Transgenic Mouse Models of BCR/ABL-Positive Chronic Myelogenous Leukemia: A Review
| Bentham Science
... xenotransplantation of primary Ph-positive CML cells into immunodeficie ... There are three methods for making chronic myelogenous leukemia (CML) mouse models: ... chronic myelogenous, cml-phenotype, bcr, abl Abstract: There are three methods for making chronic myelogenous leukemia (CML) ... Transgenic Mouse Models of BCR/ABL-Positive Chronic Myelogenous Leukemia: A Review. Author(s): Koiti Inokuchi Volume 6, Issue 2 ...
Evolving concepts in the management of chronic myeloid leukemia: recommendations from an expert panel on behalf of the European...
... has revolutionized the treatment of chronic myeloid leukemia (CML). Although experience is too limited to permit evidence-based ... Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy * Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics ... Evolving concepts in the management of chronic myeloid leukemia: recommendations from an expert panel on behalf of the European ... The introduction of imatinib mesylate (IM) has revolutionized the treatment of chronic myeloid leukemia (CML). Although ...
IntronA | European Medicines Agency
Hepatitis B, Chronic. *Hepatitis C, Chronic. *Leukemia, Myelogenous, Chronic, BCR-ABL Positive ... Treatment of adult patients with Philadelphia-chromosome- or bcr/abl-translocation-positive chronic myelogenous leukaemia. ... Chronic hepatitis B. Treatment of adult patients with chronic hepatitis B associated with evidence of hepatitis-B viral ... who have chronic hepatitis C, not previously treated, without liver decompensation, and who are positive for HCV-RNA. When ...
Eosinophilia: Practice Essentials, Pathophysiology, Etiology
Chronic myelogenous leukemia (CML), Philadelphia chromosome positive (Ph+) or BCR-ABL positive ... The FIP1L1-PDGFRalpha fusion tyrosine kinase in hypereosinophilic syndrome and chronic eosinophilic leukemia: implications for ... from chronic eosinophilic leukemia-not otherwise specified (CEL-NOS). [1] WHO diagnostic criteria for CEL-NOS are as follows:. ... chronic lymphocytic leukemia (5.8%), and multiple myeloma (4.1%). [17] ...
Connie Rong Shi, M.D. | Harvard Catalyst Profiles | Harvard Catalyst
A Study of ASTX660 Alone or Combined with ASTX727 in Subjects with Relapsed/Refractory Acute Myeloid Leukemia (AML) - Mayo...
BCR-ABL-positive leukemia (chronic myelogenous leukemia in blast crisis).. *Diagnosis of acute promyelocytic leukemia (M3 AML ... A Study of ASTX660 Alone or Combined with ASTX727 in Subjects with Relapsed/Refractory Acute Myeloid Leukemia (AML). * Print ... Liver cirrhosis, or chronic liver disease Child-Pugh Class B or C. ... Known clinically active central nervous system (CNS) leukemia.. * ... acute myeloid leukemia (AML). The duration of the study is ...
STAT5 - Wikipedia
"Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia". Oncogene. 13 (2): 247-54. PMID ... "Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells". Nat. Med. 2 (5): 561-6. ... Different inhibitors have been designed to target different kinases: Inhibition of BCR/ABl constitutes the basis of the ... Leukemia. 23 (8): 1441-5. doi:10.1038/leu.2009.50. PMID 19295546. Behbod F, Nagy ZS, Stepkowski SM, Karras J, Johnson CR, ...
Leukemia
Summary Report | CureHunter
Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck ... Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular ... Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and ... Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 5. BCR-ABL Positive Chronic Myelogenous Leukemia ...
A high-content cytokine screen identifies myostatin propeptide as a positive regulator of primitive chronic myeloid leukemia...
Ren R. Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia. Nat Rev Cancer. 2005; 5(3):172-183. PubMed ... Hantschel O, Warsch W, Eckelhart E. BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia. Nat Chem Biol ... Cell cultures of transgenic BCR-ABL mouse cells. Transgenic ScltTA/BCR-ABL mice20 were taken off tetracycline pellets to induce ... Inducible chronic phase of myeloid leukemia with expansion of hematopoietic stem cells in a transgenic model of BCR-ABL ...
Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells,...
... bcr-abl, Gene Expression, Humans, Imatinib Mesylate, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Macrolides, Mice, Mice, ... bcr-abl; Gene Expression; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Macrolides; Mice; Mice, ... a potent inhibitor of the BCR/ABL tyrosine kinase, has become standard first-line therapy for patients with chronic myeloid ... a potent inhibitor of the BCR/ABL tyrosine kinase, has become standard first-line therapy for patients with chronic myeloid ...
Treatment Outcomes in Chronic Myeloid Leukemia: Does One Size Fit All? - McMaster Experts
Leukemia, Myelogenous, Chronic, BCR-ABL Positive (MeSH) * Oncology & Carcinogenesis (Science Metrix) * Protein Kinase ... Treatment Outcomes in Chronic Myeloid Leukemia: Does One Size Fit All? Journal Articles ... With the success of tyrosine kinase inhibitors (TKIs) in achieving next-to-normal overall survival in chronic myeloid leukemia ... Discontinuation of therapy is attractive to both patients and physicians because maintaining a stable BCR-ABL transcript level ...
Cell Structure and Function
... kinase BCR-ABL activates a variety of signaling pathways and plays a causative role in the pathogenesis of chronic myelogenous ... BCR-ABL-positive granules were not colocalized with any markers for membrane-bound organelles but were colocalized with HSP90a ... leukemia (CML); however, the subcellular distribution of this chimeric protein remains controversial. Here, we report that BCR- ... Whereas wild-type BCR-ABL rescued the growth defect in IL-3-depleted Ba/F3 cells, mutant BCR-ABL lacking the N-terminal region ...
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Sinan Ozkavukcu - Fingerprint - Discovery - the University of Dundee Research Portal
Clinical detection of BCR-ABL fusion by in situ hybridization in chronic myelogenous leukemia<...
... technique to detect residual Philadelphia chromosome-positive (Ph+) cells in a patient with blastic phase chronic myelogenous ... Clinical detection of BCR-ABL fusion by in situ hybridization in chronic myelogenous leukemia. / Amiel, A.; Yarkoni, S.; Fejgin ... Clinical detection of BCR-ABL fusion by in situ hybridization in chronic myelogenous leukemia. Cancer Genetics and Cytogenetics ... Clinical detection of BCR-ABL fusion by in situ hybridization in chronic myelogenous leukemia. In: Cancer Genetics and ...
Increased c‑SRC expression is involved in acquired resistance to lenvatinib in hepatocellular carcinoma
... is widely used for treating chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia, is ... BCR-ABL, PDGFRβ, and c-Kit among tyrosine kinases and is reported as a potent inhibitor of c-SRC (IC50: 0.5 nmol/l) (46). In ... Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N Engl J Med. 354:2531-2541. 2006. View Article : ... hematologic and cytogenetic responses in adult patients with Philadelphia chromosome positive acute lymphoblastic leukemia with ...
Cytotoxic T cell response against the chimeric p210 BCR-ABL protein in patients with chronic myelogenous leukemia - Research -...
Such CTL recognize HLA-matched, BCR-ABL-positive leukemic cells, implying efficient natural processing and presentation of ... Cytotoxic T cell response against the chimeric p210 BCR-ABL protein in patients with chronic myelogenous leukemia. ... Human chronic myelogenous leukemia (CML) is characterized by a translocation between chromosomes 9 and 22 that results in a BCR ... ABL fusion gene coding for chimeric proteins. The junctional region of the BCR-ABLb3a2 molecule represents a potential leukemia ...
Chronic Myelogenous Leukemia | Treatment Update
Treatment updates have become available for people living with Chronic Myelogenous Leukemia (CML). ... PF-114 is an inhibitor of the mutated BCR-ABL gene and is active against Philadelphia chromosome-positive leukemias, and may be ... Treatment Update: Chronic Lymphocytic Leukemia. This Publication Is Tagged With. Tags:. leukemiachronic myelogenous leukemia ... in which the ABL gene is mistakenly joined to the BCR gene, forming a mutated BCR-ABL "fusion gene." The BCR-ABL gene leads to ...
Cancer Discovery News | American Association for Cancer Research
Bosutinibs (Bosulif; Pfizer) label expanded to include pediatric chronic myelogenous leukemia. The BCR-ABL and Src tyrosine ... the FDAs go-ahead as a treatment option for patients age 1 and older with chronic phase Philadelphia chromosome-positive ... Gilead pulled the plug on evaluating magrolimab in TP53-mutant acute myeloid leukemia (AML). The company concluded that its ...
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Fusion Proteins, bcr-abl | Profiles RNS
LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; and NEUTROPHILIC LEUKEMIA, CHRONIC. ... bcr-abl" by people in this website by year, and whether "Fusion Proteins, bcr-abl" was a major or minor topic of these ... Proto-Oncogene Proteins c-abl [D08.811.913.696.620.682.725.500]. *Fusion Proteins, bcr-abl [D08.811.913.696.620.682.725.500.500 ... "Fusion Proteins, bcr-abl" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ...
Adelaide Research & Scholarship: OCT-1-mediated influx is a key determinant of the intraceflular uptake of imatinib but not...
Leukemia, Myelogenous, Chronic, BCR-ABL Positive. -. dc.subject. Imatinib Mesylate. -. dc.title. OCT-1-mediated influx is a key ... IC50 values for the more potent BCR-ABL inhibitor nilotinib (AMN107) did not correlate with IC50(imatinib) (R(2) =-0.0561, P ... Intrinsic sensitivity of newly diagnosed chronic myeloid leukemia (CML) patients to imatinib (IC50(imatinib)) correlates with ...
Ablation of Fbxw7 Eliminates Leukemia-Initiating Cells by Preventing Quiescence<...
Leukemia, Myelogenous, Chronic, BCR-ABL Positive Medicine & Life Sciences 69% * Hematopoietic Stem Cells Medicine & Life ... Imatinib eradicates dividing progenitor cells of chronic myeloid leukemia (CML) but does not effectively target nondividing ... abstract = "Imatinib eradicates dividing progenitor cells of chronic myeloid leukemia (CML) but does not effectively target ... N2 - Imatinib eradicates dividing progenitor cells of chronic myeloid leukemia (CML) but does not effectively target ...
Lifestyle and dietary factors in relation to risk of chronic myeloid leukemia in the NIH-AARP diet and health study<...
Leukemia, Myelogenous, Chronic, BCR-ABL Positive Medicine & Life Sciences 100% * Life Style Medicine & Life Sciences 77% ... Lifestyle and dietary factors in relation to risk of chronic myeloid leukemia in the NIH-AARP diet and health study. In: Cancer ... Lifestyle and dietary factors in relation to risk of chronic myeloid leukemia in the NIH-AARP diet and health study. Cancer ... Lifestyle and dietary factors in relation to risk of chronic myeloid leukemia in the NIH-AARP diet and health study. / Kabat, ...
WikiGenes - Leukemia, Myeloid, Chronic
Targeting the BCR-ABL tyrosine kinase in chronic myeloid leukemia [10].. *Characteristic of chronic myelogenous leukemia (CML) ... Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in ... Isotretinoin for juvenile chronic myelogenous leukemia [15].. *Specific targeted therapy of chronic myelogenous leukemia with ... The BCR/ABL oncogene encodes an activated tyrosine kinase that causes human chronic myelogenous leukemia [30]. ...
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DeCS
Leukemia, Myelogenous, Chronic, BCR-ABL Positive Entry term(s). Chronic Granulocytic Leukemia Chronic Granulocytic Leukemias ... Myelogenous Leukemia, Ph1 Positive Myelogenous Leukemia, Ph1-Positive Myelogenous Leukemias, Chronic Myelogenous Leukemias, Ph1 ... Myelogenous Leukemia, Chronic. Myelogenous Leukemia, Ph1 Positive. Myelogenous Leukemia, Ph1-Positive. Myelogenous Leukemias, ... Chronic Myelocytic Leukemia Chronic Myelocytic Leukemias Chronic Myelogenous Leukemia Chronic Myelogenous Leukemias Chronic ...
Azacitidine
It has been approved in Europe to treat myelodysplastic syndromes, myeloid leukemia acute, and myelomonocytic leukemia chronic. ... It is used to treat myelomonocytic leukemia chronic, refractory anemia, and sideroblastic anemia in the USA. ... Bcr-abl positive chronic myelogenous leukemia. D015464. EFO_0000340. 4. 5. 1. -. -. 9. ... B-cell chronic lymphocytic leukemia. D015451. C91.1. 5. 2. -. -. -. 7. Breast neoplasms. D001943. EFO_0003869. C50. 3. 5. -. - ...
Section of Medical Oncology - Research output
- Research Profiles at Washington University School of Medicine
Concomitant JAK2 V617F-positive polycythemia vera and BCR-ABL-positive chronic myelogenous leukemia treated with ruxolitinib ... Chronic lymphocytic leukemia/small lymphocytic lymphoma, version 1.2015. Zelenetz, A. D., Gordon, L. I., Wierda, W. G., ... Extended treatment with brentuximab vedotin in patients with relapsed or refractory CD30-positive hematological malignancies. ... Leukemia and Lymphoma. 56, 9, p. 2569-2578 10 p.. Research output: Contribution to journal › Article › peer-review ...
StemTherapy: National Initiative on Stem Cells for Regenerative Therapy - Research output
- Lund University
Leukemia, Myelogenous, Chronic, BCR-ABL Positive 100% * Protein-Tyrosine Kinases 86% * Imatinib Mesylate 81% ... Chronic myeloid leukemia - A model disease for targeted therapy. Richter, J. & Stenke, L., 2017, In: Läkartidningen. 114, 39, p ... Cellular plasticity in B-cell leukemia. Somasundaram, R., Strid, T. & Sigvardsson, M., 2017, In: Cell Cycle. 16, 6, p. 495-496 ... Impact of treatment delay in acute myeloid leukemia revisited. The Swedish AML Group, 2021 Feb 9, In: Blood Advances. 5, 3, p. ...