A TCR targeting the HLA-A*0201-restricted epitope of MAGE-A3 recognizes multiple epitopes of the MAGE-A antigen superfamily in ... Identification of HLA-A2-restricted T cell epitopes from MAGE-A3. (A) Boxplots of MAGE-A3 mRNA expression level in LUAD (left, ... Global analysis of HLA-A2 restricted MAGE-A3 tumor antigen epitopes and corresponding TCRs in non-small cell lung cancer Bei ... MAGE-A3-Mp4 epitope was finally selected as a major T cell epitope from MAGE-A3. To further characterize MAGE-A3 antigen- ...

Simon M, Bourel M, Fauchet R, Genetet B (1976). "Association of HLA-A3 and HLA-B14 antigens with idiopathic haemochromatosis". ... This gene is closely linked to the HLA-A3 locus.[citation needed] Since the regulation of iron metabolism is still poorly ... HLA) region of the genome. It took 20 years for researchers at Mercator Genetics to effectively identify and clone the ... collaborators confirmed that haemochromatosis is an autosomal recessive disorder that has a link to the human leukocyte antigen ...

... because it has no HLA antigen association. However, an increased frequency of HLA-A28 and HLA-A3 has been documented in PGA-I, ... HLA alleles are not seen in polyglandular autoimmune (PGA) syndrome, type I. The postulated genetic locus is described in ... AIRE mutations and human leukocyte antigen genotypes as determinants of the autoimmune polyendocrinopathy-candidiasis- ... specific antigens. The antibodies are believed to occur as a result of a breakdown in normal immunologic tolerogenesis or as a ...

HLA-A2 interactions. The binding of the adenovirus (Ad) protein E3-19K with the human leukocyte antigen (HLA) plays an... ... Discovery of small molecule inhibitors of adenovirus by disrupting E3-19K/ ...

KIR3DL2 has shown peptide-specific binding to some HLA-A antigens, including A3 and A11 (4, 7, 8). It also binds the abnormally ... folded HLA-B27 homodimer found in spondylarthritides, but not the normal heterodimer of HLA-B27 with beta 2‑microglobulin (9, ...

Association of HLA-A3 and HLA-B14 antigens with idiopathic haemochromatosis. Gut. 1976;17(5):332-34. ...

HLA-A3 (one clone), and HLA-B7 (one clone), which previously have been shown to present minor H antigens defined in our ... This analysis was sufficient to establish that all but one of the HLA-A2-, HLA-A3-, and HLA-B7-restricted clones in Table 3 ... To determine whether these clones recognized one or more previously defined HLA-A2-, HLA-A3-, or HLA-B7-restricted minor H ... as well as allogeneic HLA-B51+ or HLA-A2+ individuals, respectively (A, C, and E), and against HLA-B51+ or HLA-A2+ RCC tumor ...

HLA) and MAGE-A4 tumor antigen. Tumor indications include endometrial, esophageal, esophagogastric junction (EGJ), gastric, ... HLA) and MAGE-A4 tumor antigen. Tumor indications include endometrial, esophageal, esophagogastric junction (EGJ), gastric, ... ADP-A2M4CD8 as Monotherapy or in Combination With Either Nivolumab or Pembrolizumab in HLA-A2+ Subjects With MAGE-A4 Positive ... the safety and tolerability of ADP-A2M4CD8 T-cell therapy in subjects who have the appropriate human leukocyte antigen ( ...

HLA class I histocompatibility antigen, A-1 alpha chain. 1A01_HUMAN HLA class I histocompatibility antigen, A-3 alpha chain ...

HLA class I histocompatibility antigen, A-3 alpha chain. View. P04626. Receptor tyrosine-protein kinase erbB-2. View. ...

In both analyses, there were multiple associations to the Human Leukocyte Antigen (HLA) region and to markers in PARK2 ( ... This SNP lies on an intronic region of the Parkinson protein 2, E3 ubiquitin protein ligase (PARK2) gene on chromosome 6. A ... Markers rs2187689 (supplementary figure S2) and rs7767277 are HLA region markers, neither of which is included in the 1KG pilot ... Parkinson protein 2, E3 ubiquitin protein ligase). Among the most significant findings (table 2) is SNP rs926849 that lies at ...

The percentage of samples co-expression HLA-A2 and CT genes were: MAGE-A3, 51.6%; MAGE-A4, 36.3%; MAGE-C2, 44.0%; and NY-ESO-1 ... 49.6% non-small cell lung cancer samples were HLA-A2 positive. CT antigens were frequently expressed in non-small cell lung ... The expression of MAGE-A3, MAGE-A4, MAGE-C2 and NY-ESO-1 in fresh cancer tissues from 113 patients with non-small cell lung ... The expression percentage of each gene in cancer tissues samples were as follows: MAGE-A3, 70.8%; MAGE-A4, 46.9%; MAGE-C2, 61.1 ...

The HLA-B gene provides instructions for making a protein that plays a critical role in the immune system. Learn about this ... HLA-B is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the immune system ... A systematic review and meta-analysis of the association with HLA-B*57:01. J Allergy Clin Immunol. 2015 Oct;136(4):1092-4.e3. ... the HLA-B47 and HLA-B51 alleles can contribute to increased risk, whereas the HLA-B7 and HLA-B57 alleles might provide some ...

... and can be used in the analysis of individual antigen-specific T cells. This product is a MHC pentam… ... HLA-A*02:01)" This peptide has a high avidity for CD8 T cells, and can be used in the analysis of individual antigen-specific T ... This product is a MHC pentamer of peptide composed MAGE-A3 derived peptide of KVAEELVHFL sequence covering 112-120 and A*02:01 ...

Melanoma antigen gene A3 (MAGE-A3) is one of the most immunogenic cancer testis antigens and is common in various types of ... Recombinant Human MAGE-A3(HLA-A*01:01) Tetramer Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus, ... Human HLA-A*01:01&B2M&MAGE-A3 (EVDPIGHLY) Tetramer on Tris-Bis PAGE under Non reducing (N) condition. The purity is greater ... The purity of Human HLA-A*01:01&B2M&MAGE-A3 (EVDPIGHLY) Tetramer is greater than 95% as determined by SEC-HPLC.. ...

Our aim was to determine whether human leukocyte antigen (HLA)-A3 and B7 alleles act as genetic modifiers of the likelihood of ... The presence or absence of HLA-B7 did not influence the outcome. Thus, HLA-A3 and HLA-B7 alleles are not associated with the ... The mean age of HLA-A3 homozygotes (n = 24), heterozygotes (n = 65) and HLA-A3 null individuals (n = 44) was 40 years. There ... Antígeno HLA-A3/genética , Haplótipos , Antígenos de Histocompatibilidade Classe I/genética , Antígeno HLA-B7/genética , ...

HLA) types have a genetic predisposition to autoimmune diseases. The histocompatibility complex profile includes HLA-A1, -A3, - ... The exact mechanism of loss of immunologic tolerance to AChR, a self-antigen, is not understood. MG can be considered a B cell- ... These are then linked to MHC-II, the molecule required for reactivity to "self-antigens." The AChR antigenic fragment and MHC ... Sensitization to a foreign antigen that has cross-reactivity with the nicotinic ACh receptor has been proposed as a cause of ...

A KIR receptor that has specificity for HLA-A3 ANTIGEN. It is an inhibitory receptor that contains D0, D1, and D2 extracellular ... HN - 2008 BX - Antigens, CD196 BX - CC Chemokine Receptor 6 BX - CCR6 Receptors BX - CD196 Antigens MH - Receptors, CCR7 UI - ... HN - 2008 BX - Antigens, CDw198 BX - CC Chemokine Receptor 8 BX - CCR8 Receptors BX - CDw198 Antigens MH - Receptors, CCR10 UI ... HN - 2008 BX - Antigens, CD185 BX - CD185 Antigens BX - CXC Chemokine Receptor 5 BX - CXCR5 Receptors MH - Receptors, Ghrelin ...

47] One woman who inherited the C282Y mutation also had human leukocyte antigen A3 (HLA-A3) and human leukocyte antigen B7 (HLA ... HLA) class I region on chromosome 6 between the genes coding for HLA-A and HLA-B. This gene is mutated in most individuals with ... 18] The gene is tightly linked to the human leukocyte antigen (HLA)-A region on the short arm of chromosome 6. HFE, a specific ... HLA haplotype A*03-B*07 in hemochromatosis probands with HFE C282Y homozygosity: frequency disparity in men and women and lack ...

A KIR receptor that has specificity for HLA-A3 ANTIGEN. It is an inhibitory receptor that contains D0, D1, and D2 extracellular ... HN - 2008 BX - Antigens, CD196 BX - CC Chemokine Receptor 6 BX - CCR6 Receptors BX - CD196 Antigens MH - Receptors, CCR7 UI - ... HN - 2008 BX - Antigens, CDw198 BX - CC Chemokine Receptor 8 BX - CCR8 Receptors BX - CDw198 Antigens MH - Receptors, CCR10 UI ... HN - 2008 BX - Antigens, CD185 BX - CD185 Antigens BX - CXC Chemokine Receptor 5 BX - CXCR5 Receptors MH - Receptors, Ghrelin ...

A KIR receptor that has specificity for HLA-A3 ANTIGEN. It is an inhibitory receptor that contains D0, D1, and D2 extracellular ... HN - 2008 BX - Antigens, CD196 BX - CC Chemokine Receptor 6 BX - CCR6 Receptors BX - CD196 Antigens MH - Receptors, CCR7 UI - ... HN - 2008 BX - Antigens, CDw198 BX - CC Chemokine Receptor 8 BX - CCR8 Receptors BX - CDw198 Antigens MH - Receptors, CCR10 UI ... HN - 2008 BX - Antigens, CD185 BX - CD185 Antigens BX - CXC Chemokine Receptor 5 BX - CXCR5 Receptors MH - Receptors, Ghrelin ...

A KIR receptor that has specificity for HLA-A3 ANTIGEN. It is an inhibitory receptor that contains D0, D1, and D2 extracellular ... HN - 2008 BX - Antigens, CD196 BX - CC Chemokine Receptor 6 BX - CCR6 Receptors BX - CD196 Antigens MH - Receptors, CCR7 UI - ... HN - 2008 BX - Antigens, CDw198 BX - CC Chemokine Receptor 8 BX - CCR8 Receptors BX - CDw198 Antigens MH - Receptors, CCR10 UI ... HN - 2008 BX - Antigens, CD185 BX - CD185 Antigens BX - CXC Chemokine Receptor 5 BX - CXCR5 Receptors MH - Receptors, Ghrelin ...

HLA-A3). The same few peptides were consistently targeted in an additional 17 persons expressing HLA-A3 and/or -B7 during acute ... These studies demonstrate a consistent pattern in the development of epitope-specific responses restricted by a single HLA ... including 15 different CTL epitopes restricted by a single HLA class I allele ( ... In this study, HIV-1-specific CD8+ T-cell responses in 18 acutely infected individuals expressing HLA-A3 and/or -B7 were ...

... a HLA-A2 and HLA-A3 restricted, CD8+ eliciting epitope) and AE37 (a HLA unrestricted, MHC class II, CD4+ eliciting epitope). ... HER2 is a commonly expressed tumor-associated antigen in breast (BrCa) and, therefore, an attractive target for immunotherapy. ...

Effect of interferon-gamma on HLA class II antigen expression and sensitivity to prostaglandin E1 by normal and leukemic ... Effect of interferon-gamma on HLA class II antigen expression and sensitivity to prostaglandin E1 by normal and leukemic ...

Thus, some authors are considering the possibility of using CAR-T cells against the MAGE-A4 antigen, which is considered a ... HLA-DR), and lower ability to present antigens [47]. ... Another possible target antigen for immunotherapy is the so- ... Development of a CD8 co-receptor independent T-cell receptor specific for tumor-associated antigen MAGE-A4 for next generation ... against various human malignant tumors expressing the antigen MAGE-A4. Epidermal growth factor receptor (EGFR) is one of the ...

Duffour M.T., Chaux P., Lurquin C., Cornells G., Boon Т., van der Bruggen P. A MAGE-A4 peptide presented by HLA-A2 is ... Van den Eynde B., Peeters O., De Backer O., Gaugier B., Lucas S., Boon T. A new family of genes coding for an antigen ... Quantification by flow cytofluorimetry of HLA class I molecules at the surface of murine cells transformed by cloned HLA genes ... Wang D., Rayani S., Marshall J.L. Carcinoembryonic antigen as a vaccine target. // Expert Rev Vaccines. 2008. V. 7. №7. P. 987- ...

The Association Between HLA DR, DQ Antigens, and Vulval Lichen Sclerosus in the UK: HLA DRB1*12 and its Associated DRB1&ast ... and MAGE-A3, was used to trigger functional multi-specific T cells ex vivo from peripheral blood mononuclear cells and tumor- ... The patients were typed for HLA-C and HLA-B. A total of 654 (64.2%) were HLA-Cw*0602 positive but 365 (35.8%) carried other HLA ... Moreover, positive correlations with type I psoriasis were detected for HLA-DQA1*0201 and HLA-DQB1*0303. The HLA-DRB1*0701/2, - ...

HUMAN HLA class I histocompatibility antigen, A-3 alpha chain OS=Homo sapiens GN=HLA-A PE=1 SV=2 ... HUMAN HLA class II histocompatibility antigen, DP beta 1 chain OS=Homo sapiens GN=HLA-DPB1 PE=1 SV=1 ... HUMAN Amyloid beta A4 precursor protein-binding family B member 1-interacting protein OS=Homo sapiens GN=APBB1IP PE=1 SV=1 ... HUMAN Amyloid-beta A4 precursor protein-binding family A member 2 OS=Homo sapiens GN=APBA2 PE=1 SV=3 ...