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*  Complement 1 Inhibitor Is a Regulator of the Alternative Complement Pathway | JEM
It is likely that C1-INH acts at these early steps in alternative pathway activation when limited amounts of C3 are activated ... This cleavage leads to the activation of the alternative pathway convertase and formation of a C3-cleaving enzyme. In the ... we studied the role of the C1-INH in inhibition of the alternative complement pathway. In the alternative complement pathway, ... as an inhibitor of the alternative complement pathway. C1-INH prevented lysis, induced by the alternative complement pathway, ...
  http://jem.rupress.org/content/194/11/1609
*  Molecular Vision: Reduction in ocular complement factor B protein in mice and monkeys by systemic administration of factor B...
C3), and serine proteases factor B and factor D are required and sufficient for formation of the alternative pathway convertase ... activated macrophages could promote the alternative pathway of complement activation in the retina via induction of RPE cell ... The initial step in the alternative pathway is proteolysis of complement C3, which plays a central role in the activation of ... Inhibition of the alternative complement pathway by antisense oligonucleotides targeting complement factor B improves lupus ...
  http://www.molvis.org/molvis/v23/561/
*  Native Properdin Binds to Chlamydia pneumoniae and Promotes Complement Activation
The alternative pathway initiates when spontaneously hydrolyzed C3 binds to activating surfaces (i.e., certain bacteria and ... due to its role as a stabilizer of the C3 and C5 convertases of the alternative pathway. This suggests that an inhibitor in ... The quantitative role of alternative pathway amplification in classical pathway induced terminal complement activation. Clin. ... pneumoniae directly or as a stabilizer of the C3 and C5 convertases of the alternative pathway, or by amplifying deposition of ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3028849/?lang=en-ca
*  An Evaluation of the Role of Properdin in Alternative Pathway Activation on Neisseria meningitidis and Neisseria gonorrhoeae |...
The role of properdin in the assembly of the alternative pathway C3 convertases of complement. J. Biol. Chem. 281: 2128-2132. ... "activated" properdin or Pn (35). Unlike the physiological forms of properdin, "activated" properdin can promote complement ... Sialic acid of group B Neisseria meningitidis regulates alternative complement pathway activation. Infect. Immun. 55: 174-180. ... Molecular architecture of human properdin, a positive regulator of the alternative pathway of complement. J. Biol. Chem. 259: ...
  http://www.jimmunol.org/content/185/1/507.long
*  Progressive Lipodystrophy: Background, Pathophysiology, Etiology
C3 nephritic factor is a serum immunoglobulin G that interacts with the C3bBb alternative pathway convertase to activate C3. ... Adipocytes synthesize factor D, the limiting component of the alternative complement pathway, which cleaves C3-bound factor B ... Adipocytes synthesize factor D, the limiting component of the alternative complement pathway, which cleaves C3-bound factor B ... prevents the alternative complement C3-convertase C3Bb from dissociative inactivation, resulting in adipocyte lysis. ...
  https://emedicine.medscape.com/article/1082489-overview
*  Barraquer-Simons syndrome - Wikipedia
C3 nephritic factor is a serum immunoglobulin G that interacts with the C3bBb alternative pathway convertase to activate C3. C3 ... due to complement activation and consumption of C3). Low C3 levels may impair complement-mediated phagocytosis and bacterial ... Around 83% of APL patients had low complement 3 (C3) levels and the presence of polyclonal immunoglobulin C3 nephritic factor. ... Lipodystrophy is often associated with glomerulonephritis, low C3 serum complement levels, and the presence of a C3 nephritic ...
  https://en.wikipedia.org/wiki/Barraquer%E2%80%93Simons_syndrome
*  Complement component 3 - Wikipedia
In the alternative complement pathway, C3 is cleaved by C3bBb, another form of C3-convertase composed of activated forms of C3 ... The resultant complex, C3bBb, is called the alternative pathway (AP) C3 convertase. C3bBb is deactivated in steps. First, the ... Its activation is required for both classical and alternative complement activation pathways. People with C3 deficiency are ... "Entrez Gene: C3 complement component 3". Sahu A, Lambris JD (Apr 2001). "Structure and biology of complement protein C3, a ...
  https://en.wikipedia.org/wiki/Complement_component_3
*  The complement system and innate immunity - Immunobiology - NCBI Bookshelf
... complement can also be activated early in infection in the absence of antibodies. Indeed, it now seems clear that complement ... This activity was said to 'complement' the antibacterial activity of antibody, hence the name. Although first discovered as an ... Complement was discovered many years ago as a heat-labile component of normal plasma that augments the opsonization of bacteria ... Hydrolysis of C3 causes initiation of the alternative pathway of complement. *Surface-bound C3 convertase deposits large ...
  https://www.ncbi.nlm.nih.gov/books/NBK27100/
*  Expression of complement regulatory proteins CD55, CD59, CD35, and CD46 in rheumatoid arthritis
In the classical and lectin pathways, C3 convertase is formed by a fragment of C4b and C2a (C4b2a), while, in the alternative ... Early complement activation. Complement is activated through three different pathways. The alternative pathway is spontaneously ... C3 convertase and amplification. C3 convertase cleaves the central component of complement, C3, into C3a, an anaphylactic and ... The complement cascade (CC) can be divided into four major phases: early complement activation; C3-convertase activation and ...
  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0482-50042011000500009&lng=en&nrm=iso&tlng=en
*  Alternate Complement Pathway | definition of Alternate Complement Pathway by Medical dictionary
Alternate Complement Pathway explanation free. What is Alternate Complement Pathway? Meaning of Alternate Complement Pathway ... Looking for online definition of Alternate Complement Pathway in the Medical Dictionary? ... C3 convertase-C3b,Bb; in the presence of properdin, C3 convertase is stabilized, activating later complement components, which ... alternative complement pathway. (redirected from Alternate Complement Pathway). Also found in: Acronyms. pathway. [path´wa] a ...
  https://medical-dictionary.thefreedictionary.com/Alternate+Complement+Pathway
*  Microbiology Unit 2 Flashcards - Cram.com
Briefly describe how the alternative complement pathway is activated and how C3 convertase is formed. ... Briefly describe how the classical complement pathway is activated and how C3 convertase is formed. ... 1. the classical complement pathway is activated by antigen-antibody complexes. 2. the lectin pathway is activated by ... To activate the classical complement pathway, IgG or IgM is made in response to an antigen. C3 is formed when antibodies Fab ...
  http://www.cram.com/flashcards/microbiology-unit-2-230905
*  Renal Fellow Network: Idiopathic MPGN and its subtypes. Or: I'm going to need the whole bottle to get through this
... resulting in perpetual breakdown of C3 and continuously activated alternative complement pathway. Factor H deficiency or ... C3 nephritic factor), which stabilizes and inhibits the inactivation of the alternative C3 convertase C3bBb, ... both of which are also caused by activation of the alternative complement pathway. With activation of the alternative pathway, ... resulting in persistent activation of the terminal pathway. With activation of the alternative and terminal pathways, C3 levels ...
  http://renalfellow.blogspot.com/2011/05/idiopathic-mpgn-and-its-subtypes-or-im.html
*  Renal Fellow Network: May 2011
... resulting in perpetual breakdown of C3 and continuously activated alternative complement pathway. Factor H deficiency or ... C3 nephritic factor), which stabilizes and inhibits the inactivation of the alternative C3 convertase C3bBb, ... both of which are also caused by activation of the alternative complement pathway. With activation of the alternative pathway, ... resulting in persistent activation of the terminal pathway. With activation of the alternative and terminal pathways, C3 levels ...
  http://renalfellow.blogspot.com/2011/05/
*  Complement C3 Plasma Level | Molecular Otolaryngology and Renal Research Laboratories
C3α and C3β). The three complement activation pathways (alternative, classical, lectin) converge at the stage of C3 cleavage to ... generate the activated form of C3, which is C3b. C3b generates new C3 convertases by interacting with factors B, D and ... including C3. Consumption of C3 is consistent with activation of the alternative pathway of complement (see Zhang et al. ... Complement C3 Plasma Level Assay Complement C3 (MW: 183 kDa) is one of the most abundant plasma proteins. It is a pivotal ...
  https://morl.lab.uiowa.edu/clinical-diagnostics/complement-assays/tests-included/complement-c3-plasma-level
*  Complement B/C2 (IPR011360) | InterPro | EMBL-EBI
Briefly, they are activated by cleavage and function as the serine protease components of the C3/C5 convertases, which play ... complement C2 and complement factor B, which, respectively, have analogous roles in the classical and alternative pathways of ... Complement B/C2 (IPR011360). Short name: Compl_C2_B Overlapping homologous superfamilies *von Willebrand factor A-like domain ... New structural motifs on the chymotrypsin fold and their potential roles in complement factor B.. EMBO J. 19 164-73 2000 ...
  http://www.ebi.ac.uk/interpro/entry/IPR011360
*  Frontiers | Extensive Basal Level Activation of Complement Mannose-Binding Lectin-Associated Serine Protease-3: Kinetic...
The lectin pathway of the complement system is initiated by mannose-binding lectin (MBL)-associated serine proteases, MASP-1, ... The third serine protease of the lectin pathway, MASP-3, was recently shown to be the major activator, and the exclusive ... The third serine protease of the lectin pathway, MASP-3, was recently shown to be the major activator, and the exclusive ... The lectin pathway of the complement system is initiated by mannose-binding lectin (MBL)-associated serine proteases, MASP-1, ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2017.01821/full
*  Frontiers | Hide and Seek: How Lyme Disease Spirochetes Overcome Complement Attack | Immunology
... terminating complement activation as well as shedding of cell-destroying complement complexes to manipulate and to ... terminating complement activation as well as shedding of cell-destroying complement complexes to manipulate and to ... and a CD59-like protein or molecules which indirectly counteract complement activation by binding various complement regulators ... and a CD59-like protein or molecules which indirectly counteract complement activation by binding various complement regulators ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2016.00385/full
*  C3a (complement) - Wikipedia
The MASPs cleave C4 and C2, resulting in C3 convertase formation. The alternative pathway of complement activation is typically ... also known as C3 convertase. The lectin pathway is activated when pattern-recognition receptors, like mannan-binding lectin or ... Levels of complement are regulated by moderating convertase formation and enzymatic activity. C3 convertase formation is ... thus preventing convertase formation. C3 convertase activity is also regulated without C3b inactivation, through complement ...
  https://en.wikipedia.org/wiki/C3a_(complement)
*  C3-convertase - Wikipedia
"C3b deposition during activation of the alternative complement pathway and the effect of deposition on the activating surface ... Since C3 convertases cleave C3 to produce C3b which can then form an additional C3 convertase through the alternative pathway, ... C3 convertase (EC 3.4.21.43, C42 , C4bC2b, C3bBb, complement C.hivin.4.hivin2, complement C3 convertase) belongs to family of ... "Formation of classical C3 convertase during the alternative pathway of human complement activation". PubMed Article. Retrieved ...
  https://en.wikipedia.org/wiki/C3-convertase
*  Complement System Made Easy- Immunology- Classical Alternate & Lectin pathway
In all three pathways, C3-convertase cleaves and activates component C3, creating C3a and C3b, and causes a cascade of further ... Three biochemical pathways activate the complement system: the classical complement pathway, the alternative complement pathway ... The three pathways of activation all generate homologous variants of the protease C3-convertase. The classical complement ... whereas the alternative pathway can be activated by C3 hydrolysis, foreign material, pathogens, or damaged cells. The mannose- ...
  https://www.technologynetworks.com/immunology/videos/complement-system-made-easy-immunology-classical-alternate-lectin-pathway-309295
*  Eosinophil colony-stimulating factor | definition of eosinophil colony-stimulating factor by Medical dictionary
C3 nephritic factor (C3 NeF) an autoantibody that stabilizes the alternative complement pathway C3 convertase, preventing its ... factor D a factor that when activated serves as a serine esterase in the alternative complement pathway. ... C3 nephritic factor (C3 NeF) an autoantibody that stabilizes the alternative complement pathway C3 convertase, preventing its ... enzyme that regulates both classical and alternative pathways of complement activation by inactivating their C3 convertases. ...
  https://medical-dictionary.thefreedictionary.com/eosinophil+colony-stimulating+factor
*  The continual presence of C3d but not IgG glomerular capillary deposition in stage I idiopathic membranous nephropathy in...
Since C3d is one of the final degradation products of C3 that is more stable in vivo, we determine if C3d staining could be ... Intensive C3d staining was present in glomerular capillary like the staining pattern of IgG and C3 in MN-I. Importantly, in 40 ... However, it is not uncommon that renal biopsy did not obtain sufficient material for electron microscopy and that IgG and C3 ... requires electron microscopy or immunohistochemistry that shows a glomerular capillary staining pattern of IgG and C3. ...
  https://diagnosticpathology.biomedcentral.com/articles/10.1186/1746-1596-7-109
*  Formation of High-Affinity C5 Convertases of the Alternative Pathway of Complement | The Journal of Immunology
C3 convertase) that cleaves C3 (1). Cleavage of C3 produces the proteolytically activated form of C3 (C3b),3 which forms the ... In the classical pathway C3 convertase C4b,C2a has a structure similar to the alternative pathway C3 convertase in having C2a ... C3 convertases of the alternative pathway (monomeric C3/C5 convertase assembled with monomeric C3b (C3b,Bb)) and the classical ... Alternative pathway of complement: recruitment of precursor properdin by the labile C3/C5 convertase and the potentiation of ...
  http://www.jimmunol.org/content/166/4/2635
*  Constrained solution scattering modelling of human antibodies and complement proteins reveals novel biological insights |...
... lectin or alternative pathways. All three pathways lead to the activation of C3, the central complement component, to C3b. C3b ... Thus FH competes with the protease that binds to C3b to form the C3b convertase, accelerates the decay of the C3 convertase ... It is activated by the presence of pathogens such as bacteria by one of three pathways, the classical, ... FH is a major essential regulator of C3b in the alternative pathway that prevents complement-mediated human host cell damage. ...
  http://rsif.royalsocietypublishing.org/content/6/Suppl_5/S679
*  Properdin Binds to Late Apoptotic and Necrotic Cells Independently of C3b and Regulates Alternative Pathway Complement...
The alternative pathway of complement is thought to be activated following hydrolysis of C3, generation of C3b, and formation ... The role of properdin in the assembly of the alternative pathway C3 convertases of complement. J. Biol. Chem. 281: 2128-2132. ... Analysis of the interaction between properdin and factor B, components of the alternative-pathway C3 convertase of complement. ... Properdin activates complement via an alternative pathway. A, Necrotic Jurkat cells were preincubated with or without properdin ...
  http://www.jimmunol.org/content/180/11/7613?ijkey=4c7ecf4340af5dabcca70ddb98a75f3703f2602d&keytype2=tf_ipsecsha