Loading...
*  Items by Bull, Steven - Opus
Asymmetric synthesis of substituted 1-aminocyclopropane-1-carboxylic acids via diketopiperazine methodology. Organic and ... Pyrene-anchored boronic acid receptors on carbon nanoparticle supports:Fluxionality and pore effects. New Journal of Chemistry ... Lewis acid activation of pyridines for nucleophilic aromatic substitution and conjugate addition. ChemSusChem. , 8 (6), pp. ... Diols and anions can control the formation of an exciplex between a pyridinium boronic acid with an aryl group connected via a ...
  http://opus.bath.ac.uk/view/person_id/981.default.html
*  Francesca Paradisi - The University of Nottingham
... she completed her PhD at the same institution with a thesis on the synthesis of non-natural amino acids via diketopiperazine ... Stabilization of Angiotensin-(1-7) by key substitution with a cyclic non-natural amino acid Amino Acids. 49, 1733-1742 ... Stabilization of Angiotensin-(1-7) by key substitution with a cyclic non-natural amino acid Amino Acids. 49, 1733-1742 ... Biological Screening of Angiotensin-(1-7) Analogues incorporating the Non-natural delta-Amino Acid ACCA AMINO ACIDS. 48(2), 636 ...
  https://www.nottingham.ac.uk/chemistry/people/francesca.paradisi
*  Pleurobranchus areolatus - Wikipedia
Rodriguesic acids and its esters (they are modified diketopiperazines) were isolated from P. areolatus in 2014. These are the ... "Rodriguesic acids, modified diketopiperazines from the gastropod mollusc Pleurobranchus areolatus". Journal of the Brazilian ... Similar diketopiperazines were isolated also from ascidians Didemnum sp. These derivatives may either result from a P. ... first diketopiperazine derivatives isolated from a mollusc. ...
  https://en.wikipedia.org/wiki/Pleurobranchus_areolatus
*  DailyMed - ALTACE- ramipril capsule
... and to the diketopiperazine ester, the diketopiperazine acid, and the glucuronides of ramipril and ramiprilat, all of which are ... Ramipril is a 2-aza-bicyclo [3.3.0]-octane-3-carboxylic acid derivative. It is a white, crystalline substance soluble in polar ... Elevations of liver enzymes, serum bilirubin, uric acid, and blood glucose have been reported, as have cases of hyponatremia ...
  https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0fc34cd8-86e6-4034-73bd-4263a68ba046
*  Altace Tablets - FDA prescribing information, side effects and uses
... and to the diketopiperazine ester, the diketopiperazine acid, and the glucuronides of ramipril and ramiprilat, all of which are ... Ramipril is a 2-aza-bicyclo [3.3.0]-octane-3-carboxylic acid derivative. It is a white, crystalline substance soluble in polar ... Elevations of liver enzymes, serum bilirubin uric acid, and blood glucose have been reported, as have cases of hyponatremia and ...
  https://www.drugs.com/pro/altace-tablets.html
*  Patents filed at Aug 16 2016 | Iridium-based complexes for ECL | Patents.com
The disclosed embodiments detail improved methods for the synthesis of diketopiperazines from amino acids. In particular ... Hydropyrrolopyrrole derivatives for use as fatty acid synthase inhibitors. Compounds of the formula I in which R.sup.1, R.sup.2 ... The invention describes novel mono or dihydroxy docosahexaenoic acid (DHA) analogs, their preparation, isolation, ... Formation of N-protected bis-3,6-(4-aminoalkyl)-2,5,diketopiperazine. ...
  http://patents.com/isd-20160816-p92.html
*  Lipid Metabolism sub-cluster 70
Synthesis of hexa- and pentasubstituted diketopiperazines from sterically hindered amino acids. Brown Zachary Z - - 2010 ... Biotransformation of cinnamic acid, p-coumaric acid, caffeic acid, and ferulic acid by ... ... Biotransformations of phenylpropanoids such as cinnamic acid, p-coumaric acid, caffeic acid, and ferulic acid were investigated ... The plant-cultured cells of E. perriniana converted cinnamic acid into cinnamic acid β-D-glucopyranosyl ester, p-coumaric acid ...
  http://www.biomedsearch.com/cluster/14/Lipid-Metabolism/sub-70-p3.html
*  The Truth About Aspartame Toxicity & Nancy Markle
... aspartic acid, phenylalanine, aspartylphenylalanine diketopiperazine (DKP), beta-aspartame, and a few odds and ends.. The ... formic acid researcher.. *Aspartic acid.. It is well-known that excitotoxic amino acids such as aspartic acid can be used in ... 6) "People ingesting aspartame do not have increases in formic acid levels". A. Formaldehyde breaks down into formic acid (aka ... The aspartic acid is in "free-form" (unbound to protein), so unike food, it is absorbed suddently, bypassing the normal ...
  http://www.holisticmed.com/aspartame/markle.html
*  SGD Group - Publications - Steve Davies Group
375). Asymmetric synthesis of substituted 1-aminocyclopropane-1-carboxylic acids via diketopiperazine methodology. Buñuel, E.; ... and trans-stereoisomers of 4-aminopyrrolidine-3-carboxylic acid and 4-aminotetrahydrofuran-3-carboxylic acid. Bunnage, M. E.; ... 368). Asymmetric synthesis of anti-(2S,3S)- and syn-(2R,3S)-diaminobutanoic acid. Bunnage, M. E.; Burke, A. J.; Davies, S. G.; ... 395). 2-Halo-diketopiperazines as chiral glycine cation equivalents. Bull, S. D.; Davies, S. G.; Garner, A. C.; Savory, E. D.; ...
  http://sdavies.chem.ox.ac.uk/2000-2004.aspx
*  Useful Chemistry: 2005-11
Solid phase synthesis of a diketopiperazine catalyst containing the unnatural amino acid (S)-norarginine Jennifer Kowalski and ... It looks like the compounds in this lot of potential anti-malarials are part of a library of 2,5-diketopiperazines. A search on ... Nucleic Acids Research, 2004, (19), 32. Raymond M. Schiffelers1, Aslam Ansari1, Jun Xu1, Qin Zhou, Qingquan Tang, Gert Storm, ... All compounds are commercially available from Sigma-Aldrich but the tBOC amino acid derivatives were not in Chmoogle. Also the ...
  http://usefulchem.blogspot.com/2005/11/
*  Patent US6071497 - Microparticles for lung delivery comprising diketopiperazine - Google Patents
... polymers of mixed amino acids (proteinoids), alginate, and poly(hydroxy acids). In another embodiment, the microparticles have ... In a preferred embodiment, the drug delivery system is based on the formation of diketopiperazine microparticles which are ... U is an acid group, such as a carboxylic acid, phosphoric acid, phosphonic acid and sulfonic acid, or a basic group, such as ... Representative synthetic materials are: diketopiperazines, poly(hydroxy acids) such as poly(lactic acid), poly(glycolic acid) ...
  http://www.google.com/patents/US6071497?dq=4,923,986
*  LSHTM Research Online
6-diketopiperazine-1-acetohydroxamic acid analogues as trypanocidal and leishmanicidal agents: an extended SAR study. Chemical ... Nucleic acids research. ISSN 0305-1048 DOI: https://doi.org/10.1093/nar/gkx1012 ...
  http://researchonline.lshtm.ac.uk/view/divisions/ITPM/2017.html
*  Formation of N-Protected bis-3,6-(4-aminoalkyl)-2,5,diketopiperazine - Patent application
... phosphoric acid, p-toluenesulfonic acid, 1-propylphosphonic acid cyclic anhydride, tributyl phosphate, phenyl phosphonic acid ... sulfuric acid, phosphoric acid, p-toluenesulfonic acid, 1-propylphosphonic acid cyclic anhydride, tributyl phosphate, phenyl ... group comprising sulfuric acid, phosphoric acid, p-toluenesulfonic acid, 1-propylphosphonic acid cyclic anhydride, tributyl ... wherein the amino acid is ε-trifluoroacetyl-L-lysine, wherein the amino acid is ε-Cbz-L-lysine, wherein the amino acid is γ- ...
  http://www.patentsencyclopedia.com/app/20130012710
*  Paradisi Research - Biocatalysis and Enzyme Engineering
2002 I completed my PhD at the same institution with a thesis on the synthesis of non-natural amino acids via diketopiperazine ... Amino Acids (2017): Stabilization of Angiotensin-(1-7) by key substitution with a cyclic non-natural amino acid. ... ... In 2013 we published the synthesis of the non-natural δ-amino acid ACCA (cis-3-(aminomethyl)cyclobutanecarboxylic acid) ( ... Albrecht in Switzerland we have started looking at the amino acid residues that hold in place a catalytic metal in the active ...
  https://www.paradisiresearch.com/
*  Marine Drugs | Free Full-Text | Bis-Indolyl Benzenoids, Hydroxypyrrolidine Derivatives and Other Constituents from Cultures of...
... benzoic acid (7), from the cultures of the marine sponge-associated fungus Aspergillus candidus KUFA 0062. Compounds 1a, 2a-e, ... chrysophanic acid (1a), emodin (1b), six bis-indolyl benzenoids including asterriquinol D dimethyl ether (2a), petromurin C (2b ... the anthraquinones chrysophanic acid and emodin, a diketopiperazine derivative, and bis-indolyl derivatives that are the ... The structures of palmitic acid, clionasterol [22], ergosterol 5,8-endoperoxides [14], chrysophanic acid (1a) [13], emodin (1b ...
  http://www.mdpi.com/1660-3397/16/4/119/htm
*  Separation of Cyclic Dipeptides (Diketopiperazines) from Their Corresponding Linear Dipeptides by RP-HPLC and Method Validation
Diketopiperazines (DKPs) are the smallest possible cyclic peptides composed of two -amino acids. They are abundant natural ... for DKPs, dipeptides, and amino acids and separation factor (. ) and resolution (. ) of two adjacent peaks at chosen separation ... A. Lin, Y. Fang, T. Zhu, Q. Gu, and W. Zhu, "A new diketopiperazine alkaloid isolated from an algicolous Aspergillus flavus ... For all DKPs, dipeptides, and amino acids, linear ranges with correlation coefficients greater than 0.998 were determined. ...
  https://www.hindawi.com/journals/cri/2013/310269/
*  Function of aspartic acid residues in optimum pH control of l-arabinose isomerase from Lactobacillus fermentum - Semantic...
In this study, we report the single- and multiple-site mutagenesis on LFAI targeting three aspartic acid residues (D268, D269, ... the three aspartic acid residues were found to be distant from the active site and possibly did not participate in substrate ... The Contributions of Various Pathways to Diketopiperazine Formation from Peptides Containing Aspartic Acid Residues in the ... General Acid-Base Chemistry in Triosephosphate Isomerase General Acid-Base Chemistry in Triosephosphate Isomerase Enzyme ...
  https://www.semanticscholar.org/paper/Function-of-aspartic-acid-residues-in-optimum-pH-of-Xu-Li/3566cdbb0b23849a6d38d8be2e6dafd5286ddaf9
*  Aspartame | European Food Safety Authority
6-dioxo-2-piperazine acetic acid (also known as 'Di-ketopiperazine' or DKP). Conversion of aspartame to DKP results in the loss ... Aspartic acid is an amino acid found in proteins. The body may convert aspartic acid into the neurotransmitter glutamate which ... Is Di-ketopiperazine (DKP) from aspartame a safety concern?. Moisture, pH, temperature and storage time can all affect the ... Phenylalanine is a so-called essential amino acid as it cannot be produced by the body and must be supplied through the diet.. ...
  https://www.efsa.europa.eu/en/topics/topic/aspartame
*  Impurity Reference Standards | EP Impurities
4S)-2-[5-(4-Hydroxyphenyl)-3,6-dioxopiperazin-2-yl]-5,5-dimethylthiazolidine-4-carboxylic Acid (Amoxicillin Diketopiperazines) ... Para-Hydroxybenzoic acid OR 4-Hydroxybenzoic Acid. Catalogue No : VL530001. *Note: COA Will be Provided on Request. Email: ... Acetylsalicylsalicylic Acid OR (2-[2-acetylhydroxybenzoyl] oxy] benzoic Acid). Catalogue No : VL530003. *Note: COA Will be ... 2-[2-(4-Chlorophenyl)acetyl]benzoic Acid; 2-[(4-Chlorophenyl)acetyl]benzoic Acid. Catalogue No : VL1100003. *Note: COA Will be ...
  https://www.veeprholabs.com/product_view.php?char=A
*  isoHunt] (Aspartame) Sweet Misery A Poisoned World [2004] Torrent Downloads - download free torrents!
... formic acid and aspartylphenylalanine diketopiperazine (DKP). Manufacturers argue that the instability of aspartame is ... ASPARTIC ACID Aspartic acid (also known as aspartate) is a non-essential amino acid that comprises 40 per cent of aspartame. In ... Formic acid can lead to accumulation of excessive acid in the body fluids - a condition known as acidosis. The small amounts of ... FORMIC ACID Formic acid is a cumulative poison produced by the breakdown of formaldehyde. It concentrates in the brain, kidneys ...
  https://www.torrentdownloads.me/torrent/1203773/%5Bisohunt%5D+%28aspartame%29+sweet+misery+a+poisoned+world+%5B2004%5D
*  AFH LIBRARY - Is the FDA Really Protecting Us? Nope...
... formic acid (ant venom), and diketopiperazine (a known carcinogenic that causes brain tumors in animals). ... Jonathan Wright in search of 'illegal' drugs such as Vitamin C, B12, and folic acid. What made the incident so remarkable was ... The FDA didn't just remove the contaminated batches of the amino acid. They forced the recall and destruction of all L- ... "It appears the problem is not with the amino acid itself, but rather with the product becoming contaminated as a result of a ...
  http://www.alkalizeforhealth.net/Library/fda.htm
*  Community Supported Agriculture
EDTA breaks down in the environment into ethylenediamine triacetic acid and then diketopiperazine. Diketopiperazine is a ... Finally, we have Sorbic Acid, Potassium Sorbate, and Potassium Sodium EDTA, 'as preservatives.' Sorbic acid occur naturally in ... On to Phosphoric Acid; got a bottle of that on your pantry shelf? It's in this dressing to make stuff taste tangy, which real ... By the way, there are plenty of other acids to use for house made dressings. Citrus is a great alternative, so try lemon, Meyer ...
  http://www.urbanmonique.net/category/community-supported-agriculture/
*  UNF - Marketing and Publications - July 2017
"Biosynthesis of new diketopiperazine natural products from unnatural amino acids," "Diversity of selected natural product ...
  http://www.unf.edu/publicrelations/marketing_publications/inside/2017/July_2017.aspx
*  Surveying the sequence diversity of model prebiotic peptides by mass spectrometry | PNAS
... potentially similar to diketopiperazine formation in amino-acid-only experiments. Because the diversity of depsipeptide ... glycolic acid (g), l-lactic acid (a), or l-malic acid (d). Each mixture contained one hydroxy acid and three amino acids (g+G+A ... as malic acid (d) is similar to aspartic acid (D) used to form Fox's proteinoids. The carboxylic acid moiety of the malic acid ... Hydroxy acids are abbreviated with lowercase letters corresponding to their analogous amino acids (e.g., glycolic acid = g; ...
  http://www.pnas.org/content/114/37/E7652
*  US5039481A - Aliphatic polycarboxylic acids as air purification compositions - Google Patents
... where livestock excrement or urine accumulates an ammonia scavenging composition that contains an aliphatic polycarboxylic acid ... Diketopiperazine-based delivery systems US5709861A (en) * 1993-04-22. 1998-01-20. Emisphere Technologies, Inc.. Compositions ... Citric Acid 10018 Oxalic Acid 50 Citric Acid 5019 Oxalic Acid 90 Boric Acid 1020 Oxalic Acid 45 Citric Acid 45 Boric Acid 1021 ... malonic acid, succinic acid, malic acid, citric acid, 1,2-cyclohexane dicarboxylic acid, 1,3-cyclohexane dicarboxylic acid, 1,4 ...
  https://patents.google.com/patent/US5039481A/en