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*  E2F1-3 Switch from Activators in Progenitor Cells to Repressors in Differentiating Cells
E2Fs function as transcription factors, with E2F1-3 as activators and E2F4-8 as repressors3-8. Although it is a maxim of ... Life and death decisions by the E2F transcription factors. Curr Opin Cell Biol. 2007;19:649-657. [PMC free article] [PubMed] ... Expression of transcription factor E2F1 induces quiescent cells to enter S phase. Nature. 1993;365:349-352. [PubMed] ... The E2F1-3 transcription factors are essential for cellular proliferation. Nature. 2001;414:457-462. [PubMed] ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2806193/
*  Cell cycle checkpoint - Wikipedia
Rb binds and represses activator E2F transcription factors (E2F1-3), while p107 and p130 bind E2F4 and E2F5 respectively to ... thereby relieving the repression of the E2F1-3 activators and translocating repressors E2F4 and E2F5 from the nucleus to the ... bind to the E2F transcription factors to prevent G1-to-S transition. ... form complexes which repress transcription of G1-to-S promoting factors (proteins). Upon the decision to progress past the G1 ...
  https://en.wikipedia.org/wiki/Cell_cycle_checkpoint
*  E2F - Wikipedia
E2F is a group of genes that codifies a family of transcription factors (TF) in higher eukaryotes. Three of them are activators ... While repressors E2F4 and 5 do not alter cell proliferation, they mediate G1 arrest. E2F activator levels are cyclic, with ... Drosophila E2F transcription factor - The Interactive Fly Drosophila E2F transcription factor 2 - The Interactive Fly. ... The E2F family is generally split by function into two groups: transcription activators and repressors. Activators such as E2F1 ...
  https://en.wikipedia.org/wiki/E2F
*  Frontiers | Skin Tumors Rb(eing) Uncovered | Oncology
... recruiting co-repressors/activators to specific transcription factors. Recent studies propose Rb proteins to bind co-repressors ... p27Kip1 represses transcription by direct interaction with p130/E2F4 at the promoters of target genes. Oncogene (2012) 31(38): ... Expression of transcription factor E2F1 induces quiescent cells to enter S phase. Nature (1993) 365(6444):349-52. doi:10.1038/ ... Yamasaki L. Growth regulation by the E2F and DP transcription factor families. Results Probl Cell Differ (1998) 22:199-227. ...
  https://www.frontiersin.org/articles/10.3389/fonc.2013.00307/full
*  Impact of Hepatitis C Virus (HCV) infection on biomolecular markers influencing the pathogenesis of bladder cancer | Infectious...
The transcription factors E2f1, E2f2 and E2f3 act as promoters of the G/S phase introduction, E2f4, E2f5, and E2f6 are ... binds to E2F family transcription factors and converts them from transcriptional activators to transcriptional repressors [37 ... the transcription factor E2F-1 is released and switches on genes (e.g. thymidine synthetase) whose products drive cells into ... a protein transcription factor, by binding with it. ... Furthermore, whenever the risk factors are demonstrated using ...
  https://infectagentscancer.biomedcentral.com/articles/10.1186/1750-9378-8-24
*  JCI - Dosage-dependent copy number gains in E2f1 and E2f3 drive hepatocellular carcinoma
The E2F transcription factor is a cellular target for the RB protein. Cell. 1991;65(6):1053-1061.. View this article via: ... activators (E2F1-3), canonical repressors (E2F4-6), and atypical repressors (E2F7 and E2F8). The complexity of the E2F family ... The E2F1-3 transcription factors are essential for cellular proliferation. Nature. 2001;414(6862):457-462.. View this article ... Duronio RJ, O'Farrell PH, Xie JE, Brook A, Dyson N. The transcription factor E2F is required for S phase during Drosophila ...
  https://5co1nn1.cn.insight.mobile.jci.org/articles/view/87583
*  Post‐transcriptional gene expression control by NANOS is up‐regulated and functionally important in pRb‐deficient cells | The...
The term "E2F" is the integrated activity of a family of proteins that contains both activators of transcription (dE2F1 (flies ... The family of E2F transcription factors plays a central role in the regulation of both proliferation and apoptosis. E2F ... E2F1‐E2F3 (humans)) and repressors of transcription (dE2F2 (flies), E2F4‐8 (humans)) (Chen et al, 2009). An additional layer of ... Chen D, Zheng W, Lin A, Uyhazi K, Zhao H, Lin H (2012) Pumilio 1 suppresses multiple activators of p53 to safeguard ...
  http://emboj.embopress.org/content/early/2014/08/06/embj.201488057
*  E2F5 Gene - GeneCards | E2F5 Protein | E2F5 Antibody
E2F Transcription Factor 5, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The ... sequence-specific DNA binding and transcription factor binding. An important paralog of this gene is E2F4. ... Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are ... Binding Sites for Transcription Factors within promoters. ENSR00000226513. 444. 1801. HDGF ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 ...
  http://www.genecards.org/cgi-bin/carddisp.pl?id_type=entrezgene&id=1875
*  E2F5 - Wikipedia
... "pRb2/p130-E2F4/5-HDAC1-SUV39H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNMT1 multimolecular complexes mediate the transcription ... Transcription factor E2F5 is a protein that in humans is encoded by the E2F5 gene. The protein encoded by this gene is a member ... "Regulation of E2F transcription by cyclin E-Cdk2 kinase mediated through p300/CBP co-activators". Nature Cell Biology. 2 (4): ... "Entrez Gene: E2F5 E2F transcription factor 5, p130-binding". Hijmans EM, Voorhoeve PM, Beijersbergen RL, van 't Veer LJ, ...
  https://en.wikipedia.org/wiki/E2F5
*  anti-E2F4 antibody (E2F Transcription Factor 4, P107/p130-Binding)</span...
Order this anti-E2F4 antibody. , Product number ABIN115206 ... Mouse Monoclonal E2F4 antibody for IF, IHC (p), WB. Published ... anti-E2F4 antibody (E2F Transcription Factor 4, P107/p130-Binding) E2F4 antibody (E2F Transcription Factor 4, P107/p130-Binding ... anti-E74-Like Factor 1 (Ets Domain Transcription Factor) Antibodies * anti-E74-Like Factor 2 (Ets Domain Transcription Factor) ... E2F transcription factor 4, E2F-4, Transcription factor E2F4, p107/p130-binding ...
  http://www.antibodies-online.com/antibody/115206/anti-E2F+Transcription+Factor+4,+P107/p130-Binding+E2F4+antibody/
*  The Dual Role of TGF in Human Cancer: From Tumor Suppression to Cancer Metastasis
TGFβ-induced gene transcription of p15 and p21 is mediated by Smad association with specific transcription factors, such as ... "The RhoA activator GEF-H1/Lfc is a transforming growth factor-β target gene and effector that regulates α-smooth muscle actin ... the repressor E2F4/5, and p107 [99] and directly leads to cell growth arrest. Interestingly, expression of the two CDKIs and is ... "Role of Smad proteins and transcription factor Sp1 in p21Waf1/Cip1 regulation by transforming growth factor-β," Journal of ...
  https://www.hindawi.com/journals/isrn/2012/381428/
*  Abstract 2984: Association of the Uracil DNA glycosylase (UNG) promoter in human lung cancer cells with the transcription...
Members of the E2F transcription factor family have been reported to bind to the UNG promoter resulting in a cell cycle ... Results of these studies show that the UNG promoter is immunoprecipitated with both E2F-1 and E2F-4 in untreated cells, but not ... we sought to identify transcriptional activators of the UNG gene that bind the UNG promoter region after treatment with DNA ... The UDG promoter region contains consensus sites for several other transcription factors including c-myc, AP-1 (c-Jun) and Sp-1 ...
  http://cancerres.aacrjournals.org/content/70/8_Supplement/2984
*  Anti-E2F4 Antibody
E2F-4/E2F4 information: Molecular Weight: 43960 MW; Subcellular Localization: Nucleus; Tissue Specificity: Found in all tissue ... Polyclonal antibody for E2F-4/E2F4 detection. Host: Rabbit.Size: 100μg/vial. Tested applications: WB. Reactive species: Human. ... Transcription factor E2F4. Molecular Weight. 43960 MW. Protein Function. Transcription activator that binds DNA cooperatively ... Background for Transcription factor E2F4. Transcription factor E2F4 is a protein that in humans is encoded by the E2F4 gene. ...
  https://www.bosterbio.com/anti-e2f4-antibody-pa2156.html
*  E2F4 Antibody (Monoclonal, 4E2F04 (WUF10))
E2F4 Monoclonal Antibody from Invitrogen for Western Blot, Immunofluorescence, Immunohistochemistry (Paraffin) and Gel Shift ... transcription factor binding. protein domain specific binding. promoter-specific chromatin binding. transcriptional activator ... Protein Aliases: E2F transcription factor 4, p107/p130-binding; E2F-4; p107/p130-binding protein; Transcription factor E2F4 ... MA5-11276 targets E2F-4 Transcription Factor in GS, IF, IHC (P), and WB applications and shows reactivity with Human and Rat ...
  https://www.thermofisher.com/antibody/product/E2F-4-Transcription-Factor-Antibody-4E2F04-WUF10-Monoclonal/MA5-11276
*  One Function-Multiple Mechanisms: The Manifold Activities of p53 as a Transcriptional Repressor
... of E2F4 and p130 to the recently identified E2F-pocketprotein complex LINC/DREAM is induced and displaces transcription factor ... T. Miyashita and J. C. Reed, "Tumor suppressor p53 is a direct transcriptional activator of the human bax gene," Cell, vol. 80 ... "p53 negatively regulates cdc2 transcription via the CCAAT-binding NF-Y transcription factor," Journal of Biological Chemistry, ... and concomitant binding of p53 and a second transcriptions factor with interaction of these two factors leading to repression ...
  https://www.hindawi.com/journals/bmri/2011/464916/
*  E2F5 Antibody (N-term) - Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab) WB, IHC-P, FC, E - Buy Now! |Abgent
Transcription factor E2F5, E2F-5, E2F5. Target/Specificity This E2F5 antibody is generated from rabbits immunized with a KLH ... It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins ... Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are ... E2F5 is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle ...
  http://www.abgent.com/products/AP9003a-E2F5-Antibody-N-term
*  Modeling Gene Regulation in Liver Hepatocellular Carcinoma with Random Forests
M. Shah, S. A. Rennoll, W. M. Raup-Konsavage, and G. S. Yochum, "A dynamic exchange of TCF3 and TCF4 transcription factors ... X. Xu, B. Mark, V. X. Jin et al., "A comprehensive ChIP-chip analysis of E2F1, E2F4, and E2F6 in normal and tumor cells reveals ... U. Wellner, J. Schubert, U. C. Burk et al., "The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting ... Lastly, we found that the transcription factor E2F6, one of the candidate regulators inferred by our model, is predictive of ...
  https://www.hindawi.com/journals/bmri/2016/1035945/
*  Anti-E2F4 antibody [EPR8259] (ab150360) | Abcam
Rabbit recombinant monoclonal E2F4 antibody [EPR8259 ] validated for WB, IHC, Flow Cyt, ICC/IF and tested in Human. Referenced ... Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found ... E2F transcription factor 4 antibody. *E2F transcription factor 4 p107/p130 binding antibody ... Agonists, activators, antagonists and inhibitors. Lysates. Multiplex miRNA assays. By research area. Cancer. Cardiovascular. ...
  http://www.abcam.com/e2f4-antibody-epr8259-ab150360.html
*  Interactive Fly, Drosophila
Binding of an activator E2F is dependent on an adjacent CCAAT site that is bound by the NF-Y transcription factor and binding ... E2F1, E2F2, and E2F3 were found to bind to the positive-acting E2F site in the cdc2 promoter, whereas E2F4 binds to the ... CPEB (Drosophila homolog: Orb) and CPEB associated factor maskin, two factors that control polyadenylation-induced translation ... The injection of oocytes with a cyclin B1 antisense RNA, which probably precludes the binding of a factor to the CPE, delays ...
  http://www.sdbonline.org/sites/fly/newgene/cyclinb2.htm
*  Meta-Analysis of Differential Connectivity in Gene Co-Expression Networks in Multiple Sclerosis
... the most significant transcription factors potentially dysregulated in MS are YY1 (yin and yang 1), E2F-1/DP-1 and E2F-4/DP-2 ... This transrepression is associated with VDIR switching from a co-activator complex containing histone acetyltransferase (HAT) ... Analysis of Enriched Transcription Factor and MicroRNA Targets. Among the genetic regulators, transcription factors (TFs) and ... Overrepresented Transcription Factors Binding Sites. Many of the transcription factor binding sites (TFBSs) enriched in both ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC4926469/
*  Human Pancreatic β-Cell G1/S Molecule Cell Cycle Atlas | Diabetes
The E2F transcription factors. A: The proproliferative E2Fs 1-3. B: Adenoviral overexpression of E2Fs enhances E2F ... E2F4 both is cytoplasmic and colocalizes with nucleoli. Coimmunolabeling for E2F4 and nucleolin suggests that E2F4 is a ... In contrast, all of the cell cycle activators appear in the cytoplasmic compartment. ... The E2F family of transcription factors, E2Fs1-8, was examined next (Fig. 2). E2Fs1-7 were observed in the human β-cell, ...
  http://diabetes.diabetesjournals.org/content/62/7/2450?cited-by=yes&legid=diabetes
*  Cancers | Free Full-Text | BRCA1 and Oxidative Stress | HTML
Table 1. Transcription factors that bind to BRCA1.. Transcription factor. Region in BRCA1 (aa). Assays. References. ... through its interaction with the signal transducer and activator of transcription 1 (STAT1) [111]. Many, not all, of the IFNγ- ... E2F4. N/D. GST. [170]. ERα. 1-300. Co-IP/GST. [135]. ... BRCA1 augments transcription by the NF-κB transcription factor ... BRCA1 also modulates transcriptional activity of diverse transcription factors including the activating transcription factor 1 ...
  http://www.mdpi.com/2072-6694/6/2/771/htm
*  SMAD (protein) - Wikipedia
When there is no TGF-B present, a repressor complex composed of Smad3, and the transcription factors E2F4 and p107 exist in the ... The transcription activators and the ubiquitin ligases both contain pairs of WW domains. These domains interact with the PY ... a transcription factor that is induced during cellular stress. Smad3 and ATF3 then coordinate to repress Id1 transcription, ... IDs are transcription factors that regulate genes involved in cell differentiation, maintaining multi-potency in stem cells, ...
  https://en.wikipedia.org/wiki/SMAD_(protein)
*  Inactivation of the RB family prevents thymus involution and promotes thymic function by direct control of Foxn1 expression
Life and death decisions by the E2F transcription factors. Curr. Opin. Cell Biol. 19:649-657 10.1016/j.ceb.2007.10.006 [PMC ... as well as a switch between the E2F3 activator and the E2F4 repressor at the Foxn1 promoter (Fig. 4 I). Collectively, these ... Through its ability to bind the E2F transcription factors, the RB family of proteins (RB, p107, and p130) plays a major role in ... Thymus organogenesis is coordinated by the successive action of a network of transcription factors (Rodewald, 2008; Manley and ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3674705/?lang=en-ca
*  Retinoblastoma protein - Wikipedia
The activator ESF's are E2F-1, E2F-2 and E2F-3 while the repressor E2Fs are E2F-4, E2F-5 and E2F-6. Activator ESF's along with ... Rb is able to bind to transcription factors in the E2F family and thereby inhibit their function. When Rb is chronically ... The TFIID binds to the TATA box in order to begin the assembly of the TFIIA, recruiting other transcription factors and ... Sutcliffe JE, Cairns CA, McLees A, Allison SJ, Tosh K, White RJ (June 1999). "RNA Polymerase III Transcription Factor IIIB Is a ...
  https://en.wikipedia.org/wiki/Retinoblastoma_protein