*  Reactome | Unblocking of NMDA receptor, glutamate binding and activation
Unblocking of NMDA receptor, glutamate binding and activation (Bos taurus) Unblocking of NMDA receptor, glutamate binding and ... Unblocking of NMDA receptor, glutamate binding and activation (Danio rerio) Unblocking of NMDA receptor, glutamate binding and ... Unblocking of NMDA receptor, glutamate binding and activation (Sus scrofa) Unblocking of NMDA receptor, glutamate binding and ... Unblocking of NMDA receptor, glutamate binding and activation (Mus musculus) Unblocking of NMDA receptor, glutamate binding and ...
  http://www.reactome.org/content/detail/438066
*  Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation |...
Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation. ... Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation ... Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation ... Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation ...
  http://www.jneurosci.org/content/15/5/3318
*  Allosteric modulators of NR2B-containing NMDA receptors: molecular mechanisms and therapeutic potential - Mony - 2009 - British...
Giffard RG, Monyer H, Christine CW, Choi DW (1990). Acidosis reduces NMDA receptor activation, glutamate neurotoxicity, and ... Chang HR, Kuo CC (2008). The activation gate and gating mechanism of the NMDA receptor. J Neurosci 28: 1546-1556. *CrossRef, ... Furukawa H, Gouaux E (2003). Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ... Neyton J, Paoletti P (2006). Relating NMDA receptor function to receptor subunit composition: limitations of the ...
  http://onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2009.00304.x/references
*  Development& Functions Of Various Parts Of Cns
li,,/ul,,ul,,ul,,li,Requires activation of the NMDA receptors for glutamate. ,/li,,/ul,,/ul,,ul,,ul,,ul,,li,Glutamate and ... Binding of glutamate to NMDA receptors and simultaneous depolarization, open receptor channels for Ca 2+ . ,/li,,/ul,,/ul,,ul,, ... Ascending Spinal Tracts ,ul,,li,Convey sensory information from cutaneous receptors, proprioceptors and visceral receptors to ... li,,/ul,,ul,,li,Stimulation of sensory receptors evokes APs that are conducted into spinal cord. ,/li,,/ul,,ul,,ul,,li,Synapses ...
  https://www.slideshare.net/rajud521/development-functions-of-various-parts-of-cns-3663587
*  Piracetam-induced changes in the functional activity of neurons as a possible mechanism for the effects of nootropic agents |...
"Nootropes potentiate the responses of nerve cells due to activation of NMDA-glutamate receptors," Byull. Éksp. Biol. Med.,115, ... S. Kaneko, H. Takahashi, M. Sugimura, and M. Satoh, "Effects of nootropic drugs on excitatory amino acid receptor-mediated ... evidence that receptor changes subserve LTP," J. Psychobiol.,18, 377 (1990).Google Scholar ...
  https://link.springer.com/article/10.1007%2FBF02359492
*  Grin2a - Glutamate receptor ionotropic, NMDA 2A precursor - Mus musculus (Mouse) - Grin2a gene & protein
Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta ... channels containing GRIN1 and GRIN2A have higher sensitivity to glutamate and faster kinetics than channels formed by GRIN1 and ... Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium ... subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics ...
  http://www.uniprot.org/uniprot/P35436
*  grin2bb - Glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b - Danio rerio (Zebrafish) - grin2bb gene ...
Unblocking of NMDA receptor, glutamate binding and activation. R-DRE-442729. CREB phosphorylation through the activation of ... Unblocking of NMDA receptor, glutamate binding and activation. R-DRE-442729. CREB phosphorylation through the activation of ... R-DRE-442982. Ras activation upon Ca2+ influx through NMDA receptor. R-DRE-5673001. RAF/MAP kinase cascade. R-DRE-8849932. ... R-DRE-442982. Ras activation upon Ca2+ influx through NMDA receptor. R-DRE-5673001. RAF/MAP kinase cascade. R-DRE-8849932. ...
  http://www.uniprot.org/uniprot/A2BH14
*  Grin2d - Glutamate receptor ionotropic, NMDA 2D precursor - Rattus norvegicus (Rat) - Grin2d gene & protein
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to ... Unblocking of NMDA receptor, glutamate binding and activation. R-RNO-442729. CREB phosphorylation through the activation of ... Unblocking of NMDA receptor, glutamate binding and activation. R-RNO-442729. CREB phosphorylation through the activation of ... Glutamate receptor ionotropic, NMDA 2DAdd BLAST. 1296. Amino acid modifications. Feature key. Position(s). DescriptionActions. ...
  http://www.uniprot.org/uniprot/Q62645
*  Camk2a - Calcium/calmodulin-dependent protein kinase type II subunit alpha - Mus musculus (Mouse) - Camk2a gene & protein
Unblocking of NMDA receptor, glutamate binding and activation. R-MMU-442729. CREB phosphorylation through the activation of ... Unblocking of NMDA receptor, glutamate binding and activation. R-MMU-442729. CREB phosphorylation through the activation of ... R-MMU-442982. Ras activation uopn Ca2+ infux through NMDA receptor. R-MMU-5673001. RAF/MAP kinase cascade. R-MMU-877300. ... R-MMU-442982. Ras activation uopn Ca2+ infux through NMDA receptor. R-MMU-5673001. RAF/MAP kinase cascade. R-MMU-877300. ...
  http://www.uniprot.org/uniprot/P11798-2
*  Synaptogenesis - Wikipedia
NMDA glutamate receptor activation increases Wnt2 expression. Long term potentiation (LTP) due to NMDA activation and ... NMDA) receptor. It has been shown that activation of NMDA receptors initiates synaptogenesis through activation of downstream ... February 2007). "Genetic program of neuronal differentiation and growth induced by specific activation of NMDA receptors". ... The NMDA receptor function is associated with the estrogen receptor in hippocampal neurons. Experiments conducted with ...
  https://en.wikipedia.org/wiki/Synaptogenesis
*  GRIN2C - Glutamate receptor ionotropic, NMDA 2C precursor - Homo sapiens (Human) - GRIN2C gene & protein
Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta ... Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium ... subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:26875626). Sensitivity to glutamate and ... Glutamate receptor ionotropic, NMDA.... Glutamate receptor ionotropic, NMDA 2C (Glutamate receptor, ionotropic, N-methyl D- ...
  https://www.uniprot.org/uniprot/Q14957
*  Pharmaceuticals | Free Full-Text | From Single Target to Multitarget/Network Therapeutics in Alzheimer's Therapy | HTML
Abeta induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss. Proc. Natl. Acad. Sci. ... Excessive activation of glutamate receptors, specifically N-methyl-d-aspartate receptors (NMDARs) has been implicated in the ... releasing more and continuously glutamate. The excessively released glutamate stimulates glutamate receptors, specifically ... It acted as a non-competitive antagonist at the 5-HT3 receptor, with potency similar to that for the NMDA receptor in vitro in ...
  http://mdpi.com/1424-8247/7/2/113/htm
*  Frontiers | Structure, function, and plasticity of GABA transporters | Frontiers in Cellular Neuroscience
Scimemi, A., Tian, H., and Diamond, J. S. (2009). Neuronal transporters regulate glutamate clearance, NMDA receptor activation ... glutamate metabotropic receptors (group I) and serotonin receptors (5-HT2) all reduce GABA transporter cell membrane expression ... in glutamate transporters. Activation of the stoichiometrically uncoupled, glutamate transporter anionic current in retinal rod ... Farrant, M., and Nusser, Z. (2005). Variations on an inhibitory theme: phasic and tonic activation of GABA(A) receptors. Nat. ...
  https://www.frontiersin.org/articles/10.3389/fncel.2014.00161/full
*  Frontiers | Inhibition of NMDARs in the nucleus reticularis of the thalamus produces delta frequency bursting | Frontiers in...
The APV-induced delta frequency bursting is abolished by dopamine D2 receptor antagonist, indicating that dopamine and NMDAR ... The APV-induced delta frequency bursting is abolished by dopamine D2 receptor antagonist, indicating that dopamine and NMDAR ... that contributes inward current at resting potential in response to ambient glutamate. The hyperpolarization produced by APV is ... that contributes inward current at resting potential in response to ambient glutamate. The hyperpolarization produced by APV is ...
  https://www.frontiersin.org/articles/10.3389/neuro.04.020.2009/full
*  HRAS HRas proto-oncogene, GTPase [Homo sapiens (human)] - Gene - NCBI
Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystemNMDA receptors are a ... Post NMDA receptor activation events, organism-specific biosystem (from REACTOME) Post NMDA receptor activation events, ... Ras activation uopn Ca2+ infux through NMDA receptor, organism-specific biosystemCa2+ influx through the NMDA receptor leads to ... Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystem (from REACTOME) ...
  https://www.ncbi.nlm.nih.gov/gene?LinkName=pubmed_gene_rif&from_uid=22499344
*  Vagal Afferent Stimulation Activates Astrocytes in the Nucleus of the Solitary Tract Via AMPA Receptors: Evidence of an...
2004) Neuronal synchrony mediated by astrocytic glutamate through activation of extrasynaptic NMDA receptors. Neuron 43:729-743 ... a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding ... was blocked by the AMPA receptor antagonist NBQX and was unaffected by antagonism of NMDA and metabotropic glutamate receptors ... mediated by activation of ionotropic receptors as opposed to metabotropic neurotransmitter receptors (Perea et al., 2009; ...
  http://www.jneurosci.org/content/31/39/14037
*  Plus it
2004) Neuronal synchrony mediated by astrocytic glutamate through activation of extrasynaptic NMDA receptors. Neuron 43:729-743 ... 2005) Glutamate receptor activation triggers a calcium-dependent and SNARE protein-dependent release of the gliotransmitter D- ... such as NMDA receptor 2A and PSD-95, through P2 purinergic receptors and prevented Aβ42-induced spine reduction in cultured ... 4A-C), but the NMDA receptor 1 (NR1) level did not change (Fig. 4A,D). To test whether ATP protects neurons from Aβ42-induced ...
  http://www.jneurosci.org/content/32/9/3081
*  Frontiers | A possible role of astrocytes in contextual memory retrieval: An analysis obtained using a quantitative framework |...
Neuronal synchrony mediated by astrocytic glutamate through activation of extrasynaptic NMDA receptors. Neuron 43, 729-743. doi ... glutamate) release/astrocyte-dependent SICs through the activation of NR2B-containing receptors on the CA1 neurons. It is ... 2005). Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memory. Neuron 47, 859-872 ... Zhuo, M. (2009). Plasticity of NMDA receptor NR2B subunit in memory and chronic pain. Mol. Brain 2, 4. doi: 10.1186/1756-6606-2 ...
  https://www.frontiersin.org/articles/10.3389/fncom.2013.00145/full
*  CAMK4 Gene - GeneCards | KCC4 Protein | KCC4 Antibody
Post NMDA receptor activation events. Activation of NMDA receptor upon glutamate binding and postsynaptic events ... In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 ( ... In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 ( ... Autophosphorylation of the N-terminus Ser-12 and Ser-13 is required for full activation. Inactivated by protein phosphatase 2A ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=CAMK4
*  Recombinant Human ACTN2, His-tagged ACTN2-31382TH - Creative BioMart
Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystem; Adherens junction, ...
  https://www.creativebiomart.net/description_61394_7.htm
*  An integrated biopsychosocial model of childhood maltreatment and psychosis | The British Journal of Psychiatry
BDNF expression is regulated by NMDA receptor activation and increases with glutamate release. Chronic activation of ... It has been proposed that N-methyl-d-aspartate (NMDA) glutamate receptor antagonism and hypofunction can damage brain areas, ... Glutamate receptor dysfunction and schizophrenia. Arch Gen Psychiatry 1995; 52: 998-1007. ... HPA, hypothamic-pituitary-adrenal axis; GR, glucocorticoid receptor; BDNF, brain-derived neurotrophic factor; NMDA, N-methyl-d- ...
  http://bjp.rcpsych.org/content/206/3/177
*  Transport along the dendritic endoplasmic reticulum mediates the trafficking of GABAB receptors | Journal of Cell Science
2E). Prolonged NMDA receptor activation with glutamate produces reversible ER fission and disrupts the transport of luminal ER ... 2010). Prolonged activation of NMDA receptors promotes dephosphorylation and alters postendocytic sorting of GABAB receptors. ... As expected, glutamate receptor activation significantly altered the structure of the ER and resulted in the co-rearrangement ... 2009). NMDA receptor stimulation induces reversible fission of the neuronal endoplasmic reticulum. PLoS ONE 4, e5250. doi: ...
  http://jcs.biologists.org/content/127/15/3382
*  Morin Attenuates Neurochemical Changes and Increased Oxidative/Nitrergic Stress in Brains of Mice Exposed to Ketamine:...
Diamond JS (2001) Neuronal glutamate transporters limit activation of NMDA receptors by neurotransmitter spillover on CA1 ... NMDA receptor antagonists ketamine and PCP have direct effects on the dopamine D(2) and serotonin 5-HT(2) receptors- ... Verma A, Moghaddam B (1996) NMDA receptor antagonists impair prefrontal cortex function as assessed via spatial delayed ... Johnston A, Chris J, McBain Andre F (2014) 5-Hydroxytryptamine1A receptor-activation hyperpolarizespyramidal cells and ...
  https://link.springer.com/article/10.1007%2Fs11064-018-2590-z
*  Exposure of Neurons to Excitotoxic Levels of Glutamate Induces Cleavage of ADAR2 and Loss of GluR2 Editing
... namely NMDA receptors, AMPA receptors and kainate receptors.. The activation of NMDA receptors and their role in glutamate- ... 3. Glutamate induced ADAR2 cleavage depends upon NMDA receptor activation. 3.1 A NMDA receptor antagonist blocks glutamate ... 3.2 ADAR2 cleavage is induced by glutamate and NMDA but not by AMPA To confirm that the activation of NMDA receptors was ... Excessive activation of NMDA receptors by glutamate can lead to excitotoxicity, however, the involvement of AMPA receptors has ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3150305/?lang=en-ca
*  Frontiers | Motor Cortical Plasticity in Parkinson's Disease | Neurology
... brain derived neurotropic factor and other neurotransmitters or receptors polymorphism), emotional state, time of the day, ... brain derived neurotropic factor and other neurotransmitters or receptors polymorphism), emotional state, time of the day, ... NMDA) receptor activation by glutamate and post-synaptic calcium influx (8). A rapid increase in post-synaptic calcium ... Subcellular segregation of distinct heteromeric NMDA glutamate receptors in the striatum. J Neurochem (2003) 85:935-43. doi: ...
  https://www.frontiersin.org/articles/10.3389/fneur.2013.00128/full