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An involvement of other ErbB family members appears unlikely because dominant-negative mutants of ErbB-1, ErbB-3, or ErbB-4 ... This finding indicates that plexin-B1 and the EGF receptor ErbB-1 interact with the same pool of ErbB-2 and that also other ... 10, A and B). In contrast, in neurons expressing ΔC-terminal mutants of ErbB-1, ErbB-3, ErbB-4, or a control plasmid, Sema4D ... ErbB-3, and ErbB-4 (Karunagaran et al., 1996; Graus-Porta et al., 1997; Holbro and Hynes, 2004), which serve as receptors for ...

... ERBB2 is a protein that is also known as HER2 (human epidermal ... It is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ERBB2 is overexpressed in ...

Other names: Human Epidermal Growth Factor Receptor; C-erbB-2 Her-2/neu is an oncogene, which is a type of gene that can ... Normal cells have two copies of the Her-2/neu gene and low levels of Her-2 protein are produced on the surface of the cells. In ... If the test result is positive, this indicates that too much Her-2/neu protein is being produced; if the test for the gene is ... The test may be used to determine the severity of a patients condition; tumours that are associated with the Her-2/neu gene ...

Correlation with hormone receptor status c-erbB-2, p53, Rb proteins and proliferation associated indices ... Correlation with hormone receptor status c-erbB-2, p53, Rb proteins and proliferation associated indices ... Correlation with hormone receptor status c-erbB-2, p53, Rb proteins and proliferation associated indices ...

Receptor, ErbB-2 / metabolism * Trastuzumab / adverse effects * Trastuzumab / therapeutic use* * Treatment Outcome ... who have residual invasive breast cancer after receiving neoadjuvant chemotherapy plus human epidermal growth factor receptor 2 ...

Antitumor Activity of Epidermal Growth Factor Receptor-Related Protein Is Mediated by Inactivation of ErbB Receptors and ... The ErbB family of type 1 receptor tyrosine kinases (RTKs) includes four members, epidermal growth factor receptor (EGFR; ErbB1 ... Antitumor Activity of Epidermal Growth Factor Receptor-Related Protein Is Mediated by Inactivation of ErbB Receptors and ... Antitumor Activity of Epidermal Growth Factor Receptor-Related Protein Is Mediated by Inactivation of ErbB Receptors and ...

Receptor, ErbB-2 / analysis* * Taxoids / administration & dosage* * Taxoids / adverse effects * Time Factors ... Sara A Hurvitz 1 , Miguel Martin 2 , W Fraser Symmans 3 , Kyung Hae Jung 4 , Chiun-Sheng Huang 5 , Alastair M Thompson 3 , ... stratified by hormone receptor status, stage at diagnosis, and geographical location. Patients received six cycles (every 3 ... 2 Instituto de Investigación Sanitaria Gregorio Marañón, Universidad Complutense, CiberOnc, GEICAM, Madrid, Spain. ...

... receptor tyrosine kinase & erb-b2 receptor tyrosine kinase 2) Engineered Antibodies products for biopharmaceutical and academic ... This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The ... Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in ... Detection Kits for Novel Coronavirus SARS-CoV-2 *The Novel Coronavirus (SARS-CoV-2) Fluorescent RT-PCR Detection Kit ...

Proto-oncogene c-ErbB-2, p185erbB2, CD340, Erbb2, Kiaa3023, NeuSpecies Reactivity: MouseTested Applications: WBUser Note: ... Receptor tyrosine-protein kinase erbB-2, Proto-oncogene Neu, ... Receptor tyrosine-protein kinase erbB-2, Proto-oncogene Neu, ... Product Name: Receptor tyrosine-protein kinase erbB-2, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, p185erbB2, CD340, Erbb2, ... Product Name: Receptor tyrosine-protein kinase erbB-2, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, p185erbB2, CD340, Erbb2, ...

Given that receptor tyrosine kinases of the ErbB family are overexpressed in a high proportion of metastatic bladder tumours, ... Given that receptor tyrosine kinases of the ErbB family are overexpressed in a high proportion of metastatic bladder tumours, ... Given that receptor tyrosine kinases of the ErbB family are overexpressed in a high proportion of metastatic bladder tumours, ... Given that receptor tyrosine kinases of the ErbB family are overexpressed in a high proportion of metastatic bladder tumours, ...

RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 18 ... Receptor Tyrosine-protein Kinase Erbb-2. (Gene symbol: ERBB2). * Click molecule labels to explore molecular sequence ...

The ErbB protein family consists of 4 members ErbB-1, also named epidermal growth factor receptor (EGFR) ErbB-2, also named ... Excessive ErbB signaling is associated with the development of a wide variety of types of solid tumor. ErbB-1 and ErbB-2 are ... The figure below shows the tridimensional structure of the ErbB family proteins, using the pdb files 1NQL (ErbB-1), 1S78 (ErbB- ... "Transactivation of ErbB Family of Receptor Tyrosine Kinases Is Inhibited by Angiotensin-(1-7) via Its Mas Receptor". PLOS ONE. ...

Nerve growth factor receptor (NGFR), a member of kinase protein, is emerging as an important target for Glioblastoma (GBM) ... Hydrazones have been reported to effectively interact with receptor tyrosine kinases (RTKs). We report herein the synthesis of ... derived growth factor receptor alpha (PDGFRA), calmodulin 3 (CALM3), cyclin‑dependent kinase 6 (CDK6), calcium/calmodulin‑ ... benzonitrile as novel inhibitor of receptor tyrosine kinase and PI3K/AKT/mTOR signaling pathway in glioblastoma.. Eur J Med ...

Receptor, erbB-2. *High-Throughput Nucleotide Sequencing. *AMP-Activated Protein Kinases. *Adenocarcinoma of Lung ... epidermal growth factor receptor (EGFR), erb-b2 receptor tyrosine kinase 4 (ERBB4), F-box and WD repeat domain containing 7 ( ... FBXW7), fibroblast growth factor receptor 1 (FGFR1), FGFR3 (fibroblast growth factor receptor 3), Kirsten rat sarcoma viral ... regulation of Wnt receptor signaling pathway - response to DNA damage stimulus - response to glucagon stimulus - response to ...

... receptor tyrosine-protein kinase erbB-2; TKR1; Tyrosine kinase-type cell surface receptor HER2; v-erb-b2 avian erythroblastic ... CD340 antigen; CD340; c-erb B2/neu protein; EC 2.7.10; EGFR2; ErbB2; HER2; HER-2; HER2EC 2.7.10.1; herstatin; Metastatic lymph ... 12 months from date of receipt, 2 to 8 °C as supplied. ... Receptor Tyrosine Kinases (RTKs) in the Akt Pathway * Receptors ... Proto-oncogene c-ErbB-2; Proto-oncogene Neu; ... 2) to provide a service, information, or data to an ...

... is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. ErbB family members serve ... JL Bramson The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity Nat ... Among ErbB family members, ErbB2 is unique in that it has no identified ligands. Rather, ErbB2 heterodimerizes with the other ... Tyrosine kinase-type cell surface receptor HER2. *v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2(neuro/ ...

Results of estrogen receptor and c-erbB-2 status using immunohistochemistry were documented. Lymph node status in specimens ... Of a total of 102 cases stained for estrogen receptor and c-erbB-2, 43 (42%) were ER-positive and 39 (38%) were c-erbB-2 ... 0.050) but not with estrogen receptor or c-erbB-2 status. When tumour size was categorized into 3 groups (as in table 1), there ... Nodal positivity correlated with histological grade and tumour size, but not with estrogen receptor or c-erbB-2 status. ...

16 McCann A H, Dervan P A, ORegan M, Codd M B, Gullick W J, Tobin B M. et al . Prognostic significance of c-erbB-2 and ... Immunhistochemical Research on Breast Cancer Cell Proliferation and Hormonal Receptor Status with Special Emphasis on HER-2/neu ... 18 Nicholson R I, McClelland R A, Finlay P, Eaton C L, Gullick W J, Dixon A R. et al . Relationship between EGF-R, c-erbB-2 ... 13 Gullick W J, Love S B, Wright C, Barnes D M, Gusterson B, Harris A L. et al . c-erbB-2 protein overexpression in breast ...

Keywords: Image Interpretation, Computer-Assisted, In Situ Hybridization, Fluorescence, Receptor, ErbB-2, Immunohistochemistry ... Accuracy of Digital Image Analysis (DIA) of Borderline Human Epidermal Growth Factor Receptor (HER2) Immunohistochemistry in ... human epidermal growth factor receptor 2 (HER2) immunohistochemistry (IHC) slides of invasive ductal carcinoma of the breast. ... In general, 2 major themes, 9 categories, and 45 related sub-categories were extracted from analyzing the findings of the ...

... receptor tyrosine-protein kinase erbB-2; ESCAT, European Society for Molecular Oncology Scale for Clinical Actionability of ... neurotrophic receptor tyrosine kinase (NTRK), and hepatocyte growth factor receptor (MET) exon 14 skipping mutations [9,10]. ... hepatocyte growth factor receptor; NSCLC, non-small cell lung cancer; NTRK, neurotrophic tyrosine receptor kinase; RET, ... hepatocyte growth factor receptor; NSCLC, non-small cell lung cancer; NTRK, neurotrophic tyrosine receptor kinase; RET, ...

The current study aimed to map the putative transactivation domains (TADs) of the HER3 receptor. To accomplish this goal, ... However, the regions of each receptor that confer transcriptional potential remain poorly defined. ... Nuclear localized HER family receptor tyrosine kinases (RTKs) have been observed in primary tumor specimens and cancer cell ... The ErbB/HER family of receptor tyrosine kinases (RTKs) consists of four family members: the epidermal growth factor receptor ( ...

Neuregulins Signaling via a Glial erbB-2-erbB-4 Receptor Complex Contribute to the Neuroendocrine Control of Mammalian Sexual ... Journal of Neuroscience 1 December 2017, 38 (2) 441-451; DOI: https://doi.org/10.1523/JNEUROSCI.1333-17.2017 ...

Neuregulins Signaling via a Glial erbB-2-erbB-4 Receptor Complex Contribute to the Neuroendocrine Control of Mammalian Sexual ...

The objective of this study was to determine the conversion rate of human epidermal growth factor receptor 2 (HER2), estrogen ... Edgerton SM, Moore D 2nd, Merkel D, Thor AD (2003) erbB-2 (HER-2) and breast cancer progression. Appl Immunohistochem Mol ... and the hormone receptors (HR), including estrogen receptor (ER) and progesterone receptor (PR), are the most relevant ... estrogen receptor (ER) and progesterone receptor (PR) between primary tumors and metastatic lesions in advanced breast cancer. ...

ErbB-3 class receptor binding. 1.34841233233438. bayes_pls_golite062009. *ErbB-2 class receptor binding ... 2. View Details. [405..474]. PSI-BLAST 89.09691 Crystal structure of P38 with triazolopyridine ...

Chromosomal assignment of five cancer-associated rat genes: Two thyroid hormone receptor (ERBA) genes, two ERBB genes and the ... Chromosomal assignment of five cancer-associated rat genes: two thyroid hormone receptor (ERBA) genes, two ERBB genes and the ... Loss of RALT/MIG-6 expression in ERBB2-amplified breast carcinomas enhances ErbB-2 oncogenic potency and favors resistance to ... CHROMOSOMAL ASSIGNMENT OF RETINOIC ACID RECEPTOR (RAR) GENES IN THE HUMAN, MOUSE, AND RAT GENOMESGenomics ...

... erb-b2 receptor tyrosine kinase 1; kinase EGFR; Oncogene ERBB; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1 ... EGFR belongs to the HER/ERbB family of proteins that includes three other receptor tyrosine kinases, ERbB2, ERbB3, ERbB4. EGFR ... Upon receptor activation and signaling, EGFR is endocytosed and targeted for degradation or recycling. Mutations in the EGFR ... MA5-14485 targets Epidermal Growth Factor Receptor in IHC (P) applications and shows reactivity with Human samples.. The MA5- ...

... is a 185 kDa receptor tyrosine kinase belonging to the epidermal growth factor receptor family, which also includes EGFR (HER-1 ... c-erbB-2/HER-2/neu (phospho-specific) Antibody Staining Protocol for Immunohistochemistry. ... Name: c-erbB-2/HER-2/neu (phospho-specific) Ab-18 Antibody ... neu and erbB-3. Tyr is the phosphorylation site that is most ... Cases of invasive breast carcinoma with the phosphorylated receptor have displayed aggressive clinicopathological features and ...

Epidermal growth factor receptor. A. 352. Homo sapiens. Mutation(s): 0 Gene Names: EGFR, ERBB1, ERBB, HER1. EC: 2.7.1.112 (PDB ... ErbB-1) and ErbB-2. We determined the crystal structure of EGFR bound to GW572016. The compound is bound to an inactive-like ... ErbB-1) and ErbB-2. We determined the crystal structure of EGFR bound to GW572016. The compound is bound to an inactive-like ... The differences in the off-rates of these drugs and the ability of GW572016 to inhibit ErbB-2 can be explained by the enzyme- ...