PALMITIC ACID, [1-14C]-, 50 µCi | PerkinElmer
50 µCi quantities of [1-14C]-Palmitic Acid are available for your research. Application of [14C]Palmitic Acid can be found in: myristic acid (unlike palmitic acid) rapidly metabolizing in cultured rat hepatocytes, palmitic acid following a different metabolic pathway than oleic acid in human skeletal muscle cells, metabolic fate of long-chain unsaturated fatty acids and their effects on palmitic acid metabolism and gluconeogenesis, phenotype of palmitic acid transport and of signalling in alveolar type II cells from E/H-FABP double-knockout mice, fatty acid-binding site environments of serum vitamin D-binding protein vs. albumin, etc. ...http://www.perkinelmer.com/product/palmitic-acid-1-14c-nec075h050uc
RNA-sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate |...
Pancreatic β-cell dysfunction and death are central in the pathogenesis of type 2 diabetes. Saturated fatty acids cause β-cell failure and contribute to diabetes development in genetically predisposed individuals.. Here we used RNA-sequencing to map transcripts expressed in five palmitate-treated human islet preparations, observing 1,325 modified genes. Palmitate induced fatty acid metabolism and endoplasmic reticulum (ER) stress. Functional studies identified novel mediators of adaptive ER stress signaling. Palmitate modified genes regulating ubiquitin and proteasome function, autophagy and apoptosis. Inhibition of autophagic flux and lysosome function contributed to lipotoxicity. Palmitate inhibited transcription factors controlling β-cell phenotype including PAX4 and GATA6. 59 type 2 diabetes candidate genes were expressed in human islets, and 11 were modified by palmitate. Palmitate modified expression of 17 splicing factors and shifted alternative splicing of 3,525 ...http://diabetes.diabetesjournals.org/content/early/2013/12/18/db13-1383?with-ds=yes
RNA Sequencing Identifies Dysregulation of the Human Pancreatic Islet Transcriptome by the Saturated Fatty Acid Palmitate |...
RNA-seq is a highly reproducible method to interrogate the whole transcriptome and identify novel cellular responses to environmental cues (25). Different from microarrays, it allows detection of high- and low-abundance genes, alternative splice variants, and novel transcripts, identifying 25-75% more genes than conventional arrays and more differentially expressed transcripts (25,66-68). We used it here to map the global response of human islets facing metabolic stress induced by palmitate. The presently used in vitro model of lipotoxicity induces cellular responses in the islets over a 48-h period, compared with slower and more heterogeneous events in vivo. The effects in vivo may also be attenuated by the presence of unsaturated FFAs that decrease the lipotoxicity of saturated FFAs (8). The picture emerging from the analysis of palmitate-treated human islets indicates a complex adaptive response, including upregulation of lipid metabolism and disposal, paralleled by inhibition of the Krebs ...http://diabetes.diabetesjournals.org/content/63/6/1978.full
IJMS | Free Full-Text | Eicosapentaenoic Acid Protects against Palmitic Acid-Induced Endothelial Dysfunction via Activation ...
Recent studies have shown that free fatty acids are associated with chronic inflammation, which may be involved in vascular injury. The intake of eicosapentaenoic acid (EPA) can decrease cardiovascular disease risks, but the protective mechanisms of EPA on endothelial cells remain unclear. In this study, primary human umbilical vein endothelial cells (HUVECs) treated with palmitic acid (PA) were used to explore the protective effects of EPA. The results revealed that EPA attenuated PA-induced cell death and activation of apoptosis-related proteins, such as caspase-3, p53 and Bax. Additionally, EPA reduced the PA-induced increase in the generation of reactive oxygen species, the activation of NADPH oxidase, and the upregulation of inducible nitric oxide synthase (iNOS). EPA also restored the PA-mediated reduction of endothelial nitric oxide synthase (eNOS) and AMP-activated protein kinase (AMPK) phosphorylation. Using AMPK siRNA and the ...http://mdpi.com/1422-0067/15/6/10334
What does palmitic acids mean?
Definition of palmitic acids in the Definitions.net dictionary. Meaning of palmitic acids. What does palmitic acids mean? Information and translations of palmitic acids in the most comprehensive dictionary definitions resource on the web.http://www.definitions.net/definition/palmitic%20acids
β-cell Adaptation to Decreased Nr4a Expression in Conditions of Elevated Palmitate Concentrations (Hyperlipidemia)
Palmitate decreases insulin secretion. Cell lines of each level of palmitate concentration were exposed to both basal (2.5 mM) and high (16.7 mM) glucose concentrations, after which glucose stimulated insulin secretion was measured. Results of 125I-labelled insulin radioimmunoassay indicated that 0.15 mM and 0.5 mM palmitate culturing significantly decreased insulin secretion rates in response to high glucose levels, though no significant change was seen for the 0.3 mM level (Fig. 1).. Palmitate decreases β-cell proliferation and viability. Contrary to preliminary data, further cell counts showed that all three palmitate cell lines had decreased proliferation compared to controls (data not shown). Similarly, cell counts following treatment with the apoptosis-inducing drug, thapsigargin, showed clear decreases in β-cell viability for all palmitate cell lines compared to controls (Fig. 2).. Palmitate decreases expression of some glycolytic genes. To determine possible mechanisms of action for ...http://jur.byu.edu/?p=22450
Cardiac muscle cells generate ATP at a high rate to support the continuous contractile function of the beating heart. Cardiac cells use various substrates to generate ATP, and the extent of substrates utilized depends on the substrate availability, the energy demand, and the physiological or pathological condition (1). In humans as well as in different animal models, obesity, insulin resistance, and type 2 diabetes are associated with an altered cardiac metabolism characterized by an enhanced reliance on fatty acids and a decreased glucose utilization. These changes play a central role in the development of diabetic cardiomyopathy (2). For instance, application of the saturated fatty acid palmitate had markedly different effects on power output and oxygen consumption in hearts of control mice and ob/ob mice, which are obese, insulin resistant, and have increased serum free fatty acid concentrations (3). Moreover, ob/ob hearts displayed a decreased ...http://diabetes.diabetesjournals.org/content/56/4/1136
The Effects of Dietary Palmitic Acid Triacylglyceride Position on Intestinal Parameters in Infants (InFat 005) - Full Text View...
InFatTM is an advanced basic-fat ingredient, which mimics the fat composition and properties of human milk fat and enabling optimal intake of the essential calcium and energy (in the form of fatty acids) and easy digestion. These benefits are the result of a unique fatty acid composition on the glycerol backbone, which ensures high level of palmitic acid at the middle (sn-2) position.. The purpose of this study is to determine the effect of high sn-2 palmitic acid based infant formula on intestinal parameters, anthropometric parameters and stool characteristics in formula fed term infants. ...https://clinicaltrials.gov/ct2/show/NCT01116115
The Effects of Dietary Palmitic Acid Triacylglyceride Position on Bone Strength Parameters in Infants - Full Text View -...
InFatTM is an advanced basic-fat ingredient, which mimics the fat composition and properties of human milk fat and enabling optimal intake of the essential calcium and energy (in the form of fatty acids) and easy digestion. These benefits are the results of a unique fatty acid composition on the glycerol backbone, which ensure high level of palmitic acid at the middle (sn-2) position.. The purpose of this study is to determine the effect of high sn-2 palmitic acid based infant formula on bone strength parameters, anthropometric parameters, wellbeing and stool characteristics in term and preterm infants. ...https://clinicaltrials.gov/ct2/show/NCT00874068
Palmitoylation of V2R was investigated by immunoprecipitation of receptor proteins expressed transiently in COS.M6 cells and detection of incorporated [3H]palmitic acid. In cells expressing the wild-type glycosylated V2R, [3H]palmitic acid incorporation resulted in the appearance of a broad radioactive band at 45-55 kDa, which is the expected size for the mature receptor form. Deglycosylation with PNGase F produced a sharp band at 40 kDa. As seen in Fig. 2, this band was identical to the band obtained from cells expressing nonglycosylated receptor (17, 18). These results demonstrated that the V2R is palmitoylated and that protein glycosylation was not required to observe palmitoylation.. Analogous to other G protein-coupled receptors, the palmitoylation site was expected to be located 10-12 amino acids downstream of the seventh transmembrane region. Some receptors, such as the α2- and β2-adrenoceptors, contain only one ...http://molpharm.aspetjournals.org/content/52/1/21
Global Palmitic Acid Market : Business Rising Awareness 2017 to 2021 - EEE Journal
Summary of the Palmitic Acid Market. The report on Palmitic Acid Market offers a complete analysis of the market. This was achieved with the help of the chronological data that was collected, the exhaustive qualitative insights, and the statistical data of the market. Thorough studies and researches were conducted and reliable methodologies were used to verify the data that was collected. Industrial experts were consulted and their opinions were taken into consideration while making studies of the market.. Primary researches were made which include surveys, opinions of seasoned analysts, and interviews. For collecting and verifying the data, the use of secondary researches was also made which includes reputable paid sources, industry body databases, entails, and trade journals. Both qualitative and quantitative assessments were made across different industrial aspects and market verticals.. Analysis of different trends that is prevailing in ...http://eeejournal.com/2017/08/01/global-palmitic-acid-market-business-rising-awareness-2017-to-2021/
Palmitic Acid - Manufacturer - Palmitic Acid - Manufacturer Exporter, Manufacturer, Supplier, Trading Company, Mumbai, India
ACME SYNTHETIC CHEMICALS - Exporter, Manufacturer, Supplier, Trading Company of Palmitic Acid - Manufacturer based in Mumbai, Indiahttp://www.acmesynthetic.com/palmitic-acid-manufacturer-1791544.html
Frontiers | Palmitic Acid: Physiological Role, Metabolism and Nutritional Implications | Physiology
Palmitic acid (PA) has been for long time negatively depicted for its putative detrimental health effects, shadowing its multiple crucial physiological activities. PA is the most common saturated fatty acid accounting for 20-30% of total fatty acids in the human body and can be provided in the diet or synthesized endogenously via de novo lipogenesis (DNL). PA tissue content seems to be controlled around a well-defined concentration, and changes in its intake do not influence significantly its tissue concentration because the exogenous source is counterbalanced by PA endogenous biosynthesis. Particular physiopathological conditions and nutritional factors may strongly induce DNL, resulting in increased tissue content of PA and disrupted homeostatic control of its tissue concentration. The tight homeostatic control of PA tissue concentration is likely related to its fundamental physiological role to guarantee membrane physical properties but ...https://www.frontiersin.org/articles/10.3389/fphys.2017.00902/full
Hyperlipid: Want some acid? Bad trip on palmitic...
Anyhoo. Half a pound of doner meat down and you are now just ravenous. You fight the hunger off for another 10 minutes, but you know you are on to a looser. You blow another £3.20 on a second portion. Sitting in Mothercare's car park, finishing your second kebab, you promise yourself that now you will just drive home and stop eating, and you actually turn on the ignition before the palmitic acid driven hunger breaks your will like a matchstick and you go back for a third portion. This time you don't leave the shop and wolf down your fourth portion, an extra large one, which gets you up to well over the two pounds of meat mark, and you need more. After that it's a race within the family to spent the week's food budget on Friday night doner kebabs. With five or six pounds of meat eaten you hopefully run out of money and the palmitic acid pusher mercilessly and mercifully kicks you out on the street, half a sheep in your stomach and ravenous ...http://high-fat-nutrition.blogspot.com/2009/09/want-some-acid-bad-trip-on-palmitic.html
Definition of palmitic acid in US English - a solid saturated fatty acid obtained from palm oil and other vegetable and animal fats.https://en.oxforddictionaries.com/definition/us/palmitic_acid
palmitic acid/trilysine vesicle
Page contains details about palmitic acid/trilysine vesicle . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.comhttp://nano.nature.com/nano/GR-M7430218
PALMITIC ACID, ETHYL ESTER (PALMITATE-U-13C16, 98%+) 95%+ PURE - Creative Proteomics
Creative-Proteomics offer cas 628-97-7 PALMITIC ACID, ETHYL ESTER (PALMITATE-U-13C16, 98%+) 95%+ PURE. We are specialized in manufacturing Stabel Isotope Labeled Analytical Standard products.https://www.creative-proteomics.com/product/detail-cpil104303_29540.htm
What does palmitic mean?
Definition of palmitic in the Definitions.net dictionary. Meaning of palmitic. What does palmitic mean? Information and translations of palmitic in the most comprehensive dictionary definitions resource on the web.http://www.definitions.net/definition/palmitic
Supplement Guide: Tetradecylthioacetic Acid | Men's Fitness
Where it comes from: Tetradecylthioacetic Acid (also known-and more easily pronounced-as TTA) is a fatty acid that does not get used for fuel by the body, but instead helps to regulate how much fat the body stores by influencing genes that control the metabolism. It's delivered to the body in supplement form.http://www.mensfitness.com/nutrition/supplements/supplement-guide-tetradecylthioacetic-acid
Hyperlipid: Palmitic acid and hyperglycaemia in diabetic heart failure (1)
I am Petro Dobromylskyj, always known as Peter. I'm a vet, trained at the RVC, London University. I was fortunate enough to intercalate a BSc degree in physiology in to my veterinary degree. I was even more fortunate to study under Patrick Wall at UCH, who set me on course to become a veterinary anaesthetist, mostly working on acute pain control. That led to the Certificate then Diploma in Veterinary Anaesthesia and enough publications to allow me to enter the European College of Veterinary Anaesthesia and Analgesia as a de facto founding member. Anaesthesia teaches you a lot. Basic science is combined with the occasional need to act rapidly. Wrong decisions can reward you with catastrophe in seconds. Thinking is mandatory. I stumbled on to nutrition completely by accident. Once you have been taught to think, it's hard to stop. I think about lots of things. These are some of them ...https://high-fat-nutrition.blogspot.com/2015/01/palmitic-acid-and-hyperglycaemia-in.html
Browse Products Containing: PALMITIC ACID || Skin Deep® Cosmetics Database | EWG
Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWG's strict health criteria. Before a company can use EWG VERIFIEDTM on such products, the company must show that it fully discloses the products' ingredients on their labels or packaging, they do not contain EWG ingredients of concern, and are made with good manufacturing practices, among other criteria. Note that EWG receives licensing fees from all EWG VERIFIED member companies that help to support the important work we do. Learn more , Legal Disclaimer ...http://www.ewg.org/skindeep/browse.php?brand_id=4947&ingred06=704412&showmore=products&atatime=100
Sources of Palmitic Acid | LIVESTRONG.COM
Fats make up an important part of your diet. They serve as a potential source of energy and fuel for your cells, and some types play a role in the health...http://www.livestrong.com/article/474633-sources-of-palmitic-acid/
GMD - palmitic acid 13C 16
The Golm Metabolome Database (GMD) facilitates the search for and dissemination of mass spectra from biologically active metabolites quantified using GC-MS.http://gmd.mpimp-golm.mpg.de/ReferenceSubstances/DFD6DDD1-E2AC-4ABC-817E-35DD3CE9DD08.aspx
Palmitic acid, iso octyl ester
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...http://webbook.nist.gov/cgi/inchi/InChI%3D1S/C24H48O2/c1-4-5-6-7-8-9-10-11-12-13-14-15-18-21-24
Palmitic acid-induces production of reactive oxygen spe | Open-i
Palmitic acid-induces production of reactive oxygen species in RINm5F insulin-producing cells that overexpress catalase in the cytosol (Cat) or in the mitochondhttps://openi.nlm.nih.gov/detailedresult.php?img=PMC3012172_zdb0011164310004&req=4