*  Adenovirus-Mediated Overexpression of c-Jun and c-Fos Induces Intercellular Adhesion Molecule-1 and Monocyte Chemoattractant...
Fos-associated protein p39 is the product of the jun proto-oncogene. Science. 1988;240:1010-1016. ... we found that the AP-1 proteins c-Fos and c-Jun directly cause phenotypic activation and induction of intercellular adhesion ... Stein B, Baldwin ASJ, Ballard DW, Greene WC, Angel P, Herrlich P. Cross-coupling of the NF-κB p65 and Fos/Jun transcription ... TTT AGC TTG GAA ATT CCG GAG CT-3′; (6) ICAM-AP-1/Ets (−940), 5′-GCT GCT GCC TCA GTT TCC CAG-3′; and (7) ICAM-TRE/AP-1 (−1290), ...
  http://atvb.ahajournals.org/content/19/9/2078
*  Plus it
... we investigated whether the transcriptional activation of RON by p65 could affect RON protein expression. We have transiently ... protein kinase C, protamine kinase, pp60c-src tyrosine kinase, p44/42 mitogen-activated protein kinase, and c-Jun-NH2-kinase ( ... Oligonucleotide primers specific for the RON promoter spanning the p65-binding sites (forward, 5′-CTC CAA GGG CCG GAA GAG TCG ... and radiosensitization effects by down-regulating the MDM2 oncogene through the PI3K/mTOR/ETS2 pathway. Cancer Res 2007; 67: ...
  http://cancerres.aacrjournals.org/content/68/13/5185
*  Critical Elements of the Immunoglobulin Heavy Chain Gene Enhancers for Deregulated Expression of Bcl-2 | Cancer Research
This expression vector, which produces a mutant IκBα protein that retains the NF-κB p50/p65 heterodimer in the cytoplasm, was ... Wilson B. E., Mochon E., Boxer L. M. Induction of bcl-2 expression by phosphorylated CREB proteins during B-cell activation and ... GGCCTATGCTGGGAGTCGAGCATCCCCAAGGCTGG. Although neither HS4 region contained an exact Sp1 binding site, both contained a GGA ... WT1 modulates apoptosis by transcriptionally upregulating the bcl-2 proto-oncogene. EMBO J., 18: 3990-4003, 1999. ...
  http://cancerres.aacrjournals.org/content/63/20/6666.long
*  Plus it
In vitro activation and nuclear translocation of NF-κB catalyzed by cyclic AMP-dependent protein kinase and protein kinase C. ... An equal amount of protein was subjected to SDS-PAGE. Proteins were transferred to polyvinylidene difluoride membranes and ... The siRNAs targeting the human GSK-3β gene (5′-AAG AAT CGA GAG CTC CAG ATC-3′, designated as #4 and 5′-AAG TAA TCC ACC TCT GGC ... p65 subunit and subsequently NF-κB transactivation in hepatocytes (15, 16). ...
  http://mct.aacrjournals.org/content/2/11/1215
*  Plus it
... protein-protein interactions, and stability of transcription factors but also to other cellular proteins by acetylation (3). ... Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofen. Oncogene 1999 ... CREB-binding protein/p300 are transcriptional coactivators of p65. Proc Natl Acad Sci U S A 1997;94:2927-32. ... GGG GTT TGT GCC ACT GGT GAG-3′; reverse: 5′-GGG AGG CAA TTC TCC ATG GTT C-3′. Values were normalized to input controls taken ...
  http://mct.aacrjournals.org/content/10/9/1644
*  Multifaceted functions and roles of HBZ in HTLV-1 pathogenesis | Retrovirology | Full Text
Although HTLV-1 harbors an oncogene, tax, that transforms T cells in vitro and induces leukemia in transgenic mice, tax ... HTLV-1 HBZ suppresses AP-1 activity by impairing both the DNA-binding ability and the stability of c-Jun protein. Oncogene. ... P/CAF and vCRE and subsequent activation of the HTLV-1 5′ LTR in vitro [6, 12] by hetero-dimerizing with CREB proteins via the ... HBZ can block the Rex-mediated nuclear export of viral structural transcripts such as Gag-Pol and thus prevent their ...
  https://retrovirology.biomedcentral.com/articles/10.1186/s12977-016-0249-x
*  Protocols and Video Articles Authored by Gaoqing Yang
The identified proteins were used to infer an overall interaction map linking the ORF3 protein with components of the host ... contexts where Wnt activation is mediated by ligand expression rather than mutations in canonical pathway members.Oncogene ... While the sequence of the decorin core protein is determined by the gene encoding its structure, the structure of its GAG chain ... Jun, 2013 , Pubmed ID: 23423786 GATA-binding protein 2 (GATA2) is a nuclear transcription factor that plays a critical role in ...
  https://www.jove.com/author/Gaoqing_Yang
*  US5962415A - Compositions comprising a peptide inhibitor of nuclear protein translocation and an immunosuppressant and methods...
Novel compositions of immunosuppressants, such as cyclosporin, and polypeptide inhibitors of cytoplasmic protein nuclear ... Ezrin: a protein requiring conformational activation to link microfilaments to the plasma membrane in the assembly of cell ... C12N15/62-DNA sequences coding for fusion proteins * C12N15/625-DNA sequences coding for fusion proteins containing a sequence ... In unstimulated cells, a major form of NF-κB is a heterodimer of p50 and p65 (RelA) subunits. Nonactive NF-κB is retained in ...
  https://patents.google.com/patent/US5962415?oq=ascentive
*  Protocols and Video Articles Authored by Jing Huang (Translated to Portuguese)
B7-H3 Augments Inflammatory Responses and Exacerbates Brain Damage Via Amplifying NF-κB P65 and MAPK P38 Activation During ... inhibitor Icotinib by analyzing protein expression and amplification of EGFR proto-oncogene in esophageal squamous cell ... interact with G-proteins and other proteins via their intracellular face as required for signal transduction. However, ... B. Jun, 2016 , Pubmed ID: 27299801 We have studied the structure of (Ala)5, a model unfolded peptide, using a combination of 2D ...
  https://www.jove.com/author/Jing_Huang?language=Portuguese
*  Patente US6025194 - Nucleic acid sequence of senescence asssociated gene - Google Patentes
... as well as peptides and antibodies corresponding to the GC6 protein can be used to identify senescent cells, distinguish ... Isolated, purified, and recombinant nucleic acids and proteins corresponding to the human GC6 gene and its mRNA and protein ... between the two fusion proteins reconstitutes the Gal4 DNA-binding domain with the Gal4 activation domain, which leads to the ... CAG TCT GAG GGT CAC TGC ACT TTG GAG TGC CT - #G GAA GAG GCT CTGGAA 1148 Gln Ser Glu Gly His Cys Thr Leu Glu Cys Le - #u Glu Glu ...
  http://www.google.es/patents/US6025194
*  AKT3 AKT serine/threonine kinase 3 [Homo sapiens (human)] - Gene - NCBI
Activation of BH3-only proteins, organism-specific biosystem (from REACTOME) Activation of BH3-only proteins, organism-specific ... RAC-gamma serine/threonine protein kinase. v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma). NP_ ... gag HIV-1 p17 induces capillary-like structures in human endothelial cells by binding to CXCR1 and CXCR2, which requires ... HIV-1 Vpr-induced upregulation of CCL5 requires p50 and p65 subunits of NF-kappaB, p38delta MAPK, Akt-2 and Akt-3, and AP-1 ...
  https://www.ncbi.nlm.nih.gov/gene/10000
*  Other | Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors
a 50-65 kDa Fcg receptor IIIa FcgRIII) AG-490 AMN-107 as well as in signal transduction and NK cell activation. The CD16 blocks ... 21 Myc protein take part in oncogenesis in a multitude of tumors by a genuine variety of different systems, including raising ... p65), RelB, NF-B1 (p50/p105), and NF-B2 (p52/p100).31 Currently, a couple of zero spontaneous animal choices for MCL, although ... GAGs) such as for example hyaluronic acidity (HA) heparan sulfate (HS) and chondroitin sulfate can be found in the vitreous gel ...
  http://researchreport-digital.com/category/other/
*  Inhibition of Elastase-Pulmonary Emphysema in Dominant-Negative MafB Transgenic Mice
... and 10 ng of nuclear protein was used to assess the activity of NF-kB p65 and AP-1, c-fos, using TransAM® NFκB Family ... also known as V-maf musculoaponeurotic fibrosarcoma oncogene homolog B, is a member of the Maf protein family and possesses a ... GCC TAC AAG GTC AAG TGC GAG AAA CTC GCC; MafB sh-RNA antisense, GGC GAG TTT CTC GCA CTT GAC CTT GTA GGC; control sh-RNA sense, ... MafB is a downstream target of the IL-10/STAT3 signaling pathway, involved in the regulation of macrophage de-activation. ...
  http://www.ijbs.com/v10p0882.htm
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Activation of immune complexes is associated with post-translational modifications (PTMs) of proteins, such as phosphorylation ... Biochemistry, Issue 82, amyloid, soluble protein oligomer, amyloid precursor, protein misfolding, amyloid fibril, protein ... nuclear translocation of the p65 subunit of NF-κB (p65), and secretion of the hallmark proinflammatory cytokine, tumor necrosis ... Yukiko Doi, Hideyuki Takeuchi, Hiroyuki Mizoguchi, Kazuya Fukumoto, Hiroshi Horiuchi, Shijie Jin, Jun Kawanokuchi, Bijay ...
  https://www.jove.com/visualize/abstract/25062013/granulocyte-colony-stimulating-factor-attenuates-oligomeric-amyloid
*  Brain Infection by Neuroinvasive but Avirulent Murine Oncornaviruses - PDF
Rabbit Polyclonal antibody to NFkB p65 (v-rel reticuloendotheliosis viral oncogene homolog A (avian)) Datasheet GeneTex, Inc : ... The upregulation of this membrane protein is a sensitive marker of microglial activation (2), and recent studies of mouse ... nonstructural proteins Why would you want to study proteins associated with viruses or virus infection? Receptors Mechanism of ... EMBO J. 16: Sitbon, M., H. Ellerbrok, F. Pozo, J. Nishio, S. F. Hayes, L. H. Evans, and B. Chesebro Sequences in the U5-gag-pol ...
  http://healthdocbox.com/Aids_and_Hiv/65517162-Brain-infection-by-neuroinvasive-but-avirulent-murine-oncornaviruses.html
*  October 2016 - New β-secretase inhibitors for treatment of Alzheimer's disease
Sequential activation of proteins kinase C (PKC)-α and PKC-ε plays a part in suffered Raf/ERK1/2 activation in endothelial ... After measuring the protein concentration 10 μg of the protein was separated by electrophoresis on 10% sodium dodecyl sulfate- ... Cdx2 can be able to connect to the p65 subunit of NFκB and for that reason avoid the NFκB binding and activation from the Cox-2 ... mRNA had been increased as soon as 4 h after initiation of lifestyle and peaked at 8 h accompanied by a rise in Env Gag/Pol and ...
  http://healthyguide.info/2016/10/