Dermatan sulfate is a component of the compound sulodexide. Dermatan sulfate may have roles in coagulation, cardiovascular ... Dermatan sulfate accumulates abnormally in several of the mucopolysaccharidosis disorders. An excess of dermatan sulfate in the ... dermatan sulfate with a high molecular weight (25,000 Da) and affinity for the heparin II cofactor. Dermatan+sulfate at the U.S ... "Dermatan sulfate". Lasierra-Cirujeda J, Coronel P, Aza M, Gimeno M (2010). "Use of sulodexide in patients with peripheral ...
Differential association of aortic chondroitin sulfate proteo glycan and dermatan sulfate proteo glycan with hyaluronic acid. ... Scott, J.E.; Orford, C.R. 1981: Dermatan sulphate-rich proteoglycan associates with rat tail-tendon collagen at the d band in ... Hayman, E.G.; Oldberg, A.; Rouslahti, E. 1981: Expression and localization of a heparan sulfate and a chondroitin sulfate ... Isolation and characterization of dermatan sulphate proteoglycan from human uterine cervix Biochemical Journal 209(2): 497-503 ...
Biological Functions of Iduronic Acid in Chondroitin/Dermatan Sulfate. In: The FEBS Journal. 2013 ; Vol. 280, No. 10. pp. 2431- ... Biological Functions of Iduronic Acid in Chondroitin/Dermatan Sulfate.. Martin Thelin, Barbara Bartolini, Jakob H Axelsson, ... Biological Functions of Iduronic Acid in Chondroitin/Dermatan Sulfate. The FEBS Journal. 2013;280(10):2431-2446. doi: 10.1111/ ... The role of IdoA in chondroitin/dermatan sulfate is underlined by the vast changes of connective tissue features in patients ...
... chondroitin sulfate B metabolism, dermatan sulfate metabolism, dermatan sulphate metabolic process, dermatan sulphate ... Parents of dermatan sulfate metabolic process (GO:0030205) subject. relation. object. dermatan sulfate metabolic process BFO: ... dermatan sulfate metabolic process is_a mucopolysaccharide metabolic process (GO:1903510) dermatan sulfate metabolic process is ... Children of dermatan sulfate metabolic process (GO:0030205) subject. relation. object. dermatan sulfate catabolic process (GO: ...
Chondroitin/dermatan sulfate (CS/DS) proteoglycans are indispensable for animal development and homeostasis but the large ...
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... Chondroitin sulphate/dermatan sulphate proteoglycans: potential regulators of corneal stem/progenitor cell phenotype in vitro. ... Here, we investigated the immunohistochemical distribution of hybrid CS/dermatan sulphate (DS) GAGs in the periphery of the ... Chondroitin sulphate (CS) proteoglycans with variable sulphation-motifs along their glycosaminoglycan (GAG) chains are closely ...
Dermatan sulfate epimerase 1 (DS-epi1, EC 5.1.3.19) catalyzes the conversion of d-glucuronic acid to l-iduronic acid on the ... The structure of human dermatan sulfate epimerase 1 emphasizes the importance of C5-epimerization of glucuronic acid in higher ... a key step in the biosynthesis of the glycosaminoglycan dermatan sulfate. Here, we present the first crystal structure of the ...
Urine test for heparan sulfate and dermatan sulfate Treatment. The medicine called idursulfase (Elaprase), which replaces the ...
2] namely dermatan sulfate (DS) and heparan sulfate (HS). This process is essential for normal growth and homeostasis of ... causes an increase in the urinary excretion of dermatan sulfate (DS) and heparan sulfate (HS). ...
Name: dermatan sulfate epimerase. Synonyms: B130024B19Rik, Sart2, DS-epi1. Type: Gene. Species: Mus musculus (mouse) ...
dermatan sulfate catabolic process Symbol. Object Name. Qualifiers. Evidence. Notes. Source. PubMed Reference(s). RGD Reference ...
Effects of sulfate deprivation on the production of chondroitin/dermatan sulfate by cultures of skin fibroblasts from normal ... Dermatan sulfate is involved in the tumorigenic properties of esophagus squamous cell carcinoma. Cancer Res. 2012 Apr 15; 72(8 ... Component of dermatan sulfate. Differs in configuration from glucuronic acid only at the C-5 position. ... of a human uronyl 2-sulfotransferase that sulfates iduronyl and glucuronyl residues in dermatan/chondroitin sulfate. J Biol ...
... correlating with altered PNN-associated sulfation patterns of chondroitin sulfate glycosaminoglycans in the MBH. Each of these ... Quantitative analysis of glycosaminoglycans, chondroitin/dermatan sulfate, hyaluronic acid, heparan sulfate and keratan sulfate ... Mizumoto, S., Yamada, S. & Sugahara, K. Molecular interactions between chondroitin-dermatan sulfate and growth factors/ ... Chondroitin 6-sulphate synthesis is upregulated in injured CNS, induced by injury-related cytokines and enhanced in axon-growth ...
Although sulfated GAGs (sGAGs) appear intracellularly, the knowledge about intracellular effects and putative interaction ... Artificial GAGs like sulfated hyaluronan (sHA) exhibit pro-osteogenic properties and boost healing processes. Hence, they are ... 2016). They focused on the interaction of plasma proteins with HE, heparan sulfate (HS), and dermatan sulfate (DS). By ... A complete list is provided in Supplementary Table 5, DS, Dermatan sulfate; EN, Endosome; ER, endoplasmatic reticulum; ES, ...
Urine test for heparan sulfate and dermatan sulfate Treatment. The medicine called idursulfase (Elaprase), which replaces the ...
Brittlestars Contain Highly Sulfated Chondroitin Sulfates/Dermatan Sulfates that Promote FGF2 Induced Cell Signaling ... A potential role for chondroitin sulfate/dermatan sulfate in arm regeneration in Amphiura filiformis ...
... chondroitin sulfate (CS) and dermatan sulfate (DS), heparin and heparan sulphate (HS), and keratan sulfate (KS). HA is ... Thus, PGs are also classified, regarding their GAG content, into heparan sulfate PGs (HSPG), chondroitin/dermatan sulfate PGs ... in the case of chondroitin sulphate and dermatan sulfate or N-acetyl-glucosamine in the case of heparin sulphate and heparin) ... It carriers either heparan sulfate or chondroitin sulfate chains depending on cell type. Korpetinou et al. [139] have shown for ...
Modular automated solid phase synthesis of dermatan sulfate oligosaccharides. Chemical Communications 50 (15), S. 1875 - 1877 ( ...
HTA samples contained keratan sulfate (KS), chondroitin/dermatan sulfate (CS/DS), and hyaluronan (HA), whereas heparan sulfate ...
p,,b,,/b,,br,,br,Iduronate 2 Sulfatase (Alpha L Iduronate Sulfate Sulfatase or Idursulfase or IDS or EC 3.1.6.13) - Iduronate 2 ... Iduronate 2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this X- ... Iduronate 2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this X- ... Report Title: Iduronate 2 Sulfatase (Alpha L Iduronate Sulfate Sulfatase or Idursulfase or IDS or EC 3.1.6.13) Development by ...
The glucuronosyl dermatan sulfate chains epimerization assessment in the course of the burned wound healing ... Salbutamol sulfate in-situ nasal gelling systems: formulation and evaluation. Spectrophotometric determination of gemifloxacin ...
2] namely dermatan sulfate (DS) and heparan sulfate (HS). This process is essential for normal growth and homeostasis of ... causes an increase in the urinary excretion of dermatan sulfate (DS) and heparan sulfate (HS). ...
Other natural GAG agents of special interest include chondroitin sulfate (arthritis) and dermatan sulfate (anticoagulation). ... The technology can be applied to prepare oligosaccharides belonging to the heparin-, heparan sulfate-, chondroitin sulfate-, ...
... is known to act on chondroitin 4-sulfate and chondroitin 6-sulfate but not on dermatan sulfate. Like other chondroitin AC ... is known to act on chondroitin 4-sulfate and chondroitin 6-sulfate but not on dermatan sulfate ... ... chondroitin 4-sulfate tetrasaccharide, CS(tetra) and hyaluronan tetrasaccharide) at resolution varying from 1.25 A to 1.9A. The ...
Sobel, R. A. & Ahmed, A. S. White Matter Extracellular Matrix Chondroitin Sulfate/Dermatan Sulfate Proteoglycans in Multiple ... BCAN and VCAN in particular both code for chondroitin sulfate proteoglycans of the ECM, which are especially crucial for ...
... and dermatan sulfate (DS) GAGs (unpublished observation). This could explain the equally robust effect of chondroitin ABC lyase ... which cleaves chondroitin and dermatan sulfates and has some activity against hyaluronan; and Heparinase III (E.C. 4.2.2.8) ... as infection of cells by AAV2 has been shown to be heparan sulfate dependent [28]. However, cell surface heparan sulfate ... Chondroitin sulfate proteoglycans are present in the ILM, in the nerve fiber-rich layers of the retina, which include the inner ...
Well known Heparanase-1 inhibitors are heparin(s) and sulodexide, a low-molecular weight heparin - dermatan sulphate blend, ... Heparanase-1, an endoglycosidase that cleaves heparan sulfate, is implicated in the pathogenesis of diabetic nephropathy and is ... a commercial dermatan sulfate (DS) from Sigma (Sigma Aldrich C-3788), and the LMWH H2046 and dermatan sulfate D2047 (Opocrin). ... To see how the relative proportions of heparin and dermatan sulfate in sulodexide could contribute to its HPSE inhibitory ...
Chondroitin sulfate/dermatan sulfate metabolism (Homo sapiens) * A tetrasaccharide linker sequence is required for GAG ... Heparan sulfate/heparin (HS-GAG) metabolism (Homo sapiens) * A tetrasaccharide linker sequence is required for GAG synthesis ( ...
Chondroitin sulfate/dermatan sulfate metabolism (Homo sapiens) * Chondroitin sulfate biosynthesis (Homo sapiens) * The addition ...