... including odorant receptors (ORs), trace amine-associated receptors (TAARs), bitter taste receptors (TAS2Rs), sweet and umami ... Approximately half of the members of the human GPCR superfamily are chemosensory receptors, ... taste receptors (TAS1Rs). Interestingly, these chemosensory GPCRs (csGPCRs) are expressed in several tissues of the body where ... G protein-coupled receptors (GPCRs) belong to the largest class of drug targets. ...

The toll-like receptor (TLR) signaling network is responsible for innate immune response. In mammalians, there are 11 TLRs that ... Receptor Cross-Talk * Receptors, Interleukin-1 * Signal Transduction* * Toll-Like Receptors* Substances * Adaptor Proteins, ... A comprehensive map of the toll-like receptor signaling network Mol Syst Biol. 2006:2:2006.0015. doi: 10.1038/msb4100057. Epub ... There is extensive crosstalk between the main bow-tie network and subsystems, as well as feedback and feedforward controls. One ...

Cross-talk between notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches. ... Dive into the research topics of Cross-talk between notch and the estrogen receptor in breast cancer suggests novel ...

"Receptor Cross-Talk" by people in this website by year, and whether "Receptor Cross-Talk" was a major or minor topic of these ... "Receptor Cross-Talk" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Receptor Cross-Talk*Receptor Cross-Talk. *Cross-Talk, Receptor. *Receptor Cross Talk ... Below are the most recent publications written about "Receptor Cross-Talk" by people in Profiles. ...

Puga A, Ma C, Marlowe JL (February 2009). "The aryl hydrocarbon receptor cross-talks with multiple signal transduction pathways ... Puga A, Tomlinson CR, Xia Y (January 2005). "Ah receptor signals cross-talk with multiple developmental pathways". Biochemical ... The aryl hydrocarbon receptor (also known as AhR, AHR, ahr, ahR, AH receptor, or dioxin receptor) is a protein that in humans ... "The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1". Archives of ...

We mapped all estrogen receptor and RNA polymerase II binding sites on a genome-wide scale, identifying the authentic cis ... The estrogen receptor is the master transcriptional regulator of breast cancer phenotype and the archetype of a molecular ... Kalaitzidis, D. & Gilmore, T.D. Transcription factor cross-talk: the estrogen receptor and NF-kappaB. Trends Endocrinol. Metab. ... The estrogen receptor enhances AP-1 activity by two distinct mechanisms with different requirements for receptor ...

This talk features in the following public collections: *Oxford Cancer Immuno-Oncology Network ...

Kantamneni S (2015) Cross-talk and regulation between glutamate and GABAB receptors. Frontiers in Cellular Neuroscience Apr ... AKAP; AMPAR; GABABR; NMDAR; Glutamate receptor; Receptor regulation; Receptor trafficking and mGluR. en_US. ... GABAB receptors also regulate glutamate receptors. There is increasing evidence that metabotropic GABAB receptors are now known ... Specifically, GABAB receptors affect the expression, activity and signaling of glutamate receptors under physiological and ...

There are examples of cross-talk between RhoA, Rac1, and Cdc42 in neurons (Kozma et al., 1997; van Leeuwen et al., 1997; Li et ... the receptor tyrosine kinase family of Trk (A, B, and C) receptors and the p75 neurotrophin receptor (NTR). Trk receptors ... For example, p75NTR receptors interact with trk receptors to modify the affinity and specificity of trk receptors (Huang and ... Neurotrophins bind two classes of receptors with different binding selectivities and signaling pathways. Trk receptors ...

However, controversies exist regarding the status of the steroid hormone receptor expr ... Early endometriosis in females is directed by immune-mediated estrogen receptor α and IL-6 cross-talk. Endocrinology. 2018;159( ... The relationship among HOXA10, estrogen receptor α, progesterone receptor, and progesterone receptor B proteins in rectosigmoid ... Estrogen receptor-β, estrogen receptor-α, and progesterone resistance in endometriosis. Semin Reprod Med. 2010;28(01):036-43 © ...

"Direct protein-protein coupling enables cross-talk between dopamine D5 and gamma-aminobutyric acid A receptors". Nature. 403 ( ... "Direct protein-protein coupling enables cross-talk between dopamine D5 and gamma-aminobutyric acid A receptors". Nature. 403 ( ... Wang H, Bedford FK, Brandon NJ, Moss SJ, Olsen RW (January 1999). "GABA(A)-receptor-associated protein links GABA(A) receptors ... Wang H, Bedford FK, Brandon NJ, Moss SJ, Olsen RW (January 1999). "GABA(A)-receptor-associated protein links GABA(A) receptors ...

2003) Cross talk between the GABA(A) receptor and the Na-K-Cl cotransporter is mediated by intracellular Cl. J Neurophysiol 89: ... This is consistent with the notion that the kinetics of these receptors is slower than the non-NMDA receptors (Collingridge and ... strong activation of NMDA receptors is at the origin of the RD and ID responses, a condition when the NMDA receptor activation ... 1995) NMDA receptor-dependent excitotoxicity: the role of intracellular Ca2+ release. Trends Pharmacol Sci 16:356-359. ...

Decades of research on this receptor has demonstrated its importance to the modulation of social recognition memory, social ... Decades of research on this receptor has demonstrated its importance to the modulation of social recognition memory, social ... The arginine vasopressin 1b receptor (Avpr1b) is involved in the modulation of a variety of behaviors and is an important part ... The arginine vasopressin 1b receptor (Avpr1b) is involved in the modulation of a variety of behaviors and is an important part ...

Receptor Cross-Talk * Signal Transduction* Substances * Hormones * Intercellular Signaling Peptides and Proteins ... In this chapter, we focus more narrowly on GH, PRL, and IGF-1 signaling, and GH-IGF-1 cross talk. We also discuss how these ... and their receptors (GHR, PRLR, and IGF-1R) are critically involved in beta-cell growth, survival, differentiation, and insulin ...

... and therefore its downstream cross-talk with other angiogenic factors), leading to compromised vascular formation. ... Inhibition of vascular smooth muscle G protein-coupled receptor kinase 2 enhances α1D-adrenergic receptor constriction. Am J ... The platelet-derived growth factor receptor-beta phosphorylates and activates G protein-coupled receptor kinase-2. A mechanism ... B and C) Proper signaling of Smads downstream of ALK1 and ALK5 receptor activation depends on GRK2 expression. (B) Grk2+/- ...

We examined the role of transcriptional regulation by retinoic acid receptor-related orphan receptor α (RORα), a nuclear ... suggesting that CYP39A1 expression is activated by RORα nuclear receptors. This may provide a way to increase CYP39A1 activity ... receptor that responds to oxysterol ligands. In humans, the promoter and first intronic regions of CYP39A1 contain two putative ... target gene and a functional cross-talk between RORα and liver X receptor (NR1H3). Mol. Pharmacol. 2008, 73, 891-899. [Google ...

Toll-like receptors (TLRs) enable innate immune cells, such as macrophages, to recognize a wide variety of microbial ligands, ... demonstrating that TLR2-EVs can act as decoy receptors. In summary, our data show that sTLR2 and full-length TLR2 are released ... TLR2 was upregulated in a GC receptor-dependent manner, as shown by Western blot and qPCR. Furthermore, long-term ... TLR2 was upregulated in a GC receptor-dependent manner, as shown by Western blot and qPCR. Furthermore, long-term ...

Prior studies suggest cross-talk between the GH receptor and EGFR signaling systems [25]. ... A GH receptor antisense oligonucleotide inhibits hepatic GH receptor expression, IGF-I production and body weight gain in ... Aryl hydrocarbon receptor-mediated suppression of GH receptor and Janus kinase 2 expression in mice. Nukaya, M., Takahashi, Y ... Developmental aspects of adipose tissue in GH receptor and prolactin receptor gene disrupted mice: site-specific effects upon ...

Pan-cancer analysis of ligand-receptor cross-talk in the tumor microenvironment. https://doi.org/10.1158/0008-5472.CAN-20-2352 ... Pan-cancer analysis of ligand-receptor crosstalk in the tumor microenvironment. Cancer Res. https://doi.org/10.1158/0008-5472. ... b The first step of the feature selection strategy: lasso feature selection, cross-validated on cancer types as folds, was ... We used 5-fold cross-validation to train lasso models on these cancer-type-specific training sets. For experiments where ...

Traynor JR and Elliott J (1993) δ opioid receptor subtypes and cross-talk with μ receptors. Trends Pharmacol Sci 14: 84-86. ... ABBREVIATIONS: GPCR, G-protein-coupled receptors; CDK, coexpressed δ-κ opioid receptors; MDK, mixed δ and κ opioid receptors ... Opioid receptors belong to rhodopsin receptor family of GPCRs. All three major types (δ, κ, and μ) of opioid receptors share ... The cells coexpressing δ and κ opioid receptors close to a ratio of 1:1 (Bmax values of δ and κ opioid receptors are 854.2 and ...

FPRs cross-talk with uPAR and integrins led to Rac1 and ERKs activation. Rac1 is a cytosolic component of the NADPH oxidase ... N-Formyl peptide receptors (FPRs) are chemotactic receptors involved in inflammation. Three FPRs have been identified: FPR1, FPR2 ... N-FORMYL PEPTIDE RECEPTORS; UPAR; OXIDATIVE STRESS; SYSTEMIC SCLEROSIS. Settori scientifico-disciplinari del MIUR:. Area 06 - ... Napolitano, Filomena (2017) N-FORMYL PEPTIDE RECEPTORS AND UPAR FOSTER THE OXIDATIVE STRESS IN SYSTEMIC SCLEROSIS. [Tesi di ...

Cross-Talk between different pathways and messenger molecules.. Enzyme Linked Receptors:. Receptor tyrosine kinases (RTKs), e. ... G-Protein Coupled Receptors:. Receptors coupled to heterotrimeric guanine nucleotide binding proteins (G proteins). Composition ... It then focuses on nuclear, G-protein coupled, and enzyme linked receptors covering in molecular detail these receptors and ... Nuclear Receptors:. Cellular location and molecular organisation of receptors. Structure/function/activity relationships. ...

Cross-talk between estrogen receptor and growth factor pathways as a molecular target for overcoming endocrine resistance. Clin ... Dual Inhibition of mTOR and Estrogen Receptor Signaling In vitro Induces Cell Death in Models of Breast Cancer Anne Boulay; ... The estrogen receptor (ER) is an important predictive and prognostic marker in human breast cancer, being expressed in ∼60% of ... ErbB (HER) receptors can abrogate antiestrogen action in human breast cancer by multiple signaling mechanisms. Clin Cancer Res ...

AKI Mechanisms: Cellular and Organ Cross-Talk. November 02, 2023 , Location: Room 118, Pennsylvania Convention Center. Abstract ... Novel Anti-Inflammatory Effects of IL-1 Receptor in Kidney Myeloid Cells Following AKI. November 02, 2023 , 05:06 PM - 05:15 PM ... As IL1R1 is known to signal through the pro-inflammatory Toll-like receptor (TLR)/MyD88 pathway, we initially hypothesized that ... Novel Anti-Inflammatory Effects of IL-1 Receptor in Kidney Myeloid Cells Following AKI. Session Information. * ...

6] and fibroblast growth factor receptor 2, involved in epithelial-mesenchymal cross-talk, [7] may play a role in the growth of ... Ishigami T, Hida Y, Matsudate Y, Murao K, Kubo Y. The involvement of fibroblast growth factor receptor signaling pathways in ... The expression levels and the differential expression of transforming growth factor-beta receptors in dermatofibroma and ...

Sparks and puffs in oligodendrocyte progenitors: cross talk between ryanodine receptors and inositol trisphosphate receptors. J ... Sparks and puffs in oligodendrocyte progenitors: cross talk between ryanodine receptors and inositol trisphosphate receptors. J ... However, applications of drugs affecting either ryanodine receptors or inositol 1,4,5-trisphosphate receptors terminated [Ca2+] ... The conserved sites for the FK506-binding proteins in ryanodine receptors and inositol 1,4,5-trisphosphate receptors are ...

Scimemi A, Fine A, Kullmann DM, Rusakov DA (2004). NR2B-containing receptors mediate cross talk among hippocampal synapses. J ... Scimemi A, Semyanov A, Sperk G, Kullmann DM, Walker MC (2005). Multiple and plastic receptors mediate tonic GABAA receptor ... Rusakov DA, Scimemi A, Walker MC, Kullmann DM (2004). Comment on "Role of NMDA receptor subtypes in governing the direction of ... Chaudhry C, Scimemi A, Kumar J (2011). Building and breaking interfaces: how a receptor takes shape. J Neurosci 31(30):10749-51 ...

Cross talk between vascular redox and calcium signalling in hypertension involves transient receptor melastatin 2 cation ... Epidermal growth factor signals through transient receptor potential melastatin 7 (TRPM7) cation channel in vascular smooth ...

... and Toll-like receptor 4(TLR4) in microglia in neuropathic pain rats, so as to explore the role of cross-talk between KOR and ... κ-opioid receptor is involved in electroacupuncture analgesia via inhibition of spinal microglial Toll-like receptor 4 in ... κ-opioid receptor is involved in electroacupuncture analgesia via inhibition of spinal microglial Toll-like receptor 4 in ... κ-opioid receptor is involved in electroacupuncture analgesia via inhibition of spinal microglial Toll-like receptor 4 in ...

There was a potential cross-talking between receptors. Related: Liver Cancer AKT1 Signal Transduction TNF MAPK1 ... suggesting usage of other receptors or co-receptors.. METHODS: To study the usage of different receptors and co- receptors that ... XMRV: usage of receptors and potential co-receptors.. Virol J. 2011; 8:423 [PubMed] Free Access to Full Article Related ... CC chemokine receptor 3 (CCR3), the sole receptor for eotaxins, is expressed on eosinophils and T helper type 2 (Th2) cells. In ...