NIH Guide: TRANSGENIC RAT FOR STROKE RESEARCH
The term transgenic rat is used here broadly to include rats that demonstrate overexpression of genes, deletion of genes ( ... TRANSGENIC RAT FOR STROKE RESEARCH NIH GUIDE, Volume 24, Number 5, February 10, 1995 BAA/RFP AVAILABLE: NIH-NINDS-95-11 P.T. 34 ... Independent design and construction of transgenic rats for research concerning the diagnosis, pathophysiology, pathogenesis, ... is soliciting proposals for developing transgenic rats as an experimental model for the study of cerebral ischemia and stroke ...
P23H rhodopsin transgenic rat: correlation of retinal function with histopathology
However, the normal bleach recovery and the normal phototransduction sensitivity in this rat model are different from human ... The P23H transgenic rat has a slow rod degeneration with initially normal cone function, consistent with clinical findings of ... P23H rhodopsin transgenic rat: correlation of retinal function with histopathology Invest Ophthalmol Vis Sci. 2000 Sep;41(10): ... Purpose: To correlate retinal functional changes with structural changes in P23H rhodopsin transgenic rats as a model of ...
A Transgenic Rat for Specifically Inhibiting Adult Neurogenesis - PubMed
Here we report a transgenic rat (TK rat) that expresses herpes simplex virus thymidine kinase in GFAP+ cells. Upon treating TK ... A Transgenic Rat for Specifically Inhibiting Adult Neurogenesis Jason S Snyder 1 , Laura Grigereit 2 , Alexandra Russo 2 , ... in transgenic rats. B, Following valganciclovir treatment beginning at 8 weeks of age (7.5 mg/d, weekdays), v-TK rats gained ... A Transgenic Rat for Specifically Inhibiting Adult Neurogenesis Jason S Snyder et al. eNeuro. 2016. . ...
Neuron-Specific Genome Modification in the Adult Rat Brain Using CRISPR-Cas9 Transgenic Rats - PubMed
Here, we have developed several transgenic tools, including viral vectors and transgenic ra … ... Limitations in genome modification have, however, caused a lag in their use compared to the bevy of available transgenic mice. ... the rat has been the preferred animal model for behavioral studies. ... Neuron-Specific Genome Modification in the Adult Rat Brain Using CRISPR-Cas9 Transgenic Rats Susanne Bäck et al. Neuron. 2019. ...
RGD Reference Report - Cardiac hypertrophy in transgenic rats expressing a dominant-negative mutant of the natriuretic peptide...
In transgenic rats, NPR-BDeltaKC expression selectively reduced NPR-B but not NPR-A signaling. NPR-BDeltaKC transgenic rats ... Cardiac hypertrophy in transgenic rats expressing a dominant-negative mutant of the natriuretic peptide receptor B.. ... Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature ... was used to characterize CNP-dependent NPR-B signaling in vitro and in transgenic rats. Here we demonstrate that reduced CNP- ...
Chemical Chaperones and TUDCA Partially Suppress Degeneration of Retinal Photoreceptor Cells in Transgenic Mutant Rhodopsin...
Methods: : Transgenic rats and 661W cells were kindly provided by Dr. Matthew La Vail (UCSF) and by Muayyad Al-Ubaidi ( ... One purpose of this study was to investigate whether ER stress is induced in transgenic mutant rhodopsin S334ter-3 rats, which ... Conclusions: : The UPR appears to play a vital role in the transgenic mutant rhodopsin S334ter-3 rats. Chemical chaperones and ... Two hundred and fifty to five hundred mg of chemical chaperones were administered to newly born rats twice a day by gavage or ...
Transgenic model evaluation (Cyclophosphamide monohydrate) M970045
Early intraneuronal amyloid triggers neuron-derived inflammatory signaling in APP transgenic rats and human brain<...
Early intraneuronal amyloid triggers neuron-derived inflammatory signaling in APP transgenic rats and human brain. In: ... Early intraneuronal amyloid triggers neuron-derived inflammatory signaling in APP transgenic rats and human brain. Proceedings ... Laser microdissected neurons extracted from preplaque amyloid precursor protein (APP) transgenic rats were found to produce a ... Laser microdissected neurons extracted from preplaque amyloid precursor protein (APP) transgenic rats were found to produce a ...
Testimonials - Customized Transgenic Mouse and Rat Models | PolyGene
Cyclooxygenase-2 and ERBB-2 in Cholangiocarcinoma
Neu and COX-2 in Rat and Transgenic Mouse Models of Cholangiocarcinogenesis. Intrahepatic ChCs induced in the furan rat model ... Neu and COX-2 in Rat and Transgenic Mouse Models of Cholangiocarcinogenesis ... Neu and COX-2 in Rat and Transgenic Mouse Models of Cholangiocarcinogenesis ... the rat homologue of ERBB-2 (2 132). (D) Neoplastic gland in a well-differentiated rat tubular ChC exhibiting strongly positive ...
New Insight into Intrachromosomal Deletions Induced by Chrysotile in the gpt delta Transgenic Mutation Assay | Environmental...
Mutagenesis by asbestos in the lung of lambda-lacI transgenic rats. Mutat Res 553(1-2):67-78. 15288534. . Crossref, Medline, ... 2002). Recently, 8-hydroxydeoxyguanosine, an oxidative DNA damage marker, has been detected in Big Blue lacI transgenic rats ... mutation induction factors ranging from 1.1 to 3.2 in the omenta have been reported in Big Blue lacI transgenic rats injected ... The use of transgenic mouse systems carrying bacterial reporter genes such as lacZ, lacI, and cII has opened a promising ...
HLA-B27 transgenic Lewis rats and iritis after gram negative infection - Fingerprint - Oregon Health & Science University
Knockout rat - Wikipedia
Knockout rat models can also complement existing transgenic mouse models. Comparing mouse and rat mutants can facilitate the ... Biobreeding rat Genetics Gene knockout Lab animals Transgenic animal Abbott A: Laboratory animals: the Renaissance rat. Nature ... NIH Rat Genome & Genetics Scientists Compare Rat Genome With Human, Mouse Knock Out Rat Consortium (KORC) website National ... Rats are physiologically more similar to humans than are mice. For example, rats have a heart rate more similar to that of ...
NP03, a microdose lithium formulation, blunts early amyloid post-plaque neuropathology in McGill-R-Thy1-APP Alzheimer-like...
We administered NP03 (40 µg Li/kg; 1 ml/kg body weight) to McGill-R-Thy1-APP transgenic rats for 12 weeks spanning the ... The novel microdose lithium formulation, NP03, has disease-modifying effects in the McGill-R-Thy1-APP transgenic rat model of ... blunts early amyloid post-plaque neuropathology in McGill-R-Thy1-APP Alzheimer-like transgenic rats BIBLIOGRAPHIC THERAPEUTIC ...
Stopping Neurogenesis in Transgenic Mice and Rat Models that Express the HSV-thymidine kinase Gene in Neuronal Precursor Cells ...
Stopping Neurogenesis in Transgenic Mice and Rat Models that Express the HSV-thymidine kinase Gene in Neuronal Precursor Cells ... Stopping Neurogenesis in Transgenic Mice and Rat Models that Express the HSV-thymidine kinase Gene in Neuronal Precursor Cells ... These mice and rats are being used to inhibit adult neurogenesis in order to study the normal function of adult neurogenesis ... These transgenic animals could be used as models for diseases thought to feature deficits in adult neurogenesis, including ...
Genetic Toxicity Evaluation of Transgenic Model (Cyclophosphamide Monohydrate) (6055-19-2) in Micronucleus Study G10351 in...
... in Micronucleus Study G10351 in Wistar Han Rats. Genetic Toxicology. Summary and Individual Animal Data. * G04 - In Vivo ... Home » Chemical Effects in Biological Systems (CEBS) » Genetic Toxicity Evaluation of Transgenic Model (Cyclophosphamide ... Genetic Toxicity Evaluation of Transgenic Model (Cyclophosphamide Monohydrate) (6055-19-2) ... Monohydrate) (6055-19-2) in Micronucleus Study G10351 in Wistar Han Rats ...
Analysis of rat insulin II promoter-ghrelin transgenic mice and rat glucagon promoter-ghrelin transgenic mice - Keio...
Analysis of rat insulin II promoter-ghrelin transgenic mice and rat glucagon promoter-ghrelin transgenic mice. In: Journal of ... Analysis of rat insulin II promoter-ghrelin transgenic mice and rat glucagon promoter-ghrelin transgenic mice. Journal of ... Analysis of rat insulin II promoter-ghrelin transgenic mice and rat glucagon promoter-ghrelin transgenic mice. / Iwakura, ... title = "Analysis of rat insulin II promoter-ghrelin transgenic mice and rat glucagon promoter-ghrelin transgenic mice", ...
Sub-chronic (13-week) oral toxicity study in rats with recombinant human lactoferrin produced in the milk of transgenic cows |...
rat. toxicity testing. transgenic animal. Animals. Animals, Genetically Modified. Behavior, Animal. Blood Cell Count. Blood ... Sub-chronic (13-week) oral toxicity study in rats with recombinant human lactoferrin produced in the milk of transgenic cows. ... Sub-chronic (13-week) oral toxicity study in rats with recombinant human lactoferrin produced in the milk of transgenic cows. ... produced in the milk of transgenic cows was investigated in Wistar rats by daily administration via oral gavage for 13 ...
Ricebag to treat soft tissue injuries | ScienceDaily
Proton-gated Ca2+-permeable TRP channels damage myelin in conditions mimicking ischaemia | Nature
Experiments used Sprague-Dawley rats or transgenic mice of either sex. Data are from rats unless stated otherwise. Animal ... Using in situ hybridization, a TRPA1 probe labelled cerebellar white matter in rat and mouse, while a TRPV3 probe labelled rat ... in rats and mice) and TRPV3 mRNA is present (in rats but not mice) in myelinating oligodendrocytes (Olig2+, CC1+: arrowheads) ... a, In situ data for TRPA1 and TRPV3 in the cerebellum of rats and mice show TRPA1 messenger RNA in white matter (WM) cells in ...
Biomarkers Search
Pluripotent stem cell-derived organogenesis in the rat model system.. Hirabayashi M; Goto T; Hochi S. Transgenic Res; 2019 Aug ... 2. Generation of rat pancreas in mouse by interspecific blastocyst injection of pluripotent stem cells.. Kobayashi T; Yamaguchi ... Contribution of rat embryonic stem cells to xenogeneic chimeras in blastocyst or 8-cell embryo injection and aggregation. ... 1. Generation of pluripotent stem cell-derived mouse kidneys in Sall1-targeted anephric rats.. Goto T; Hara H; Sanbo M; Masaki ...
Anti-Beta-Amyloid Passive Immunotherapy for Alzheimer's Dementia and Amyloid Related Imaging Abnormalities (ARIA): What's Next?...
Transgenic rats may be a more promising model than mice for CAA. They are phylogenetically closer to humans than mice, have ... Another rat model is rTg-D (Dutch mutation), which mimics CAA-Type 2 (larger vessels) and has more muted CAA-ri and ... rTg-DI, a rat model that expresses human APP with Dutch Iowa mutations, is good for studying CAA-type 1 (capillary amyloidosis ... Transgenic mice with CAA-related mutations in APP have also been well-characterized and, depending on the mutated gene, can ...
LE-Tg(Cx3cr1-cre/ERT2)3Ottc - Ontology Report - Rat Genome Database
LE transgenics. 0. Ottc:LE transgenics. 0. LE-Tg(Cx3cr1-cre/ERT2)3Ottc. 0. ... Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature ... The Rat Strain Ontology (RS) is currently being developed at the Rat Genome Database. For more information about this ... Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal ...
Biblio | Page 3 | Linus Pauling Institute | Oregon State University
National Institute of Environmental Health Sciences: Carcinogenicity Health Effects Innovation
These highlights do not include all the information needed to use BOSULIF safely and effectively. See full prescribing...
Bosutinib was not carcinogenic in rats or transgenic mice. The rat 2-year carcinogenicity study was conducted at bosutinib oral ... In a rat fertility and early embryonic development study, bosutinib was administered orally to female rats for approximately 3 ... In a rat fertility study, drug-treated males were mated with untreated females, or untreated males were mated with drug-treated ... In a rat pre- and postnatal development study, bosutinib was administered orally to pregnant animals during the period of ...