*  Platelet-activating factor acetylhydrolase and transacetylase activities in human plasma low-density lipoprotein | Biochemical...
In this study, we demonstrate the presence of a transacetylase activity in human plasma low-density lipoprotein (LDL) that transfers short-chain fatty acids from platelet-activating factor (PAF) and its close ether- and ester-linked analogues to ether/ester-linked lysophospholipids (lyso-PL). We show evidence that both PAF acetylhydrolase (PAF-AH) and transacetylase activities are inhibited to the same extent by serine esterase inhibitors, are resistant to heat treatment, and exhibit identical distributions in lipoprotein classes and in LDL subfractions. Additionally, the competitive inhibition of PAF-AH by lyso-PL, and the evidence that the recombinant PAF-AH also showed a similar transacetylase activity, suggest that PAF-AH is responsible for both activities. Using PAF as a donor molecule and lyso-PAF (1-O-alkyl-sn-glycero-3-phosphocholine) as an acceptor, the transacetylase activity showed typical allosteric kinetics, due to the positive co-operativity of ...
*  Atomic resolution structure of human alpha-tubulin acetyltransferase bound to acetyl-CoA :: MPG.PuRe
Author: Taschner, Michael et al.; Genre: Journal Article; Published in Print: 2012-11-27; Keywords: HISTONE DEACETYLASE INHIBITORS; MICROTUBULES; SUPERFAMILY; MECHANISMS;|br/| P300/CBP; DOMAIN; SITEcilium; crystal structure; post-translational modification; ; Title: Atomic resolution structure of human alpha-tubulin acetyltransferase|br/| bound to acetyl-CoA
*  Partial purification and characterization of 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine:acetyl-CoA acetyltransferase from rat...
The enzyme 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine: acetyl-CoA acetyltransferase (EC was purified from rat spleen approx. 1500-fold in 1.6% yield. The specific activity of the purified enzyme was 0.317 +/- 0.089 mumol/min per mg of protein (mean +/- S.D., n = 6). The Km for the substrate acetyl-CoA was 137 +/- 13 microM and the pH optimum was about 8. Incubation of the purified enzyme was 1-O-[3H]octadecyl-2-lyso-sn-glycero-3-phosphocholine followed by electrophoresis resulted in the incorporation of radioactivity into a protein of Mr 29,000. The enzyme was most active towards 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine as substrate, 1-palmitoyl-2-lyso-glycero-3-phosphocholine being a poor substrate. In addition, the enzyme preferred acetyl-CoA to palmitoyl-CoA or oleoyl-CoA as substrate.. ...
*  Dde 3044 - GCN5-related N-acetyltransferase - Desulfovibrio alaskensis (strain G20) - Dde 3044 gene & protein
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
*  Choline o-acetyltransferase - definition of Choline o-acetyltransferase by The Free Dictionary
Define Choline o-acetyltransferase. Choline o-acetyltransferase synonyms, Choline o-acetyltransferase pronunciation, Choline o-acetyltransferase translation, English dictionary definition of Choline o-acetyltransferase. intr.v. chat·ted , chat·ting , chats 1. To converse in an easy, familiar manner; talk lightly and casually. 2. Computers To participate in a synchronous...
*  WikiGenes - ELOVL6 - ELOVL fatty acid elongase 6
The world's first wiki where authorship really matters. Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts.
*  OriGene - SAT1 (NM 002970) cDNA Clone
SAT1 - SAT1 (untagged)-Human spermidine/spermine N1-acetyltransferase 1 (SAT1), transcript variant 1 available for purchase from OriGene - Your Gene Company.
*  2b3v - TOPSAN
Structures of wild-type and mutant human spermidine/spermine N1-acetyltransferase, a potential therapeutic drug target. Proc.Natl.Acad.Sci.Usa 103 2063-2068 ...
*  SAGA/TFTC is a histone acetyltransferase organic which has a second enzymatic - Role of adrenergic receptors in human coronary...
SAGA/TFTC is a histone acetyltransferase organic which has a second enzymatic activity due to the current presence GSK126 of a deubiquitination component (DUBm). of multiprotein coactivator complexes are structured into sophisticated systems to provide accurate and precise functioning from the RNA polymerase II (RNAP II) equipment. Furthermore different transcription levels are intimately linked to each other also to mRNP development and nuclear export. SAGA is normally a big multifunctional multisubunit coactivator complicated that possesses histone acetyltransferase and histone deubiquitination enzymatic actions and it is extremely conserved through the advancement of eukaryotes (1). The histone acetyltransferase module of SAGA consists of a Gcn5-catalytic subunit and works by checking the chromatin surroundings towards Rabbit polyclonal to AGAP. the binding of GSK126 extra transcription elements which leads to PIC formation (2-4). The deubiquitination module (DUBm) of candida SAGA comprises ...
*  Epigenetics - Wikipedia
Mechanisms of heritability of histone state are not well understood; however, much is known about the mechanism of heritability of DNA methylation state during cell division and differentiation. Heritability of methylation state depends on certain enzymes (such as DNMT1) that have a higher affinity for 5-methylcytosine than for cytosine. If this enzyme reaches a "hemimethylated" portion of DNA (where 5-methylcytosine is in only one of the two DNA strands) the enzyme will methylate the other half.. Although histone modifications occur throughout the entire sequence, the unstructured N-termini of histones (called histone tails) are particularly highly modified. These modifications include acetylation, methylation, ubiquitylation, phosphorylation, sumoylation, ribosylation and citrullination. Acetylation is the most highly studied of these modifications. For example, acetylation of the K14 and K9 lysines of the tail of histone H3 by histone acetyltransferase enzymes (HATs) is generally related ...
*  Spermidine/spermine N(1)-acetyltransferase-like protein 1 (Q86VE3) | InterPro | EMBL-EBI
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
*  VackvSuG: KAT2B K(lysine) acetyltransferase 2B, associated with reverse autoacetylation (deacetylation)
KAT2B K(lysine) acetyltransferase 2B, CBP-associated protein PCAF interact with each other, bind to many sequence-specific factors through a TBP-free TAF-containing-TATA-less promoters complex (called TFTC) and GCN5: [§§] locus: 3p24. In contrast to yeast Gcn5, numerous genes require the histone acetyltransferase (HAT) activities of CBP-associated protein PCAF and the MYST (histone acetyltransferase 1) family members, due to the absence of a Gcn5 homologue (a novel cofactor, ACTR) also demonstrated HAT activity paralogs play roles in the remodeling of chromatin and maintain mitotic H('histones')-K(lysine) chromatin assembly through cell division permits circadian gene expression. MDM2 regulates the stability of PCAF. Poly-ADP-ribose polymerase-2 (PARP-2) is a substrate for the histone, acetyltransferases PCAF and GCN5L, appeared to be the co-repressor protein CtBP an antagonist of the epithelial phenotype and anoikis. p300 HAT was approximately 1000-fold more efficient than ...
*  Histone Methylases, Acetyltransferases and Associated Proteins Research Areas: R&D Systems
Find Histone Methylases, Acetyltransferases and Associated Proteins research area related information and Histone Methylases, Acetyltransferases and Associated Proteins research products from R&D Systems. Learn more.
*  "Role for ADA/GCN5 products in antagonizing chromatin-mediated transcri" by Kerri Jeanne Pollard and Craig L. Peterson
The Saccharomyces cerevisiae SWI/SNF complex is a 2-MDa multimeric assembly that facilitates transcriptional enhancement by antagonizing chromatin-mediated transcriptional repression. We show here that mutations in ADA2, ADA3, and GCN5, which are believed to encode subunits of a nuclear histone acetyltransferase complex, cause phenotypes strikingly similar to that of swi/snf mutants. ADA2, ADA3, and GCN5 are required for full expression of all SWI/SNF-dependent genes tested, including HO, SUC2, INO1, and Ty elements. Furthermore, mutations in the SIN1 gene, which encodes a nonhistone chromatin component, or mutations in histone H3 or H4 partially alleviate the transcriptional defects caused by ada/gcn5 or swi/snf mutations. We also find that ada2 swi1, ada3 swi1, and gcn5 swi1 double mutants are inviable and that mutations in SIN1 allow viability of these double mutants. We have partially purified three chromatographically distinct GCN5-dependent acetyltransferase activities, and we show that these
*  HTATIP - Wikipedia
La histona acetiltransferasa KAT5 (HTATIP) es una enzima codificada en humanos por el gen kat5.[1]​[2]​ La proteína HTATIP pertenece a la familia MYST de histona acetiltransferasas (HATs) y fue originalmente aislada como una proteína de interacción con TAT de VIH-1. Las HATs juegan un importante papel en la regulación de la remodelación de la cromatina, de la transcripción y de otros procesos nucleares por acetilación de proteínas histonas y no histonas. Esta proteína es una histona actiltransferasa que actúa en la reparación del ADN y en procesos de apoptosis, y se piensa que juega un importante papel en la transducción de señales. Se han descrito numerosas variantes transcripcionales del gen que codifica esta enzima.[2]​ La proteína HTATIP ha demostrado ser capaz de interaccionar con: HDAC7A[3]​ FANCD2[4]​ CREB1[5]​ ETV6[6]​ Mdm2[7]​ Myc[8]​ BCL3[9]​ Receptor androgénico[10]​ Receptor de endotelina tipo A[11]​ PLA2G4A[12]​ Kamine J, Elangovan B, ...
*  Structure and Function of Protein Acetyltransferases - Ronen Marmorstein
The overall goal of this project is to elucidate the molecular basis for how protein acetyltransferases (PATs) recognize and acetylate their cognate protein sub...
*  Plus it
The histone acetyltransferases (HAT) CBP and p300 are important coactivators favoring transcription. Their involvement in various pathologic processes has been extensively studied in the past (1). In fact, CBP and p300 are known as functional paralogues and their HAT domains show sequence identity of more than 90% (2). Both proteins are fundamental coactivators of a large number of transcription factors by remodeling chromatin. Moreover, p300 and CBP can bind not only to target proteins and regulate DNA binding affinity, transcriptional activation, protein-protein interactions, and stability of transcription factors but also to other cellular proteins by acetylation (3). For that reason, HATs are also named lysine acetyltransferases (KAT; ref. 4).. In cancer, the role of p300 and CBP is not clear and may depend on the physiologic background of the tumor. The fact that p300 is targeted by viral oncoproteins and is often found mutated or in a truncated form in breast, ...
*  anti-Elovl6 antibody | GeneTex
Elovl6 antibody (ELOVL fatty acid elongase 6) for ELISA, IHC, WB. Anti-Elovl6 pAb (GTX48702) is tested in Human, Mouse, Rat, Bovine samples. 100% Ab-Assurance.
*  Jawaharlal Nehru Centre for Advanced Scientific Research
S. Chatterjee, P. Mizar, R. Cassel, R. Neidl, B. R. Selvi, D.V Mohankrishna, B. Vedamurthy, A. Schneider, O. Bousiges, C. Mathis, J.C. Cassel, M. Eswaramoorthy, T. K. Kundu and A. L. Boutillier, A novel activator of CBP/p300 acetyltransferases promotes neurogenesis and extends memory duration in adult mice, J. Neuro Science 33, 10698 - 10712 (2013 ...
*  SAOUHSC 00324 - AureoWiki
Cellular processesCellular processesToxin production and resistanceaminoglycoside N(6')-acetyltransferase, AacA4 family (TIGR04431; EC; HMM-score: 21) ...
*  SACOL RS02630 - AureoWiki
Genetic information processingProtein synthesisRibosomal proteins: synthesis and modificationribosomal-protein-alanine acetyltransferase (TIGR01575; EC; HMM-score: 18.8) ...
*  NWMN 1957 - AureoWiki
Genetic information processingProtein synthesisRibosomal proteins: synthesis and modificationribosomal-protein-alanine acetyltransferase (TIGR01575; EC; HMM-score: 117.7) ...
*  SA2076 - AureoWiki
Genetic information processingProtein synthesisRibosomal proteins: synthesis and modificationribosomal-protein-alanine acetyltransferase (TIGR01575; EC; HMM-score: 16.2) ...
*  SAUSA300 2003 - AureoWiki
Staphylococcus aureus; strain: USA300_FPR3757; locus tag: SAUSA300_2003 (SAUSA300_RS11015); symbol: rimI; product: ribosomal-protein-alanine acetyltransferase
*  hat - Everything2.com
In busking, the amount of money that you collect at the end of the show. Your hat is usually a reflection of the quality of your show. The worst hats ar...