An Ether-a-go-go potassium channel is a Potassium channel which is Inwardly-rectifying and voltage-gated. Examples include hERG ... v t e (Articles lacking sources from November 2019, All articles lacking sources, Potassium channels, All stub articles, ...

The KCNH2 gene belongs to a large family of genes that provide instructions for making potassium channels. Learn about this ... ether-a-go-go related gene potassium channel 1. *H-ERG. *HERG ... POTASSIUM CHANNEL, VOLTAGE-GATED, SUBFAMILY H, MEMBER 2; KCNH2 ... potassium channel, voltage gated eag related subfamily H, member 2. *potassium voltage-gated channel, subfamily H (eag-related ... The KCNH2 gene belongs to a large family of genes that provide instructions for making potassium channels. These channels, ...

ERG1 Potassium Channel * Ether-A-Go-Go Potassium Channels / antagonists & inhibitors * Ether-A-Go-Go Potassium Channels / ... G Protein-Coupled Inwardly-Rectifying Potassium Channels / genetics * G Protein-Coupled Inwardly-Rectifying Potassium Channels ... Candidate targets for anti-AF drugs include a potassium channel K(v)1.5, and the ionic currents I(KACh) and late I(Na), along ... G Protein-Coupled Inwardly-Rectifying Potassium Channels / antagonists & inhibitors * ...

1981) Modification of sodium and potassium channel gating kinetics by ether and halothane. The Journal of General Physiology. ...

Schönherr, Löber, Heinemann: "Inhibition of human ether à go-go potassium channels by Ca(2+)/calmodulin." in: The EMBO journal ... Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 1 (KCNH1)). Voltage-gated potassium (Kv) channels represent ... potassium voltage-gated channel subfamily H member 1 (LOC490277) Antikörper. potassium voltage-gated channel, subfamily H (eag- ... potassium voltage-gated channel subfamily H member 1 (Kcnh1) Antikörper. potassium voltage-gated channel, subfamily H (eag- ...

Briefly, in vitro effects of compound AVR-25 on the hERG (human ether-à-go-go-related gene) potassium channel current (a ... The in vitro effects of AVR-25 on the hERG potassium channel current (a surrogate for IKr, delayed rectifier cardiac potassium ... The initial mutagenicity and hERG (human ether-à-go-go-related gene) channel activity were assessed in vitro for compound AVR- ... AVR-25 did not inhibit the hERG channel and IC50 was ,300 µM, thus confirming no adverse cardiac effects (Supplementary Table ...

Clancy and colleagues chose the hERG (human Ether-à-go-go-Related Gene) potassium channel in the heart as the drug target in ... Cell (journal) JAMA Journal of Experimental Medicine Nature (journal) NEJM Neurology (journal) PLoS View all Journal Channels ... Behavioral Science Education Government History Politics Social Media View all Life Channels arrow_right_alt ... CHANNELS. All Journal News Cardiovascular Health Heart Disease Pharmaceuticals Supercomputing National Institutes of Health ( ...

Expression of the ether-a-go-go (ERG) potassium channel in smooth muscle of the equine gastrointestinal tract and influence on ... Objective-To determine whether ether-a-go-go (ERG) potassium channels are expressed in equine gastrointestinal smooth muscle, ... Conclusions and Clinical Relevance-The ERG potassium channels modulate motility of intestinal muscles in horses and may be a ... Loss of mineral opacity, increased vascular channels in the subchondral bone, and thickening within the soft tissues of the ...

The human Ether-a-go-go-Related Gene (hERG) encodes one of the major repolarizing potassium channels in the heart (KV11.1). ... Thallium (Tl+) flux is a standard screening tool for monovalent ion channels used widely in industry and academia. This ... There is possibility of transferring knowledge from KV11.1 trafficking to other ion channel disorders. ... and led to the discovery that KV11.1 channel variants can be chaperoned by . Unfortunately, to date there are no new drug ...

The role of potassium channels in tumours of the gastrointestinal tract: a focus on the human ether-à-go-go related gene 1 ... She also focused on the role of potassium channels, in particular the hERG1 channel, in the govern of the resting potential, ... DAmico M;Gasparoli L;Arcangeli A (2013). Potassium channels: novel emerging biomarkers and targets for therapy in cancer.. ... Arcangeli integrating biophysical, biomolecular and genetic approaches unravelled the role of potassium channels and their ...

HERG (human ether-a-go-go-related gene) encodes a potassium ion channel important for maintaining normal cardiac rhythm and ... The gene HERG1 encodes a potassium-selective ion channel important in maintaining normal cardiac rhythm and cell growth. Learn ... Sulfonylurea receptors (SURs) regulate the opening and closing of ATP-sensitive potassium channels (KATP). They play important ... Sulfonylurea receptors (SURs) regulate the opening and closing of ATP-sensitive potassium channels (KATP). They play important ...

Rac and Rho mediate opposing hormonal regulation of the ether-a-go-go-related potassium channel. Curr. Biol. 12, 27-33. ... Rac and Rho mediate opposing hormonal regulation of the ether-a-go-go-related potassium channel. Curr. Biol. 12, 27-33. ... Rac and Rho mediate opposing hormonal regulation of the ether-a-go-go-related potassium channel. Curr. Biol. 12, 27-33. ...

... led to a decreased expression and function of the channel. On the contrary, the variant p.Q854R showed an increase in TRPM4 ... led to a decreased expression and function of the channel. On the contrary, the variant p.Q854R showed an increase in TRPM4 ... a non-selective cation channel, mediates cell membrane depolarization in immune response, insulin secretion, neurological ... a nonselective cation channel, mediates cell membrane depolarization in immune response, insulin secretion, neurological ...

Prediction of pIC50 values for inhibition of human Ether-a-go-go Related Gene (hERG) potassium channels expressed in mammalian ...

Prediction of pIC50 values for inhibition of human Ether-a-go-go Related Gene (hERG) potassium channels expressed in mammalian ...

... therapeutic compounds causing QT prolongation are associated with direct block of the cardiac potassium channel human ether a- ... ABBREVIATIONS: TdP, torsades de pointes; hERG, human ether a-go-go-related gene; IKr, rapidly activating delayed rectifier K ... prolongs the cardiac action potential by block of hERG trafficking and reduction of the number of functional hERG channels at ...

... potassium channel (Krishna et al. 2022). This function regulates heart rhythm and is often involved in drug-induced ... As part of this project, a computational approach was developed to predict whether a chemical would affect the human ether-a-go ...

keywords = "Gastrointestinal motility, Pacemaker activity, Potassium channels",. author = "White, {Elizabeth J.} and Park, { ... Ether-a-go-go-related gene 3 is the main candidate for the E-4031-sensitive potassium current in the pacemaker interstitial ... Ether-a-go-go-related gene 3 is the main candidate for the E-4031-sensitive potassium current in the pacemaker interstitial ... Ether-a-go-go-related gene 3 is the main candidate for the E-4031-sensitive potassium current in the pacemaker interstitial ...

Both loperamide and methadone block a potassium ion channel, the human ether-a-go-go related gene (hERG) channel, which leads ... noting that there hasnt been adequate research involving ECGs or evaluation of ion channels with the substance. These studies ... and its possible kratom is increasing arrhythmias via other routes besides the hERG channel. ...

... related outward potassium channel, and transplacental exposure to these antibodies in utero is responsible for congenital AV ... Anti-Ro/SSA antibodies may produce a long QT interval syndrome by inhibiting the human ether-a-go-go-related gene (hERG) ... Either gain of function or loss of function in these ion channels, particularly when the abnormal channels are unevenly ... The ion channels affected include those responsible for the inward sodium or calcium currents and those responsible for the ...

This syndrome results when drugs interact with potassium channels (usually with human ether-a-go-go-related gene (HERG) ... A virtual screening method for prediction of the hERG potassium channel liability of compound libraries. Chembiochem 3:455-459. ... Effects on Ion Channel Activity and Electrophysiology. A number of assays can predict possible effects on the electrophysiology ... to the development of well-accepted in vitro assays to identify drugs that may exert this adverse effect on potassium channels ...

Sphingosine 1-phosphate (S1P) receptors and human ether-a 0 -go-go-related gene (HERG (KCNH2)) potassium channels are important ... Sphingosine 1-phosphate and human ether-a′-go-go-related gene potassium channels modulate migration in human anaplastic thyroid ... A group of channels participating in these processes is the transient receptor potential (TRP) family of cation channels. These ... One of these subfamilies is the transient receptor potential canonical (TRPC) family of channels. This ion channel family ...

Ferreira, N. R.; Mitkovski, M.; Stühmer, W.; Pardo, L. A.; Del Bel, E. A.: Ether-à-go-go 1 (Eag1) potassium channel expression ... Issy, A. C.; Fonseca, J. R.; Pardo, L. A.; Stühmer, W.; Del Bel, E. A.: Hippocampal ether-à-go-go1 potassium channels blockade ... Agarwal, J. R.; Griesinger, F.; Stühmer, W.; Pardo, L. A.: The potassium channel Ether a go-go is a novel prognostic factor ... Urrego, D.; Tomczak, A. P.; Zahed, F.; Stühmer, W.; Pardo, L. A.: Potassium channels in cell cycle and cell proliferation. ...

Astemizole inhibits cell proliferation in human prostate tumorigenic cells expressing ether í -go-go-1 potassium channels ...

Sphingosine 1-phosphate and human ether-a′-go-go-related gene potassium channels modulate migration in human anaplastic thyroid ...

... related outward potassium channel, and transplacental exposure to these antibodies in utero is responsible for congenital AV ... Anti-Ro/SSA antibodies may produce a long QT interval syndrome by inhibiting the human ether-a-go-go-related gene (hERG) ... Either gain of function or loss of function in these ion channels, particularly when the abnormal channels are unevenly ... The ion channels affected include those responsible for the inward sodium or calcium currents and those responsible for the ...

1998) KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science 282:1890-1893. doi:10.1126/ ... XE991 has been also shown to block ether-a-go-go-related (ERG, KCNH family) K+ channels (Wang et al., 1998; Elmedyb et al., ... It should be noted that XE991 does not selectively block M-current/KCNQ channels and may influence other potassium channels ( ... 2005) Pathways modulating neural KCNQ/M (Kv7) potassium channels. Nat Rev Neurosci 6:850-862. doi:10.1038/nrn1785 pmid:16261179 ...

RUZURGI is a potassium channel blocker indicated for the treatment of Lambert-Eaton myasthenic syndrome (LEMS) in patients 6 to ... In vitro, RUZURGI did not inhibit the human ether-à-go-go-related gene ion channel. ... RUZURGI (amifampridine) is a potassium channel blocker available as functionally scored tablets for oral administration. ...

Issy, A. C., Fonseca, J. R., Pardo, L. A., Stühmer, W., & del Bel, E. A. (2014). Hippocampal ether-à-go-go1 potassium channels ... kinase 3 signaling modulate prepulse inhibition of the acoustic startle response by altering cortical M-Type potassium channel ...

Molecular regulation of the HERG potassium channel  Kagan, Anna (ProQuest Dissertations & Theses, 2004) ... Human Ether-a-go-go Related Gene (HERG) encodes the pore-forming K+ ... ...