... a Hydroxymethylglutaryl-CoA reductase (EC 1.1.1.88) is an enzyme that catalyzes the chemical reaction (R)-mevalonate + CoA + 2 ... acylating CoA)". Biochemistry. 4 (10): 2086-2090. doi:10.1021/bi00886a025. Hydroxymethylglutaryl-CoA+reductase at the U.S. ... beta-hydroxy-beta-methylglutaryl CoA-reductase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and hydroxymethylglutaryl ... CoA, and NAD+, whereas its 3 products are 3-hydroxy-3-methylglutaryl-CoA, NADH, and H+. This enzyme belongs to the family of ...

HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS drug classes, patent expirations, and list of drugs by class ... Drugs in MeSH Category Hydroxymethylglutaryl-CoA Reductase Inhibitors. ⮩ Send this page by email. ✉ Email this page to a ...

ATP + L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase] <=> ADP + H(+) + O-phospho-L-seryl-[3-hydroxy-3-methylglutaryl- ... hydroxymethylglutaryl-CoA reductase (NADPH)] kinase Alternative Name(s). [hydroxymethylglutaryl-CoA reductase (NADPH2)] kinase ... hydroxymethylglutaryl-CoA reductase kinase. hydroxymethylglutaryl coenzyme A reductase kinase. hydroxymethylglutaryl coenzyme A ... beta-hydroxy-beta-methylglutaryl-CoA reductase kinase. HMG-CoA reductase kinase. ...

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HMG-CoA) reductase and thereby reducing cholesterol synthesis. In X-ray crystallographic studies, we have determined the ... Hydroxymethylglutaryl CoA Reductases / metabolism * Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use* * Liver ... Statin inhibition of HMG-CoA reductase: a 3-dimensional view Atheroscler Suppl. 2003 Mar;4(1):3-8. doi: 10.1016/s1567-5688(03) ... Statins act by inhibiting 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and thereby reducing cholesterol synthesis ...

ClinicalTrials.gov: Hydroxymethylglutaryl-CoA Reductase Inhibitors (National Institutes of Health) * ClinicalTrials.gov: ...

... hydroxymethylglutaryl-CoA synthase/reductase; LDLR, low-density lipoprotein receptor; LPIN, lipin; MMP9, matrix ... h Liver acetyl-CoA levels. i qPCR analysis of liver mRNA levels of gt/gt mice relative to wt, studied relative to TATA-box- ... ACSL1, acyl-CoA synthetase long-chain family member 1; AUC, area under the curve; CEBPA, CCAAT-enhancer-binding protein alpha; ... ACSL1, acyl-CoA synthetase long-chain family member 1; ACTA2, actin alpha 2, smooth muscle; ALT, alanine aminotransferase; AST ...

Hydroxymethylglutaryl-CoA Reductase Inhibitors / adverse effects* * Hydroxymethylglutaryl-CoA Reductase Inhibitors / ...

HMGCoA-reductase. hydroxymethylglutaryl-CoA-reductase (EC 1.1.1.34). HPLC. high-performance liquid chromatography. LDH. lactate ... These results suggest an indirect modulation of hydroxymethylglutaryl-CoA-reductase activity as the most likely inhibitory ... the inhibiting effect of artichoke extracts indicating an inhibition at the level of hydroxymethylglutaryl-CoA-reductase. ... In addition, the stimulation of HMGCoA-reductase activity by insulin was efficiently blocked by the extracts, although other ...

JID: 7902782; 0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors); R16CO5Y76E ( ...

Geelen, M. H., Gibson, D. & Rodwell, V. Hydroxymethylglutaryl-CoA reductase-the rate-limiting enzyme of cholesterol ... Grundy, S. M. HMG-CoA reductase inhibitors for treatment of hypercholesterolemia. N. Engl. J. Med. 319, 24-33 (1988). ... Highly sensitive assay of HMG-CoA reductase activity by LC-ESI-MS/MS. J. Lipid Res. 48, 1212-1220 (2007). ... Thyroid-stimulating hormone decreases HMG-CoA reductase phosphorylation via AMP-activated protein kinase in the liver. J. Lipid ...

KEY WORDS: Dyslipidemias; Diabetes mellitus, type 2; Lipids; Cholesterol; Hydroxymethylglutaryl-CoA reductase inhibitors ...

Unexpectedly, HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase) and G6PD (glucose-6-phosphate dehydrogenase), the rate-limiting ... and C19-steroids upon hepatic sterol synthesis and hydroxymethylglutaryl-CoA reductase activity. Arch Biochem Biophys. 1970;140 ... Unexpectedly, HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase) and G6PD (glucose-6-phosphate dehydrogenase), the rate-limiting ... 3-hydroxy-3-methylglutaryl-CoA reductase) and G6DP (glucose-6-phosphate dehydrogenase), the rate-limiting enzymes of ...

5. Hepatic cholesterol synthesis and hydroxymethylglutaryl CoA reductase activity after injection of methylazoxymethanol ...

There are two distinct classes of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase enzymes: class I consists of eukaryotic ... Class I HMG-CoA reductases catalyse the NADP-dependent synthesis of mevalonate from 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA). ... Class II HMG-CoA reductases catalyse the reverse reaction of class I enzymes, namely the NAD-dependent synthesis of HMG-CoA ... In archaea, HMG-CoA reductase is a cytoplasmic enzyme involved in the biosynthesis of the isoprenoids side chains of lipids [ ( ...

... acetylating-CoA); 3-hydroxy-3-methylglutaryl CoA reductase (NADPH); hydroxymethylglutaryl-CoA reductase (NADPH2). ... hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} and reactivated by EC 3.1.3.47 {[hydroxymethylglutaryl-CoA reductase ( ... hydroxymethylglutaryl-CoA reductase (NADPH). Reaction:. (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 ... S-3-hydroxy-3-methylglutaryl-CoA reductase (ambiguous); NADPH-hydroxymethylglutaryl-CoA reductase; HMGCoA reductase-mevalonate: ...

Hydroxymethylglutaryl-CoA Reductase Inhibitors 90% * Case-Control Studies 74% * Registries 73% * Population Control 10% ...

... coenzyme A reductase or HMG-CoA (statins are also called HMG-CoA inhibitors). HMG-CoA is one step in the process the liver ... Statins like Mevacor and Zocor bind with a cholesterol precursor chemical called hydroxymethylglutaryl- ...

Hydroxymethylglutaryl-CoA Reductase Inhibitors, Peripheral Arterial Disease, Risk Factors ...

... a moderate dose of a hydroxymethylglutaryl coenzyme A (HMG CoA) reductase inhibitor may be appropriate if the amount of ... HMG-CoA reductase inhibitors (statins). For patients with mixed hyperlipidemias (elevations of both LDL cholesterol and ...

... human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor ... Williams D and Feely J (2002) Pharmacokinetic-pharmacodynamic drug interactions with HMG-CoA reductase inhibitors. Clin ... In the last few years, statins, HMG-coenzyme A reductase inhibitors, became an important class of drugs, widely used in clinics ...

This explains why bacterial fermentation and inhibition of hydroxymethylglutaryl-CoA reductase, a protein that regulates ...

By inhibiting the 3-hydroxy-methylglutaryl coenzyme A (HMG-CoA) reductase, statins block the conversion of 3-hydroxy- ... U. Laufs, V. La Fata, J. Plutzky, and J. K. Liao, "Upregulation of endothelial nitric oxide synthase by HMG CoA reductase ... GPx oxidizes GSH to form glutathione disulfide (GSSG), a reaction that is reversed by the glutathione reductase, a NADPH- ... The thioredoxin (TRX) system, integrated by thioredoxin, NADPH, and thioredoxin reductase, regulates the equilibrium between ...

... in Agrobacterium tumefaciens by the additional use of a truncated version of the enzyme hydroxymethylglutaryl CoA reductase ( ... Y. lipolytica possesses a high concentration of acetyl-CoA, which is essential to enhance the production of β-carotene (Gao et ...

HMGR Hydroxymethylglutaryl-CoA reductase, ISPG (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase, ISPH 4-hydroxy-3- ... including hydroxymethylglutaryl-CoA reductase (HMGR), (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase (ISPG), 4-hydroxy-3 ... AACT Acetyl-CoA C-acetyltransferase, HMGS Hydroxymethylglutaryl-CoA synthase, ISPE 4-diphosphocytidyl-2-C-methyl-D-erythritol ... acetyl-CoA C-acetyltransferase (AACT) and hydroxymethylglutaryl-CoA synthase (HMGS). There was only 1 enzyme involved in ...

Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase ... Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. Gene Name:. SLC27A1. Uniprot ID:. Q6PCB7 Molecular ... Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters ...

Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase ... acyl-CoA) to form lysophosphatidic acid, which is then acylated with another molecule of acyl-CoA to yield phosphatidic acid. ... Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. Gene Name:. SLC27A1. Uniprot ID:. Q6PCB7 Molecular ... Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters ...

HMG-COA REDUCTASE INHIBITOR [EPC], HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS [MOA] These are the reported pharmaceutical ... LIPITOR (atorvastatin) is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. Atorvastatin calcium is [R ...