*  Coordinated Expression of Pax-5 and FAK1 in Metastasis | BenthamScience
Title: Coordinated Expression of Pax-5 and FAK1 in Metastasis. VOLUME: 11 ISSUE: 7. Author(s):Nicolas Crapoulet, Pierre O'Brien, Rodney J. Ouellette and Gilles A. Robichaud. Affiliation:Universite de Moncton, Moncton, NB, Canada, E1A 3E9.. Keywords:Cancer, cell signaling, FAK1, focal adhesion, metastasis, Pax-5, B lymphopoiesis, cell differentiation, homeostasis, leukemia. Abstract: The Pax-5 gene encodes a B-cell-specific activator protein (BSAP) that plays a key role in B lymphocyte differentiation and embryogenesis. The deregulation of this transcription factor is also linked to B cell malignancies and recently to other cancers. More specifically, the downstream effects of Pax-5 promote cell-cell interactions and mediate the activation of adhesion genes which result in an epithelial phenotypic behavior of human carcinoma ...
*  TAF4B gene - Genetics Home Reference
Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAF4B is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Plays a role in spermiogenesis and oogenesis. ...
*  dU Oligo Modifications from Gene Link
Deoxyuridine (dU) is a pyrimidine deoxyribonucleoside, and a derivative of the nucleoside uridine, with the only difference being that, in dU, a hydrogen (-H) group is substituted for uridine s OH group located at the 2 -position of the ribose. dU is generated in cellular DNA as a deamination product of dC (deoxycytidine), with the deamination process catalyzed by the enzyme AID (activation-induced cytidine deaminase) (1). AID is a B cell-specific gene that is necessary for antibody gene diversification via class-switch recombination and somatic hypermutation (2, 3). The dC-to-dU conversion(s) by AID occurs in the IgG locus, with various gene diversification pathways arising from the different DNA repair mechanisms used by B-cells to repair the dU lesion (1).. dC-to-dU conversion via cytidine deamination is also implicated in innate immunity to retroviruses. Here deamination of dC is mediated by the enzyme APOBEC3G, which is present in T ...
*  Plus it
Oncogenic lesions in multi-potent progenitor cells often give rise to either B-cell or myeloid lineage leukemia. While transformed by the same oncogenes (e.g. BCR-ABL1, RAS), B-lineage and myeloid leukemias are distinct diseases. Given that oncogenic tyrosine kinase signaling (e.g. BCR-ABL1) imposes significant metabolic requirements on energy supply, biogenesis and metabolic fitness, we studied whether the divergent characteristics of myeloid and B-lineage leukemias have a metabolic basis.. Metabolic analyses revealed that B-lineage acute lymphoblastic leukemia (Ph+ ALL) cells proliferate at maximum capacity of their glycolytic machinery. In contrast to myeloid leukemia (CML), B-lineage ALL cells lack metabolic adaptive fitness in response to metabolic fluctuations. C/EBPα-mediated reprogramming of B-lineage cells into the myeloid lineage induced glycolytic gene expression (Insr, Slc2a1, G6pdx, G6pd2, and Hk3). Frequent ...
*  PLOS Pathogens: A Peer-Reviewed Open-Access Journal
Although bats are recognized as major reservoir hosts of emerging infectious diseases, Joffrin and colleagues highlight that a significant knowledge gap on transmission mechanisms remains and needs further exploration. They question whether bat bites are the exception rather than the rule, and ask whether other animals can transmit bat-borne pathogens. They conclude by questioning what we can learn from bat-to-bat transmission.. ...
*  PLOS Pathogens: A Peer-Reviewed Open-Access Journal
Kempkes and colleagues show that EBNA2 can form complexes with early B cell factor 1 (EBF1), a B cell specific DNA binding transcription factor, and EBF1 stabilizes EBNA2 chromatin binding. This EBNA2/EBF1 complex might serve as a novel target to develop future small molecule strategies that act as antivirals in latent B cell infection.. ...
*  PAX3 in neuroblastoma: oncogenic potential, chemosensitivity a...
PAX3 in neuroblastoma: oncogenic potential, chemosensitivity and signalling pathways.: Transcription factor PAX3/Pax3 contributes to diverse cell lineages durin
*  BearShare Acceleration Patch Download - BSAP is an add-on for BearShare utility.
BearShare Acceleration Patch is an add-on for people who use BearShare P2P file sharing utility to download music, movies, books and any other files.
*  Role of the developmental regulator Gon4-like in B lymphopoiesis - John Colgan
B cells represent a critical component of the immune system: in the absence of these cells, the ability to fight infections and to establish long-term protectiv...
*  PAX6抗体[EPR3352(2)]|Abcam中国|Anti-PAX6抗体[EPR3352(2)]
PAX6兔单克隆抗体[EPR3352(2)](ab109233)可与小鼠, 大鼠, 人样本反应并经WB, Flow Cyt实验严格验证。中国75%以上现货,所有产品提供质保服务。
*  PAX3抗体|Abcam中国|Anti-PAX3抗体(ab15717)
PAX3山羊多克隆抗体(ab15717)可与小鼠, 人样本反应并经WB, IP, IHC实验严格验证,被2篇文献引用并得到2个独立的用户反馈。所有产品均提供质保服务,中国75%以上现货。
*  PAX8抗体|Abcam中国
PAX8兔多克隆抗体(ab97477)可与人样本反应并经WB, ICC/IF实验严格验证并得到1个独立的用户反馈。所有产品均提供质保服务,中国75%以上现货。
*  重组人PAX3蛋白(ab114320)|Abcam中国
购买我们的重组人PAX3蛋白。Ab114320为全长蛋白,在小麦胚芽中生产并经过ELISA, SDS-PAGE, Western blot实验验证。Abcam提供免费的实验方案,操作技巧及专业的支持。
*  Best 25+ Bester friseur münchen ideas on Pinterest | Bob frisuren 2015 hinterkopf, Bob kurze nackenpartie and Kurzhaarschnitt...
Find and save ideas about Bester friseur münchen on Pinterest. | See more ideas about Bob frisuren 2015 hinterkopf, Bob kurze nackenpartie and Kurzhaarschnitt nackenpartie.
*  Bob Enyart Live
Greetings to the brightest audience in the country. I am Bob Enyart...... discuss Bob's shows here! Bob's show is aired live on the radio and rebroadcast at: KGOV.com
*  POWER FIRST Cable Tie,Standard,14.5 in.,Blk,PK100 - 36J166|36J166 - Grainger
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*  Сопот: Bob Sinclar уже 12 июля в Затоце Штуки (Zatoka Sztuki) - КУЛЬТУРА, СОБЫТИЯ, КОНЦЕРТЫ,МЕРОПРИЯТИЯ И СПОРТ - GIDpl.ru
Культовая личность мировой танцевальной музыки и одновременно, икона клубной сцены выступит в ближайшую субботу в 19.00. Цены билетов: Зона А - от 100 pln
*  What the Bible Teaches Course Intro
What the Bible Teaches: A Guide to Total Christian Commitment is a concise overall view of God's Word from Genesis to Revelation.
*  Clinical Trials Registry | Internet Stroke Center
This project is supported in part by the NIH Specialized Programs of Translational Research in Acute Stroke (SPOTRIAS) Network, and NINDS grant 3P50NS055977 to Washington University in St. Louis School of Medicine and UT Southwestern Medical Center.. ...
*  Effect of dsRNA on Mesangial Cell Synthesis of Plasminogen Activator Inhibitor Type 1 and Tissue Plasminogen Activator
Background/Aims: Viral infections are a major problem worldwide and many of them are complicated by virally induced glomerulonephritides. Progression of kidney disease to renal failure is mainly attributed to the development of renal fibrosis characterized by the accumulation of extracellular matrix components in the mesangial cell compartment and the glomerular basement membrane. Plasminogen activator inhibitor type 1 (PAI-1) and tissue plasminogen activator (t-PA) are major regulators of plasmin generation and play an important role in generation and degradation of glomerular extracellular matrix components. Viral receptors expressed by mesangial cells (MC) are known to be key mediators in immune-mediated glomerulonephritis. We investigated the effect of stimulation of the viral receptors toll-like receptor 3 (TLR3) and retinoic acid-inducible gene I ...
*  Plasminogen activator inhibitor-1 - Wikipedia
Plasminogen activator inhibitor-1 (PAI-1) also known as endothelial plasminogen activator inhibitor or serpin E1 is a protein that in humans is encoded by the SERPINE1 gene. Elevated PAI-1 is a risk factor for thrombosis and atherosclerosis PAI-1 is a serine protease inhibitor (serpin) that functions as the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), the activators of plasminogen and hence fibrinolysis (the physiological breakdown of blood clots). It is a serine protease inhibitor (serpin) protein (SERPINE1). The other PAI, plasminogen activator inhibitor-2 (PAI-2) is secreted by the placenta and only present in significant amounts during pregnancy. In addition, protease ...
*  Predictive value for thrombotic disease of plasminogen activator inhibitor-1 plasma levels | IRIS Università degli Studi di...
Abstract: Plasminogen activator inhibitor-I plays a major role in the fibrinolytic system as the main physiological inhibitor of both tissue-type and urinary-type plasminogen activators. The inhibitor is present in plasma in small amounts and derives mainly from endothelial cells. Positive correlations have been reported between plasma levels and different parameters, such as serum triglycerides, insulin plasma levels and body mass index. Moreover, high plasma inhibitor concentrations have been observed in different disease states, but it must be stressed that plasminogen activator inhibitor-1 behaves as an acute-phase reactant and measurement of plasma levels is not significant in the acute phase of the disease. A possible predictive value of inhibitor levels for thrombotic events such as ...
*  Induction of plasminogen activator inhibitor type-1 (PAI-1) by hypoxia and irradiation in human head and neck carcinoma cell...
As PAI-1 is involved in the invasion and migration of tumour cells and is an established marker for poor outcome, it is crucial to investigate the exact mechanisms leading to increased PAI-1 levels. Although previous studies have shown that both, hypoxia and irradiation are able to up-regulate PAI-1 in different cell lines, no study has investigated the influence of hypoxia, reoxygenation and irradiation on PAI-1 expression and secretion in the frequently hypoxic tumour entity, SCCHN. Therefore, in the present study, we investigated the influence of these parameters on PAI-1 expression and secretion in the two SCCHN cell lines, BHY and FaDu. Furthermore, we analyzed in detail the kinetics of PAI-1 induction by hypoxia.. The only data available so far on hypoxia kinetics for SCCHN cell lines is by Koong et al. [17]. However, they only investigated one cell line (FaDu) on the transcriptional and not on the ...
*  Thrombin neutralizes plasminogen activator inhibitor 1 (PAI-1) that is complexed with vitronectin in the endothelial cell...
Vitronectin endows plasminogen activator inhibitor 1 (PAI-1), the fast-acting inhibitor of both tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA), with additional thrombin inhibitory properties. In view of the apparent association between PAI-1 and vitronectin in the endothelial cell matrix (ECM), we analyzed the interaction between PAI-1 and thrombin in this environment. Upon incubating 125I-labeled alpha-thrombin with endothelial cell matrix (ECM), the protease formed SDS-stable complexes exclusively with PAI-1, with subsequent release of these complexes into the supernatant. Vitronectin was required as a cofactor for the association between PAI-1 and thrombin in ECM. Metabolic labeling of endothelial cell proteins, followed by incubation of ECM with ...