunctional reagent wherein one functional group is an active ester. Exemplary active esters are NHS ester or pentafluor ... 0031] 5. Protein Linker and Tag-Sequences: SEQ ID NO:13=GGGGS (=G4S) motif (e.g. as part of a polypeptide linker) SEQ ID NO:14= ... 0302] Pertuzumab (formerly 2C4) is the first of a new class of agents known as HER dimerization inhibitors (HDIs). Pertuzumab ...
  http://patents.com/us-20160194410.html
*  Patent US6693122 - Nitrosated and nitrosylated potassium channel activators, compositions and ... - Google Patents
... thromboxane synthase inhibitors, and dual acting thromboxane synthase inhibitors and thromboxane receptor antagonists. ... The amount of active ingredient that can be combined with the carrier materials to produce a single dosage form will vary ... Use of a substance agonist of a receptor associated with a chlorine or potassium canal for treating sensitive skins. ... The reactions are performed in solvents appropriate to the reagents, and materials used are suitable for the transformations ...
  http://www.google.com/patents/US6693122?dq=6978253
*  EPCAM APTAMER FOR DETECTION OF CANCER STEM CELLS - DEAKIN UNIVERSITY
The surviving expression levels were normalised as the ratio of survivin protein expression levels to that of β-actin protein. ... or any diagnostic detection reagent, to capture or immobilise reagents for diagnostic, detection or quantitative studies. ... Under these circumstances, a competitive binding assay for the target molecule or other candidate substance can be conducted ... Examples of toxins include cytotoxins, metabolic disrupters (inhibitors and activators) that disrupt enzymatic activity and ...
  http://www.freepatentsonline.com/y2015/0197755.html
*  Patent US4806312 - Multizone analytical element having detectable signal concentrating zone - Google Patents
Labeled reagent which does not become bound to the immobilized reagent in the reagent layer migrates into the detection layer ... The immobilized reagent in the reagent layer and the labeled reagent comprise specific binding partners which will bind to each ... The test device preferably comprises multilayers including a reagent layer incorporated with an immobilized reagent and a ... As a result, reverse migration of the labeled reagent, and preferably the detectable reaction product from the detection layer ...
  http://www.google.com/patents/US4806312?dq=3657699
*  Protective effect of rutin supplementation against cisplatin-induced Nephrotoxicity in rats | BMC Nephrology | Full Text
Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal Biochem. 1968;25(1): ... Nowak G. Protein kinase C-alpha and ERK1/2 mediate mitochondrial dysfunction, decreases in active Na+ transport, and cisplatin- ... Quercetin and rutin as inhibitors of azoxymethanol-induced colonic neoplasia. Carcinogenesis. 1991;12(7):1193-6.View Article ... This reaction producing a thiobarbituric acid reactive substance (TBARS), pink color, measured spectrophotometrically at 532 nm ...
  https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-017-0601-y
*  Patent US9272074 - Surgical fasteners and methods for sealing wounds - Google Patents
... protein inhibitors, protein antagonists, and protein agonists; nucleic acids, such as antisense molecules, DNA and RNA; ... Sulfhydryl groups (e.g., as found on cysteine residues) may also be used as a reactive group for attaching PEG. In addition, ... Active Materials Inc.. Cycloaddition functional polymers from (vinyl) polystyrene. US6552103. 19 May 2000. 22 Apr 2003. The ... The term "bioactive agent", as used herein, is used in its broadest sense and includes any substance or mixture of substances ...
  http://www.google.ca/patents/US9272074
*  Patente US20020143188 - Nitrosated and nitrosylated potassium channel activators, compositions and ... - Google Patentes
... thromboxane synthase inhibitors, and dual acting thromboxane synthase inhibitors and thromboxane receptor antagonists. ... The amount of active ingredient that can be combined with the carrier materials to produce a single dosage form will vary ... The reactions are performed in solvents appropriate to the reagents, and materials used are suitable for the transformations ... Examples include polynitrosylated albumin where one or more thiol or other nucleophilic centers in the protein are modified. ...
  http://www.google.es/patents/US20020143188
*  Flavokawain A, a Novel Chalcone from Kava Extract, Induces Apoptosis in Bladder Cancer Cells by Involvement of Bax Protein...
Part 1. Isolation of an active substance, xanthoangelol. Int J Cancer 2003; 106: 429-37. ... Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against ... Hashimoto T, Suganuma M, Fujiki H, Yamada M, Kohno T, Asakawa Y. Isolation and synthesis of TNF-α release inhibitors from ... Louis, MO). Chemiluminescence Western blot detection reagents were from Amersham Life Sciences, Inc. (Arlington Heights, IL). ...
  http://cancerres.aacrjournals.org/content/65/8/3479.long
*  Patent US20070154513 - Medical devices having multiple charged layers - Google Patents
... inhibitors of HSP 90 protein (i.e., Heat Shock Protein, which is a molecular chaperone or housekeeping protein and is needed ... Therapeutic agents may be themselves pharmaceutically active, or they may converted in vivo into pharmaceutically active ... Amphiphilic substances include any substance having hydrophilic and hydrophobic groups. Where used, the amphiphilic substance ... Covalent linkage may proceed via a number of chemically reactive functional groups, including amino, hydroxyl, sulfhydryl, ...
  http://www.google.com/patents/US20070154513?dq=6377161
*  Patent US5935804 - Method for detecting eubacteria in biological samples with catalytically ... - Google Patents
Protein assay reagents, ion exchange resins (e.g., BioRex-70), and gel filtration resins were from Bio-Rad Laboratories ( ... Representative examples of enzyme active site inhibitors that may be useful in preparing MBP include Allosamidin (7) and the ... In one example, a reactive sulfhydryl in HRP is generated by reacting free amino groups with SPDP (N-succinimidyl-3-(2- ... As such, an endogenous MBP could conceivably constitute a confounding substance in an assay according to the invention. ...
  http://www.google.com/patents/US5935804?dq=7125605
*  US Patent # 4,806,312. Multizone analytical element having detectable signal concentrating zone - Patents.com
... for the determination of analyte from a liquid test medium upon contact with the liquid test medium and a labeled reagent ... reagent is incorporated in said reagent zone and detectable chemical group in the labeled reagent is an enzymatically active ... Usually, the analyte is an immunologically-active polypeptide or protein, usually having a molecular weight of between about ... or be modified to comprise a binding site for a distinct binding substance which in turn can be immobilized in the reagent ...
  http://patents.com/us-4806312.html
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
The protein transduction technique enables the direct delivery of biologically active material into mammalian cells [for review ... Moreover, the mice and the reagents for the assay are commercially available. Here we describe in detail how this model can be ... By thiolation of gelatin, the sulfhydryl groups could be introduced into the polymer and would form disulfide bond within ... Moreover, explants culture can be manipulated by addition of inhibitors, blocking antibodies, growth factors, or even cells or ...
  https://www.jove.com/visualize/abstract/21698151/the-loss-p53-activator-hipk2-is-responsible-for-galectin-3
*  IJMS | Free Full-Text | Antioxidant Properties and PC12 Cell Protective Effects of a Novel Curcumin Analogue (2E,6E)-2,6-Bis(3...
Triton X-100 and several protein inhibitors such as sodium pyrophosphate, β-glycerophosphate, EDTA, Na3PO4 and leupeptin ( ... A 50% reduction in H2O2-induced cell death (EC50) was achieved with the reference substance curcumin at 9.85 ± 0.66 μM and the ... Shanghai, China). All other chemicals were analytical reagent (AR)-grade.. 4.2. Synthesis of MCH. MCH was synthesized according ... Further research into the development of the synthetic analogues has resulted in the discovery of several active molecules [15 ...
  http://www.mdpi.com/1422-0067/15/3/3970/htm