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*  Frontiers | Fragile X mental retardation protein: from autism to neurodegenerative disease | Frontiers in Cellular Neuroscience
... synaptic dysfunction and behavioral phenotypes in fragile X syndrome (Wang et al., 2012; Sidorov et al., 2013; Suhl et al., ... More and more potential FMRP mRNA targets and interacting proteins have been identified in the mammalian brain, supporting the ... is a RNA binding protein, the absence of which due to silencing of the FMR1 gene causes fragile X syndrome, an X-linked ... critical roles of FMRP in neurodevelopment, synaptic plasticity and other neurological disorders apart from fragile X syndrome ...
  https://www.frontiersin.org/articles/10.3389/fncel.2015.00043/full
*  Signaling pathways involved in enhanced NMDA receptor-dependent excitotoxicity in a mouse model of Huntington disease - UBC...
Synaptic RAS GTPase-activating protein (SynGAP) is another abundant PSD protein that binds to PSD-95 (Bezprozvanny and Hayden, ... SynGAP regulates synaptic strength and mitogen-activated protein kinases in cultured neurons. Proc Natl Acad Sci U S A. 103, ... 1.3 MAGUKs MAGUKs are a family of synaptic proteins that share high homology structures of three PSD/Discs-large/ZO-1 (PDZ), ... 1 SPN Supernatant Src Sarcoma STEP Striatal-enriched protein tyrosine phosphatase SynGAP Synaptic RAS GTPase-activating protein ...
  https://open.library.ubc.ca/cIRcle/collections/ubctheses/24/items/1.0072317
*  Dok2 mediates the CD200Fc attenuation of Aβ-induced changes in glia | Journal of Neuroinflammation | Full Text
To further examine the impact of inflammatory changes on synaptic plasticity, the effect of CD200Fc on Aβ-induced impairment of ... whereas activation of the receptor by CD200 fusion protein (CD200Fc) ameliorates inflammatory changes which are evident in the ... Ras GTPase activating protein. SHIP: SH2-containing inositol phosphatase. SHP: Src homology 2 domain containing phosphatase ... This study highlights the negative effect that activated microglia exert on synaptic plasticity but, importantly, it identifies ...
  https://jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-9-107
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
A key regulator of mitogenic signaling is Grb2, a modular protein composed of an internal SH2 (Src Homology 2) domain flanked ... Grb2 is constitutively associated with the GTPase Son-Of-Sevenless (SOS) via its N-terminal SH3 domain. The SH2 domain of Grb2 ... Plasma membrane receptors that bind Grb2 such as activated Epidermal Growth Factor Receptor (EGFR) recruit GFP-Grb2 to the ... We have looked for alternative strategies for activating such signals and found that low-intensity pulsed ultrasound (LIPUS) ...
  https://www.jove.com/visualize/abstract/21731601/specific-syndecan-1-domains-regulate-mesenchymal-tumor-cell-adhesion
*  AGAP3 and Arf6 Regulate Trafficking of AMPA Receptors and Synaptic Plasticity | Journal of Neuroscience
1998) A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II. Neuron 20:895-904, doi:10.1016/S0896- ... GTPase activating proteins (GAPs) and GTP exchange factors (GEFs) are necessary to inactivate and activate these signaling ... AGAP3 contains multiple signaling domains, a GTPase-like domain, a pleckstrin homology domain, and an ArfGAP domain, and exists ... SynGAP contains a Ras GTPase activating protein domain (RasGAP) and plays an important role in linking NMDA receptors to Ras/ ...
  http://www.jneurosci.org/content/33/31/12586.full
*  CALM2 calmodulin 2 [Homo sapiens (human)] - Gene - NCBI
Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for ... RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream ... organism-specific biosystemCa2+ signal generated through NMDA receptor in the post-synaptic neuron activates adenylate cyclase ... organism-specific biosystemIQGAPs constitute a family of scaffolding proteins characterized by a calponin homology (CH) domain ...
  https://www.ncbi.nlm.nih.gov/gene/805
*  Frontiers | SynProt: A Database for Proteins of Detergent-Resistant Synaptic Protein Preparations | Frontiers in Synaptic...
For a comprehensive understanding of synaptic networks the entire ensemble of synaptic proteins has to be considered. To ... For a comprehensive understanding of synaptic networks the entire ensemble of synaptic proteins has to be considered. To ... Both pre- and postsynaptic protein networks represent the molecular substrates for synaptic plasticity. Their function can be ... Both pre- and postsynaptic protein networks represent the molecular substrates for synaptic plasticity. Their function can be ...
  https://www.frontiersin.org/articles/10.3389/fnsyn.2012.00001/full
*  Gene Report for G00001924 - Genes2Cognition Neuroscience Research Programme
... ras) GTPase-activating protein and COOH-terminal Grb2. Distinct sites in the proline-rich COOH-terminal region of synapsin I ... Amphiphysin (Amph) is a src homology 3 domain-containing protein that has been implicated in synaptic vesicle endocytosis as a ... calmodulin-dependent protein kinase II or mitogen-activated protein kinase modulated the binding to the SH3 domains of ... Many important protein-protein interactions are mediated by peptide recognition modular domains, such as the Src homology 3 ( ...
  http://www.genes2cognition.org/db/Gene/G00001924
*  Plus it
1998) A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM Kinase II. Neuron 20:895-904. ... protein PSD-95. Here, we report that citron, a protein target for the activated form of the small GTP-binding protein Rho, ... Ring-H2, Ring-H2 finger domain; PH, pleckstrin homology domain;CMG, citron/MRCK/Gek domain; tSXV, terminal S/TXV motif ... In contrast to citron, p135 SynGAP, an abundant synaptic Ras GTPase-activating protein that can bind to all three PDZ domains ...
  http://www.jneurosci.org/content/19/1/96
*  NUS Department of Physiology
Here, we demonstrate that RASAL2, which encodes a RAS-GTPase-activating protein (RAS-GAP), is a functional target of anti- ... synaptic capture, whereby the synaptic tag interacts with newly synthesized plasticity-related proteins (PRPs). Much of the ... Of note, the identification of specific domains within the Bcl-2 family of proteins (Bcl-2 homology domains; BH domains) has ... Furthermore, DP103 enhanced TGF-β-activated kinase-1 (TAK1) phosphorylation of NF-κB-activating IκB kinase 2 (IKK2), leading to ...
  http://medicine.nus.edu.sg/phys/Research_Highlights.html
*  The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits
GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins. Annu ... G protein alpha subunits activate tubulin GTPase and modulate microtubule polymerization dynamics. J Biol Chem. 1999 ;274(19): ... All three proteins possess an RGS-box N-terminal to DH (Dbl-homology) and PH (pleckstrin-homology) domains that, as a tandem, ... "synaptic protein interaction") region of the N-type calcium channel (Cav2.2); this interaction is dependent on neurotransmitter ...
  http://www.ijbs.com/v01p0051.htm
*  Calm1 calmodulin 1 [Rattus norvegicus (Norway rat)] - Gene - NCBI
Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for ... Title: Nuclear translocation of cardiac G protein-Coupled Receptor kinase 5 downstream of select Gq-activating hypertrophic ... RHO GTPases activate PAKs, organism-specific biosystem (from REACTOME) RHO GTPases activate PAKs, organism-specific biosystem ... RHO GTPase Effectors, organism-specific biosystem (from REACTOME) RHO GTPase Effectors, organism-specific biosystem ...
  https://www.ncbi.nlm.nih.gov/gene/24242
*  GNB2 G protein subunit beta 2 [Homo sapiens (human)] - Gene - NCBI
... isoforms are activated by G-protein beta:gamma in the order PLCB3 , PLCB2 , PLCB1. Gbeta:gamma binds to the pleckstrin homology ... Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for ... The synapse involves a pre-synaptic neuron and a post-synaptic neuron,... ... Genes with a similar profile of promoter-activating H3K4me3 modifications across several tissue types ...
  https://www.ncbi.nlm.nih.gov/gene/2783
*  C-terminal EH-domain-containing proteins: consensus for a role in endocytic trafficking, EH? | Journal of Cell Science
Some EHD proteins (e.g. Reps1 and POB1) regulate actin microfilaments by interacting with GTPase-activating proteins (GAPs) for ... Yamaguchi, A., Urano, T., Goi, T. and Feig, L. A. (1997). An Eps homology (EH) domain protein that binds to the Ral-GTPase ... All mammalian C-terminal EHD proteins contain a putative P-loop motif, an ATP/GTP-binding site found in Ras-family proteins, ... and binding to the Wiscott Aldrich Syndrome protein (WASp) (McGavin et al., 2001). WASp activates the Arp2/3 complex and ...
  http://jcs.biologists.org/content/118/18/4093
*  gq g11 gtp binding protein alpha subunits
Research Grants about gq g11 gtp binding protein alpha subunits ... Mitogen activated protein kinases regulation-PTH/PTHrP. Hesham ... Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology ... Differential contribution of GTPase activation and effector antagonism to the inhibitory effect of RGS proteins on Gq-mediated ... Activation and regulation of platelet-activating factor receptor: role of G(i) and G(q) in receptor-mediated chemotactic, ...
  https://www.labome.org/topics/chemicals/and/peptides/intracellular/heterotrimeric/gtp/gq-g11-gtp-binding-protein-alpha-subunits-12352.html
*  Tobias Meyer | Stanford Medicine Profiles
Here, we show that 21 small GTPase homologs activate PI3K. Using a microscopy-based binding assay, we show that K-Ras, H-Ras, ... We show here that a regulated interaction of the endocytic adaptor RalBP1 with two synaptic proteins, the small GTPase RalA and ... by plasma membrane translocation of a green fluorescent protein-Akt pleckstrin homology domain fusion protein, and by ... We show that each Ca(2+) pulse triggers contraction of actin filaments by activating myosin light-chain kinase and myosin II ...
  https://med.stanford.edu/profiles/tobias-meyer
*  Annular PIP3 accumulation controls actin architecture and modulates cytotoxicity at the immunological synapse | JEM
Ras is strongly activated by TCR signaling (Genot and Cantrell, 2000), but whether it promotes synaptic PIP3 accumulation ... by class IA phosphoinositide 3-kinases that associate with T cell receptor microclusters and are activated by the GTPase Ras. ... and it is also unclear how these proteins might be recruited and activated by TCR signaling. Previous studies in T cells have ... Specificity and promiscuity in phosphoinositide binding by pleckstrin homology domains. J. Biol. Chem. 273:30497-30508. doi: ...
  http://jem.rupress.org/content/210/12/2721
*  CDH1 cadherin 1 [Homo sapiens (human)] - Gene - NCBI
GTPase activating protein binding IPI Inferred from Physical Interaction. more info. PubMed ... regulation of protein catabolic process at postsynapse, modulating synaptic transmission IEA Inferred from Electronic ... RHO GTPases activate IQGAPs, organism-specific biosystemIQGAPs constitute a family of scaffolding proteins characterized by a ... Homology *Homologs of the CDH1 gene: The CDH1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, ...
  https://www.ncbi.nlm.nih.gov/gene/999
*  LSD1 - Page 2 - PKD Inhibitors for Treatment of Tumor
The Rho GTPase-activating proteins (RhoGAPs) play an essential role in regulating. by biopaqc on September 3, 2017. ... Ras association), and a low-similarity Pleckstrin-homology (PH) website. The Arhgap20 protein is indicated in brain, liver and ... Studies in also have implicated HGS in synaptic proteins homeostasis and synaptic vesicle rejuvenation [25]. Nevertheless, ... Letrozole CD44 is strongly expressed on antigen\activated T cells4,12 and on T cells with a transendothelial migratory capacity ...
  http://www.biopaqc.com/category/lsd1/page/2/
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
A key regulator of mitogenic signaling is Grb2, a modular protein composed of an internal SH2 (Src Homology 2) domain flanked ... Specifically, γHV68 infection activates IKKβ and that activated IKKβ phosphorylates RelA to accelerate RelA degradation. As ... synaptic plasticity, nerve growth, inflammation and the immune response. A number of proteins help regulate these pathways ... Grb2 is constitutively associated with the GTPase Son-Of-Sevenless (SOS) via its N-terminal SH3 domain. The SH2 domain of Grb2 ...
  https://www.jove.com/visualize/abstract/23990909/suppressor-cytokine-signaling-socs-5-utilises-distinct-domains-for
*  HRAS HRas proto-oncogene, GTPase [Homo sapiens (human)] - Gene - NCBI
Ras family small GTP binding protein H-Ras. c-has/bas p21 protein. c-ras-Ki-2 activated oncogene. p19 H-RasIDX protein. ... including the Rac-family GTPase-activating protein RLIP (also known as RLIP76 and ralA binding protein 1 (RALBP1)), CDC42(cell ... The synapse involves a pre-synaptic neuron and a post-synaptic neuron,... ... Homology *Homologs of the HRAS gene: The HRAS gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, ...
  https://www.ncbi.nlm.nih.gov/gene?LinkName=pubmed_gene_rif&from_uid=22499344