Cidofovir Injection - FDA prescribing information, side effects and uses
Metabolic Acidosis: A diagnosis of Fanconi's syndrome, as manifested by multiple abnormalities of proximal renal tubular ... Table 4. Serious Clinical Adverse Events or Laboratory Abnormalities Occurring in , 5% of Patients. * Patients receiving 5 mg/ ... Probenecid is known to interact with the metabolism or renal tubular excretion of many drugs (see PRECAUTIONS). The safety of ... Probenecid is known to interact with the metabolism or renal tubular excretion of many drugs (e.g., acetaminophen, acyclovir, ...https://www.drugs.com/pro/cidofovir-injection.html
Vistide (Cidofovir): Side Effects, Interactions, Warning, Dosage & Uses
Metabolic Acidosis: A diagnosis of Fanconi's syndrome, as manifested by multiple abnormalities of proximal renal tubular ... Table 4. Serious Clinical Adverse Events or Laboratory Abnormalities Occurring in , 5% of Patients. N = 135*. # patients (%). ... Table 5. All Clinical Adverse Events, Laboratory Abnormalities or Intercurrent Illnesses Regardless of Severity Occurring in , ... Probenecid is known to interact with the metabolism or renal tubular excretion of many drugs (see PRECAUTIONS). The safety of ...https://www.rxlist.com/vistide-drug.htm
Enchondromatosis, Multiple, Ollier Type disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials
asymmetric tubular bone abnormality Misc:. most cases sporadic Clinical features from OMIM: 166000 ... MalaCards integrated aliases for Enchondromatosis, Multiple, Ollier Type:. Name: Enchondromatosis, Multiple, Ollier Type 54 25 ... UniProtKB/Swiss-Prot : 71 Enchondromatosis multiple: A condition characterized by multiple formation of enchondromas, benign ... Copy number variations for Enchondromatosis, Multiple, Ollier Type from CNVD:. 7 (show all 16) id. CNVD ID. Chromosom. Start. ...http://www.malacards.org/card/enchondromatosis_multiple_ollier_type
Bee Venom Uses, Benefits & Dosage - Drugs.com Herbal Database
... and acute tubular necrosis. Nonanaphylactic responses to multiple stings often will be apparent within the first several hours ... Renal insufficiency and electrolyte abnormalities such as hyperkalemia may occur secondary to rhabdomyolysis, hemolysis, ... Multiple sclerosis (MS). Uses for bee venom, although poorly substantiated, include the treatment of diseases of the locomotor ... Immediate effects after multiple stings include localized pain, swelling, and erythema at individual sting sites. Stings to the ...https://www.drugs.com/npp/bee-venom.html
Nephrotoxicity of HAART
Kidney abnormalities tend to develop in the setting of multiple treatments and cannot be always attributed to a specific drug. ... P. Labarga, P. Barreiro, L. Martin-Carbonero et al., "Kidney tubular abnormalities in the absence of impaired glomerular ... These injuries occur via multiple mechanisms, including direct tubular toxicity, allergic reactions, and precipitation of ... While NGAL indicates glomerular or proximal tubular dysfunction, RBP and NAG may reflect proximal renal tubular dysfunction [92 ...https://www.hindawi.com/journals/art/2011/562790/
Distal myopathy with tubular aggregates: a new phenotype associated with multiple deletions in mitochondrial DNA? | Journal of...
The pattern of abnormality on his muscle biopsy was also of interest: the density of TA seen was in keeping with a diagnosis of ... tubular aggregates. Multiple deletions of mitochondrial DNA (mtDNA) are recognised in association with a number of clinical ... Distal myopathy with tubular aggregates: a new phenotype associated with multiple deletions in mitochondrial DNA? ... Distal myopathy with tubular aggregates: a new phenotype associated with multiple deletions in mitochondrial DNA? ...http://jnnp.bmj.com/content/73/2/207
Study of the Pathophysiological Mechanisms Involved in Bleeding Events - Full Text View - ClinicalTrials.gov
Renal Tubular Transport, Inborn Errors. Kidney Diseases. Urologic Diseases. Abnormalities, Multiple. Congenital Abnormalities. ... Characterization of abnormalities in platelet-signalling pathways [ Time Frame: 18 months ]. Characterization of abnormalities ... The characterization of a platelet activation abnormality in Lowe patients could lead to major benefit for the patients with ... Patient with a clinical syndrome of Lowe (congenital cataracts, renal tubular dysfunction and neuromuscular damage) with a ...https://clinicaltrials.gov/ct2/show/NCT01314560?cond=%22Aniridia%22&rank=7
Genetic Analysis of Oculocerebrorenal Syndrome of Lowe - Full Text View - ClinicalTrials.gov
Renal Tubular Transport, Inborn Errors. Kidney Diseases. Urologic Diseases. Abnormalities, Multiple. Congenital Abnormalities. ... characterized by renal tubular dysfunction. These data, and the variability in the renal and CNS abnormalities that occur in ... Male gender, history of congenital cataracts, proximal renal tubular dysfunction, and developmental delay. ... and renal tubular dysfunction. Patients with known or suspected OCRL were enrolled under previous protocol 96-HG-0008 that ...https://clinicaltrials.gov/ct2/show/NCT00359515?cond=LOWE+OCULOCEREBRORENAL+SYNDROME&rank=1
Bile Nephropathy in Flucloxacillin-Induced Cholestatic Liver Dysfunction
Tubular lumens demonstrate heavily pigmented granular casts (black arrows). (b) Multiple densely stained cellular and granular ... Immunofluorescence and electron microscopy showed no abnormalities. The biopsy was consistent with acute tubular necrosis with ... for 7 days before CBDL prevented tubular epithelial injury at 3 days . The authors propose that the tubular injury by bile ... It has been proposed that the bile casts may have a direct tubular toxic effect and an obstructive effect similar to that of ...https://www.hindawi.com/journals/crin/2016/4162674/
A case of multiple metastatic low-grade endometrial stromal sarcoma arising from an ovarian endometriotic lesion
Histologically, the tumor appeared to be a tubular adenoma. On the basis of these findings, we performed an exploratory ... Other examinations, including urinalysis, liver function tests and renal function tests, revealed no abnormalities. ... particularly with regard to multiple extrauterine ESS. Here we report a case of endometrial stromal sarcoma with multiple ... A case of multiple metastatic low-grade endometrial stromal sarcoma arising from an ovarian endometriotic lesion. Joo Yeon Kim, ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2704994/
IgA-kappa type multiple myeloma affecting proximal and distal...
IgA-kappa type multiple myeloma affecting proximal and distal renal tubules.: A 45-year-old male was admitted because of chest ... and abnormalities in distal nephron such as distal renal tubular acidosis and renal diabetes insipidus. Further exploration ... IgA-kappa type multiple myeloma affecting proximal and distal renal tubules.. Authors * Minemura, K ... Although the osteomalacia was relieved by medical treatment, the urinary Bence Jones protein and the renal tubular defects were ...https://www.mysciencework.com/publication/show/iga-kappa-type-multiple-myeloma-affecting-proximal-distal-renal-tubules-187bd0ed
Multiple factors may be found in any one child.. Metabolic abnormalities, in ,50% of children withnephrolithiasis (e.g., distal ... Distal renal tubular acidosis is associated with persistently alkaline urine and can predispose to calcium phosphate stones. ... Specific metabolic abnormalities may have targeted preventive therapies.. With calcium oxalate and calcium phosphate forming up ... The color and character can be an objective documentation of abnormality. The color of the urine can be affected by many drugs ...https://www.infectiousdiseaseadvisor.com/pediatrics/urolithiasis/article/620733/
Renal abnormalities in patients with sickle cell-beta thalassemia.
We examined renal abnormalities in Greek patients with sickle-cell beta thalassemia (S-beta thal). A total of 17 patients aged ... We conclude that patients with S-beta thal, like sickle-cell anemia patients, present multiple abnormalities of renal function. ... Five patients had incomplete distal renal tubular acidosis. Four had mild proteinuria, and six had microalbuminuria. Serum EPO ... We examined renal abnormalities in Greek patients with sickle-cell beta thalassemia (S-beta thal). A total of 17 patients aged ...http://www.biomedsearch.com/nih/Renal-abnormalities-in-patients-with/9238625.html
AMERICAN COLLEGE OF VETERINARY RADIOLOGY 2012 Annual Scientific Conference October 18-21
Patient 3 presented with multiple problems including electrolyte abnormalities, anemia, anorexia, lethargy, and dysuria ... sepsis and multiple organ pathology. Abdominal ultrasound detected two hypoechoic tubular structures extending cranially and ... Discussion/Conclusion: SCI can prevent the echo drop-out artifact because of the multiple insonation angles (multiple ... Ligament abnormalities have been described using MRI in dogs, but are not a determining factor in the development of clinical ...http://spotidoc.com/doc/24458/american-college-of-veterinary-radiology-2012-annual-scie..
Disorders of Phosphorus: Hyperphosphatemia and Hypophosphatemia - ONA
Non-pharmacological proximal tubular defects such as Fanconi's syndrome are also encountered in complex, hospitalized patients ... Multiple mechanisms can cause hyperphosphatemia. Because Phos is predominantly intracellular, any process that results in ... Anticipate Phos derangements in conditions which have associated Phos abnormalities such as DKA, hypoparathyroidism, or ... Normally, even small increases in serum Phos levels trigger a reduction in tubular reabsorption, resulting in increased ...https://www.oncologynurseadvisor.com/pediatrics/disorders-of-phosphorus-hyperphosphatemia-and-hypophosphatemia/article/619694/
The structure of a PKD domain from polycystin‐1: implications for polycystic kidney disease | The EMBO Journal
ADPKD is characterized by the formation of multiple cysts in both kidneys derived from tubular epithelium which, in addition to ... cardiac valvular abnormalities and intracranial vascular malformations (Pirson et al., 1998). ... several multiple transmembrane domains and a short cytoplasmic C‐terminal region (Hughes et al., 1995; The International ... suggesting that PKD1 and PKD2 are components of a common signalling pathway that regulates renal tubular cell function. The N‐ ...http://emboj.embopress.org/content/18/2/297
Low Levels of Antibodies Against Donated Organs Increases Risk of Organ Rejection Among Kidney Transplant Recipients
Renal Tubular Acidosis. Renal tubular acidosis/RTA results in acid content of the blood being higher than normal and that of ... Tongue Abnormalities. Tongue is the only muscle that is attached to only one end. The abnormalities of the tongue include ... Ultrasound scan reveals multiple cysts and there is no function on that kidney when tested on DMSA scan. A vast majority of ... Tongue Abnormalities Urinary Stones In Children Vesico-Ureteric Reflux Causing UTI in Children Hydronephrosis / Antenatal ...https://www.medindia.net/news/low-levels-of-antibodies-against-donated-organs-increases-risk-of-organ-rejection-among-kidney-transplant-recipients-110164-1.htm
Cystic Fibrosis Imaging: Overview, Radiography, Computed Tomography
Periostitis is seen in the diaphyses of the tubular bones, and it may involve single or multiple layers or a solid cloaking of ... Hepatobiliary abnormalities. Fatty infiltration of the liver is commonly seen, and gallbladder abnormalities are found during ... Multiple scoring systems can be used to categorize the chest radiographic findings in CF and to assess the severity of disease. ... Duodenal abnormalities are seen in 80% of patients with cystic fibrosis and are most prominent in the first and second parts of ...https://emedicine.medscape.com/article/354931-overview
Chronic Pneumonia (not TB) - ONA
The radiographic abnormalities found among patients with chronic pneumonia are highly varied. As noted, an infiltrate of some ... Elevated renal function tests can be helpful in discerning conditions associated with multiple organ dysfunction. Urinalysis ... to urinary sediment should be performed as this can provide information suggesting renal damage and a glomerular or tubular ... Both of these assays are typically elevated among patients with chronic pneumonia, but they are nonspecific abnormalities. ...https://www.oncologynurseadvisor.com/infectious-diseases/chronic-pneumonia-not-tb/article/609564/
Update on adult renal cystic diseases
... genetics and molecular biology have shown that functional and structural abnormality of the primary cilia of the renal tubular ... Multiple, bilateral medullary cysts in small to normal sized kidneys in appropriate clinical setting favor the diagnosis of ... Multiple, noncommunicating cysts in an enlarged, non-reniform shaped kidney without any functioning renal parenchyma is the ... Multiple, bilateral renal angiomyolipomas intermixed with renal cysts in normal to enlarged kidneys is typically seen in ...http://appliedradiology.com/articles/update-on-adult-renal-cystic-diseases
Large plaque-like glomangioma in a patient with multiple glomus tumours: review of imaging and histology - Tony - 2013 -...
a) Axial and (b) coronal sagittal short TI inversion recovery images showing multiple high-signal round and tubular structures ... but no obvious bony abnormality Fig. 1(c). Spectral greyscale ultrasonography (US) of the discoloured area showed multiple, ... In our case, US scans of the affected area showed multiple dilated hypoechoic rounded and tubular noncompressible structures ... showed multiple round and tubular lesions, , 10 mm in size, within the thickened and hypertrophied dermis, corresponding to the ...http://onlinelibrary.wiley.com/doi/10.1111/ced.12122/full
Genetic diagnosis of X-linked dominant hypophosphatemic rickets in a cohort study: Tubular reabsorption of phosphate and 1,25...
... the PHEX gene was sequenced in all of the patients and in 13 cases the study was complemented by mRNA sequencing and Multiple ... Tubular reabsorption of phosphate (TRP) and 1,25(OH)2D serum levels were significantly lower in patients carrying clearly ... MRC-Holland, Amsterdam, Netherlands). DNA sequence abnormalities were analyzed in the parents and other relatives of the ... AD age at diagnosis (months), H height SDS, P phosphate serum levels, TRP tubular reabsorption of phosphate, 1,25(OH)2D 1,25 ...https://0-bmcmedgenet-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/1471-2350-12-116
Osseous metaplasia in an ulcerating tubular adenoma of the colon: a case report | Journal of Medical Case Reports | Full Text
A repeat gastroscopy revealed no abnormality. A colonoscopy was performed which revealed a pedunculated polyp in the proximal ... Histological examination demonstrated multiple areas of osseous metaplasia within the polyp stroma. ... There are only three other cases reported of ossification specifically in a tubular adenomas [7, 8, 12]. Osseous metaplasia can ... Al-Daraji WI, Abdellaoui A, Salman WD: Osseous metaplasia in a tubular adenoma of the colon. J Clin Pathol. 2005, 58: 220-221. ...https://jmedicalcasereports.biomedcentral.com/articles/10.1186/1752-1947-2-130
Elvitegravir, Cobicistat, Emtricitabine, and Tenofovir Disoproxil Fumarate (Professional Patient Advice) - Drugs.com
Avoid use of tenofovir with multiple NSAIDs or any NSAID given at a high dose. Consider therapy modification ... If abnormalities are suspected, expert assessment is recommended.. • Immune reconstitution syndrome: Patients may develop ... Cobicistat inhibits tubular creatinine secretion without affecting glomerular filtration; may cause modest declines in ... Avoid use of tenofovir with multiple NSAIDs or any NSAID given at a high dose. Consider therapy modification ...https://www.drugs.com/ppa/elvitegravir-cobicistat-emtricitabine-and-tenofovir-disoproxil-fumarate.html
Organic anion transporter 1 - Wikipedia
... acute tubular necrosis with distinctive clinical, pathological, and mitochondrial abnormalities". Kidney Int. 78 (11): 1171- ... 2007). "Mitochondrial toxicity of indinavir, stavudine and zidovudine involves multiple cellular targets in white and brown ... and the basolateral membrane of proximal tubular cells of the kidneys. It plays a central role in renal organic anion transport ... "OAT1 Knock-out Mice Define Its Role in Tenofovir Transport and Renal Proximal Tubular Mitochondrial Toxicity". FASEB J. 24 (1_ ...https://en.wikipedia.org/wiki/Organic_anion_transporter_1