Other names in common use include Delta9-desaturase, acyl-CoA desaturase, fatty acid desaturase, and stearoyl-CoA, hydrogen- ... Stearoyl-CoA desaturase-1 is a key enzyme in fatty acid metabolism. It is responsible for forming a double bond in stearoyl-CoA ... Stearoyl-CoA desaturase (Δ-9-desaturase) is an endoplasmic reticulum enzyme that catalyzes the rate-limiting step in the ... "Entrez Gene: Stearoyl-CoA desaturase (delta-9-desaturase)". Retrieved 2011-09-29. Paton, Chad M.; Ntambi, James M. (2017-03-08 ...

... is a membrane-embedded metalloenzyme that catalyzes the formation of a double bond on a saturated acyl-CoA. SCD1 has a diiron ... Increasing peak of oleoyl-CoA and simultaneous decreasing peak of stearoyl-CoA confirmed stearoyl-CoA to oleoyl-CoA conversion ... Structure and Mechanism of a Unique Diiron Center in Mammalian Stearoyl-CoA Desaturase Jiemin Shen 1 , Gang Wu 2 , Ah-Lim Tsai ... Structure and Mechanism of a Unique Diiron Center in Mammalian Stearoyl-CoA Desaturase Jiemin Shen et al. J Mol Biol. 2020. . ...

Stearoyl-CoA Desaturase 1 Protects Ovarian Cancer Cells from Ferroptotic Cell Death Lia Tesfay; Lia Tesfay ... Stearoyl-CoA desaturase-1 mediated cell apoptosis in colorectal cancer by promoting ceramide synthesis ... A commentary has been published: Stearoyl CoA Desaturase Regulates Ferroptosis in Ovarian Cancer Offering New Therapeutic ... Stearoyl CoA Desaturase Regulates Ferroptosis in Ovarian Cancer Offering New Therapeutic Perspectives ...

Stearoyl CoA desaturase 1 (SCD1) is the rate-limiting enzyme in the synthesis of monounsaturated fatty acids (MUFAs). ... Alpha-linolenic acid increases cholesterol efflux in macrophage-derived foam cells by decreasing stearoyl CoA desaturase 1 ... Alpha-linolenic acid increases cholesterol efflux in macrophage-derived foam cells by decreasing stearoyl CoA desaturase 1 ...

Regulation of stearoyl-CoA desaturase expression. Ntambi JM, Miyazaki M, Dobrzyn A. Ntambi JM, et al. Lipids. 2004 Nov;39(11): ... Adipose tissue stearoyl-CoA desaturase 1 index is increased and linoleic acid is decreased in obesity-prone rats fed a high-fat ... Plasma stearoyl-CoA desaturase indices: association with lifestyle, diet, and body composition. Vinknes KJ, Elshorbagy AK, Nurk ... Stearoyl-CoA desaturase regulates inflammatory gene expression by changing DNA methylation level in 3T3 adipocytes. Malodobra- ...

"Ubiquitin-proteasome-dependent degradation of mammalian ER stearoyl-CoA desaturase",. abstract = "Mammalian Δ9 stearoyl-CoA ... N2 - Mammalian Δ9 stearoyl-CoA desaturase 1 (SCD1) is a key enzyme in the biosynthesis of mono-unsaturated fatty acids in the ... AB - Mammalian Δ9 stearoyl-CoA desaturase 1 (SCD1) is a key enzyme in the biosynthesis of mono-unsaturated fatty acids in the ... Mammalian Δ9 stearoyl-CoA desaturase 1 (SCD1) is a key enzyme in the biosynthesis of mono-unsaturated fatty acids in the ...

Decreases in Circulating Estrogens Leads to Increased Hepatic Stearoyl CoA Desaturase Activity. Although we did not find large ... is regulated enzymatically by the enzyme stearoyl CoA desaturase (SCD-1). In addition, we found a significant increase in the ... Sedentary OVX animals exhibited significant increases in hepatic stearoyl CoA desaturase (SCD-1) content compared with all ... Sedentary OVX animals exhibited significant increases in hepatic stearoyl CoA desaturase (SCD-1) content compared with all ...

Kakuma, T., Lee, Y. H., & Unger, R. H. (2002). Effects of leptin, troglitazone, and dietary fat on stearoyl CoA desaturase. ... Effects of leptin, troglitazone, and dietary fat on stearoyl CoA desaturase. / Kakuma, Tetsuya; Lee, Young H; Unger, Roger H. ... Kakuma, T, Lee, YH & Unger, RH 2002, Effects of leptin, troglitazone, and dietary fat on stearoyl CoA desaturase, Biochemical ... Kakuma, Tetsuya ; Lee, Young H ; Unger, Roger H. / Effects of leptin, troglitazone, and dietary fat on stearoyl CoA desaturase ...

Stearoyl-CoA desaturase (SCD) is conserved in all eukaryotes and introduces the. Stearoyl-CoA desaturase (SCD) is conserved in ... We modeled a stearoyl-CoA molecule into this density although we were unable to distinguish between oleoyl-CoA and stearoyl-CoA ... are strongly conserved among known stearoyl-CoA desaturases including human SCD1 but not among stearoyl-lipid desaturases ( ... This tunnel is usually sharply kinked where it binds to C9 and C10 on stearoyl-CoA the atoms involved in formation of the has a ...

... and dramatically reduced liver stearoyl-CoA desaturase-1 (SCD-1) activity underlying their phenotype. Taken together with the ...

Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity. Proc Natl Acad Sci USA 99. :11482-11486, PMID: ... stearoyl-CoA desaturase; SREBP-1c, sterol regulatory element binding protein-1c. * p. ,. 0.05. ; # One-way ANOVA for all groups ... aP2-Cre-mediated inactivation of acetyl-CoA carboxylase 1 causes growth retardation and reduced lipid accumulation in adipose ...

Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss. Science 297, 240-243 (2002). ... Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP- ...

... including stearoyl CoA desaturase-1 and FA synthase, which in turn reduce PA levels and promote GC cell growth and metastasis. ... stearoyl-CoA desaturase 5; SLC25A21-AS1, SLC25A21 antisense RNA 1; SPRY4IT-1, SPRY4 intronic transcript 1; SYBU, syntabulin; TG ... Long-chain acyl CoA synthetase 4 (ACSL4), a member of the acyl CoA synthetase 4 family, is a key regulator of lipid metabolism ... Acetyl-CoA also synthesizes FAs and palmitic acid is an FA that produces diglycerides, which may be interconverted with ...

An intriguing example is the enzyme Stearoyl-CoA Desaturase 5. SCD5 is not present in rodents (Wang et al., 2005). We found a ... 2005). Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primates. Biochem. Biophys. Res. Commun. 332 ... encoding a primate-specific isoform of Stearoyl-CoA Desaturase (Wang et al., 2005), and the microtubule-associated protein ... Sinner, D. I., Kim, G. J., Henderson, G. C., and Igal, R. A. (2012). StearoylCoA desaturase-5: a novel regulator of neuronal ...

1. Stearoyl-CoA Desaturase Promotes Liver Fibrosis and Tumor Development in Mice via a Wnt Positive-Signaling Loop by ... 2. Stearoyl-CoA desaturase and tumorigenesis.. Kikuchi K; Tsukamoto H. Chem Biol Interact; 2020 Jan; 316():108917. PubMed ID: ... Sphere-forming culture enriches liver cancer stem cells and reveals Stearoyl-CoA desaturase 1 as a potential therapeutic target ...

Title: Transcriptomic profiling of curcumin-treated human breast stem cells identifies a role for stearoyl-coa desaturase in ... Stearoyl-CoA Desaturase/genetics*; Stem Cells/drug effects; Stem Cells/metabolism ...

Tracz-Gaszewska, Z. & Dobrzyn, P. Stearoyl-CoA desaturase 1 as a therapeutic target for the treatment of cancer. Cancers 11, ...

... stearoyl-CoA desaturase-1; DGAT1, acyl CoA:diacylglycerol acyltransferase 1; 11β-HSD1, 11β-hydroxysteroid dehydrogenase type 1 ...

MONOUNSATURATED FATTY ACIDS GENERATED VIA STEAROYL COA DESATURASE-1 ARE ENDOGENOUS INHIBITORS OF FATTY ACID AMIDE HYDROLASE ... including stearoyl-CoA desaturase-1 (SCD1). Mice deficient in CB1R or SCD1 remain lean and insulin-sensitive on an HFD, ...

Rapid Alpha-Synuclein Toxicity in a Neural Cell Model and Its Rescue by a Stearoyl-CoA Desaturase Inhibitor ...

Susceptibility of podocytes to palmitic acid is regulated by stearoyl-CoA desaturases 1 and 2. Am J Pathol. 2013;183(3):735-744 ... Peroxisome proliferator-activated nuclear receptor alpha (PPARA), acyl-coA dehydrogenase medium chain (ACADM), and acyl-coA ... Susceptibility of podocytes to palmitic acid is regulated by fatty acid oxidation and inversely depends on acetyl-CoA ...

The Role of Stearoyl-CoA Desaturase in N-(4-Hydroxyphenyl)retinamide-Induced Apoptosis of Human Retinal Pigment Epithelial ...

Triglyceride Paradox Is Related to Lipoprotein Size, Visceral Adiposity and Stearoyl-CoA Desaturase Activity in Black Versus ...

Testosterone enhances stearoyl-CoA desaturase mRNA levels in mouse male and female meibomian glands [27,28], and the targeted ... and stearoyl-CoA desaturase, an iron-containing enzyme that catalyzes the synthesis of unsaturated fatty acids. ... Targeted disruption of stearoyl-CoA desaturase1 gene in mice causes atrophy of sebaceous and meibomian glands and depletion of ...

Pyridazine derivatives and their use in the inhibition of stearoyl-CoA desaturase ...

Zheng Y, Prouty SM, Harmon A, Sundberg JP, Stenn KS, Parimoo S: Scd3-a novel gene of the stearoyl-CoA desaturase family with ... Miller CW, Ntambi JM: Peroxisome proliferators induce mouse liver stearoyl-CoA desaturase 1 gene expression. Proc Natl Acad Sci ... Kurebayashi S, Hirose T, Miyashita Y, Kasayama S, Kishimoto T: Thiazolidinediones downregulate stearoyl-CoA desaturase 1 gene ... Scd1 (stearoyl-coenzyme A desaturase) NM_009127 Lipid desaturase TGF-β, Insulin, PPAR-γ ...

Kim: The asebia mouse, which harbors mutations in the stearoyl-CoA desaturase 1 (Scd1) gene, was previously proposed as a model ...

Loss of Stearoyl-CoA desaturase-1 attenuates adipocyte inflammation: effects of adipocyte-derived oleate. Arterioscler Thromb ... stearoyl-CoA desaturase 1). When scientists remove SCD1 activity in lab animals, their levels of fat tissue inflammation fall ...

... whereas genes encoding for desaturases, such as FADS1, appear to be modulated by dietary silage level. Our results indicate ... Fatty acid indices of stearoyl Co-A desaturase activity do not reflect actual stearoyl Co-A desaturase enzyme activity in ... Chung KY, Lunt DK, Kawachi H, Yano H, Smith SB: Lipogenesis and stearoyl-CoA desaturase gene expression and enzyme activity in ... Chang JHP, Lunt DK, Smith SB: Fatty acid composition and fatty acid elongase and stearoyl-CoA desaturase activities in tissues ...