Germline Mutations in the Polyposis-Associated Genes BMPR1A, SMAD4, PTEN, MUTYH and GREM1 Are Not Common in Individuals with...
PTEN Phosphohydrolase * PTEN protein, human * DNA Glycosylases * mutY adenine glycosylase Grants and funding * R01 CA123010/CA/ ... A novel variant in intron 2 (c.164+223T,C) of PTEN was identified in one individual and was predicted by in silico analysis to ... Results: We found no variants that were likely to be deleterious germline mutations in the SPS cases in the PTEN, SMAD4, and ... Individuals with SPS were tested for coding mutations and large deletions in the PTEN, SMAD4, and BMPR1A genes, for the MUTYH ...
Category:Hydrolases - Wikimedia Commons
Hamartoma and lentiginosis syndromes: clinical and molecular aspects
PTEN Phosphohydrolase * Peutz-Jeghers Syndrome / genetics* * Phenotype * Phosphoric Monoester Hydrolases / genetics* * Tumor ... PTEN hamartoma-tumour syndrome [111]. Germline PTEN mutations are unlikely to cause JPS. However, germline SMAD4 mutation, ... Germline PTEN mutations appear to cause both CS and BRR. These two syndromes are therefore likely to be different ... It has been suggested that PTEN mutation-positive CS and BRR should be grouped as a single entity for clinical purposes and ...
Medical Science Monitor | Shikonin Inhibites Migration and Invasion of Thyroid Cancer Cells by Downregulating DNMT1 - Article...
Overexpression of DNMT1 promoted the migration of TPC-1 cells and the methylation of PTEN. Levels of protein expression of PTEN ... CONCLUSIONS:Shikonin suppressed the expression of DNMT1, reduced PTEN gene methylation, and increased PTEN protein expression, ... The methylation of PTEN was suppressed by shikonin, which also reduced the expression of DNMT1 in a dose-dependent manner, and ... Western blot was performed to determine the expression levels of PTEN and DNMT1 genes. A methylation-specific polymerase chain ...
Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase - Wikipedia
Other names in common use include PTEN,[citation needed] MMAC1, and phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase ... PTEN also refers to a member of the class, phosphatase and tensin homolog.[citation needed] This enzyme participates in 10 ... Maehama T, Dixon JE (1998). "The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, ... The systematic name is 1-phosphatidyl-D-myoinositol-3,4,5-trisphosphate 3-phosphohydrolase. ...
DeCS
PTEN Phosphohydrolase [D08.811.277.352.650.850] PTEN Phosphohydrolase Fructose-Bisphosphatase - Preferred Concept UI. M0010334 ... 1-Phosphohydrolase, D-Fructose-1,6-Bisphosphate D Fructose 1,6 Bisphosphate 1 Phosphohydrolase D-Fructose-1,6-Bisphosphate 1- ... 1-Phosphohydrolase, D-Fructose-1,6-Bisphosphate. D Fructose 1,6 Bisphosphate 1 Phosphohydrolase. D-Fructose-1,6-Bisphosphate 1- ... D-Fructose-1,6-bisphosphate 1-phosphohydrolase Public MeSH Note:. 94; was FRUCTOSE-1,6-DIPHOSPHATASE 1989-93; was ...
Leff, Alan | Profiles RNS
This is a "connection" page, showing publications Alan Leff has written about PTEN Phosphohydrolase. ... TAT-protein blockade during ischemia/reperfusion reveals critical role for p85 PI3K-PTEN interaction in cardiomyocyte injury. ... A novel pharmacological strategy by PTEN inhibition for improving metabolic resuscitation and survival after mouse cardiac ...
Cell survival. Medical search. Definitions
PTEN Phosphohydrolase. A lipid phosphatase that acts on phosphatidylinositol-3,4,5-trisphosphate to regulate various SIGNAL ... Epidermal Growth FactorMicrotubule-Associated ProteinsSurvival of Motor Neuron 1 ProteinPTEN PhosphohydrolaseCell Cycle ... Mutations in PTEN are associated with COWDEN DISEASE and PROTEUS SYNDROME as well as NEOPLASTIC CELL TRANSFORMATION.. ...
Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells - Projects - Discovery ...
Woojin Jeong - Research output - Ewha Womans University
Section of Medical Oncology - Research output
- Research Profiles at Washington University School of Medicine
Ryan Doan, Ph.D. | Harvard Catalyst Profiles | Harvard Catalyst
Fine-Tuning of PI3K/AKT Signalling by the Tumour Suppressor PTEN Is Required for Maintenance of Flight Muscle Function and...
Our data demonstrate that IIS levels must be precisely regulated by Pten in adults to maintain the function of the highly ... Adults carrying combinations of this allele, Pten5, combined with strong loss-of-function Pten mutations exhibit subtle or no ... We identified a novel hypomorphic allele of PI3Ks direct antagonist, Phosphatase and tensin homologue on chromosome 10 (Pten ... Animals, Drosophila Proteins, Drosophila melanogaster, Female, PTEN Phosphohydrolase, Phosphatidylinositol 3-Kinases, Protein ...
Loss of PTEN facilitates HIF-1-mediated gene expression. - Department of Oncology
Restoration of wild-type PTEN to glioblastoma cell lines lacking functional PTEN ablates hypoxia and IGF-1 induction of HIF-1- ... However, in these cell lines PTEN regulates hypoxia- and IGF-1-induced angiogenic gene expression by regulating Akt activation ... We propose that loss of PTEN during malignant progression contributes to tumor expansion through the deregulation of Akt ... In addition, Akt activation leads to HIF-1alpha stabilization, whereas PTEN attenuates hypoxia-mediated HIF-1alpha ...
Nilanjana Chatterjee | UCSF Profiles
Cyclins | Profiles RNS
PTEN Phosphohydrolase. *Receptor-Like Protein Tyrosine Phosphatases. *rho-Associated Kinases. *Ribosomal Protein S6 Kinases ...
Alonzo Ross's research topics | Profiles RNS
PTEN Phosphohydrolase * Tumor Suppressor Proteins * Glioblastoma * Brain Neoplasms * Phosphoric Monoester Hydrolases Explore _ ...
Modeling prostate cancer in mice: something old, something new, something premalignant, something metastatic. - Radcliffe...
PTEN Phosphohydrolase, Precancerous Conditions, Prostatic Neoplasms, Proto-Oncogenes, Signal Transduction ...
Igf2 ligand dependency of Pten(+/-) developmental and tumour phenotypes in the mouse. - Oxford Neuroscience
Importantly, we also show that the effects of Pten loss in vivo are modified by Igf2 supply, as lack of Igf2 results in ... However, it remains unknown whether neoplasia associated with Pten loss is dependent on upstream IGF ligand supply in vivo. We ... These data indicate that the effects of Pten loss at heterozygote levels commonly observed in human tumours are modified by ... A context-dependent interplay between IGFs and PTEN exists in normal tissue and tumours; increased IGF2 ligand supply induces ...
High expression of obesity-linked phosphatase SHIP2 in invasive breast cancer correlates with reduced disease-free survival. -...
PTEN Phosphohydrolase, Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases, Phosphoric Monoester Hydrolases, Prognosis, ...
BRCA1 Protein | Profiles RNS
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. | Profiles RNS
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature. 2005 Aug 04; 436(7051 ... Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. ... Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. ...
DeCS
AMP-Activated Protein Kinases | Profiles RNS
PTEN Phosphohydrolase. *Receptor-Like Protein Tyrosine Phosphatases. *rho-Associated Kinases. *Ribosomal Protein S6 Kinases ...
Taojian Tu | USC Profiles
4-Nitrophenylphosphatase | Profiles RNS
Mucin-4 | Profiles RNS
PTEN Phosphohydrolase. *Receptor-Like Protein Tyrosine Phosphatases. *rho-Associated Kinases. *Ribosomal Protein S6 Kinases ...
Adaptor Proteins, Signal Transducing | Profiles RNS
PTEN Phosphohydrolase. *Receptor-Like Protein Tyrosine Phosphatases. *rho-Associated Kinases. *Ribosomal Protein S6 Kinases ...