*  Subcellular Targeting of PDE4 in Cardiac Myocytes and Generation of Signaling Compartments | SpringerLink
Of the 11 families of phosphodiesterases found in the human genome, three decades of pharmacological data have clearly ... Implications for the mechanism of action of selective phosphodiesterase inhibitors. Biochem J 241(2):535-541CrossRefPubMed ... The oligomerization state determines regulatory properties and inhibitor sensitivity of type 4 cAMP-specific phosphodiesterases ... Liu S, Li Y, Kim S, Fu Q, Parikh D, Sridhar B, Shi Q, Zhang X, Guan Y, Chen X, Xiang YK (2012) Phosphodiesterases coordinate ...
  https://link.springer.com/chapter/10.1007/978-3-319-54579-0_8
*  Kudos - helping increase the reach and impact of research
Disaggregatory action of phosphodiesterase inhibitors. Published in:Pharmacological Research Communications. Publication date: ... Mechanisms of action of proteinase-activated receptor agonists on human platelets. Published in:British Journal of Pharmacology ... Identification, regulation and role of tissue inhibitor of metalloproteinases-4 (TIMP-4) in human platelets. Published in: ... N-Substituted homopiperazine barbiturates as gelatinase inhibitors. Published in:Bioorganic & Medicinal Chemistry. Publication ...
  https://www.growkudos.com/profiles/15089
*  A Comprehensive Generic Drug Naming Resource - DrugPatentWatch
inhibitors of phosphodiesterase PDE5 with vasodilator action. -aj-. antiarrhythmics, ajmaline derivatives. -al. aldehydes. ... angiotensin-converting enzyme inhibitors. -prim. antibacterials, dihydrofolate reductase (DHFR) inhibitors, trimethoprim ... neuraminidase inhibitors. -ampanel. antagonists of the ionotropic non-NMDA (N-methyl-D-aspartate) glutamate receptors (Namely ... serine/threonine kinase inhibitors. -setron. serotonin receptor antagonists (5-HT3) not fitting into other established groups ...
  https://www.drugpatentwatch.com/blog/a-comprehensive-generic-drug-naming-resource/
*  Phytotherapeutic Alternatives to Testosterone Replacement (Jan 2016) Townsend Letter, Alternative Medicine Magazine
Epimedium sagittatum contains icariin, which has phosphodiesterase-5 (PDE5) inhibitor action affecting all three PDE5 isoforms. ... may be attributed to the PDE5 inhibitor actions.16,17 PDE5 inhibitors can potentiate the sexual response in both men and women. ... In addition, many of these herbs improve sexual function through mechanisms beyond the actions of testosterone. Some may ... Epimedium sagittatum (horny goat weed extract) promotes testosterone production through the action of icariin, a flavonol that ...
  http://townsendletter.com/Jan2016/phyto0116.html
*  Inhibiting the microglia activation improves the spatial memory and adult neurogenesis in rat hippocampus during 48 h of sleep...
... effect of minocycline in amelioration of spatial memory decline during SD by its anti-inflammatory and neuroprotective actions ... Peixoto CA, Nunes AK, Garcia-Osta A. Phosphodiesterase-5 inhibitors: action on the signaling pathways of neuroinflammation, ... 5e). Minocycline, a microglia activation inhibitor, effectively decreased the immunoreactivity of Iba-1 during 48 h SD in DG ( ... Temozolomide, an alkylating/anti-proliferating agent, has been used as a neurogenesis inhibitor [31]. Temozolomide (Sigma- ...
  https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-017-0998-z
*  Anagrelide - Wikipedia
The exact mechanism of action is unclear, although it is known to be a phosphodiesterase inhibitor. It is a potent (IC50 = 36nM ... inhibitor of phosphodiesterase-II.[citation needed] It inhibits PDE-3 and phospholipase A2. Phosphodiesterase inhibitor with ... Jones GH, Venuti MC, Alvarez R, Bruno JJ, Berks AH, Prince A (February 1987). "Inhibitors of cyclic AMP phosphodiesterase. 1. ...
  https://en.wikipedia.org/wiki/Anagrelide
*  Role of AC-cAMP-PKA Cascade in Antidepressant Action of Electroacupuncture Treatment in Rats
... a phosphodiesterase inhibitor, which inhibits the cAMP metabolism. Rolipram has been reported to have antidepressant effects in ... cascades are involved in the selective serotonin reuptake inhibitors (SSRIs)-induced antidepressant actions [24, 25]. ... "Antidepressant-like effects of rolipram and other inhibitors of cyclic adenosine monophosphate phosphodiesterase on behavior ... Role of AC-cAMP-PKA Cascade in Antidepressant Action of Electroacupuncture Treatment in Rats. Jian-hua Liu,1 Zhi-feng Wu,2 Jian ...
  https://www.hindawi.com/journals/ecam/2012/932414/
*  NURSING - Hondros college of Nursing - Course Hero
... phosphodiesterase (PDE) inhibitor Route: PO Drug Action: Enhances vasodilation eff ... PO Drug Action: Ace Inhibitor Uses: Mild to moderate hypertensio ... PO Drug Action: as it is excreted through the urinary tract, ... PO Drug Action: Semisynthetic derivative of an opium alkaloid with actions ... PO Drug Action: tramadol binds to receptors in the brain (narcotic or opioid recepto ...
  https://www.coursehero.com/sitemap/schools/126510-Hondros-college/departments/775835-NURSING/
*  The Role of Cyclic AMP in the Octopaminergic Modulation of Flight Muscle in the Locust | Journal of Experimental Biology
Surprisingly, the phosphodiesterase inhibitors used were not able to potentiate the actions of octopamine on this preparation. ... These include the use of phosphodiesterase inhibitors to block the metabolism of cyclic nucleotides, the use of forskolin, the ... diterpene activator of adenylate cyclase, and the direct application of permeable and phosphodiesterase-resistant analogues of ...
  http://jeb.biologists.org/content/161/1/423
*  THE POSSIBLE MEDIATION BY CYCLIC AMP OF THE STIMULATION OF THYMOCYTE PROLIFERATION BY VASOPRESSIN AND THE INHIBITION OF THIS...
... effects of imidazole and thyrocalcitonin on vasopressin's mitogenic action are both overcome by the phosphodiesterase inhibitor ... This mitogenic action of vasopressin, again like that of cyclic AMP, is potentiated by caffeine, an inhibitor of the ... On the other hand, vasopressin's mitogenic action (also like that of cyclic AMP) is blocked by imidazole, an activator of ... It is concluded from these observations that the mitogenic action of vasopressin is mediated by cyclic AMP. (Author)(* ...
  http://oai.dtic.mil/oai/oai?verb=getRecord&metadataPrefix=html&identifier=AD0712179
*  Bucladesine - Wikipedia
Bucladesine is a cyclic nucleotide derivative which mimics the action of endogenous cAMP and is a phosphodiesterase inhibitor. ... In addition, its high dose (200nM/mouse) combination with H-89, as a protein kinase inhibitor, had additive attenuating effect ... "Dual effect of cAMP agonist on ameliorative function of PKA inhibitor in morphine-dependent mice". Fundamental & Clinical ...
  https://en.wikipedia.org/wiki/Bucladesine
*  Patent US6063407 - Treatment of vascular thrombosis and restenosis with inhaled nitric oxide - Google Patents
Ichinose, et al., "Prolonged Duration of Action of Inhaled Nitric Oxide by Zaprinast, A cGMP Phosphodiesterase Inhibitor, in ... This invention may be practiced with other phosphodiesterase inhibitors. Various phosphodiesterase inhibitors are known in the ... Ichinose, et al., Prolonged Duration of Action of Inhaled Nitric Oxide by Zaprinast, A cGMP Phosphodiesterase Inhibitor, in ... Alternatively, the inhibitor may be inhaled by the mammal. For inhalation, the phosphodiesterase inhibitor is advantageously ...
  http://www.google.com/patents/US6063407?dq=6,243,373
*  Tezosentan in Pulmonary Arterial Hypertension - Full Text View - ClinicalTrials.gov
Phosphodiesterase 5 Inhibitors. Tezosentan. Epoprostenol. Molecular Mechanisms of Pharmacological Action. Phosphodiesterase ... Patients who have received any endothelin receptor antagonist (ERA) and/or any phosphodiesterase-5 (PDE-5) inhibitor within 28 ...
  https://clinicaltrials.gov/ct2/show/NCT01077297
*  Mycophenolate Mofetil, Carnitine and PDE5 Inhibitor, Three Potential Treatments for Resistant Proteinuria Slowing Diabetic...
aside to the conventional treatment patients will receive PDE5 inhibitor. Drug: Mycophenolate Mofetil (MMF) ,phosphodiesterase ... The beneficial effect of MMF was not related to its action on glomerular hemodynamic or improvement of metabolic control, but ... Phosphodiesterase 5 Inhibitors. Antibiotics, Antineoplastic. Antineoplastic Agents. Antibiotics, Antitubercular. Antitubercular ... Drug: Mycophenolate Mofetil (MMF) ,phosphodiesterase 5 inhibitors , CARNITINE effect of MMF on diabetic nephropathy patients by ...
  https://clinicaltrials.gov/ct2/show/NCT01566006?recr=Open&cond=%22Urination+Disorders%22&rank=17
*  AP 155 - AdisInsight
Mechanism of Action Cyclic AMP phosphodiesterase inhibitors; Platelet aggregation inhibitors * Orphan Drug Status Orphan ...
  http://adisinsight.springer.com/drugs/800011038?error=cookies_not_supported&code=eab99bdd-8f2b-4e6c-9036-9e1350a952d7
*  Pentoxifylline Neuroprotective Effects Are Possibly Related to Its Anti-Inflammatory and TNF-Alpha Inhibitory Properties, in...
... is a phosphodiesterase inhibitor with anti-TNF-alpha activity, associated with its anti-inflammatory action. Considering ... G. S. Viana, F. A. O. Garcia, S. Pinto et al., "Pentoxifylline, a phosphodiesterase inhibitor decreases hyperglycemia. Glycated ... PTX, besides being a phosphodiesterase inhibitor, increases cAMP levels and decreases TNF-alpha, presenting anti-inflammatory ... E. Beshay, F. Croze, and G. J. Prud'homme, "The phosphodiesterase inhibitors pentoxifylline and rolipram suppress macrophage ...
  https://www.hindawi.com/journals/pd/2015/108179/
*  Tina Seelig's Profile | Stanford Profiles
Similar effects of db-cAMP and a phosphodiesterase inhibitor were seen on intracellularly recorded action potentials of single ... Dibutyryl cAMP (db-cAMP) and isoproterenol reduced the amplitude of the compound action potential and decreased the ability of ...
  https://profiles.stanford.edu/tina-seelig?tab=teaching
*  Plus it
Anti-inflammatory action of exendin-4 in human islets is enhanced by phosphodiesterase inhibitors: potential therapeutic ... Dipeptidyl peptidase-4 inhibitors in the treatment of type 2 diabetes: a comparative review. Diabetes Obes Metab 2011;13:7-18 ... Linagliptin: a novel dipeptidyl peptidase 4 inhibitor with a unique place in therapy. Adv Ther 2011;28:447-459pmid:21603986. ... The DPP-4 Inhibitor Linagliptin Counteracts Stroke in the Normal and Diabetic Mouse Brain. A Comparison With Glimepiride. ...
  http://diabetes.diabetesjournals.org/content/62/4/1289
*  Phosphodiesterase-5 Inhibitor in Eisenmenger Syndrome - Full Text View - ClinicalTrials.gov
Phosphodiesterase 5 Inhibitors. Vasodilator Agents. Phosphodiesterase Inhibitors. Enzyme Inhibitors. Molecular Mechanisms of ... Phosphodiesterase-5 Inhibitor in Eisenmenger Syndrome. The safety and scientific validity of this study is the responsibility ... Mukhopadhyay S, Sharma M, Ramakrishnan S, Yusuf J, Gupta MD, Bhamri N, Trehan V, Tyagi S. Phosphodiesterase-5 inhibitor in ... Clinical Efficacy of Phosphodiesterase-5 Inhibitor Tadalafil in Eisenmenger Syndrome - A Randomised, Placebo Controlled, Double ...
  https://clinicaltrials.gov/ct2/show/NCT01200732
*  Current Medicinal Chemistry | BenthamScience
Phosphodiesterase 4 Inhibitors in Immune-mediated Diseases: Mode of Action, Clinical Applications, Current and Future ... A Systematic Analysis of Physicochemical and ADME Properties of All Small Molecule Kinase Inhibitors Approved by US FDA from ... Osteonecrosis of the Jaw and Angiogenesis inhibitors: A Revival of a Rare but Serous Side Effect ... Recent Progress in the Development of MNK Inhibitors ...
  http://www.eurekaselect.com/node/602/novel-antibacterial-compounds-and-their-drug-targets-successes-and-challenges/most-download-articles
*  Caffeine's Vascular Mechanisms of Action
It intervenes as an antagonist of the adenosine receptors, inhibitor of phosphodiesterase enzymes, sensitizer of calcium ... cGMP phosphodiesterase [20], stimulating even more accumulation of cGMP.. 6. Other Mechanisms of Action. 6.1. Action through ... 5. Caffeine Mechanisms of Action on Smooth Muscle Cells. Caffeine may exert vascular mechanisms of action through its direct or ... Caffeine is a nonselective competitive inhibitor of the phosphodiesterase enzymes [40]. These enzymes have the capacity to ...
  https://www.hindawi.com/journals/ijvm/2010/834060/
*  Enoximone - AdisInsight
... inhibitor licensed in by Myogen from Hoechst Marion Roussel Inc. (later sanofi-aventis) ... Mechanism of Action Type 3 cyclic nucleotide phosphodiesterase inhibitors * Orphan Drug Status Orphan designation is assigned ...
  https://adisinsight.springer.com/drugs/800014135?error=cookies_not_supported&code=476fda43-198f-4da7-b2c3-f6f6a4aeaf59
*  Roflumilast - Nycomed - AdisInsight
Roflumilast is a selective phosphodiesterase IV inhibitor developed by Nycomed (now Takeda Pharmaceuticals International) as an ... Mechanism of Action Type 4 cyclic nucleotide phosphodiesterase inhibitors * Orphan Drug Status Orphan designation is assigned ...
  https://adisinsight.springer.com/drugs/800010714?error=cookies_not_supported&code=cd6e2e7f-5010-47ec-9144-76e49b9dfa88
*  The use of F-arginine and phosphodiesterase inhibitor (dipyridamole) to wean from inhaled nitric oxide | Springer for Research ...
Mechanism of enhancement of adenosine action by dipyridamole and lidoflazine in dogs.Arch Int Pharmacodyn Ther 1971; 194:181- ... Al-Alaiyan S, Al-Omran A, Dyer D. The use of phosphodiesterase inhibitor (dipyridamole) to wean from inhaled nitric oxide. ... Primary sequences of cyclic nucleotide phosphodiesterase isoenzymes and the design of selective inhibitors.Trends Pharmacol Sci ... The use of F-arginine and phosphodiesterase inhibitor (dipyridamole) to wean from inhaled nitric oxide. ...
  https://rd.springer.com/article/10.1007/BF02722041