... pronunciation and example sentences for b-lymphocyte mu chain gene rearrangement ... b-lymphocyte mu chain gene rearrangement meaning and definition : [Medicine]Ordered rearrangemen.... click for more detailed ... b-lymphocyte mu chain gene rearrangement meaning. [Medicine]. Ordered rearrangement of B-lymphocyte variable gene regions ... b cell mu chain gene rearrangement: [Medicine]Ordered .... *b lymphocyte heavy chain gene rearrangement: [Medicine]Ordered ... ...

BCL6 gene rearrangements have been frequently observed. B symptoms are uncommon. The characteristics of NLPHL differ from ... Wlodarska I, Stul M, De Wolf-Peeters C, Hagemeijer A (August 2004). "Heterogeneity of BCL6 rearrangements in nodular lymphocyte ... January 2003). "Frequent occurrence of BCL6 rearrangements in nodular lymphocyte predominance Hodgkin lymphoma but not in ... Lymphocyte predominant HL is an uncommon subtype composed of vague nodules of numerous reactive lymphocytes admixed with large ...

Analysis of V gene rearrangements. In three cases of lymphocyte predominant HL we performed single cell PCR to analyse V gene ... Intraclonal diversity in V gene rearrangements as a result of active somatic hypermutation is a typical feature of GC B cells. ... L&H cells for micromanipulation were selected on the basis of morphological criteria, and we performed V gene rearrangement ... and subjected to PCR for V gene rearrangements at the IgH (immunoglobulin heavy chain), Igκ, and Igλ (κ and λ light chain) loci ...

Gene Expression Regulation * Gene Rearrangement, B-Lymphocyte * Gene Rearrangement, T-Lymphocyte * Humans ...

T-cell receptor gene rearrangements are demonstrated in many. These T cells produce high levels of IL-5, thought to cause the ... A number of hypereosinophilic syndrome (HES) cases exhibit clonal expansion of abnormal lymphocytes. Immunophenotypically, they ... Myeloproliferative disorder with eosinophilia and ETV6-ABL gene rearrangement: efficacy of second-generation tyrosine kinase ... These patients demonstrate CHIC2 gene deletion in peripheral blood mononuclear cells as a result of this fusion gene. ...

Chapter8 Lymphocyte Development and Antigen Receptor Gene Rearrangement. Chapter9 Activation of T Lymphocytes ... Chapter6 Antigen Presentation to T Lymphocytes and the Functions of MHC Molecules ...

Few cells expressed CD8 and were interpreted as reactive lymphocytes. We did not detect a clonal rearrangement of the TCR-γ- ... chain gene. We established, according to the recent WHO/EORTC classification on cutaneous lymphoma, the diagnosis of type-A LyP ... This wedge-shaped infiltrate was composed of large atypical lymphocytes mixed with small lymphocytes, neutrophils, eosinophils ... Figure 2. CD30+ Immunostaining, × 400: Dense infiltrate in the dermis with CD30+ large atypical lymphocytes mixed with small ...

Rearrangement of the immunoglobulin genes throughout lymphocyte maturation offers rise to antigenic specificity; it ... V (variable) gene phase the 5 coding portion of rearranged immunoglobulin and T-cell receptor genes. V (D)J recombinase the set ... These modifications of gene-targeting know-how have been pivotal in the determination of the consequences of explicit genes in ... The Cre/lox system can be used to activate gene expression in a selected tissue. Just as the lack of a specific gene could ...

T lymphocytes lack rearrangement of the bcr gene in Philadelphia chromosome-positive chronic myelocytic leukemia. Bartram, C.R ... wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary ... Evidence for pluripotent stem cell origin of idiopathic myelofibrosis: clonal analysis of a case characterized by a N-ras gene ... Distinct patterns of Fas cell surface expression during development of T- or B-lymphocyte lineages in normal, scid, and mutant ...

... are features of undifferentiated lymphocytes. Except for the B3B3 line that has undergone unproductive gene rearrangement, all ... They also express Rag 1, Rag 2, and TdT that are involved in Ig and TCR rearrangements, and as such, ...

We are interested in the molecular basis for developmentally regulated rearrangement and expression of murine TCR genes. One ... T lymphocytes. ... gene segments during T cell development, and is essential for ... The process of V(D)J recombination assembles T cell receptor (TCR) genes (α,β,γ,δ) from variable (V), ...

... gene rearrangement [2]. The etiology of IMT is uncertain, including ALK gene rearrangement, virus infection, trauma, and ... Y. J. Cha and H. S. Shim, "PD-L1 expression and CD8+ tumor-infiltrating lymphocytes are associated with ALK rearrangement and ... but without identification of gene rearrangement. Other kinase fusions in addition to ALK were identified in IMT, which were ... IMT comprises proliferated spindle cells and a large number of inflammatory cells mainly including plasma cells and lymphocytes ...

... and polymer chain reaction to assess antigen receptor gene rearrangements (PARR). PARR improves diagnosis by amplifying genes ... The precise mechanism for cross-lineage rearrangement in lymphocytes is unclear. In any event, this phenomenon may have ... Cross Lineage Rearrangement in Feline Enteropathy-Associated T-cell Lymphoma. Vet Pathol. 2016 May;53(3):559-62. DOI: 10.1177/ ... When this occurs, it is termed cross-lineage rearrangement and it has been documented in humans and canine lymphoid cancers. ...

... lymphocytes ... genes ... rearrangement ...

... to describe a group of lymphoproliferative disorders characterized by localization of neoplastic T lymphocytes to the skin. ( ... Immunologically, atypical lymphocytes stain positively for CD3 and CD8, with clonal rearrangement of the T-cell receptor gene ... most neoplastic lymphocytes show an aberrant CD4-positive phenotype with clonal rearrangement of T-cell receptor genes. Results ... The T-cell gene rearrangement is demonstrated by molecular or cytogenetic techniques and/or an expansion of cells with a ...

Lymphocyte cultures from homozygotes for the beta-thalassaemia gene were found to contain chromosomal gaps, breaks, and ... rearrangements more often than those from controls. Culture time seemed to have a determinant effect on the results. The ...

My lab is interested in what controls the initiation of antibody gene rearrangement during B cell development. In order to pin- ... B1b lymphocytes confer T cell-independent long-lasting immunity. Immunity. 2004 Sep; 21(3):379-90. PMID: 15357949. ... J recombination and the activity of genes of interest (using GFP as a reporter of gene expression) can be detected as ... The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes. J Immunol. 2003 ...

Original experiments in the thymus, where T lymphocytes undergo chromosomic rearrangement in their antigen receptor genes, ... A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis. Cell. (1991) 65:677-89. doi: 10.1016/0092- ... Magnus T, Chan A, Linker RA, Toyka KV, Gold R. Astrocytes are less efficient in the removal of apoptotic lymphocytes than ... Immunological Genome C. Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and ...

... assemble diverse lymphocyte antigen receptor genes through the genomic rearrangement of leucine-rich repeat (LRR) - encoding ... The field of Lymphocyte Surface Antigens and Activation Mechanisms is examined in two chapters. Cytotoxic T lymphocyte- ... A failure of regulatory mechanisms can cause lymphocyte depletion and immunodeficiency as well as an excess of lymphocytes and ... Much information has been obtained on the area of Lymphocyte Development and Differentiation. NK cells coordinate tumor ...

... including the RAG endonuclease-mediated rearrangement of antigen receptor genes during the normal development of lymphocytes. ... We identified a central lymphocyte-specific transcriptional response common to both physiologic and genotoxic breaks, which ... We previously showed that physiologic breaks initiate lymphocyte development-specific transcriptional programs. Here we compare ... includes many lymphocyte developmental processes. Genotoxic damage causes robust alterations to pathways associated with B cell ...

The products of the Rag1 and Rag2 genes drive genomic V(D)J rearrangements that assemble functional immunoglobulin and T cell ... The resolution of bacteremia coincided with an expansion and persistence of B1b lymphocytes, and purified B1b lymphocytes from ... the hypothesis that one or both of the Rag genes were coopted after horizontal gene transfer and assembled into a Rag1/2 gene ... wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary ...

... upon successful rearrangement, expands the pools of progenitor lymphocytes. Here we show that in developing B lymphocytes, the ... underpinned by the failure to demethylate a small group of TS cell genes. Forced expression of these non-reprogrammed genes ... Mutations and gene amplifications that confer drug resistance emerge frequently during chemotherapy, but their mechanism and ... The ERK1/2 signalling pathway is best known for its role in connecting activated growth factor receptors to changes in gene ...

Its expression is initiated by functional rearrangement and expression of IgM heavy chain genes and is down-regulated when ... C57BL/6 mouse cytotoxic T lymphocyte cell line CTLL-2 was stained with Rat Anti-Mouse CD25-APC (SB Cat. No. 1600-11). ... Expression of CD25 on activated T lymphocytes is transitory and endogenously regulated. CD25 is expressed on precursor B cells ...

Rearrangement and proteasome-mediated splicing of noncontiguous peptides encoded by the SP110 gene create a human minor ... Additional cells were cryopreserved for subsequent donor lymphocyte infusion as needed. A maximum of four donor lymphocyte ... The candidate region, which encompasses the kallikrein gene cluster, does not contain any genes that previously have been ... lysis by cytotoxic T-lymphocyte clones isolated from peripheral blood lymphocytes and tumor-infiltrating lymphocytes. Int J ...

... that mutations in a gene called EZH2 are present in more than 80 per cent of lymphomas derived from antibody-making lymphocytes ... Re-arrangements of MYC and BCL2 cause particularly aggressive types of lymphoma. ... We have described previously unknown errors in the genetic code of lymphocytes that transform normal lymphocytes into malignant ... Our immune system lymphocytes face a unique challenge compared to most cells in our body. They must proliferate (give rise to ...

Immunoglobulin gene rearrangement can sometimes be detected. Cases with both T-cell and B-cell gene rearrangement have been ... This is because, as described above, the lymphocytes in CLL/SLL can be heterogeneous in the same way as reactive lymphocytes. A ... Miyahara M, Shimamoto Y, Sano M, Nakano H, Shibata K, Matsuzaki M. Immunoglobulin gene rearrangement in T-cell-rich reactive ... T-cell receptor gene rearrangement is characteristically negative. EBV can be detected in the tumor cells in most cases.[34] ...

This rearrangement changes the position and functions of certain genes, which results in uncontrolled cell growth. Other ... The lymphocytes normally fight infection. With acute lymphocytic leukemia, the bone marrow makes too many of these lymphocytes ... Normal lymphoid cells mature into either B-lymphocytes or T-lymphocytes. If the leukemia is among these cells, it is called ... This means that gene mutations and chromosome abnormalities in cells occur sporadically (by chance) and are not inherited from ...

... β and γ gene rearrangements. PCR primer sequences were those used by the Biomed-2 consortium and have been shown to detect ... In the diagnosis of microscopic colitis, we defined this condition as , 20 lymphocytes per 100 epithelial cells in the ... γ gene rearrangement, detectable by polymerase chain reaction (PCR) analysis of biopsy specimens. The presence of this aberrant ... Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene ...

Translocations are thought to occur during normal gene rearrangements (Ig, T-cell receptor). ... whereas malignant mature lymphocytes (i.e. follicular lymphoma) behave indolently. ... results in activation of the BCL-2 gene and suppression of apoptosis. ...