*  C2 Gene - GeneCards | CO2 Protein | CO2 Antibody
Complement C2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene ... Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or ... activated by C1r to form C2a and C2b,combining with C4A and C4B to form C3/C5 convertase,classical pathway of C3 activation *C2 ... C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase. *CO2_HUMAN, ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=C2
*  Reactome | Lectin pathway of complement activation
C2a. The active form of MASP1 was reported to cleave C2 in a manner similar to MASP2 (Matsushita et al. 2000, Chen & Wallis ... Complement cascade (Homo sapiens) * Initial triggering of complement (Homo sapiens) * Creation of C4 and C2 activators (Homo ... 2002). MASP1, MASP2 and MASP3 have all been reported to mediate complement activation. Upon binding of human lectin to the ... The mannan-binding lectin pathway of complement activation: biology and disease association. Mol Immunol. 2001. ...
  http://www.reactome.org/content/detail/166662
*  Frontiers | The Complement System: A Prey of Trypanosoma cruzi | Microbiology
... a key step in the activation of complement. Moreover, T. cruzi promotes secretion of plasma membrane-derived vesicles from host ... cruzi in order to circumvent the activation of complement and, consequently, its biological effects. ... The complement consists of at least 35 or more plasma proteins and cell surface receptors/regulators, which can be activated by ... The complement consists of at least 35 or more plasma proteins and cell surface receptors/regulators, which can be activated by ...
  https://www.frontiersin.org/articles/10.3389/fmicb.2017.00607/full
*  GENTAUR antibody-antibodies.com The Marketplace for Antibodies : Suppression of Sirtuin-1 Increases IL-6 Expression by...
Suppression of Sirtuin-1 Increases IL-6 Expression by Activation of the Akt Pathway During Allergic Asthma. ... WP545: Complement Activation, Classical Pathway. WP751: Complement Activation, Classical Pathway. WP81: Complement Activation, ... Activated C1 cleaves C2 into C2a and C2b. C2a leads to activation of C3. Deficiency of C2 has been reported to associated with ... WP859: Complement Activation, Classical Pathway. WP977: Complement Activation, Classical Pathway. WP1: Statin Pathway. WP10: IL ...
  http://www.antibody-antibodies.com/pubmed-29055943-Suppression_of_Sirtuin1_Increases_IL6_Expression_by_Activation_of_the_Akt_Pathway_During_Allergic_Asthma.html
*  Complement in Immune and Inflammatory Disorders: Pathophysiological Mechanisms | The Journal of Immunology
... complement activation was found significantly elevated in preterm birth, and complement activation products such as Bb or C3a ... The enzymatic fragment of C2 is referred to as C2b in this review; the same fragment is sometimes designated as C2a in ... It becomes evident that excessive activation or insufficient control of complement activation on host cells can cause an immune ... were linked to complement. When affected vascular endothelial surfaces trigger complement activation, the generated C5a ...
  http://www.jimmunol.org/content/190/8/3831
*  Complement System: Pathways, Functions and Regulation - microbeonline
Complement activation is triggered by an antibody when it is bound to the antigen. It can also be triggered by some components ... Now, C4b attracts C2 which is also cleaved into C2a and C2b. C2a binds C4b forming the C4b2a complex whereas C2b goes away. The ... Activation of mast cells and basophils and enhancement of inflammation. The proteolytic complement fragments, C5a, C4a, and C3a ... Deficiencies of regulatory proteins lead to too much activation of complements in wrong time and place which leads to unwanted ...
  https://microbeonline.com/complement-system-pathways-functions-regulation/amp/
*  A new treatment for neurogenic inflammation caused by EV71 with CR2-targeted complement inhibitor | Virology Journal | Full Text
Complement activation can generate inflammatory products including C2a, C3a, C4a and C5a which mediate tissue injury[18, 23]. ... Complement receptor 2-mediated targeting of complement inhibitors to sites of complement activation. J Clin Invest 2003, 111: ... which targets the sites of complement activation, is proposed as a specific inhibitor of local complement activation without ... Inflammatory injury induced by invading pathogens is associated with complement activation. Complement is a key system for ...
  https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-9-285
*  'Complement component 2' -...
Complement component 2' . Aromatherapy Blends to Reduce Irritability. for proper medical treatment. Blend #1 * 3 drops Mandarin ... pathway of complement activation, activated C1 cleaves C4a and C4b, and cleaves C2 into C2a and C2b. The complex of the large ... Complement component 2. Disease. Complement C2 is a protein that in humans is encoded by the C2 gene. The protein encoded by ... that complements the beet's crunch and earthy taste. And even though the ingredients are plant-based and raw, the cashew ...
  http://en.natvim.com/search?q=Complement+component+2
*  anti-CD55 antibody | GeneTex
the amplification convertases of the complement cascade. Also acts as the receptor for echovirus 7 and related viruses ( ... condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation ... and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a ... Immunogen Sequence: GI # 10835143, sequence 36-129 Recombinant decay accelerating factor for complement. ...
  http://www.genetex.com/CD55-antibody-GTX82412.html
*  Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex | The EMBO Journal
Complement activation and the structure of the C5-CVF complex. (A) The three activation pathways of complement (left) induce ... C4b2a is the widely used short‐hand nomenclature for the C4b-C2a complex in the complement field, and similar nomenclature is ... Rawal N, Rajagopalan R, Salvi VP (2008) Activation of complement component C5: comparison of C5 convertases of the lectin ... Complement acts as a danger‐sensing system in the innate immune system, and its activation initiates a strong inflammatory ...
  http://emboj.embopress.org/content/30/3/606
*  Complement system - Wikipedia
The end result of this complement activation or complement fixation cascade is stimulation of phagocytes to clear foreign and ... Some sources designate the larger and smaller fragments as C2a and C2b respectively[13][14][15][16][17][18][19][20][21] while ... complement factor B, and complement factor I, as well as deletion of complement factor H-related 3 and complement factor H- ... When complement is activated on a cell surface, the activation is limited by endogenous complement regulatory proteins, which ...
  https://en.m.wikipedia.org/wiki/Complement_system
*  Anti-CD55 antibody (FITC) [MEM-118] | Abcam
Belongs to the receptors of complement activation (RCA) family.. Contains 4 Sushi (CCP/SCR) domains. ... and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a ... Expressed on the plasma membranes of all cell types that are in intimate contact with plasma complement proteins. It is also ... Dcay accelerating factor for complement (CD55, Cromer blood group system) antibody. *Decay accelarating factor 1, isoform CRA_a ...
  http://www.abcam.com/cd55-antibody-mem-118-prediluted-fitc-ab28112.html
*  Anti-CD55 antibody [MEM-118] (ab1422) | Abcam
Effect of IL-6 and IL-8 on the expression of the complement activation inhibitors MAC-inhibitory protein and decay-accelerating ... and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a ... Belongs to the receptors of complement activation (RCA) family.. Contains 4 Sushi (CCP/SCR) domains. ... Expressed on the plasma membranes of all cell types that are in intimate contact with plasma complement proteins. It is also ...
  http://www.abcam.com/cd55-antibody-mem-118-ab1422.html
*  Complement component 2 - Wikipedia
In the classical and lectin pathways of complement activation, formation of the C3-convertase and C5-convertases requires ... C2a is released into the fluid phase. ENSG00000235017, ENSG00000235696, ENSG00000226560, ENSG00000204364, ENSG00000166278, ... Gagnon J (Sep 1984). "Structure and activation of complement components C2 and factor B". Philosophical Transactions of the ... Complement C2 is a protein that in humans is encoded by the C2 gene. The protein encoded by this gene is part of the classical ...
  https://en.wikipedia.org/wiki/Complement_component_2
*  C4BPA抗体|Abcam中国|Anti-C4BPA抗体(ab121123)
Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then ... It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha ...
  http://www.abcam.cn/c4bpa-antibody-ab121123.html
*  Evolving Immunity
... preventing complement activation against self-molecules, the requirement for lectin activation of complement became ... C2 can then attach to C4b, and is then cleaved by C1 into C2a and C2b. C2b and C4b then form the second serine protease in the ... innate immune systems possess all three complement activation pathways (classical, alternative, lectin), and their complement ... Antibodies are not required for complement activation Aside from his typical complaint that this system is "too complex to have ...
  http://www.talkdesign.org/faqs/Evolving_Immunity1.2.html
*  Classical complement pathway - Wikipedia
Activation of the complement pathway through the classical, lectin or alternative complement pathway is followed by a cascade ... The activated C1s cleaves C4 into C4a and C4b, and C2 into C2a and C2b. The larger and active fragments, C4b and C2b form ... Alternative complement pathway - another complement system pathway Lectin pathway - another complement system pathway Noris, ... Classical complement activation has also been shown to combat Methicillin-resistant Staphylococcus aureus. Certain variants of ...
  https://en.wikipedia.org/wiki/Classical_complement_pathway
*  Immune response Classical complement pathway
C2a, CD59, C2+H(2)O =C2a+C2b, Membrane attack complex, C1, C2b, Complement component C3b + H(,2)O = Complement component iC3b, ... which translates the activation of the Complement component C1 complex into complement activation via cleavage of C4 and C2 to ... complement component C3a + complement component C3b, H(,2)O + Complement component iC3b = Complement component C3c + complement ... The terminal sequence of complement activation involves Complement components C5b, C6, C7, C8, and C9, which interact ...
  http://pathwaymaps.com/maps/477/
*  C3a (complement) - Wikipedia
The classical pathway of complement activation is initiated when the C1 complex, made up of C1r and C1s serine proteases, ... C2a, and C2b). C4a and C2b form C4bC2b, also known as C3 convertase. The lectin pathway is activated when pattern-recognition ... The alternative pathway of complement activation is typically always active at low levels in blood plasma through a process ... C3a formation occurs through activation and cleavage of complement component 3 in a reaction catalyzed by C3-convertase. There ...
  https://en.wikipedia.org/wiki/C3a_(complement)
*  Complement system - Wikipedia
When complement is activated on a cell surface, the activation is limited by endogenous complement regulatory proteins, which ... which can then split C4 into C4a and C4b and C2 into C2a and C2b. C4b and C2a then bind together to form the classical C3- ... Polymorphisms of complement component 3, complement factor B, and complement factor I, as well as deletion of complement factor ... The end result of this complement activation or complement fixation cascade is stimulation of phagocytes to clear foreign and ...
  https://en.wikipedia.org/wiki/Complement_system
*  C1 complex - Wikipedia
Activation of the C1 complex initiates the classical complement pathway. This occurs when C1q binds to antigen-antibody ... Active C1s splits C4 and then C2, producing C4a, C4b, C2a and C2b. The classical pathway C3-convertase (C4bC2b complex) is ... Deciphering the fine details of C1 assembly and activation mechanisms: "mission impossible"? Complement C1 at the US National ... The C1 complex (complement component 1, C1) is a protein complex involved in the complement system. It is the first component ...
  https://en.wikipedia.org/wiki/C1_complex
*  Pattern recognition receptor - Wikipedia
MASP1 and MASP2 and initiate the lectin pathway of complement activation which is somewhat similar to the classical complement ... Together, MBL, C4b and C2a are known as the C3 convertase. C3 is cleaved into its a and b subunits, and C3b binds the ... Alongside the listed molecules, which lead to activation of NLRP3 inflammasome, the assembly and activation can also be induced ... Complement receptors, collectins, ficolins, pentraxins such as serum amyloid and C-reactive protein, lipid transferases, ...
  https://en.wikipedia.org/wiki/Pattern_recognition_receptor
*  C3-convertase - Wikipedia
Hourcade D, Holers VM, Atkinson JP (1989). "The regulators of complement activation (RCA) gene cluster". Adv Immunol. Advances ... The smaller C2a produced by C2 hydrolysis can then attach to the C4b to form the classical C3 convertase. The fragments C4a and ... Properdin (Factor P) is the only known positive regulator of complement activation that stabilizes the alternative C3 ... "Formation of classical C3 convertase during the alternative pathway of human complement activation". PubMed Article. Retrieved ...
  https://en.wikipedia.org/wiki/C3-convertase
*  The Complement System Andrew E Thompson MD FRCPC Fellow in Rheumatology University of British Columbia. - ppt download
Objectives Discuss the role of complement in the immune system. Discuss complement regarding its: Components Activation ... Only IgG and IgM can activate complement -Once activated C1s is eventually cleaved which activates C4 and C2 -C4b & C2a come ... OF COMPLEMENT COMPONENTS CONSUMPTION OF COMPLEMENT COMPONENTS DEFICIENCY OF COMPLEMENT COMPONENTS DEFICIENCY OF COMPLEMENT ... Activation pathways Effector functions Regulation of complement activation. ...
  http://slideplayer.com/slide/3317721/
*  A functional SNP in the regulatory region of the decay-accelerating factor gene associates with extraocular muscle pareses in...
Complement activation in myasthenia gravis (MG) may damage muscle endplate and complement regulatory proteins such as decay- ... DAF inhibits the assembly of C3 convertases by dissociating C2a and Bb. J Exp Med. 1987;166:1221-1228. [PMC free article] [ ... Medof ME, Kinoshita T, Nussenzweig V. Inhibition of complement activation on the surface of cells after incorporation of decay ... Innate complement control mechanisms include complement regulatory proteins expressed on all serum-exposed cells, each of which ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2834500/