*  TWEAK binding to the Fn14 cysteine-rich domain depends on charged residues located in both the A1 and D2 modules | Biochemical...
TWEAK [TNF (tumour necrosis factor)-like weak inducer of apoptosis] is a member of the TNF superfamily of cytokines. TWEAK ... Abbreviations: APRIL, a proliferation-inducing ligand; BAFF, B-cell activation factor; BCA, bicinchoninic acid; BCMA, B-cell ... calcium modulator and cyclophilin ligand) interactor; TNF, tumour necrosis factor; TNFR, TNF receptor; TWEAK, TNF-like weak ... tumour necrosis factor-like weak inducer of apoptosis (TWEAK). ... tumour necrosis factor (TNF). tumour necrosis factor-like weak ...
  http://www.biochemj.org/content/397/2/297
*  TNFSF11- Tumor Necrosis Factor Ligand Superfamily Member 11 Pipeline Review Market Report by Radiant Insights | US Financial...
Factor Kappa B Ligand or Osteoclast Differentiation Factor or TNF Related Activation Induced Cytokine or Osteoprotegerin Ligand ... The report reviews Tumor Necrosis Factor Ligand Superfamily Member 11 (Receptor Activator Of Nuclear Factor Kappa B Ligand or ... The report assesses Tumor Necrosis Factor Ligand Superfamily Member 11 (Receptor Activator Of Nuclear Factor Kappa B Ligand or ... Radiant Insights's 'Tumor Necrosis Factor Ligand Superfamily Member 11 (Receptor Activator Of Nuclear Factor Kappa B Ligand or ...
  http://www.usfinancialnewstoday.com/story/103913/tnfsf11-tumor-necrosis-factor-ligand-superfamily-member-11-pipeline-review-market-report-by-radiant-insights.html
*  Vascular endothelial growth inhibitor - Wikipedia
It belongs to tumor necrosis factor (ligand) superfamily, where it is member 15. It is the sole known ligand for death receptor ... a novel tumor necrosis factor-like cytokine, induces apoptosis in endothelial cells. Involvement of activation of stress ... "Entrez Gene: TNFSF15 tumor necrosis factor (ligand) superfamily, member 15". Wang EC (Sep 2012). "On death receptor 3 and its ... The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is ...
  https://en.wikipedia.org/wiki/Vascular_endothelial_growth_inhibitor
*  TNFSF11 TNF superfamily member 11 - Gene - GTR - NCBI
... kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, ... cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and ... T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. ... activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent ...
  https://www.ncbi.nlm.nih.gov/gtr/genes/8600/
*  Professor Guenther Eissner | UCD Conway
Pro-inflammatory mediators, such as members of the tumor necrosis factor superfamily, contribute to the pleiotropy of ... Schulz C, Farkas L;Wolf K;Kratzel K;Eissner G;Pfeifer M (2002) 'Differences in LPS-induced activation of bronchial epithelial ... reverse signaling by members of the TNF superfamily enhance the plasticity of the immune system'. Cytokine & Growth Factor ... Eissner G, Kolch W, Scheurich P (2004) 'Ligands working as receptors: ...
  http://www.ucd.ie/conway/research/researchers/conwayfellowsa-z/professorguenthereissner/
*  Death receptor 6 - Wikipedia
"Tumor necrosis factor-alpha induces the expression of DR6, a member of the TNF receptor family, through activation of NF-kappaB ... also known as tumor necrosis factor receptor superfamily member 21 (TNFRSF21), is a cell surface receptor of the tumor necrosis ... APP (amyloid precursor protein) is the natural ligand of DR6 and is first cleaved into Aβ and N-APP. N-APP is the fragment that ... "Enhanced CD4+ T cell proliferation and Th2 cytokine production in DR6-deficient mice". Immunity. 15 (1): 23-34. doi:10.1016/ ...
  https://en.wikipedia.org/wiki/Death_receptor_6
*  Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 [Mus musculus (house mouse)] - Gene - NCBI
tumor necrosis factor ligand superfamily member 11. Names. OPG ligand. TNF-related activation-induced cytokine. osteoclast ... Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 [Mus musculus] Tnfsf11 tumor necrosis factor (ligand) superfamily ... receptor activator of nuclear factor kappa-B ligand. tumor necrosis factor-related activation-induced cytokine. ... tumor necrosis factor (ligand) superfamily, member 11provided by MGI. Primary source. MGI:MGI:1100089 See related. Ensembl: ...
  https://www.ncbi.nlm.nih.gov/gene?LinkName=pubmed_gene_rif&from_uid=21715325
*  Biomolecules | Free Full-Text | Role of Transcription Factors in Steatohepatitis and Hypertension after Ethanol: The Epicenter...
These Kupffer cells and circulating macrophages secrete various cytokines. The level of tumor necrosis factor-α (TNFα), ... from intestine causing activation of immune response. In addition, the metabolic product, acetaldehyde, modifies the proteins ... An increase in ROS activates nuclear factor erythroid-2-related factor-2 (Nrf2) and hypoxia inducible factor (HIF) to provide ... In addition to elevation of these cytokines, the peripheral iron (Fe2+) is also mobilized. An increased level of hepatic iron ...
  http://www.mdpi.com/2218-273X/6/3/29/htm
*  Role of ADAMs in Endothelial Cell Permeability | Circulation Research
ADAM-17 (tumor necrosis factor-converting enzyme or TACE) was the first member of the ADAM family, with a defined role as a ... Matrix metalloproteinase-2 induced venous dilation via hyperpolarization and activation of K+ channels: relevance to varicose ... are members of the metzincin zinc-dependent metalloprotease superfamily. At least thirty members of the ADAMs protein family ... Modulation of calcium current in arteriolar smooth muscle by αvβ3 and α5β1 integrin ligands. J Cell Biol. 1998; 143: 241-252. ...
  http://circres.ahajournals.org/content/102/10/1139
*  Zerumbone Abolishes RANKL-Induced NF-κB Activation, Inhibits Osteoclastogenesis, and Suppresses Human Breast Cancer-Induced...
... and its ligand, RANKL. The latter is a member of the tumor necrosis factor (TNF) superfamily of cytokines ( 3), and its ... Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ... Zerumbone abrogates RANKL-induced NF-κB activation. To investigate whether zerumbone modulates RANKL-induced NF-κB activation ... on RANKL-induced NF-κB activation and osteoclastogenesis induced by both RANKL and tumor cells. ...
  http://cancerres.aacrjournals.org/content/69/4/1477
*  Rat TNF-alpha Antibody MAB510-100: R&D Systems
... tumor necrosis factor alpha; Tumor necrosis factor ligand superfamily member 2; tumor necrosis factor; tumor necrosis factor- ... In vivo modulation of LPS-induced alterations in brain and peripheral cytokines and HPA axis activity by cannabinoids.. Authors ... It also promotes inflammatory responses by inducing the activation of vascular endothelial cells and macrophages (2). TNF-alpha ... TNFSF2TNF superfamily, member 2; tumor necrosis factor (TNF superfamily, member 2); ...
  https://www.rndsystems.com/products/rat-tnf-alpha-antibody-45418_mab510
*  Plus it
... forms a CD40 trimer that induces the recruitment of adaptor proteins known as tumor necrosis factor receptor-associated factors ... CD40 signaling is induced upon binding to its ligand (CD40L and CD154), a 39 kDa type II transmembrane protein member of the ... is a TH2-type cytokine that signals predominantly via JAK1 and JAK3 and subsequently induces phosphorylation and activation of ... TNF gene superfamily (20). CD40L is expressed on activated CD4+ T cells and activated platelets, however, a wide variety of ...
  http://clincancerres.aacrjournals.org/content/18/2/417
*  Recombinant Human TNFSF18 protein (ab113132) | Abcam
Tumor necrosis factor ligand superfamily member 18. see all. * Function. Cytokine that binds to TNFRSF18/AITR/GITR. Important ... Activation-inducible TNF-related ligand. *AITR ligand. *AITRL. *GITR ligand. *GITRL. *Glucocorticoid induced TNF related ligand ... Tumor necrosis factor (ligand) superfamily member 18. *Tumor necrosis factor ligand 2A ...
  http://www.abcam.com/recombinant-human-tnfsf18-protein-ab113132.html
*  Fractalkine (CX3CL1) and Its Receptor CX3CR1 May Contribute to Increased Angiogenesis in Diabetic Placenta
... including cytokines, histamine, bradykinin, prostaglandins, leukotrienes, PAF, biological response modifiers and the family of ... Strongly upregulated by hypoxia and/or inflammation-induced inflammatory cytokines secretion, especially tumor necrosis factor ... Chemokines form a superfamily of cytokines with the major roles involved in the modulation of immune response and the guidance ... J. Ryu, C.-W. Lee, K.-H. Hong et al., "Activation of fractalkine/CX3CR1 by vascular endothelial cells induces angiogenesis ...
  https://www.hindawi.com/journals/mi/2013/437576/
*  Biomarkers of Atherosclerotic Plaque Instability and Rupture | Arteriosclerosis, Thrombosis, and Vascular Biology
Soluble CD40 Ligand. CD40 and CD40L (CD 154), both members of the TNF superfamily, are coexpressed by all major cells ... SPLA2-II production is upregulated in response to proinflammatory compounds such as IL-1β, IL-6, tumor necrosis factor (TNF)-α ... like cytokines, chemokines, growth-factors, enzymes, and disintegrins, which lead to activation of endothelial cells, ... Platelet activation induced by plaque rupture results in increased surface expression of CD40L, which is then cleaved. ...
  http://atvb.ahajournals.org/content/27/1/15
*  TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFα
... free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI ... Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-κB activation and protection from cell death. J. Biol. ... TNF receptor superfamily; TRAF, Tnf receptor-associated factor; TRAIL, TNF-related apoptosis-inducing ligand; TWEAK, TNF-like ... a reduction in prosurvival NF-kB signal from TNFα is the reason for TWEAK-induced sensitization to TNFα when the two cytokines ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2447903/?lang=en-ca
*  004321 - B6.129S2-Mapk9|tm1Flv|/J
Tumor necrosis factor-induced toxic liver injury results from JNK2-dependent activation of caspase-8 and the mitochondrial ... Synergistic effect of TGF-beta superfamily members on the induction of Foxp3+ Treg. Eur J Immunol 40(1):142-52. PubMed: ... Ligand-directed c-Jun N-terminal kinase activation disrupts opioid receptor signaling. Proc Natl Acad Sci U S A 107(25):11608- ... JNK3 is abundant in insulin-secreting cells and protects against cytokine-induced apoptosis. Diabetologia 52(9):1871-80. PubMed ...
  https://www.jax.org/strain/004321
*  Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof - Patent # 6410294 ...
... and pro-inflammatory cytokinessuch as tumor necrosis factor (TNF) and interleukin-1 (IL- 1).. PRK (proliferation-related kinase ... or transcription factor.. The kinases comprise the largest, known protein group, a superfamily of enzymes with widely varied ... germ cell tumor tissue, and primary cancers. The art has clearly established the commercial importance of members of this ... or exogenous factor such asa hormone or other ligand. A variety of vectors providing for constitutive and inducible expression ...
  http://www.patentgenius.com/patent/6410294.html
*  Dominant-Negative Inhibitors of Soluble TNF Attenuate Experimental Arthritis without Suppressing Innate Immunity to Infection |...
Tumor necrosis factor induces distinct patterns of caspase activation in WEHI-164 cells associated with apoptosis or necrosis ... reverse signaling by members of the TNF superfamily enhance the plasticity of the immune system. Cytokine Growth Factor Rev. 15 ... The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor. ... Blocking soluble tumor necrosis factor signaling with dominant-negative tumor necrosis factor inhibitor attenuates loss of ...
  http://www.jimmunol.org/content/179/3/1872.long
*  TNFSF12 - Wikipedia
Tumor necrosis factor ligand superfamily member 12 also known as TNF-related weak inducer of apoptosis (TWEAK) is a protein ... TWEAK can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to ... Excessive activation of the TWEAK pathway in chronic injury has been described to promote pathological tissue changes including ... "Entrez Gene: TNFSF12 tumor necrosis factor (ligand) superfamily, member 12". Maecker H, Varfolomeev E, Kischkel F, Lawrence D, ...
  https://en.wikipedia.org/wiki/TNFSF12
*  SMART: Secondary literature for TNF domain
... tumor necrosis factor-related apoptosis-inducing ligand) is a recently identified member of the tumor necrosis factor cytokine ... TR6, a member of the tumor necrosis factor (TNF) receptor superfamily, has recently been shown to bind to Fas ligand (FasL) and ... Evidence that tumor necrosis factor alpha (TNF)-induced activation of neutrophil respiratory burst on biologic surfaces is ... Rapid progress in the discovery of members of the tumor necrosis factor receptor/ligand superfamilies has been made, mainly ...
  http://smart.embl-heidelberg.de/smart/show_secondary.cgi?domain=TNF
*  Discovery Biology News
The researchers identified that glycoprotein OX40L ligand (OX40L, member of the tumor necrosis factor superfamily) plays a key ... Article: Baer C, et al. Suppression of microRNA activity amplifies IFN-γ-induced macrophage activation and promotes anti-tumor ... It is also found that TLRs induce secretion of cytokines including interleukin-10 proteins and type 1 interferons (IFN-1). IL- ... Targeting fibroblast activation protein in tumor stroma with chimeric antigen receptor T cells can inhibit tumor growth and ...
  https://www.genscript.com/DiscoveryBiology_news.html
*  RANKL - Wikipedia
... also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), TNF-related activation-induced cytokine (TRANCE), ... "Entrez Gene: TNFSF11 tumor necrosis factor (ligand) superfamily, member 11". Coleman RE (2001). "Metastatic bone disease: ... RANKL is a member of the tumor necrosis factor (TNF) cytokine family, it binds to RANK on cells of the myeloid lineage and ... RANKL is known as a type II membrane protein and is a member of the tumor necrosis factor (TNF) superfamily. RANKL has been ...
  https://en.wikipedia.org/wiki/RANKL
*  Frontiers | The Molecular Mechanism of Natural Killer Cells Function and Its Importance in Cancer Immunotherapy | Immunology
NK cells have been used in several clinical trials to control tumor growth. However, the results are encouraging only in ... In this review, we discussed the NK cell phenotypes and its effector function and impact of the tumor microenvironment on ... NK cells have been used in several clinical trials to control tumor growth. However, the results are encouraging only in ... In this review, we discussed the NK cell phenotypes and its effector function and impact of the tumor microenvironment on ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2017.01124/full
*  Activation of Tubular Epithelial Cells in Diabetic Nephropathy | Diabetes
... if NF-κB activation in humans would be as short lasting as in tissue culture after tumor necrosis factor stimulation. Thus, in ... To further prove an AGE/CML-induced NF-κB activation in pTECs, NF-κB activation was studied in cultured human pTECs by ... there is evidence that RAGE-ligand interaction contributes to sustained NF-κBp65 activation (41,68-70,83,121,122). The long- ... One of these receptors is the receptor for AGEs (RAGE) (59,63,68-76,79-94). RAGE is a 35-kDa receptor of the IgG superfamily, ...
  http://diabetes.diabetesjournals.org/content/51/12/3532.full