Hypoxia-inducible factor-proline dioxygenase - Wikipedia
... hypoxia-inducible factor-trans-4-hydroxy-L-proline + succinate + CO2 Hypoxia-inducible factor-proline dioxygenase contains iron ... Hypoxia-inducible factor-proline dioxygenase (EC 1.14.11.29, HIF hydroxylase) is an enzyme with systematic name hypoxia- ... Hypoxia-inducible+factor-proline+dioxygenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: ... In humans, there are three isoforms of hypoxia-inducible factor-proline dioxygenase. These are PHD1, PHD2 and PHD3. PHD2, in ...
Research resource: Transcriptional profiling reveals different pseudohypoxic signatures in SDHB and VHL-related...
Hypoxia-Inducible Factor 1, alpha Subunit / metabolism * Hypoxia-Inducible Factor-Proline Dioxygenases ... The analysis revealed a hypoxia-inducible factor (HIF)-related signature common to succinate dehydrogenase (SDH) and von Hippel ... Hypoxia-Inducible Factor 1, alpha Subunit / genetics * ... Hypoxia-Inducible Factor-Proline Dioxygenases * SDHB protein, ...
Albumin suppresses vascular endothelial growth factor via alteration of hypoxia-inducible factor/hypoxia-responsive element...
Procollagen-Proline Dioxygenase Neuroscience 16% View full fingerprint Cite this. * APA * Author ... Albumin suppresses vascular endothelial growth factor via alteration of hypoxia-inducible factor/hypoxia-responsive element ... Albumin suppresses vascular endothelial growth factor via alteration of hypoxia-inducible factor/hypoxia-responsive element ... title = "Albumin suppresses vascular endothelial growth factor via alteration of hypoxia-inducible factor/hypoxia-responsive ...
"Evolutionary history of Tibetans inferred from whole-genome sequencing" by Hao Hu, Nayia Petousi et al.
Hypoxia-Inducible Factor-Proline Dioxygenases; Male; Molecular Sequence Annotation; Proteins; Receptors, Calcitriol; Selection ... Adaptation, Physiological; Altitude; Basic Helix-Loop-Helix Transcription Factors; Cytochrome P-450 Enzyme System; Female; ...
Section of Medical Oncology - Research output
- Research Profiles at Washington University School of Medicine
Lyons, O. T.<...
Vitamin C1 | Basicmedical Key
Four prolyl 4-hydroxylases add hydroxyl groups to proline in hypoxia-inducible factor (HIF) (17). Two additional dioxygenases, ... Nine dioxygenases add hydroxyl groups to proline or lysine. Of these, three prolyl 4-hydroxylase isoenzymes add hydroxyl groups ... In mammals, vitamin C is a cofactor for 14 different enzymes that are either monooxygenases or dioxygenases (Table 29.1). The ... The remaining 12 mammalian enzymes are dioxygenases, which incorporate molecular oxygen (O2), but with each oxygen atom ...
Endogenous 2-oxoacids differentially regulate expression of oxygen sensors<...
keywords = "Hypoxia, Hypoxia-inducible factor (HIF), Oxaloacetate, Oxygen sensor, Prolyl hydroxylase, Pyruvate", ... These enzymes are oxygen-, iron- and 2-oxoglutarate-dependent dioxygenases that hydroxylate key proline and asparagine residues ... Such adaptations rely upon gene expression regulated by the heterodimeric transcription factors HIFs (hypoxia-inducible factors ... Such adaptations rely upon gene expression regulated by the heterodimeric transcription factors HIFs (hypoxia-inducible factors ...
Ferrous gluconate: Uses, Interactions, Mechanism of Action | DrugBank Online
... the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific ... Peptidyl-proline dioxygenase activity. Specific Function. Cellular oxygen sensor that catalyzes, under normoxic conditions, ... Transcription factor binding. Specific Function. Responsible for the deacetylation of lysine residues on the N-terminal part of ... Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and ...
Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1). - Target...
The hypoxic response in animals is mediated via the transcription factor hypoxia-inducible factor (HIF). An oxygen-sensing ... Hypoxia-Inducible Factor 1, Hypoxia-Inducible Factor-Proline Dioxygenases, Molecular Sequence Data, Nitric Oxide, Procollagen- ... The hypoxic response in animals is mediated via the transcription factor hypoxia-inducible factor (HIF). An oxygen-sensing ... Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1). ...
Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases. - Immunology
... hypoxia) in animals. The levels of HIF-α isoforms are regulated in an oxygen-dependent manner by the activity of the HIF prolyl ... The hypoxia inducible factor (HIF) system is central to the signaling of low oxygen ( ... Hypoxia-Inducible Factor 1, alpha Subunit, Hypoxia-Inducible Factor-Proline Dioxygenases, Inhibitory Concentration 50, Models, ... The hypoxia inducible factor (HIF) system is central to the signaling of low oxygen (hypoxia) in animals. The levels of HIF-α ...
Therapeutic manipulation of the HIF hydroxylases. - Department of Physiology, Anatomy and Genetics (DPAG)
By regulating the expression of a large array of target genes during hypoxia, these proteins also direct adaptive changes in ... family of transcription factors is responsible for coordinating the cellular response to low oxygen levels in animals. ... regulate the stability and transcriptional activity of the HIF-alpha subunit by catalyzing hydroxylation of specific proline ... The hypoxia-inducible factor (HIF) family of transcription factors is responsible for coordinating the cellular response to low ...
DeCS 2014 - New terms
Hypoxia-Inducible Factor-Proline Dioxygenases. Prolina Dioxigenases do Fator Induzível por Hipóxia. Prolina Dioxigenasas del ... MEF2 Transcription Factors. Fatores de Transcrição MEF2. Factores de Transcripción MEF2. Mad2 Proteins. Proteínas Mad2. ... Factor Inducible por Hipoxia. Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase. 3-Hidroxiacil-CoA Desidrogenase de Cadeia Longa. 3- ... D23 - Biological Factors. Histocompatibility Antigen H-2D. Antígeno de Histocompatibilidade H-2D. Antígeno de ...
DeCS 2014 - Novos termos
DeCS 2014 - Novos termos
DeCS 2014 - New terms
Hypoxia-Inducible Factor-Proline Dioxygenases. Prolina Dioxigenases do Fator Induzível por Hipóxia. Prolina Dioxigenasas del ... MEF2 Transcription Factors. Fatores de Transcrição MEF2. Factores de Transcripción MEF2. Mad2 Proteins. Proteínas Mad2. ... Factor Inducible por Hipoxia. Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase. 3-Hidroxiacil-CoA Desidrogenase de Cadeia Longa. 3- ... D23 - Biological Factors. Histocompatibility Antigen H-2D. Antígeno de Histocompatibilidade H-2D. Antígeno de ...
DeCS 2014 - New terms
Hypoxia-Inducible Factor-Proline Dioxygenases. Prolina Dioxigenases do Fator Induzível por Hipóxia. Prolina Dioxigenasas del ... MEF2 Transcription Factors. Fatores de Transcrição MEF2. Factores de Transcripción MEF2. Mad2 Proteins. Proteínas Mad2. ... Factor Inducible por Hipoxia. Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase. 3-Hidroxiacil-CoA Desidrogenase de Cadeia Longa. 3- ... D23 - Biological Factors. Histocompatibility Antigen H-2D. Antígeno de Histocompatibilidade H-2D. Antígeno de ...
DeCS 2014 - Novos termos
DeCS 2014 - New terms
Hypoxia-Inducible Factor-Proline Dioxygenases. Prolina Dioxigenases do Fator Induzível por Hipóxia. Prolina Dioxigenasas del ... MEF2 Transcription Factors. Fatores de Transcrição MEF2. Factores de Transcripción MEF2. Mad2 Proteins. Proteínas Mad2. ... Factor Inducible por Hipoxia. Long-Chain-3-Hydroxyacyl-CoA Dehydrogenase. 3-Hidroxiacil-CoA Desidrogenase de Cadeia Longa. 3- ... D23 - Biological Factors. Histocompatibility Antigen H-2D. Antígeno de Histocompatibilidade H-2D. Antígeno de ...
Hypoxia inducible element 1 (Hif1) is a tension responsive transcription element, - New dimension in therapeutic targeting of...
Prolyl hydroxylases (PH) are people of a protracted category of Fe (II) and 2-oxoglutarate reliant dioxygenases [22], which ... is usually a cell-permeable inhibitor of both proline and asparaginyl hydroxylases 1234423-95-0 supplier [24], that may ... molecule inhibitors of prolylhydroxylases consist of compounds that are structural analogs towards the 2-oxoglutarate co-factor ... Hypoxia escalates the degrees of the hypoxia inducible element (HIF), a transcription element that alters gene manifestation ...
The Nobel Prize in Physiology or Medicine 2019 - Advanced information - NobelPrize.org
... hypoxia inducible factor) transcription factor. The discovery of this factor had its roots in the work done by a number of ... Proline hydroxylation requires oxygen, and thus the elegant mechanism of post-translational regulation of HIF-1α and EPAS1 ... elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 107, 43-54 ... hypoxia). The latter factor was consequently termed the hypoxia-inducible factor (HIF) by Semenza (Semenza and Wang, 1992). ...
Celastrol inhibits the HIF-1α pathway by inhibition of mTOR/p70S6K/eIF4E and ERK1/2 phosphorylation in human hepatoma cells
Among these transcription factors, hypoxia-inducible factor-1 (HIF-1) is one of the most important factors that play a critical ... Epstein AC, Gleadle JM, McNeill LA, et al: C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that ... Ivan M, Kondo K, Yang H, et al: HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 ... Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which ...
Browse Items · NEOMED Bibliography Database
... hypoxia, Hypoxia-Inducible Factor 1, Hypoxia-Inducible Factor-Proline Dioxygenases/antagonists & inhibitors/metabolism, Inbred ... The stromal cell-derived factor-1 (SDF-1):CXCR4 is important in myocardial repair. In this study we tested the hypothesis that ... Cell Hypoxia, Cell Line, Chilian William M, CXCR4/deficiency/genetics/*metabolism, Department of Integrative Medical Sciences, ... Time Factors, Up-Regulation, Ventricular Function, Weber Kristal ...
Browse Items · NEOMED Bibliography Database
... hypoxia, Hypoxia-Inducible Factor 1, Hypoxia-Inducible Factor-Proline Dioxygenases/antagonists & inhibitors/metabolism, Inbred ... The stromal cell-derived factor-1 (SDF-1):CXCR4 is important in myocardial repair. In this study we tested the hypothesis that ... Cell Hypoxia, Cell Line, Chilian William M, CXCR4/deficiency/genetics/*metabolism, Department of Integrative Medical Sciences, ... Time Factors, Up-Regulation, Ventricular Function, Weber Kristal ...
Frontiers | Carnosine Supplementation Enhances Post Ischemic Hind Limb Revascularization
1996). Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol. Cell. Biol. 16, ... 2001). C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell ... 2001). HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 292, 464- ... Berra, E., Ginouves, A., and Pouyssegur, J. (2006). The hypoxia-inducible-factor hydroxylases bring fresh air into hypoxia ...
The use of dioxygen by HIF prolyl hydroxylase (PHD1). - NDM Research Building
The hypoxic response in animals is mediated by hydroxylation of proline residues in the alpha-subunit of hypoxia inducible ... factor (HIF). Hydroxylation is catalysed by prolyl-4-hydroxylases (PHD isozymes in humans) which are iron(II) and 2- ... hypoxic response in animals is mediated by hydroxylation of proline residues in the alpha-subunit of hypoxia inducible factor ( ... Procollagen-Proline Dioxygenase, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ...
DeCS 2017 - July 04, 2017 version
Factor-Proline Dioxygenase, Hypoxia-Inducible use Hypoxia-Inducible Factor-Proline Dioxygenases Factor-Proline Dioxygenases, ... Hypoxia-Inducible use Hypoxia-Inducible Factor-Proline Dioxygenases Factories, Industrial use Manufacturing and Industrial ... Factor-beta, Glia Maturation use Glia Maturation Factor Factor-Hemagglutinin, Lymphocytosis-Promoting use Virulence Factors, ... Factor, Brain-Derived Neurotrophic use Brain-Derived Neurotrophic Factor Factor, C-Subunit CCAAT-Binding use CCAAT-Binding ...
SMART: Secondary literature for P4Hc domain
Our results indicate that PHalpha(I), an essential enzyme for collagen synthesis, is a target gene for hypoxia-inducible factor ... Prolyl 4-hydroxylase [procollagen-proline, 2-oxyglutarate 4-dioxygenase; procollagen-L-proline, 2-oxoglutarate:oxygen ... Electrophoretic mobility shift assay revealed that hypoxia-inducible factor-1 was stimulated and bound to the PHalpha(I) HRE ... L-proline) binding of the type II prolyl 4-hydroxylase. Keywords: collagen/dioxygenases/peptide-binding domain/ proline-rich/ ...
Tryptophan | Encyclopedia MDPI
Similar to hypoxia, tissue inflammation activates hypoxia-inducible factor 1α, which modifies tissue metabolism to impaired ... 3-dioxygenase; IDO, Indoleamine 2,3-dioxygenase; KynU, Kynureninase; KATs, Kynurenine aminotransferases; KMO, Kynurenine 3- ... Metabolomic analyses show an association between low Trp and histidine levels and elevated glutamine and proline levels in age- ... In addition to the Trp signaling cascade directly inducing the expression of myogenic factors in C2 C12 myoblasts, a second Trp ...
O(2)-sensing signal cascade: clamping of O(2) respiration, reduced ATP utilization, and inducible fumarate respiration. |...
Hypoxia-Inducible Factor 1, alpha Subunit. * Lactic Acid. * Mice. * Myocardial Contraction. * Myocytes, Cardiac ... Procollagen-Proline Dioxygenase. * Signal Transduction. authors with profiles * Craig Cano Beeson. * Robin C. Muise-Helmericks ... O(2)-sensing signal cascade: clamping of O(2) respiration, reduced ATP utilization, and inducible fumarate respiration. Am J ... O(2)-sensing signal cascade: clamping of O(2) respiration, reduced ATP utilization, and inducible fumarate respiration. ...