Transcription factors GATA-4 and GATA-6 in normal and neoplastic human gastrointestinal mucosa. Haveri, Hanna; Westerholm-Ormio ... Both factors were also present in Barretts esophagus and metaplasia of the stomach. GATA-6 expression was reduced in colon ... We studied in detail the expression patterns of these two GATA factors and a GATA-6 down-stream target, Indian hedgehog (Ihh), ... GATA transcription factors direct cell proliferation and differentiation in many organs, and are implicated in tumorigenesis. ...

Transcription factor GATA-6, also known as GATA-binding factor 6 (GATA6), is protein that in humans is encoded by the GATA6 ... GATA-6, a zinc finger transcription factor, is important in the endodermal differentiation of organ tissues. It is also ... Kiiveri S, Liu J, Heikkilä P, Arola J, Lehtonen E, Voutilainen R, Heikinheimo M (2005). "Transcription factors GATA-4 and GATA- ... Liu C, Glasser SW, Wan H, Whitsett JA (2002). "GATA-6 and thyroid transcription factor-1 directly interact and regulate ...

We examined expression patterns of key transcription factors (Sox2, Oct4, Nanog, Cdx2, Gata6, Sox17, and Yy1) during pre- and ... tissue-specific GATA6 levels; and (3) a striking pattern of SOX17 that is suggestive of a functional role either directing or ...

"Regulation of the calreticulin gene by GATA6 and Evi-1 transcription factors." Biochemistry.. 2008 Mar 25; 47(12):3697-704. ... "Master regulatory GATA transcription factors: mechanistic principles and emerging links to hematologic malignancies." Nucleic ... "Gene expression profiling of ErbB receptor and ligand-dependent transcription." Oncogene.. 2004 Feb 19; 23(7):1428-38. ... "Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)." Cell ...

The transcription factor GATA6 enables self-renewal of colon adenoma stem cells by repressing BMP gene expression ... Specific GATA Factors Act as Conserved Inducers of an Endodermal-EMT. Campbell K; Whissell G; Franch-Marro X; Batlle E; ... Zonation of Ribosomal DNA Transcription Defines a Stem Cell Hierarchy in Colorectal Cancer ...

Herein, we demonstrated that the small RNA molecule miR-301a can induce the expression of cardiac transcription factors and ... GATA6, and TBX5. Thereafter, signaling pathways, including fibroblast growth factors and bone morphogen proteins, modulate the ... Cardiac cell differentiation from the precursor cell population is initiated and guided by transcription factors, such as ... Overexpression of miR-301a in mouse embryonic stem cells significantly induced the expression of cardiac transcription factors ...

J:101349 Fischer A, et al., Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict ... J:58781 Nakagawa O, et al., HRT1, HRT2, and HRT3: a new subclass of bHLH transcription factors marking specific cardiac, ... J:80681 Sakata Y, et al., Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2. Proc ... J:103925 Sakata Y, et al., Transcription factor CHF1/Hey2 regulates neointimal formation in vivo and vascular smooth muscle ...

9d). We then checked the expression of multiple lineage-specific transcription factors, which differentially marked the ExEM ... in addition to GATA6+, GATA4+ and PDGFRA+); ExEM-like (in total four clusters: FOXF1+, VIM+ and BST2+, in addition to GATA6+ ... The donor vector carries M2RtTa and a site for cDNA insert of the transcription factor of interest. We used this vector to ... which require the overexpression of ectopic transcription factors4,9,14,15. This is consistent with our observation that ...

TNF-insulin crosstalk at the transcription factor GATA6 is revealed by a model that links signaling and transcriptomic data ... Quantitative reverse transcription PCR and qPCR arrays. RNA was extracted using the RNeasy Kit (Qiagen), and equal amounts were ... 4D) and that c-Jun has been implicated in HIF2α transcription in GBM (39). In differentiated GBM cells and GSCs, SHP2 knockdown ... In a previous study from our lab, SHP2 knockdown impeded GBM cell/tumor growth and hypoxia-inducible factor (HIF) expression ...

Our results demonstrate compensatory mechanisms in the pancreatic transcription factor network due to mutant HNF1BS148L/+ ... The lack of suppression of PDX1, PTF1A, GATA4, and GATA6 indicates that MODY5-mediated pancreatic hypoplasia is mechanistically ... mutation causes a compensatory increase in several pancreatic transcription factors, and surprisingly, a decrease in PAX6 ...

TCF7L2 (Transcription Factor 7-Like 2) Regulation of GATA6 (GATA-Binding Protein 6)-Dependent and -Independent Vascular Smooth ... TCF7L2 (Transcription Factor 7-Like 2) Regulation of GATA6 (GATA-Binding Protein 6)-Dependent and -Independent Vascular Smooth ... Transcription Factor 7-Like ) Regulation of GATA6 (GATA-Binding Protein 6)-Dependent and -Independent Vascular Smooth Muscle ... The Protective Effect of Transcription Factor 7-Like 2 Risk Allele rs7903146 against Elevated Fasting Plasma Triglyceride in ...

Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart ... Direct activation of a Gata6 cardiac enhancer by Nkx2.5: evidence for a reinforcing regulatory network of Nkx2.5 and Gata ... A Gata family transcription factor is expressed along the embryonic dorsoventral axis in Drosophila melanogaster. Development ... A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease. Cell ...

... the lineage-determining transcription factor driving extraembryonic endoderm development. Moreover, loss of MLL3/4 enzymatic ... However, they fail to differentiate to extraembryonic endoderm cells due to markedly reduced enhancer binding of GATA6, ... are critical for enhancer activation and cell-type-specific transcription during development and cell differentiation. However ...

Transcription Factor GATA 6 100% * GATA6 100% * Regulatory Mechanism 33% * Family 33% ... A role for GATA-6 in vertebrate chondrogenesis. Alexandrovich, A., Qureishi, A., Coudert, A., Zhang, L., Grigoriadis, A., Shah ... Small Molecule Inhibition of Transforming Growth Factor Beta Signaling Enables the Endogenous Regenerative Potential of the ... Differential regulation of human bone marrow mesenchymal stromal cell chondrogenesis by Hypoxia Inducible Factor-1α hydroxylase ...

A Stromal Niche Defined by Expression of the Transcription Factor WT1 Mediates Programming and Homeostasis of Cavity-Resident ...

about iDeal ChIP-seq kit for Transcription Factors, iDeal ChIP-seq kit for Transcription Factors, iDeal ChIP-seq Kit for ... We performed ChIPmentation with IP-Star automated system for GATA6 in 2 million GATA6-overxpressing iPS cells. The result ... about iDeal ChIP-seq kit for Transcription Factors, iDeal ChIP-seq kit for Transcription Factors, iDeal ChIP-seq Kit for ... To solve this issue, we used the Diagenode ChIPmentation solution composed of iDeal ChIP-seq Kit for Transcription Factor, TAG ...

GATA6, a well-established transcription factor, plays a crucial role in tissue injury and epithelial regenerative repair. This ... which was suppressed by GATA6 knockdown and induced by GATA6 overexpression. Finally, the downregulation of GATA6 alleviated ... Additionally, the role of GATA6 downregulation in tracheal injury was verified in rats. GATA6 expression and NLRP3 inflammasome ... Fator de Transcrição GATA6 , Proteína 3 que Contém Domínio de Pirina da Família NLR , Piroptose , Animais , Humanos , Ratos , ...

This p roject will determine the mechanism and pathological effects of this switch in GATA transcription factor expression . In ... Our studies will identify the specific genes directly governed by GATA2 in healthy tissue and GATA6 in diseased tissue. These ... and that the targets of GATA transcription factors in these cells contribute to the pathogenesis of endometriosis. ... We hypothesize that inherited or acquired epigenetic defects alter GATA expression, and the switch from GATA2 to GATA6 ...

TCF7L2 (Transcription Factor 7-Like 2) Regulation of GATA6 (GATA-Binding Protein 6)-Dependent and -Independent Vascular Smooth ...

If it is a cause, then DNA methylation may affect the affinity of transcription factors (TFs) for their binding sites (TFBSs). ... GATA6, NR1I2, OTX2, SOX2, SOX5, SOX17). Interestingly, these 7 TFs all have highly AT-rich binding sites with very low ... Medvedeva, Y.A., Khamis, A.M., Kulakovskiy, I.V. et al. Effects of cytosine methylation on transcription factor binding sites. ... If it is a cause, then DNA methylation may affect the affinity of transcription factors (TFs) for their binding sites (TFBSs). ...

iDeal ChIP-seq kit for Transcription Factors x24 ... with IP-Star automated system for GATA6 in 2 million GATA6- ... Diagenodes iDeal ChIP-seq Kit for Transcription Factors is a highly validated solution for robust transcription factor and ... The iDeal ChIP-seq kit for Transcription Factors is compatible for cells or tissues: ... The iDeal ChIP-seq Kit for Transcription Factors is compatible with a broad variety of cell lines, tissues and species - some ...

TNDM is caused by mutations in the GATA6 gene in rare cases. This gene encodes a transcription factor that is important for the ... Background: Hepatocyte nuclear factor 1β (HNF1β) is a critical transcription factor that regulates the development of the ... Neonatal diabetes mellitus in a patient with a novel heterozygous mutation in GATA6. Sechko Elena , Raykina Elizaveta , Kuraeva ... Therefore, it is important to determine the factors that may affect the follow-up for diabetes. Some studies conducted on ...

JASPAR is the largest open-access database of curated and non-redundant transcription factor (TF) binding profiles from six ... Following is more information on formats and the DNA binding profile for GATA6 transcription factor (JASPAR ID MA1104.2) as an ... transcription factor, based on the TFClass system. Family. Structural sub-class of the transcription factor, based on the ... transcription factor, based on the TFClass system. Family. Structural sub-class of the transcription factor, based on the ...

The whole adipogenic process was driven by a coordinated activation of transcription factors and epigenetic modulators. Overall ... Proliferation was characterized by enrichment in genes involved in basic cellular and metabolic processes (transcription, ... GATA5 and GATA6 (Fig. 3b); however, to the best of our knowledge the implication of these members in adipogenesis has not been ... E2F, C/EBP, Krüppel-like factor (KLF) and GATA families. The E2F family of transcription factors is known to regulate cell ...

... is a core transcription factor that contributes to pluripotency along with octamer binding transcription factor-4 (OCT4) and ... In NANOG-overexpressing blastocysts, caudal type homeobox 2 (CDX2-), SOX17-, and GATA6-positive cells were decreased. The ... We analyzed the relationship between NANOG and pluripotent core transcription factors and other lineage makers. Results: In ... of miR-188-5p in goat muscle tissues at different developmental stages was detected by quantitative reverse transcription ...

The mouse Muc5b mucin gene is transcriptionally regulated by thyroid transcription factor-1 (TTF-1) and GATA-6 transcription ... Transcription factor GATA-6 is expressed in quiescent myofibroblasts in idiopathic pulmonary fibrosis. Am J Respir Cell Mol ... and small airway development-associated transcription factors GATA6 and SOX9 [24,25,26,27] are enriched in the small airway ... LTF and small airway development relevant transcription factors NKX2-1, GATA6, SOX9, HOPX, ID2 and ETV5. Lentivirus-mediated ...

... transcription factor, and PTF1A gene which is associated with an autosomal recessive syndrome of neonatal diabetes mellitus ... Recently, heterozygous pathogenic variants in GATA6 are considered as the most common cause of pancreatic agenesis. This panel ... Pancreatic agenesis has been associated with pathogenic variants in the PDX1 gene, which encodes the insulin promoter factor-1 ...

Selected Advances in Lung Cancer Research Two transcription factors, GATA6 and HOPX, are critical nodes in a lung cell ... by quitting smoking and by eliminating or reducing exposure to secondhand smoke and environmental and workplace risk factors. ...

Four EAC-specific master regulatory transcription factors, ELF3, KLF5, GATA6, and EHF form interconnected regulatory loops, ... super-enhancer regions are occupied by a higher density of transcription-related factors including transcription factors (TFs ... Master transcription factors and mediator establish super-enhancers at key cell identity genes. Cell. 2013;153:307-19 ... TP63 transcription factor induces SE-dependent transcription of LINC01503, which subsequently promotes proliferation, migration ...