*  Anti-mouse Integrin alphaV Antibody, clone RMV-7 (Preservative free) | CBL1346Z-I
Flow Cytometry for the detection of mouse Integrin alphaV. Find MSDS or SDS, a COA, data sheets and more information. ... This Anti-mouse Integrin alphaV Antibody, clone RMV-7 (Preservative free) is validated for use in Western Blotting, ... The alphaV integrins have varied functions in development, stimulation/activation and homeostasis. The primary ligands for ... Anti-mouse Integrin alphaV, clone RMV-7 2472968 Anti-mouse Integrin alphaV, clone RMV-7 (Preservative free) - Q2067202 Q2067202 ...
  http://www.merckmillipore.com/INTL/en/product/Anti-mouse-Integrin-alphaV-Antibody-clone-RMV-7-Preservative-free,MM_NF-CBL1346Z-I
*  uPA Binding to PAI-1 Induces Corneal Myofibroblast Differentiation on Vitronectin | IOVS | ARVO Journals
Integrin-mediated transforming growth factor-beta activation, a potential therapeutic target in fibrogenic disorders. Am J ... and integrins through the LRP receptor. 26,27 The cycle of integrin internalization leading to the disruption of integrin/ ... leads to an increase in Mf cell adhesion by increasing total integrin levels and integrin-matrix binding. The αv integrins ( ... Stefansson S Su EJ Ishigami S The contributions of integrin affinity and integrin-cytoskeletal engagement in endothelial and ...
  http://iovs.arvojournals.org/article.aspx?articleid=2168214
*  The effect of antisense RNA to fibronectin on the malignancy of hybrids between melanoma cells and normal fibroblasts | Journal...
Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration ... of the PIDDosome multiprotein complex and recent advances that link PIDDosome-dependent CASP2 activation to p53 activation in ...
  http://jcs.biologists.org/content/93/3/515
*  Dystroglycan loss disrupts polarity and beta-casein induction in mammary epithelial cells by perturbing laminin anchoring. -...
Division of labor among the alpha6beta4 integrin, beta1 integrins, and an E3 laminin receptor to signal morphogenesis and beta- ... Sustained activation of STAT5 is essential for chromatin remodeling and maintenance of mammary-specific function. *Ren Xu. , ...
  https://www.semanticscholar.org/paper/Dystroglycan-loss-disrupts-polarity-and-beta-casei-Weir-Oppizzi/f3cbdae2b82f2730a12de5c79dc5919888a787ac
*  PKCδ Is Necessary for Smad3 Expression and Transforming Growth Factor β-Induced Fibronectin Synthesis in Vascular Smooth Muscle...
Activation of PKCδ by TGFβ1. Because the novel PKC isoform PKCδ has been implicated in the regulation of TGFβ-dependent elastin ... alpha}5{beta}1 Integrin expression and luminal edge fibronectin matrix assembly by smooth muscle cells after arterial injury. ... Stimulation of A10 SMCs with TGFβ led to a rapid activation of PKCδ. Additionally, inhibition of PKCδ activity by a selective ... Protein kinase Cdelta activation by interleukin-1beta stabilizes inducible nitric-oxide synthase mRNA in pancreatic beta-cells ...
  http://atvb.ahajournals.org/content/26/4/780
*  Focal adhesion kinase modulates cell adhesion strengthening via integrin activation.
During the early stages of adhesion, FAK expression in FAK-null cells enhances integrin activation to promote integrin binding ... FAK expression regulated integrin activation, and talin was required for the FAK-dependent effects. A role for FAK in integrin ... This work demonstrates a novel role for FAK in integrin activation and the time-dependent generation of cell-ECM forces.. ... Integrin alpha5beta1 / metabolism*. Integrins / metabolism*. Kinetics. Mice. Phosphorylation / drug effects. Phosphotyrosine / ...
  http://www.biomedsearch.com/nih/Focal-adhesion-kinase-modulates-cell/19297531.html
*  Smurf1 inhibits integrin activation by controlling Kindlin-2 ubiquitination and degradation | JCB
F) A hypothetical model for Smurf1 modulation of integrin activation. Both Talin and Kindlin-2 stimulate integrin activation ... β1 integrin activation was detected in Smurf1−/−, WT, or Smurf1 rescue MEFs using an activation-specific integrin β1 mAb 9EG7. ... Smurf1 does not influence integrin activation mediated by Talin alone. Collectively, Smurf1 controls proper integrin activation ... Integrin activation was analyzed using an activation-specific αIIbβ3 mAb PAC1. The values were controlled for cell-surface ...
  http://jcb.rupress.org/content/early/2017/04/12/jcb.201609073/tab-figures-data
*  A peptide derived from tenascin-C induces beta1 integrin activation through syndecan-4. | Sigma-Aldrich
A peptide derived from tenascin-C induces beta1 integrin activation through syndecan-4.. [Yohei Saito, Hisae Imazeki, Shogo ... by inducing activation of beta1 integrin. The active site of TNIIIA2 appeared cryptic in the TN-C molecule but was exposed by ... participated in TNIIIA2-induced beta1 integrin activation: 1) TNIIIA2 bound to cell surface HSPG via its HS chains, as examined ... heparitinase I treatment of cells abrogated beta1 integrin activation induced by TNIIIA2; 3) syndecan-4 was isolated by ...
  https://www.sigmaaldrich.com/catalog/papers/17901052
*  Selectin catch-bonds mechanotransduce integrin activation and neutrophil arrest on inflamed endothelium under shear flow |...
E-selectin-mediated rolling transmits signals into neutrophils that trigger activation of high-affinity β2-integrins necessary ... Selectin catch-bonds mechanotransduce integrin activation and neutrophil arrest on inflamed endothelium under shear flow. ... Selectin catch-bonds mechanotransduce integrin activation and neutrophil arrest on inflamed endothelium under shear flow. Blood ... Selectin catch-bonds mechanotransduce integrin activation and neutrophil arrest on inflamed endothelium under shear flow ...
  http://www.bloodjournal.org/content/130/19/2101?sso-checked=true
*  Cell-generated traction forces induce integrin activation resulting in focal adhesion cell - Aurora Kinases as Druggable...
Cell-generated traction forces induce integrin activation resulting in focal adhesion cell. December 5, 2016. FFA1 Receptors ... Integrin receptors go through conformational activation from a minimal affinity to high affinity condition [8 9 and these ... Indeed immediate activation of integrins via manganese (Mn2+) [10] or conformation-modulating antibodies [11] seems to enhance ... In this study we found that β1 integrin activation via increased fibronectin (FN) density or Mn2+ network marketing leads to ...
  http://www.exposed-skin-care.net/2016/12/05/cell-generated-traction-forces-induce-integrin-activation-resulting-in-focal-adhesion-cell/
*  Conformational equilibria and intrinsic affinities define integrin activation | The EMBO Journal
Activation models in the integrin field have previously been discussed conceptually but not quantitatively. All integrin β‐ ... Figure 1. Thermodynamic equilibria of integrin α5β1 and relation to other receptors. *. A-C Integrins. (A) Integrin structure ... Nishida N, Xie C, Shimaoka M, Cheng Y, Walz T, Springer TA (2006) Activation of leukocyte β2 integrins by conversion from bent ... Smagghe B, Huang P, Ban Y‐E, Baker D, Springer TA (2010) Modulation of integrin activation by an entropic spring in the β‐knee ...
  http://emboj.embopress.org/content/36/5/629
*  Nanopatterning reveals an ECM area threshold for focal adhesion assembly and force transmission that is regulated by integrin...
... reveals an ECM area threshold for focal adhesion assembly and force transmission that is regulated by integrin activation and ... reveals an ECM area threshold for focal adhesion assembly and force transmission that is regulated by integrin activation and ... reveals an ECM area threshold for focal adhesion assembly and force transmission that is regulated by integrin activation and ... reveals an ECM area threshold for focal adhesion assembly and force transmission that is regulated by integrin activation and ...
  http://jcs.biologists.org/content/125/21/5110.supplemental
*  Threonine 788 in integrin subunit β1 regulates integrin activation :: MPG.PuRe
... activation; threonine; phosphorylation; Title: Threonine 788 in integrin subunit β1 regulates integrin activation ... Threonine 788 in integrin subunit β1 regulates integrin activation. Experimental Cell Research, 312(6), 844-853. ...
  http://pubman.mpdl.mpg.de/pubman/faces/viewItemOverviewPage.jsp?itemId=escidoc:1580572
*  Abstract 16907: Activation of Integrin αMβ2 on Human Monocytes Regulates Alternative Activation of Macrophages: Inhibition of...
In contrast, activation of β1 integrins had no effect on 15-LO level. Analysis of integrin clustering through αM, αL, αX and αD ... Abstract 16907: Activation of Integrin αMβ2 on Human Monocytes Regulates Alternative Activation of Macrophages: Inhibition of ... Abstract 16907: Activation of Integrin αMβ2 on Human Monocytes Regulates Alternative Activation of Macrophages: Inhibition of ... Abstract 16907: Activation of Integrin αMβ2 on Human Monocytes Regulates Alternative Activation of Macrophages: Inhibition of ...
  http://circ.ahajournals.org/content/122/Suppl_21/A16907
*  Activation of Integrin-Linked Kinase Is a Critical Prosurvival Pathway Induced in Leukemic Cells by Bone Marrow-Derived Stromal...
Integrin-linked kinase (ILK) was proposed to play a central role in integrin activation and signaling ( 4). ILK is a highly ... Activation of Integrin-Linked Kinase Is a Critical Prosurvival Pathway Induced in Leukemic Cells by Bone Marrow-Derived Stromal ... Activation of Integrin-Linked Kinase Is a Critical Prosurvival Pathway Induced in Leukemic Cells by Bone Marrow-Derived Stromal ... Activation of Integrin-Linked Kinase Is a Critical Prosurvival Pathway Induced in Leukemic Cells by Bone Marrow-Derived Stromal ...
  http://cancerres.aacrjournals.org/content/67/2/684
*  Integrins and the activation of latent transforming growth factor beta1 - an intimate relationship - Infoscience
Two main models are proposed how integrins contribute to latent TGF-beta1 activation: (1) In a protease-dependent mechanism, ... 2) Integrins alphavbeta3, alphavbeta5, alphavbeta6, and alphavbeta8 appear to change the conformation of the latent TGF-beta1 ... Understanding that different integrins use different mechanisms to activate latent TGF-beta1 opens new possibilities to develop ... We here review the more recently discovered role of integrins in activating the pleiotrophic cytokine transforming growth ...
  https://infoscience.epfl.ch/record/147739
*  VEGFRs in PI 3-kinase and integrin activation. (A) VEGF | Open-i
VEGFRs in PI 3-kinase and integrin activation. (A) VEGFR knockdown. HUVECs transfected with the indicated siRNAs for 72 h were ... fig5: VEGFRs in PI 3-kinase and integrin activation. (A) VEGFR knockdown. HUVECs transfected with the indicated siRNAs for 72 h ... fig5: VEGFRs in PI 3-kinase and integrin activation. (A) VEGFR knockdown. HUVECs transfected with the indicated siRNAs for 72 h ... VEGFR2 is required for shear-mediated activation of PI3K and integrins, and for cell alignment. We therefore performed shear ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4384728_JCB_201408103_Fig5&req=4
*  Scientific Protocols - Protocols to examine integrin binding with Talin and protocol to test integrin activation by talin
Add activation specific antibody, PAC1 to assess the activation state of the integrins and incubate at room temperature for ... Protocols to examine integrin binding with Talin and protocol to test integrin activation by talin ... PROTOCOL 1 - Talin F2F3 activates integrin and talin mutations that disrupt integrin beta3 tail binding block activation. ... which is a reflection of the integrin activation state.. *Repeat the experiment with F2F3 mutant that does not bind to integrin ...
  https://protocols.scienceexchange.com/protocols/protocols-to-examine-integrin-binding-with-talin-and-protocol-to-test-integrin-activation-by-talin
*  Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles...
Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles ... Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles ... of integrin aggregation and occupancy of receptors.. S Miyamoto, H Teramoto, J S Gutkind, K M Yamada ...
  http://jcb.rupress.org/content/135/6/1633/tab-article-info
*  Disruption of disulfide restriction at integrin knees induces activation and ligand-independent signaling of α4β7 | Journal of...
2C), indicating the activation of α4β7. Thus, integrin activation induced by breaking the two disulfide bonds at the knees of α ... 4A,B), suggesting activation of integrin outside-in signaling. We further investigated the activation of FAK and paxillin, two ... Our findings reveal a novel mechanism of integrin activation under specific reducing conditions by which integrin can signal ... The biological functions of integrins rely on dynamic regulation of integrin affinity and signaling. Integrin affinity can be ...
  http://jcs.biologists.org/content/126/21/5030
*  Distinct FAK-Src activation events promote α5β1 and α4β1 integrin-stimulated neuroblastoma cell motility
... Lihua Wu,1,#¶ Joie A ... Alternatively, integrin-regulated dephosphorylation of Src at Y529 can enhance Src activation (Zeng et al., 2003). In both ... Integrin α4β1 Promotes Focal Adhesion Kinase-Independent Cell Motility via α4 Cytoplasmic Domain-Specific Activation of c-Src. ... Although previous studies have implicated integrin β1 in mediating FAK-Src activation after α5β1-stimulation of cells (Mitra ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2593630/?lang=en-ca
*  Angiopoietin-Like 3 Induces Podocyte F-Actin Rearrangement through Integrin /FAK/PI3K Pathway-Mediated Rac1 Activation
We also found that these effects could be blocked by an integrin inhibitor, implicating integrin as the Angptl3 receptor in its ... Angiopoietin-Like 3 Induces Podocyte F-Actin Rearrangement through Integrin /FAK/PI3K Pathway-Mediated Rac1 Activation. Yi Lin, ... and that this process was mediated by integrin -mediated FAK and PI3K phosphorylation and Rac1 activation. Our results might ... In this study, we found that recombinant Angptl3 treatment, together with the activation of Rac1, could cause F-actin ...
  https://www.hindawi.com/journals/bmri/2013/135608/abs/
*  HGF induces FAK activation and integrin-mediated adhesion in MTLn3 breast carcinoma cells | Lucia Beviglia; Randall H. Kramer |...
HGF induces FAK activation and integrin-mediated adhesion in MTLn3 breast carcinoma cells , Lucia Beviglia; Randall H. Kramer ... HGF induces FAK activation and integrin-mediated adhesion in MTLn3 breast carcinoma cells. Lucia Beviglia; Randall H. Kramer ... HGF induces FAK activation and integrin-mediated adhesion in MTLn3 breast carcinoma cells. ...
  http://en.booksc.org/book/33878/cb64a2
*  Stretch-Induced MAP Kinase Activation in Cardiac Myocytes: Differential Regulation through β1-Integrin and Focal Adhesion Kinase
β1 integrin was required for FAK independent activation of all three MAP kinases, whereas cross-talk between β1 integrin and ... Integrin-mediated activation of MAP kinase is independent of FAK: evidence for dual integrin signaling pathways in fibroblasts ... The coupling of β1 integrin to MAP kinase activation, independent of FAK activation, is poorly understood. In keratinocytes, ... The predominant integrin expressed in cardiac myocytes is β1. To test whether β1 integrin couples to stretch-induced activation ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2039913/?lang=en-ca
*  basic science - The Scientific Activist
Two New Papers on Integrin Activation. Posted by Nick Anthis on October 20, 2009 ... One family of proteins in particular, the integrins, plays a key role in this process by acting as the hands of the cell. ...
  http://scienceblogs.com/scientificactivist/category/basic_science/