Reperfusion injury - Wikipedia
Reperfusion injury, sometimes called ischemia-reperfusion injury (IRI) or reoxygenation injury, is the tissue damage caused ... Reperfusion injury plays a major part in the biochemistry of hypoxic brain injury in stroke. Similar failure processes are ... Reperfusion injury is distinct from cerebral hyperperfusion syndrome (sometimes called "Reperfusion syndrome"), a state of ... Reperfusion can cause hyperkalemia. Reperfusion injury is a primary concern in liver transplantation surgery. However,[ ...
Anticerebral Ischemia-Reperfusion Injury Activity of Synthesized Puerarin Derivatives
The mouse model of cerebral artery ischemia/reperfusion injury was established to test the anticerebral ischemia-reperfusion ... derivatives of puerarin may serve as promising approach to improve neuron function in ischemia-reperfusion brain injury-related ... improving the protective effects against cerebral ischemia/reperfusion injury. Therefore, ... Puerarin has shown protective effect on injury of neural cell. In order to enhance this protective effect of puerarin, puerarin ...
ISCHEMIA AND REPERFUSION INJURY IN CRYONICS
... warm ischemia and reperfusion injury with emphasis on cryonics technology ... ISCHEMIC INJURY IN BRAIN AND ELSEWHERE *REPERFUSION INJURY AND NO REFLOW *STROKE THERAPY *HIBERNATION AND ESTIVATION *ORGAN ... BRAIN DAMAGE DUE TO ISCHEMIA/REPERFUSION *PREVENTING ISCHEMIC/REPERFUSION INJURY IN CRYONICS *PRE-TREATMENT FOR CRYONICS ... and can thereby worsen damage from reperfusion injury if given in delayed reperfusion. Treatment with tPA is generally deemed ...
New aspects of p66Shc in ischaemia reperfusion injury and other cardiovascular diseases
... Br J Pharmacol. 2017 Jun;174(12):1690- ... Here, we review the information linking the adaptor protein p66Shc with cardiac injury induced by ischaemia and reperfusion (I/ ... Deletion of p66Shc has been shown to reduce I/R injury as well as vascular abnormalities associated with diabetes and ageing. ... ROS formation is also involved in insulin signalling and might contribute to self-endogenous defenses against mild I/R injury. ...
Sestrin2 prevents age-related intolerance to ischemia and reperfusion injury by modulating substrate metabolism
... pertinent stress-activated kinase that has been shown to have cardioprotective capabilities against myocardial ischemic injury ... Sestrin2 prevents age-related intolerance to ischemia and reperfusion injury by modulating substrate metabolism FASEB J. 2017 ... and reperfusion- induced injury). Adeno-associated virus-Sesn2 was delivered to aged hearts via a coronary delivery approach ... Sestrin2 prevents age-related intolerance to ischemia and reperfusion injury by modulating substrate metabolism. ...
Reperfusion Injury in Stroke: Overview, Symptoms of Cerebral Reperfusion Syndrome, Causes of Cerebral Reperfusion Injury
... or reperfusion syndrome, is a rare, but serious, complication following revascularization. Hyperperfusion is defined as a major ... encoded search term (Reperfusion Injury in Stroke) and Reperfusion Injury in Stroke What to Read Next on Medscape ... Prevention of Reperfusion Injury. Blood pressure control. The most important factor in preventing reperfusion syndrome is early ... Causes of Cerebral Reperfusion Injury. Pathophysiology. Several mechanisms have been proposed for the pathogenesis of cerebral ...
Researchers interested in Myocardial Reperfusion Injury | Internal Medicine
Haemoxygenase modulates cytokine induced neutrophil chemoattractant in hepatic ischemia reperfusion injury
Shift Work Increases Myocardial Infarction Reperfusion Injury
Disruption of Circadian Rhythms by Shift Work Exacerbates Reperfusion Injury in Myocardial Infarction. Learn about the link ... imaging after reperfusion therapy. The main outcome was the size of the CMR-defined post-reperfusion infarct. The composite of ... For a study, researchers sought to determine the effect of shift work on reperfusion damage, which is a significant driver of ... A recent study discovered that shift employment causes myocardial infarction reperfusion damage. It discovered a new nuclear ...
Hyperbaric Normothermic Perfusion Mitigates Reperfusion Injury in Porcine Vascular Composite Allotransplantation (VCA) - SAGES...
To mitigate obligate reperfusion injury in VCA, we evaluate the efficacy of a novel normothermic hyperbaric oxygen warm ex-vivo ... Hyperbaric Normothermic Perfusion Mitigates Reperfusion Injury in Porcine Vascular Composite Allotransplantation (VCA). ... Injuries secondary to ischemia and cold preservation are mitigated. This technology has the potential to extend the window of ... but flaps placed on hyperbaric ex-vivo perfusion support showed decreased histologic evidence of ischemic injury or necrosis ...
IJMS | Free Full-Text | Nicotinamide Mononucleotide Prevents Retinal Dysfunction in a Mouse Model of Retinal Ischemia...
... injury can cause severe vision impairment. Retinal I/R injury is associated with pathological increases in reactive oxygen ... However, it remains unclear whether NMN can prevent retinal I/R injury. Thus, we aimed to determine whether NMN therapy is ... One day after NMN intraperitoneal (IP) injection, adult mice were subjected to retinal I/R injury. Then, the mice were injected ... useful for retinal I/R injury-induced retinal degeneration. ... Retinal ischemia/reperfusion (I/R) injury can cause severe ...
JCI - Deletion of thioredoxin-interacting protein in mice impairs mitochondrial function but protects the myocardium from...
... cellular ATP content and lactate formation were higher in Txnip-KO hearts after ischemia-reperfusion injury. Pharmacologic ... protein in mice impairs mitochondrial function but protects the myocardium from ischemia-reperfusion injury. ... protein in mice impairs mitochondrial function but protects the myocardium from ischemia-reperfusion injury. ... Surprisingly, Txnip-KO hearts had greater recovery of cardiac function after an ischemia-reperfusion insult. Similarly, ...
Frontiers | Pioglitazone Ameliorates Renal Ischemia-Reperfusion Injury via Inhibition of NF-κB Activation and Inflammation in...
... is considered as a major cause of acute kidney injury. In this study, we investigated the role of the NF-κB signaling pathway ... is considered as a major cause of acute kidney injury. In this study, we investigated the role of the NF-κB signaling pathway ... Renal ischemia-reperfusion injury (IRI) is considered as a major cause of acute kidney injury. In this study, we investigated ... Citation: Zou G, Zhou Z, Xi X, Huang R and Hu H (2021) Pioglitazone Ameliorates Renal Ischemia-Reperfusion Injury via ...
Molecules | Free Full-Text | Protective Effect of the Total Flavonoids from Rosa laevigata Michx Fruit on Renal Ischemia...
In the present work, a hypoxia/reoxygenation (H/R) model in NRK-52E cells and ischemia-reperfusion model in rats were used. The ... is a major cause of acute kidney injury (AKI). Our previous studies have shown that the total flavonoids (TFs) from Rosa ... which should be developed as a new therapeutic agent or food additives to treat acute kidney injury in the future. ... results showed that the TFs significantly attenuated cell injury and markedly decreased serum creatinine (Cr) and blood urea ...
HSP90β regulates EAAT2 expression and participates in ischemia‑reperfusion injury in rats
Primary ischemia-induced brain injury and secondary ischemia reperfusion injury (3). A study has shown that neurons in the ... Yu X, Luo Y, Yang L, Chen P and Duan X: P-hydroxybenzyl alcohol ameliorates neuronal cerebral ischemia-reperfusion injury by ... HSP90β regulates EAAT2 expression and participates in ischemia‑reperfusion injury in rats. *Authors: *Tao Liang ... The MCAO model was introduced to simulate the pathological process of ischemia-reperfusion injury, Thus, it is widely used to ...
Stealth Reports Positive Results from Ischaemia Reperfusion Injury Study - Pharmaceutical Technology
Ischaemia reperfusion injury is the tissue damage caused when blood supply returns to the tissue after a period of ischemia, ... Stealth Reports Positive Results from Ischaemia Reperfusion Injury Study. Stealth Peptides has reported positive results from a ... a novel compound that targets the mitochondria to treat ischaemia reperfusion injury. The study enrolled healthy volunteers, ... a novel compound that targets the mitochondria to treat ischaemia reperfusion injury. ...
Ginsenoside Rh2 attenuates myocardial ischaemia‑reperfusion injury by regulating the Nrf2/HO‑1/NLRP3 signalling pathway
Shen Y, Liu X, Shi J and Wu X: Involvement of Nrf2 in myocardial ischemia and reperfusion injury. Int J Biol Macromol. 125:496- ... Shi X, Tao G, Ji L and Tian G: Sappanone a protects against myocardial ischemia reperfusion injury by modulation of Nrf2. Drug ... Shen S, He F, Cheng C, Xu B and Sheng J: Uric acid aggravates myocardial ischemia-reperfusion injury via ROS/NLRP3 pyroptosis ... Wang Y, Hu Z, Sun B, Xu J, Jiang J and Luo M: Ginsenoside Rg3 attenuates myocardial ischemia/reperfusion injury via Akt/ ...
Transcriptome-based exploration of potential molecular targets and mechanisms of selenomethionine in alleviating renal ischemia...
Renal ischemia-reperfusion injuries (IRIs) are one of the leading causes of acute kidney injuries (AKIs). Selenium, as an ... Glutathione peroxidase 3 (Gpx3), Inflammation, Ischemia-reperfusion injury, Kidney, Oxidative stress, Selenomethionine ... exploration of potential molecular targets and mechanisms of selenomethionine in alleviating renal ischemia-reperfusion injury ... Interleukin-17D produced by alveolar epithelial type II cells alleviates LPS-induced acute lung injury via the Nrf2 pathway ...
Oral pre-treatment with thiocyanate (SCN-) protects against myocardial ischaemia-reperfusion injury in rats - Resultat
Oral pre-treatment with thiocyanate (SCN-) protects against myocardial ischaemia-reperfusion injury in rats. Publikation: ... Oral pre-treatment with thiocyanate (SCN−) protects against myocardial ischaemia-reperfusion injury in rats Forlagets udgivne ... Oral dosing of rats with SCN-, before acute ischemia-reperfusion injury (30 min occlusion, 24 h or 4 week recovery), ... can protect against acute ischemia-reperfusion injury. ...
p53-Rb signaling pathway is involved in tubular cell senescence in renal ischemia/reperfusion injury
... and Rb during the late phase of ischemia/reperfusion (IRI) in the kidney, and assess the effects of the p53-Rb pathway on ... p53-Rb signaling pathway is involved in tubular cell senescence in renal ischemia/reperfusion injury. LI KAILONG1,2, DU XIAOLAN ... 2007). p53-Rb signaling pathway is involved in tubular cell senescence in renal ischemia/reperfusion injury. BIOCELL, 31(2), ... cell senescence, cell cycle regulatory protein, ischemia/reperfusion injury, kidney Cite This Article. KAILONG, L., XIAOLAN, D ...
Mild hypothermia attenuates ischemia/reperfusion injury - insights from serial non-invasive pressure-volume loops | Lund...
... we observed that mild hypothermia at reperfusion alleviates the hearts work after ischemia/reperfusion injuries during the ... we observed that mild hypothermia at reperfusion alleviates the hearts work after ischemia/reperfusion injuries during the ... Mild hypothermia attenuates ischemia/reperfusion injury - insights from serial non-invasive pressure-volume loops. *Mark ... BACKGROUND: Mild hypothermia, 32-35°C, reduces infarct size in experimental studies, potentially mediating reperfusion injuries ...
Sevoflurane improves renal ischemia-reperfusion injury in rats through RISK signaling pathway | Tropical Journal of...
Purpose: To investigate the effect of sevoflurane on renal ischemia-reperfusion injury (IRI) in rats and its regulatory effect ... Sevoflurane improves renal ischemia-reperfusion injury in rats through RISK signaling pathway ... on reperfusion injury salvage kinase (RISK) signaling pathway.. Methods: A total of thirty (30) Sprague-Dawley rats were ... Renal injury was determined using hematoxylin and eosin (HE) staining. Blood urea nitrogen (BUN) and serum creatinine (Scr) ...
"The role of DLC1β in attenuating cardiac ischemia-reperfusion injury d" by Samantha L. Collings
In vitro, HL-1 cells (mouse cardiomyocytes) received chamber hypoxia-oxygenation reperfusion (H/R) for 24H4R with/without DLC1β ... Treatment with DLC1β-OE reduced IRI as evidenced by decreased cumulative injury via histopathology. In summary, future ... in vivo grafts demonstrated reduced neutrophilic infiltrate/fibrosis/overall injury. ... Cardiac ischemia-reperfusion injury (IRI) occurs intra-operatively during heart transplantation (HTx), underpinning graft ...
Additional file 1 of Long non-coding RNA TUG1 knockdown promotes autophagy and improves acute renal injury in ischemia...
Additional file 1 of Long non-coding RNA TUG1 knockdown promotes autophagy and improves acute renal injury in ischemia- ... reperfusion-treated rats by binding to microRNA-29 to silence PTEN ... Renal ischemia-reperfusionAutophagyApoptosisLong noncoding RNA TUG1PTENmcroRNA-29 ... file 1 of Long non-coding RNA TUG1 knockdown promotes autophagy and improves acute renal injury in ischemia-reperfusion-treated ...
Differential sensitivity of proximal and distal coronary arteries to a nitric oxide donor following reperfusion injury or...
Differential sensitivity of proximal and distal coronary arteries to a nitric oxide donor following reperfusion injury or ... D.T.it, E.F.; Miyashiro, J.; Mccarty, J.; Opie, L.H. 1996: Paradoxical attenuation of ischaemic/reperfusion injury by both ... This inhibition is abolished following reperfusion injury or inhibition of NO synthesis.. PDF emailed within 0-6 h: $19.90. . ... Differential sensitivity of proximal and distal coronary arteries to a nitric oxide donor following reperfusion injury or ...
Corrigendum to "Kaempferol Attenuates Myocardial Ischemic Injury via Inhibition of MAPK Signaling Pathway in Experimental Model...
Hence, we investigated the effect of KMP in ischemia-reperfusion (IR) model of myocardial injury in rats. We studied male ... Hence, we investigated the effect of KMP in ischemia-reperfusion (IR) model of myocardial injury in rats. We studied male ... Yu, J., Wang, L., Akinyi, M.. Danshensu protects isolated heart against ischemia reperfusion injury through activation of Akt/ ... Jennings, R. B.. Historical perspective on the pathology of myocardial ischemia/reperfusion injury. Circulation Research . 2013 ...
FTY720 impairs necrosis development after ischemia-reperfusion injury
Ischemia-reperfusion (IR) injury is a common early feature that contributes to graft damage by impairing resident cell function ... It has also been shown to be protective against IR injury in rats. We sought to evaluate the role of FTY720 in a murine IR ... More studies are required to identify the mechanisms involved in the protective activity of FTY720 in the IR injury model. ... Our previous results showed that IR injury impaired renal function, by causing extensive tubular necrosis and increasing MHC ...
Assessment of focal renal ischemia-reperfusion injury in a porcine model using hyperpolarized [1-13 C]pyruvate MRI - Research -...
MRI, acute kidney injury, hyperpolarization, ischemia, Kidney/diagnostic imaging, Reperfusion Injury/diagnostic imaging, ... Assessment of focal renal ischemia-reperfusion injury in a porcine model using hyperpolarized [1-13 C]pyruvate MRI. Research ... RESULTS: The focal ischemia-reperfusion injury resulted in injured areas with a mean size of 0.971 cm 3 (±1.019). Compared with ... Here, we assessed the metabolic alterations following subclinical focal ischemia-reperfusion injury with hyperpolarized [1- 13 ...
Renal Endothelial Dysfunction in Acute Kidney Ischemia Reperfusion Injury | Bentham Science
Acute kidney injury is associated with alterations in vascular tone that contribute to an overall reduction in GFR. Studies in ... Renal Endothelial Dysfunction in Acute Kidney Ischemia Reperfusion Injury. Author(s): David P. Basile and Mervin C. Yoder ... Basile P. David and Yoder C. Mervin, Renal Endothelial Dysfunction in Acute Kidney Ischemia Reperfusion Injury, Cardiovascular ... Acute kidney injury is associated with alterations in vascular tone that contribute to an overall reduction in GFR. Studies in ...
US Patent Application for POLYPEPTIDE FOR THE PROTECTION AGAINST HEART ISCHEMIA-REPERFUSION INJURY Patent Application ...
... or certain analogues of said GLP-1 peptide can be used for the treatment and prophylaxis of heart ischemia-reperfusion injury ... This is called reperfusion injury. The phenomenon may be modelled in an experimental setting, in this case on an isolated rat ... Ischemia-reperfusion injury (IRI) is a syndrome affecting the myocardium upon blood flow restoration following a sufficiently ... 4] Bose A. K., Mocanu M M, Carr R D, Yelton D M (2007) Myocardial ischaemia-reperfusion injury is attenuated by intact glucagon ...