*  Items by Bull, Steven - Opus
Asymmetric synthesis of substituted 1-aminocyclopropane-1-carboxylic acids via diketopiperazine methodology. Organic and ... Pyrene-anchored boronic acid receptors on carbon nanoparticle supports:Fluxionality and pore effects. New Journal of Chemistry ... Lewis acid activation of pyridines for nucleophilic aromatic substitution and conjugate addition. ChemSusChem. , 8 (6), pp. ... Diols and anions can control the formation of an exciplex between a pyridinium boronic acid with an aryl group connected via a ...
  http://opus.bath.ac.uk/view/person_id/981.default.html
*  Francesca Paradisi - The University of Nottingham
... she completed her PhD at the same institution with a thesis on the synthesis of non-natural amino acids via diketopiperazine ... Stabilization of Angiotensin-(1-7) by key substitution with a cyclic non-natural amino acid Amino Acids. 49, 1733-1742 ... Stabilization of Angiotensin-(1-7) by key substitution with a cyclic non-natural amino acid Amino Acids. 49, 1733-1742 ... Biological Screening of Angiotensin-(1-7) Analogues incorporating the Non-natural delta-Amino Acid ACCA AMINO ACIDS. 48(2), 636 ...
  https://www.nottingham.ac.uk/chemistry/people/francesca.paradisi
*  Pleurobranchus areolatus - Wikipedia
Rodriguesic acids and its esters (they are modified diketopiperazines) were isolated from P. areolatus in 2014. These are the ... "Rodriguesic acids, modified diketopiperazines from the gastropod mollusc Pleurobranchus areolatus". Journal of the Brazilian ... Similar diketopiperazines were isolated also from ascidians Didemnum sp. These derivatives may either result from a P. ... first diketopiperazine derivatives isolated from a mollusc. ...
  https://en.wikipedia.org/wiki/Pleurobranchus_areolatus
*  Patents filed at Aug 16 2016 | Iridium-based complexes for ECL | Patents.com
The disclosed embodiments detail improved methods for the synthesis of diketopiperazines from amino acids. In particular ... Hydropyrrolopyrrole derivatives for use as fatty acid synthase inhibitors. Compounds of the formula I in which R.sup.1, R.sup.2 ... The invention describes novel mono or dihydroxy docosahexaenoic acid (DHA) analogs, their preparation, isolation, ... Formation of N-protected bis-3,6-(4-aminoalkyl)-2,5,diketopiperazine. ...
  http://patents.com/isd-20160816-p92.html
*  DailyMed - ALTACE- ramipril capsule
... and to the diketopiperazine ester, the diketopiperazine acid, and the glucuronides of ramipril and ramiprilat, all of which are ... Ramipril is a 2-aza-bicyclo [3.3.0]-octane-3-carboxylic acid derivative. It is a white, crystalline substance soluble in polar ... Elevations of liver enzymes, serum bilirubin, uric acid, and blood glucose have been reported, as have cases of hyponatremia ...
  https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0fc34cd8-86e6-4034-73bd-4263a68ba046
*  Lipid Metabolism sub-cluster 70
Synthesis of hexa- and pentasubstituted diketopiperazines from sterically hindered amino acids. Brown Zachary Z - - 2010 ... Biotransformation of cinnamic acid, p-coumaric acid, caffeic acid, and ferulic acid by ... ... Biotransformations of phenylpropanoids such as cinnamic acid, p-coumaric acid, caffeic acid, and ferulic acid were investigated ... The plant-cultured cells of E. perriniana converted cinnamic acid into cinnamic acid β-D-glucopyranosyl ester, p-coumaric acid ...
  http://www.biomedsearch.com/cluster/14/Lipid-Metabolism/sub-70-p3.html
*  The Truth About Aspartame Toxicity & Nancy Markle
... aspartic acid, phenylalanine, aspartylphenylalanine diketopiperazine (DKP), beta-aspartame, and a few odds and ends.. The ... formic acid researcher.. *Aspartic acid.. It is well-known that excitotoxic amino acids such as aspartic acid can be used in ... 6) "People ingesting aspartame do not have increases in formic acid levels". A. Formaldehyde breaks down into formic acid (aka ... The aspartic acid is in "free-form" (unbound to protein), so unike food, it is absorbed suddently, bypassing the normal ...
  http://www.holisticmed.com/aspartame/markle.html
*  SGD Group - Publications - Steve Davies Group
375). Asymmetric synthesis of substituted 1-aminocyclopropane-1-carboxylic acids via diketopiperazine methodology. Buñuel, E.; ... and trans-stereoisomers of 4-aminopyrrolidine-3-carboxylic acid and 4-aminotetrahydrofuran-3-carboxylic acid. Bunnage, M. E.; ... 368). Asymmetric synthesis of anti-(2S,3S)- and syn-(2R,3S)-diaminobutanoic acid. Bunnage, M. E.; Burke, A. J.; Davies, S. G.; ... 395). 2-Halo-diketopiperazines as chiral glycine cation equivalents. Bull, S. D.; Davies, S. G.; Garner, A. C.; Savory, E. D.; ...
  http://sdavies.chem.ox.ac.uk/2000-2004.aspx
*  Useful Chemistry: 2005-11
Solid phase synthesis of a diketopiperazine catalyst containing the unnatural amino acid (S)-norarginine Jennifer Kowalski and ... It looks like the compounds in this lot of potential anti-malarials are part of a library of 2,5-diketopiperazines. A search on ... Nucleic Acids Research, 2004, (19), 32. Raymond M. Schiffelers1, Aslam Ansari1, Jun Xu1, Qin Zhou, Qingquan Tang, Gert Storm, ... All compounds are commercially available from Sigma-Aldrich but the tBOC amino acid derivatives were not in Chmoogle. Also the ...
  http://usefulchem.blogspot.com/2005/11/
*  Patent US6071497 - Microparticles for lung delivery comprising diketopiperazine - Google Patents
... polymers of mixed amino acids (proteinoids), alginate, and poly(hydroxy acids). In another embodiment, the microparticles have ... In a preferred embodiment, the drug delivery system is based on the formation of diketopiperazine microparticles which are ... U is an acid group, such as a carboxylic acid, phosphoric acid, phosphonic acid and sulfonic acid, or a basic group, such as ... Representative synthetic materials are: diketopiperazines, poly(hydroxy acids) such as poly(lactic acid), poly(glycolic acid) ...
  http://www.google.com/patents/US6071497?dq=4,923,986
*  Formation of N-Protected bis-3,6-(4-aminoalkyl)-2,5,diketopiperazine - Patent application
... phosphoric acid, p-toluenesulfonic acid, 1-propylphosphonic acid cyclic anhydride, tributyl phosphate, phenyl phosphonic acid ... sulfuric acid, phosphoric acid, p-toluenesulfonic acid, 1-propylphosphonic acid cyclic anhydride, tributyl phosphate, phenyl ... group comprising sulfuric acid, phosphoric acid, p-toluenesulfonic acid, 1-propylphosphonic acid cyclic anhydride, tributyl ... wherein the amino acid is ε-trifluoroacetyl-L-lysine, wherein the amino acid is ε-Cbz-L-lysine, wherein the amino acid is γ- ...
  http://www.patentsencyclopedia.com/app/20130012710
*  Marine Drugs | Free Full-Text | Bis-Indolyl Benzenoids, Hydroxypyrrolidine Derivatives and Other Constituents from Cultures of...
... benzoic acid (7), from the cultures of the marine sponge-associated fungus Aspergillus candidus KUFA 0062. Compounds 1a, 2a-e, ... chrysophanic acid (1a), emodin (1b), six bis-indolyl benzenoids including asterriquinol D dimethyl ether (2a), petromurin C (2b ... the anthraquinones chrysophanic acid and emodin, a diketopiperazine derivative, and bis-indolyl derivatives that are the ... The structures of palmitic acid, clionasterol [22], ergosterol 5,8-endoperoxides [14], chrysophanic acid (1a) [13], emodin (1b ...
  http://www.mdpi.com/1660-3397/16/4/119/htm
*  Aspartame | European Food Safety Authority
6-dioxo-2-piperazine acetic acid (also known as 'Di-ketopiperazine' or DKP). Conversion of aspartame to DKP results in the loss ... Aspartic acid is an amino acid found in proteins. The body may convert aspartic acid into the neurotransmitter glutamate which ... Is Di-ketopiperazine (DKP) from aspartame a safety concern?. Moisture, pH, temperature and storage time can all affect the ... Phenylalanine is a so-called essential amino acid as it cannot be produced by the body and must be supplied through the diet.. ...
  https://www.efsa.europa.eu/en/topics/topic/aspartame
*  isoHunt] (Aspartame) Sweet Misery A Poisoned World [2004] Torrent Downloads - download free torrents!
... formic acid and aspartylphenylalanine diketopiperazine (DKP). Manufacturers argue that the instability of aspartame is ... ASPARTIC ACID Aspartic acid (also known as aspartate) is a non-essential amino acid that comprises 40 per cent of aspartame. In ... Formic acid can lead to accumulation of excessive acid in the body fluids - a condition known as acidosis. The small amounts of ... FORMIC ACID Formic acid is a cumulative poison produced by the breakdown of formaldehyde. It concentrates in the brain, kidneys ...
  https://www.torrentdownloads.me/torrent/1203773/%5Bisohunt%5D+%28aspartame%29+sweet+misery+a+poisoned+world+%5B2004%5D
*  Community Supported Agriculture
EDTA breaks down in the environment into ethylenediamine triacetic acid and then diketopiperazine. Diketopiperazine is a ... Finally, we have Sorbic Acid, Potassium Sorbate, and Potassium Sodium EDTA, 'as preservatives.' Sorbic acid occur naturally in ... On to Phosphoric Acid; got a bottle of that on your pantry shelf? It's in this dressing to make stuff taste tangy, which real ... By the way, there are plenty of other acids to use for house made dressings. Citrus is a great alternative, so try lemon, Meyer ...
  http://www.urbanmonique.net/category/community-supported-agriculture/
*  Surveying the sequence diversity of model prebiotic peptides by mass spectrometry | PNAS
... potentially similar to diketopiperazine formation in amino-acid-only experiments. Because the diversity of depsipeptide ... glycolic acid (g), l-lactic acid (a), or l-malic acid (d). Each mixture contained one hydroxy acid and three amino acids (g+G+A ... as malic acid (d) is similar to aspartic acid (D) used to form Fox's proteinoids. The carboxylic acid moiety of the malic acid ... Hydroxy acids are abbreviated with lowercase letters corresponding to their analogous amino acids (e.g., glycolic acid = g; ...
  http://www.pnas.org/content/114/37/E7652
*  中国科学院昆明植物研究所机构知识库(KIB
Seven compounds including ergosterols, unsarurated fatty acid, cerebroside and diketopiperazines were isolated from the extract ... Six compounds consisting of nonactic acid series and cycloheximide were isolated from the extract of strain Tn48. No ... Two types of antibiotics including nonactic acid series and cycloheximide produced by strain Tn48 indicated that lots of ...
  http://ir.kib.ac.cn/handle/151853/776
*  Protocols and Video Articles Authored by Javier D. Murillo
... azido acids and for the synthesis of diketopiperazines using solid-supported N methylmorpholine. Owing to their robust and ... folic acid) and AFS (alcohol + Se + folic acid). Duodenal Se-Met transport was performed using an in vivo perfusion method. Se ... in the phytic acid content of the sample. Recoveries of phytic acid averaged 91%, which is a substantial improvement with ... and its amino acid conjugate indoleacetic acid-lysine (iaaL gene), and the repertoire of strain-specific putative type III ...
  https://www.jove.com/author/Javier+D._Murillo
*  US5039481A - Aliphatic polycarboxylic acids as air purification compositions - Google Patents
... where livestock excrement or urine accumulates an ammonia scavenging composition that contains an aliphatic polycarboxylic acid ... Diketopiperazine-based delivery systems US5709861A (en) * 1993-04-22. 1998-01-20. Emisphere Technologies, Inc.. Compositions ... Citric Acid 10018 Oxalic Acid 50 Citric Acid 5019 Oxalic Acid 90 Boric Acid 1020 Oxalic Acid 45 Citric Acid 45 Boric Acid 1021 ... malonic acid, succinic acid, malic acid, citric acid, 1,2-cyclohexane dicarboxylic acid, 1,3-cyclohexane dicarboxylic acid, 1,4 ...
  https://patents.google.com/patent/US5039481A/en
*  Diketopiperazine - Wikipedia
2,5-Diketopiperazines are cyclodipeptides often obtainable via condensation of two α-amino acids. 2,6-Diketopiperazines may be ... A diketopiperazine (DKP), also known as a dioxopiperazine or piperazinedione, is a class of organic molecules in which the two ... Of these three isomeric diketopiperazines, the 2,5-derivatives have attracted the greatest interest. DPKs can be visualized as ... The 2,3-diketopiperazines may be viewed as oxamides obtained from ethylenediamine. ...
  https://en.wikipedia.org/wiki/Diketopiperazine
*  Spiroligomer - Wikipedia
Spiroligomer diketopiperazines can be created between either end of a bis-amino acid. Spiroligomers are known to be ... and Pentasubstituted Diketopiperazines from Sterically Hindered Amino Acids" Organic Letters, (2010), 12(7), 1436-1439 doi: ... Spiroligomers are synthesized in a step-wise approach by adding a single bis-amino acid at each stage of the synthesis. This ... Spiroligomers (also known as bis-peptides) are synthetic oligomers made by coupling pairs of bis-amino acids into a fused ring ...
  https://en.wikipedia.org/wiki/Spiroligomer
*  X-Ray Diffraction Studies of Crystalline Amino Acids and Peptides | Springer for Research & Development
Corey, R. B.: The Crystal Structure of Diketopiperazine. J. Amer. chem. Soc. 60, 1598 (1938).CrossRefGoogle Scholar ... Corey, R. B.: X-Ray Studies of Amino Acids and Peptides. Adv. Protein Chem. 4, 385 (1948).CrossRefGoogle Scholar ... Meyer, C. E. and W. C. Rose: The Spatial Configuration of α-Amino-ß-hydroxy-n-butyric acid. J. biol. Chemistry 115, 721 (1936). ... Structural Characteristics of Some Amino Acids. J. physic. Chem. 47, 24 (1943)•CrossRefGoogle Scholar ...
  https://rd.springer.com/chapter/10.1007/978-3-7091-7172-1_9
*  Medical Isotopes, Inc.
Enalapril Cyclohexyl Analogue Trifluoroacetic Acid Salt Request Quote. 45996. Enalapril Diketopiperazine 25 mg. $650. Add to ... Enalaprilat Butyl Ester Oxalic Acid Salt 2.5 mg. $675. Add to Cart. 25 mg. $2,400. Add to Cart. ... N-[(1S)-1-(Carboxy)-(3-phenyl-d5)propyl]-L-alanyl]-L-proline Dihydrate; Enalaprilic Acid-d5; MK-422-d5; Vasotec IV-d5; 98%D 1 ... 2S)-1-[(2S)-2-[[(1S)-1-Carboxy-3-phenyl-propyl]amino]propanoyl] pyrrolidine-2-carboxylic acid; Vasotec; 100 mg. $850. Add to ...
  http://medicalisotopes.com/productlisting.php?group=Enalapril
*  Glycylglycine - Wikipedia
The compound was first synthesized by Emil Fischer and Ernest Fourneau in 1901 by boiling 2,5-diketopiperazine (glycine ... anhydride) with hydrochloric acid. Shaking with alkali and other synthesis methods have been reported. Because of its low ...
  https://en.wikipedia.org/wiki/Glycylglycine
*  Aspartame - Rumsfeld's Bioweapon Legacy - ariannelot
All metabolites of aspartame (formaldehyde, methanol, diketopiperazine and formic acid) are toxic to the human body and are ... John Olney,s 1971 study which showed that aspartic acid caused lesions in the brains of infant mice. According to Turner, ... The substance, comprised of 50 percent synthetic phenylalanine, 40 percent synthetic aspartic acid and 10 percent methanol, was ...
  https://ariannelot.wordpress.com/2013/10/22/aspartame-rumsfelds-bioweapon-legacy-2/