Loading...
*  Live Imaging of Neuroinflammation Reveals Sex and Estrogen Effects on Astrocyte Response to Ischemic Injury | Stroke
Stoll G, Jander S. The role of microglia and macrophages in the pathophysiology of the CNS. Prog Neurobiol. 1999; 58: 233-247. ... In addition, to further confirm the effects of higher levels of estrogen on astrocyte activation, we investigated GFAP signal ... Pekny M, Nilsson M. Astrocyte activation and reactive gliosis. Glia. 2005; 50: 427-434. ... The images were longitudinally recorded from the same experimental animal and reveal the dynamics of astrocyte activation ...
  http://stroke.ahajournals.org/content/39/3/935
*  Tetrahydroxystilbene Glucoside Attenuates Neuroinflammation through the Inhibition of Microglia Activation
The hallmark of neuroinflammation is the microglia activation. Upon activation, microglia are capable of producing various ... κB activation suppressed microglia activation and the consequent release of proinflammatory factors and were eventually ... The hallmark of neuroinflammation is considered to be the activation of glial cells, particular microglia [3]. Microglia are ... A wide range of stimuli disrupts brain physiological homeostasis and triggers microglia activation. Once activated, microglia ...
  https://www.hindawi.com/journals/omcl/2013/680545/
*  MicroRNA-125b regulates microglia activation and motor neuron death in ALS. | Sigma-Aldrich
MicroRNA-125b regulates microglia activation and motor neuron death in ALS.. [C Parisi, G Napoli, S Amadio, A Spalloni, S ... In amyotrophic lateral sclerosis (ALS), classical NF-κB pathway is related to persistent microglia activation and motor neuron ... of A20 function by miR-125b strengthens and prolongs the noxious P2X7 receptor-dependent activation of NF-κB in microglia, with ... Understanding the means by which microglia self-regulate the neuroinflammatory response helps modulating their reaction during ...
  https://www.sigmaaldrich.com/catalog/papers/26794445
*  Microglia Activation in the Brain as Inflammatory Biomarker of Alzheimer's Disease Neuropathology and Clinical Dementia
... ... suggesting increased microglia activation begins with amyloid NP deposition. In the hippocampus, a significant increase in ... These results suggest that microglia activation increases with the progression of AD, with the increase varying depending on ... DR immunohistochemistry to examine microglia activation in the progression of AD assessed by pre-mortem clinical dementia ...
  https://www.hindawi.com/journals/dm/2006/276239/abs/
*  Microglia activation mediates fibrillar amyloid-β toxicity in the aged primate cortex
Inhibition of fAβ activated microglia. We used MIF to investigate the effects of inhibition of microglia activation on fAβ ... Injection or pump delivery of macrophage/microglia inhibitory factor (MIF) significantly reduced activation of microglia and ... Microglia activation mediates fibrillar amyloid-β toxicity in the aged primate cortex. Elaine Leung,a,b Ling Guo,a Jing Bu,a,b ... a marker of microglia activation. The presence of microglia was confirmed using a monoclonal antibody to CD68 (1/500; Dako). ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2888944/
*  CCL2 is a key mediator of microglia activation in neuropathic pain states - Thacker - 2012 - European Journal of Pain - Wiley...
CCL2 is a key mediator of microglia activation in neuropathic pain states. ... CCL2 is a key mediator of microglia activation in neuropathic pain states. European Journal of Pain, 13: 263-272. doi: 10.1016/ ...
  http://onlinelibrary.wiley.com/doi/10.1016/j.ejpain.2008.04.017/references
*  P2X4 receptor controls microglia activation and favors remyelination in autoimmune encephalitis | EMBO Molecular Medicine
Majumdar A, Cruz D, Asamoah N, Buxbaum A, Sohar I, Lobel P, Maxfield FR (2007) Activation of microglia acidifies lysosomes and ... Rasmussen S, Wang Y, Kivisäkk P, Bronson RT, Meyer M, Imitola J, Khoury SJ (2007) Persistent activation of microglia is ... Li WW, Setzu A, Zhao C, Franklin RJ (2005) Minocycline‐mediated inhibition of microglia activation impairs oligodendrocyte ... P2X4 receptor controls microglia activation and favors remyelination in autoimmune encephalitis. Alazne Zabala, Nuria Vazquez‐ ...
  http://embomolmed.embopress.org/content/10/8/e8743
*  Induction of microglia activation after infection with the non-neurotropic A/CA/04/2009 H1N1 influenza virus. | Sigma-Aldrich
Induction of microglia activation after infection with the non-neurotropic A/CA/04/2009 H1N1 influenza virus.. [Shankar ... possibility that influenza and perhaps other non-neurotropic viruses can initiate inflammatory signals via microglia activation ... M2 markers for microglia. Given that neuroinflammation contributes to generation and progression of a number of ... increase in microglial activity in the brain characterized by an increase in the number of activated Iba-1-positive microglia ...
  https://www.sigmaaldrich.com/catalog/papers/25861024
*  Kiwifruit Alleviates Learning and Memory Deficits Induced by Pb through Antioxidation and Inhibition of Microglia Activation In...
Kiwifruit Alleviates Learning and Memory Deficits Induced by Pb through Antioxidation and Inhibition of Microglia Activation In ... Pb compromised the enzymatic activity and transcriptional levels of SOD and GSH-Px and decreased the microglial activation, ... suggest that kiwifruit could alleviate Pb-induced cognitive deficits possibly through antioxidative stress and microglia ...
  https://www.hindawi.com/journals/omcl/2017/5645324/abs/
*  Toll-Like Receptor 4 Promotes Autonomic Dysfunction, Inflammation and Microglia Activation in the Hypothalamic Paraventricular...
Further inhibition of TLR4 or ER stress was able to attenuate the LPS-induced microglia activation. Conclusions & Implications ... inflammation and microglia activation, through neuronal ER stress, in the PVN. ...
  http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0122850
*  Microglia Activation and Polarization Associated with Retinal Inflammation and Degeneration in rd1 mouse model | IOVS | ARVO...
... indicating microglia activation at the acute stage. Morphologically, activated microglia was characterized by round shape with ... The microglia maker Iba-1, activation marker CD68 and CX3CR1, and phenotype markers CD86, CD206 and CD16/32, as well as pro- ... This study was to explore the activation and phenotype of microglia in rd1 mice, a widely used animal model of retinitis ... Microglia Activation and Polarization Associated with Retinal Inflammation and Degeneration in rd1 mouse model ...
  https://iovs.arvojournals.org/article.aspx?articleid=2642263
*  Naloxone Protects Rat Dopaminergic Neurons against Inflammatory Damage through Inhibition of Microglia Activation and...
Naloxone inhibited LPS-induced activation of microglia and release of proinflammatory factors, and inhibition of microglia ... Activation of microglia has been reported when brain glia or glia-neuron cultures are treated with LPS, the HIV-1 coat protein ... Naloxone Prevents Activation of Microglia and Inhibits Production and Release of Proinflammatory Factors.. To examine the ... Microglia were prepared from the brains of 1-day-old rat pups as described in Materials and Methods. Enriched microglia (105 ...
  http://jpet.aspetjournals.org/content/293/2/607
*  "Activation of Microglia" by Tuoxin Caou, Amanda M. Lisembee et al.
These data confirm concomitant classical activation and de-activation phenotypes of microglia after diffuse TBI, which are ... Evidence for alternative activation (arginase I) was not observed. Daily anti-inflammatory ibuprofen administration (20 mg/kg, ... Microglial activation was determined by immunohistochemistry, receptor autoradiography, and quantitative real-time PCR in the ... At seven days post-injury in both relays of the whisker circuit, classical activation (CD45) and acquired deactivation (TGFl, ...
  https://uknowledge.uky.edu/kaleidoscope/vol10/iss1/26/
*  Early Activation of Microglia Triggers Long-Lasting Impairment of Adult Neurogenesis in the Olfactory Bulb | Journal of...
... during which microglia selectively eliminate maturing neurons. Interestingly, microglia activation largely precedes the ... Early Activation of Microglia Triggers Long-Lasting Impairment of Adult Neurogenesis in the Olfactory Bulb. Françoise Lazarini ... Early Activation of Microglia Triggers Long-Lasting Impairment of Adult Neurogenesis in the Olfactory Bulb ... Early Activation of Microglia Triggers Long-Lasting Impairment of Adult Neurogenesis in the Olfactory Bulb ...
  http://www.jneurosci.org/content/32/11/3652
*  Microglia Activation in the Brain as Inflammatory Biomarker of Alzheimer's Disease Neuropathology and Clinical Dementia -...
... suggesting increased microglia activation begins with amyloid NP deposition. In the hippocampus, a significant increase in ... These results suggest that microglia activation increases with the progression of AD, with the increase varying depending on ... DR immunohistochemistry to examine microglia activation in the progression of AD assessed by pre-mortem clinical dementia ... a significant increase in microglia immunostaining was found only in mid-to-late stages (NP 3) and reduced staining was seen in ...
  https://www.semanticscholar.org/paper/Microglia-Activation-in-the-Brain-as-Inflammatory-Xiang-Haroutunian/fa5cc53e3a416652259043c99b995ac7866f0fac
*  P2X7 signaling promotes microsphere embolism-triggered microglia activation by maintaining elevation of Fas ligand | Journal of...
The FasL expression was continuously elevated and was spatiotemporally related to microglia activation following microsphere ... primary microglia from mice genetically deficient in P2X7 were used to further establish a linkage between microglia activation ... FasL functions as a key component of an immunoreactive response loop by recruiting microglia to the lesion sites through a P2X7 ... Here, we examined the contribution of microglia-derived FasL to brain inflammatory injury, with a focus on the potential to ...
  https://jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-9-172
*  Frontiers | Acute Hypoxia Induced an Imbalanced M1/M2 Activation of Microglia through NF-κB Signaling in Alzheimer's Disease...
... findings revealed that acute hypoxia facilitated the activation of M1 microglia and attenuated the activation of M2 microglia ... findings revealed that acute hypoxia facilitated the activation of M1 microglia and attenuated the activation of M2 microglia ... We found that acute hypoxia facilitated the activation of M1 microglia in both Tg and Wt mice as evidenced by the elevated M1 ... We found that acute hypoxia facilitated the activation of M1 microglia in both Tg and Wt mice as evidenced by the elevated M1 ...
  https://www.frontiersin.org/articles/10.3389/fnagi.2017.00282/full
*  Abstract 81: Activation of Microglia in the PVN Precedes Increase in Blood Pressure in Chronic Angiotensin II Infusion Rat...
Therefore, activation of microglia precedes the increase in blood pressure. This implicates the microglia in the dysregulation ... We hypothesize that activation of the microglia in the PVN is a possible precursor to the ANS dysfunction and the blood ... Abstract 81: Activation of Microglia in the PVN Precedes Increase in Blood Pressure in Chronic Angiotensin II Infusion Rat ... Abstract 81: Activation of Microglia in the PVN Precedes Increase in Blood Pressure in Chronic Angiotensin II Infusion Rat ...
  http://hyper.ahajournals.org/content/60/Suppl_1/A81
*  Amelioration of LPS-Induced Inflammation Response in Microglia by AMPK Activation
... Chin-Chen Chen,1 Jiun-Tsai Lin,2 Yi-Fang ... in microglia BV2 cells stimulated by LPS. We examined the effects of ENERGI-F704 on AMPK activation. We also assessed its anti- ... Upon activation, however, microglia secrete a variety of proinflammatory cytokines or other cytotoxic factors, which are ... Microglia are myeloid-lineage cells residing in the central nervous system. As a neuron protector, microglia are sensitive to ...
  https://www.hindawi.com/journals/bmri/2014/692061/
*  Microglia activation in Alzheimer's disease
... a well-defined model of microglia activation whereby the intraperitoneal delivery of LPS results in CNS microglia activation ... a well-defined model of microglia activation whereby the intraperitoneal delivery of LPS results in CNS microglia activation ... Microglia activation in Alzheimer's disease. Creator: Townsend, Kirk Phillip Place of Publication: [Tampa, Fla.]. Publisher: ... Microglia activation in Alzheimer's disease. Aggregation. USF Electronic Theses and Dissertations. Format. Book. ...
  http://digital.lib.usf.edu/SFS0025180/00001
*  Inhibiting the microglia activation improves the spatial memory and adult neurogenesis in rat hippocampus during 48 h of sleep...
It is plausible that microglia activation could be involved in the SD-induced cognitive impairment by modulation of neuronal ... Microglial activation is involved in SD-induced changes in inflammatory molecules, neurogenesis, and spatial memory. ... We scrutinized the effect of minocycline on the inflammatory cytokine levels associated with glial cells (microglia and ... We observed a significant correlation of neurogenesis with microglial activation, cytokine levels, and spatial memory during SD ...
  https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-017-0998-z
*  Acetate supplementation reduces microglia activation and brain interleukin-1β levels in a rat model of Lyme neuroborreliosis |...
We found that acetate supplementation significantly reduced microglia activation by 2-fold as determined by immunohistochemical ... On the other hand, the inoculation of rats with B. burgdorferi had no effect on astroglial activation as determined by ... These results suggest that microglial activation is an essential component to neuroborreliosis and that acetate supplementation ... neuroglial activation, and brain and circulating levels of interleukin 1β. Statistical analysis was performed using one-way ...
  https://jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-9-249
*  IJMS | Free Full-Text | Aged Mouse Cortical Microglia Display an Activation Profile Suggesting Immunotolerogenic Functions
The data presented in the current study indicate that aged mouse cortical microglia adopt a distinct activation profile, which ... that aging is associated with decreased numbers of cortical microglia and the establishment of a distinct microglia activation ... and M2-like activation markers. Iba1 immunohistochemistry, isolation of cortical microglia followed by fluorescence-activated ... In the present study, we addressed the age-dependent changes in cortical microglia gene expression patterns and the expression ...
  http://www.mdpi.com/1422-0067/19/3/706
*  Tyrosine kinase-mediated signaling pathways are characteristically concerned in the activation response of microglia to...
Tyrosine kinase-mediated signaling pathways are characteristically concerned in the activation response of microglia to ... Tyrosine kinase-mediated signaling pathways are characteristically concerned in the activation response of microglia to ...
  https://wallinside.com/post-497421-tyrosine-kinase-mediated-signaling-pathways-are-characteristically-conce-ed-in-the-activation-response-of-microglia-to-stimulation.html
*  Maternal inflammation induces immune activation of fetal microglia and leads to disrupted microglia immune responses, behavior,...
Maternal inflammation induces immune activation of fetal microglia and leads to disrupted microglia immune responses, behavior ... induced a pro-inflammatory response in fetal microglia. Adult whole brain microglia of mice that were exposed to LPS during ... Microglia-derived BDNF has been shown to be important for learning and memory processes. In line with these observations, ... In contrast, hippocampal microglia of these mice displayed an increased inflammatory response to an LPS re-challenge. In ...
  https://www.sigmaaldrich.com/catalog/papers/28751257