*  Donna M. Bouley | Stanford Medicine Profiles
In the absence of Ubb, spermatocytes and oocytes arrest during meiotic prophase, before metaphase of the first meiotic division ... The mouse polyubiquitin gene Ubb is essential for meiotic progression MOLECULAR AND CELLULAR BIOLOGY Ryu, K., Sinnar, S. A., ... Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1 NATURE Broz, P., Ruby, T., Belhocine, K ... These results indicate that caspase-11-dependent cell death is detrimental to the host in the absence of caspase-1-mediated ...
  https://med.stanford.edu/profiles/donna-bouley
*  Germ-line tumor formation caused by activation of glp-1, a Caenorhabditis elegans member of the Notch family of receptors |...
In the absence of GLP-1, all proliferative germ cells exit the mitotic cell cycle and enter meiotic prophase. We have ... The mutant receptor is constitutively active, promoting proliferation in the absence of ligand. The normal distal-proximal ...
  http://dev.biologists.org/content/124/4/925
*  The APC/C activator FZR1 coordinates the timing of meiotic resumption during prophase I arrest in mammalian oocytes |...
B) The fully grown oocyte is normally prophase I/GV arrested; however, in the absence of FZR1, increased cyclin B1 levels ... 2005). Regulation of meiotic prophase arrest in mouse oocytes by GPR3, a constitutive activator of the Gs G protein. J. Cell ... The APC/C activator FZR1 coordinates the timing of meiotic resumption during prophase I arrest in mammalian oocytes ... The APC/C activator FZR1 coordinates the timing of meiotic resumption during prophase I arrest in mammalian oocytes ...
  http://dev.biologists.org/content/138/5/905.long
*  The Nucleoporin Nup2 Contains a Meiotic-Autonomous Region that Promotes the Dynamic Chromosome Events of Meiosis | Genetics
We next examined if meiotic prophase events preceding nuclear division are delayed in the absence of Nup2. First, we examined ... albeit with delay in nuclear division and progression through meiotic prophase. In the absence of both Ndj1 and Nup2, ... The events of meiotic prophase follow a specialized round of DNA replication when the meiotic chromosome axis is formed. The ... and acts as part of the meiotic checkpoint signaling apparatus (Kleckner et al. 2004). Over the course of meiotic prophase, the ...
  http://www.genetics.org/content/206/3/1319
*  Evidence for a dual role of actin in regulating chromosome organization and dynamics in yeast | Journal of Cell Science
During meiotic prophase, actin-dependent localization and dynamics of telomeres is impaired in the absence of either Csm4 (a ... 2009). Live imaging of rapid chromosome movements in meiotic prophase I in maize. Proc. Natl. Acad. Sci. USA 106, 20989-20994. ... During meiotic prophase, a dynamic reorganization of the chromosomes is ensured by the LINC complex (Horn et al., 2013; Rog and ... During yeast meiotic prophase, the actin cytoskeleton drives movements of the nuclear envelope LINC complex (Conrad et al., ...
  http://jcs.biologists.org/content/129/4/681
*  Membrane proteins Bqt3 and -4 anchor telomeres to the nuclear envelope to ensure chromosomal bouquet formation | JCB
6 E). During meiotic prophase, Rap1-GFP-Bqt4-dN partially restored meiotic telomere clustering in bqt4Δ cells. The frequency of ... which is mediated through its interaction with the Rap1 telomere protein in both vegetative and meiotic cells in the absence of ... A cytoplasmic dynein heavy chain is required for oscillatory nuclear movement of meiotic prophase and efficient meiotic ... Chromosome mobility during meiotic prophase in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA. 104:16934-16939. doi: ...
  http://jcb.rupress.org/content/187/3/413/
*  Trip13 - Pachytene checkpoint protein 2 homolog - Mus musculus (Mouse) - Trip13 gene & protein
Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of ... Recombination defects are evident very early in meiotic prophase, soon after DSB formation (PubMed:20711356). These results ... the numbers of crossovers and chiasmata are reduced in the absence of TRIP13, and their distribution along the chromosomes is ... reciprocal meiotic recombination Source: UniProtKB ,p>Inferred from Mutant Phenotype,/p> ,p>Describes annotations that are ...
  http://www.uniprot.org/uniprot/Q3UA06
*  Anne Villeneuve | Stanford Medicine Profiles
A specialized meiotic DSBR mode is engaged at the onset of meiotic prophase, coincident with assembly of meiotic chromosome ... Further, persistence of RAD-51 foci and absence of crossover products in meiotic mutants suggests that SC central region ... Finally, we have exploited S-phase labeling to monitor the timing of progression through meiotic prophase. Meiotic prophase for ... In addition to genes involved in key meiotic prophase events, we identified genes involved in meiotic progression, germline ...
  https://med.stanford.edu/profiles/anne-villeneuve
*  Analysis of tubulin and DNA staining pattern of KAR3 | Open-i
We demonstrate here that, in the absence of the molecular motor, Kar3p, meiotic cells are blocked with prophase monopolar ... We demonstrate here that, in the absence of the molecular motor, Kar3p, meiotic cells are blocked with prophase monopolar ... in the absence of the molecular motor, Kar3p, meiotic cells are blocked with prophase monopolar microtubule arrays and ... in the absence of the molecular motor, Kar3p, meiotic cells are blocked with prophase monopolar microtubule arrays and ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC2139793_JCB.14528f1&req=4
*  Mouse TRIP13/PCH2 Is Required for Recombination and Normal Higher-Order Chromosome Structure during Meiosis
Recombination defects are evident very early in meiotic prophase, soon after DSB formation. These findings provide evidence for ... Furthermore, the numbers of crossovers and chiasmata are reduced in the absence of TRIP13, and their distribution along the ... participates in coordinating these key aspects of meiotic chromosome behavior ...
  http://dare.uva.nl/search?metis.record.id=341053
*  Mechanics and regulation of chromosome dynamics in meiotic prophase - Michael Dresser
In the absence of these rapid prophase movements (RPMs), crossover numbers and positions are aberrant, crossing over between ... On entry into meiotic prophase in S. cerevisiae, telomeres connect across the nuclear envelope to elements of the actin ... Mechanics and regulation of chromosome dynamics in meiotic prophase Dresser, Michael Edward Oklahoma Medical Research ... Mechanics and regulation of chromosome dynamics in meiotic prophase. Dresser, Michael Edward / Oklahoma Medical Research ...
  http://grantome.com/grant/NIH/R01-GM087516-04
*  Philosophical Transactions of the Royal Society B: Biological Sciences
Release of the prophase I arrest in oocytes and progression into the meiotic divisions is termed oocyte maturation. During ... Knockdown of Xkid leads to misaligned chromosomes and to the absence of the polar body extrusion during the first meiotic ... 2005 Exploring meiotic division in Cargese. Meeting on meiotic divisions and checkpoints. EMBO Rep. 6, 821-825. doi:10.1038/sj. ... 2006 Bruno inhibits the expression of mitotic cyclins during the prophase I meiotic arrest of Drosophila oocytes. Dev. Cell 10 ...
  http://rstb.royalsocietypublishing.org/content/366/1584/3638.full
*  SirT1 is required in the male germ cell for differentiation and fecundity in mice | Development
To determine whether the absence of elongating spermatids in the KO animals at 5 weeks of age is due to a delay in pre-meiotic ... SYCP3 and γH2AX to stage the cells of meiotic prophase. We did not observe any differences in γH2AX localization in leptotene, ... Alternatively, the defect could be a result of SirT1 absence in meiotic cells, which persists to result in the incomplete ... 4B). If there is a defective histone to protamine transition in the absence of SirT1, then we would expect sperm from SirT1 KO ...
  http://dev.biologists.org/content/141/18/3495
*  Anatomy Atlases: Atlas of Microscopic Anatomy: Section 1 - Cells
Note their distinctive meiotic prophase nuclei. Division of primary spermatocytes (meiosis 1) gives rise to daughter cells, the ... This accounts for the absence of a luminal profile in this tubule and the predominance of round spermatids. Next Page , ... These, in turn, complete the second meiotic division, giving rise to haploid daughter cells, the round spermatids (upper right ...
  http://www.anatomyatlases.org/MicroscopicAnatomy/Section14/Plate14267.shtml
*  Etoposide damages female germ cells in the developing ovary | BMC Cancer | Full Text
Sycp3 immunohistochemistry: meiotic progression in mouse oocytes. Progression through meiotic prophase I was monitored by ... Oocytes from cultured fetal ovaries progress through prophase I of meiosis in the presence or absence of etoposide. Fetal ... Sycp3 is a component of the axial/lateral element of the synaptonemal complex (SC) that assembles during meiotic prophase I [35 ... A new culture technique that allows in vitro meiotic prophase development of fetal human oocytes. Hum Reprod. 2010;25(1):74-84. ...
  https://bmccancer.biomedcentral.com/articles/10.1186/s12885-016-2505-9
*  RARA Antibody (C-term) - Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab) WB, IF, IHC-P, FC, E - Buy Now! |Abgent
In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, ... In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors ... Transloaction to the nucleus in the absence of ligand is dependent on activation of PKC and the downstream MAPK phosphorylation ... Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. ...
  http://www.abgent.com/products/AP13849b-RARA-Antibody-C-term
*  AtCTF7 is required for establishment of sister chromatid cohesion and association of cohesin with chromatin during meiosis in...
... sister chromatid cohesion during meiosis in Arabidopsis and is required for association of cohesin with chromatin in prophase ... M-O, P-R) Early meiotic prophase, showing more than 10 centromeric signals. (S-U, V-X) Mid meiotic prophase stages, showing ... K) Mid-prophase showing unpaired, discontinuous chromatin and absence of synizetic knot. (L) Late prophase stage, showing ... The meiotic phenotypes comprised defects early in prophase which presented as discontinuities in the thread-like appearance ...
  https://bmcplantbiol.biomedcentral.com/articles/10.1186/1471-2229-13-117
*  Organelles associated with male sex hormones. Organelles associated with male sex hormones.
At the end of prophase, the meiotic cells proceed through two rapid and successive reductive divisions to yield haploid ... In contrast to androgens, spermatogenesis can proceed in the absence of FSH; however, testes are smaller and sperm output is ... At the end of prophase, the meiotic cells proceed through two rapid and successive reductive divisions to yield haploid ... In contrast to androgens, spermatogenesis can proceed in the absence of FSH; however, testes are smaller and sperm output is ...
  http://comgranada.org/organelles-associated-with-male-sex-hormones.php
*  Roles of the Drosophila NudE protein in kinetochore function and centrosome migration | Journal of Cell Science
2). During meiotic prophase, the protein is found at the nuclear envelope. Localization to kinetochores and (presumably) KMTs ... However, in the absence of NudE, the `shedding' of proteins off the kinetochore is abrogated and the SAC cannot be turned off, ... Cenp-meta targeting to the nuclear membrane does not require NudE either during meiotic prophase (data not shown) or during ... detached from the meiotic spindle; by contrast, cenp-meta (cmetΔ) mutant spermatocytes form meiotic spindles with centrosomes ...
  http://jcs.biologists.org/content/122/11/1747
*  TDRD5 is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis in mice | JCB
B) Nuclear-spread analysis of the meiotic prophase in Tdrd5+/+ (left) and Tdrd5−/− (right) testes. Meiotic spermatocytes were ... although its absence impacts the meiosis at a low frequency), but that it is indispensable for proper spermiogenesis, playing a ... At P20, many of the germ cells are still in the meiotic prophase, but some finish meiosis and a few round spermatids just begin ... In Tdrd1 or Tdrd9 mutants, the spermatogenesis is arrested at the meiotic prophase with accumulation of the LINE-1 mRNAs and ...
  http://jcb.rupress.org/content/192/5/781
*  Interactive Fly, Drosophila
The APC/C activator FZR1 is essential for meiotic prophase I in mice. Fizzy-related 1 (FZR1) is an activator of the Anaphase ... activity in the male germline led to both a mitotic and a meiotic testicular defect resulting in infertility due to the absence ... It is concluded that APC/C(FZR1) is an essential regulator of spermatogonial proliferation and early meiotic prophase I in both ... In the absence of APC, Cdc20 and Cdh1 bind substrates reflecting Cdc20-APC and Cdh1-APC specificity. The N termini of Cdc20 and ...
  http://www.sdbonline.org/sites/fly/newgene/fizyrel2.htm
*  Peter K. Jackson | Stanford Medicine Profiles
Mammalian oocytes are arrested in prophase of the first meiotic division. Progression into the first meiotic division is driven ... In the absence of CPLANE, defective IFT-A particles enter the axoneme and IFT-B trafficking is severely perturbed. Accordingly ... Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo DEVELOPMENTAL CELL Guardavaccaro, D., Kudo, ... Prophase I arrest and progression to metaphase I in mouse oocytes are controlled by Emi1-dependent regulation of APC(Cdh1) ...
  https://med.stanford.edu/profiles/peter-jackson
*  Roles for Caenorhabditis elegans rad-51 in Meiosis and in Resistance to Ionizing Radiation During Development | Genetics
mre-11 in C. elegans is therefore required for repair of radiation-induced DSBs during meiotic prophase (Chin and Villeneuve ... In the absence of MRE-11, as in the absence of SPO-11, RAD-51 depletion has no effect on the chromosomes, which appear intact, ... In the proximal part of the gonad, next to the spermatheca, oocyte nuclei are in late meiotic prophase (diakinesis). At this ... We have investigated the role of Caenorhabditis elegans RAD-51 during meiotic prophase and embryogenesis, making use of the ...
  http://www.genetics.org/content/160/2/471
*  Synapsis - Wikipedia
... meiotic chromosome synapsis occurs in the absence of recombination. Thus synapsis in Drosophila is independent of meiotic ... Revenkova E, Jessberger R (2006). "Shaping meiotic prophase chromosomes: cohesins and synaptonemal complex proteins" (PDF). ... McKim KS, Green-Marroquin BL, Sekelsky JJ, Chin G, Steinberg C, Khodosh R, Hawley RS (1998). "Meiotic synapsis in the absence ... Mitosis also has prophase, but does not ordinarily do pairing of two homologous chromosomes. When the non-sister chromatids ...
  https://en.wikipedia.org/wiki/Synapsis
*  Cyclin-dependent kinase directly regulates initiation of meiotic recombination
The events of meiotic prophase must thus occur in a strict temporal order, but the molecular controls coordinating these events ... It has proven more difficult to establish whether CDK also directly promotes meiotic recombination. In the absence of Clb5 and ... DSB formation is restricted to a narrow window of time around the beginning of meiotic prophase (Figure 6C) (Padmore et al., ... We propose that this function of Cdc28 helps to coordinate the events of meiotic prophase with each other and with progression ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC1950680/?lang=en-ca