cGAS-STING drives ageing-related inflammation and neurodegeneration
Cytosolic DNA released from perturbed mitochondria elicits cGAS activity in old microglia, defining a mechanism by which cGAS- ... Here we show that the cGAS-STING signalling pathway, which mediates immune sensing of DNA3, is a critical driver of chronic ... Nucleotidyltransferases* / metabolism * Organ Specificity * Signal Transduction Substances * cGAS protein, human * cGAS protein ...
Isolation of a terminal DNA-nucleotidyl transferase from calf thymus non histone chromatin proteins - Wikidata
Isolation of a terminal DNA-nucleotidyl transferase from calf thymus non histone chromatin proteins. scientific article ... Isolation of a terminal DNA-nucleotidyl transferase from calf thymus non-histone chromatin proteins (English) ... Isolation of a terminal DNA-nucleotidyl transferase from calf thymus non histone chromatin proteins (English) ... Partial Purification of a DNA-polymerase from the Non-histone Chromatin Proteins of Rat Liver ...
RCSB PDB - 1ZQW: DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7), 31-KD DOMAIN; SOAKED IN THE PRESENCE OF CSCL (150 MILLIMOLAR)
DNA POLYMERASE BETA (POL B) (E.C.2.7.7.7), 31-KD DOMAIN; SOAKED IN THE PRESENCE OF CSCL (150 MILLIMOLAR) ... Classification: NUCLEOTIDYLTRANSFERASE. *Organism(s): Rattus norvegicus. *Expression System: Escherichia coli. *Mutation(s): No ... DNA POLYMERASE BETA. A. 248. Rattus norvegicus. Mutation(s): 0 Gene Names: POL, Polb. EC: 2.7.7.7 (PDB Primary Data), 4.2.99 ( ... Characterization of the metal ion binding helix-hairpin-helix motifs in human DNA polymerase beta by X-ray structural analysis. ...
Nucleotidyltransferase - Wikipedia
DNA synthesis by a nucleotidyltransferase, 4) removal of the 5-dRP group by a-elimination reaction, and 5) nick sealing by ... Later, a nucleotidyl transferase is used to fill in the gap with the correct base, using the template strand as the reference. ... DNA ligase (36, 37) Nucleotidyltransferases at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: ... These are 1) removal of a modified base by a lesion-specific monofunctional DNA N-glycosylase, 2) 5-incision of the abasic ...
Advanced Search Results - Public Health Image Library(PHIL)
WO2017124100A1 - Methods for extending the replicative capacity of somatic cells during an ex vivo cultivation process ...
C12N9/1241-Nucleotidyltransferases (2.7.7) * C12N9/1276-RNA-directed DNA polymerase (2.7.7.49), i.e. reverse transcriptase or ... Each plasmid DNA stock is aliquoted in a 2:1 ratio of Cas9 plasmid DNA: gRNA plasmid for a total DNA amount of 2 μg and mixed ... The total DNA is diluted to a concentration of 1 μg/50 μΐ, in sterile deionized water. Fugene HD is added to the DNA mixture at ... Genomic DNA is extracted from primary cell isolates with the E.Z.N.A. Tissue DNA Extraction kit (Omega Bio-tek) for each ...
KEGG T01015: 4333066
positive regulation of DNA-directed DNA polymerase activity - Ontology Report - Rat Genome Database
activation of DNA duplicase activity; activation of DNA nucleotidyltransferase (DNA-directed) activity; activation of DNA ... upregulation of DNA duplicase activity; upregulation of DNA nucleotidyltransferase (DNA-directed) activity; upregulation of DNA ... activation of DNA polymerase I; activation of DNA polymerase II; activation of DNA polymerase III; activation of DNA polymerase ... up regulation of DNA duplicase activity; up regulation of DNA nucleotidyltransferase (DNA-directed) activity; up regulation of ...
TERT telomerase reverse transcriptase [Homo sapiens (human)] - Gene - NCBI
enables RNA-directed DNA polymerase activity IDA Inferred from Direct Assay. more info ... enables template-free RNA nucleotidyltransferase IDA Inferred from Direct Assay. more info ... enables telomeric DNA binding IBA Inferred from Biological aspect of Ancestor. more info ... enables RNA-directed DNA polymerase activity TAS Traceable Author Statement. more info ...
SCOPe 2.08: Domain d2fmqa3: 2fmq A:149-335
Superfamily d.218.1: Nucleotidyltransferase [81301] (16 families) *. Family d.218.1.2: DNA polymerase beta-like [81300] (5 ... PDB Description: Sodium in active site of DNA Polymerase Beta. PDB Compounds: (A:) DNA polymerase beta. SCOPe Domain Sequences ... Fold d.218: Nucleotidyltransferase [81302] (1 superfamily). core: alpha-beta-turn-beta-X-beta-(alpha); mixed beta-sheet, order ... Protein DNA polymerase beta, catalytic (31 kD) fragment [81578] (2 species). *. Species Human (Homo sapiens) [TaxId:9606] [ ...
Production and characterization of a broad-spectrum antimicrobial 5-butyl-2-pyridine carboxylic acid from Aspergillus fumigatus...
6d) like ciprofloxacin which acts on bacterial topoisomerase II (DNA gyrase) and topoisomerase IV, streptomycin that binds ... and aminoglycoside nucleotidyltransferase. However, the metabolites acting on respiratory enzymes are very rare. The present ... like DNA-gyrase, topoisomerase IV, dihydrofolate reductase, transcriptional regulator TcaR (protein), ... it inhibits dopamine beta-hydroxylase enzymes that convert dopamine to norepinephrine and inhibits cell proliferation and DNA ...
ExplorEnz: EC 2.7.7.101
nucleotide 5′-triphosphate:single-stranded DNA nucleotidyltransferase (DNA-RNA hybrid synthesizing). Comments:. The enzyme ... DNA-directed DNA polymerase. It is found in bacteria and archaea. The latter also have a second primase system (EC 2.7.7.102, ... Frick, D.N. and Richardson, C.C. DNA primases. Annu. Rev. Biochem. 70 (2001) 39-80. [PMID: 11395402] ... An enzyme which starts DNA chains. J. Biol. Chem. 253 (1978) 758-764. [PMID: 340457] ...
Tn5 insertion specificity is not influenced by IS50 end sequences in target DNA.
"Tn5 insertion specificity is not influenced by IS50 end sequences in target DNA." Mol Gen Genet, vol. 228, no. 1-2, Aug. 1991, ... "Tn5 insertion specificity is not influenced by IS50 end sequences in target DNA." Mol Gen Genet 228, no. 1-2 (August 1991): 312 ... Tn5 insertion specificity is not influenced by IS50 end sequences in target DNA.. Publication , Journal Article ... These results support models in which the ability of Tn5 to find its preferred sites depends on several features of DNA ...
The replication machinery of LUCA: common origin of DNA replication and transcription | BMC Biology | Full Text
Origin of DNA replication is an enigma because the replicative DNA polymerases (DNAPs) are not homologous among the three ... a common ancestor that functioned as an RNA-dependent RNA polymerase in the RNA-protein world that predated the advent of DNA ... To DNA template and product at origin(?). PolC. Polβ-like nucleotidyl-transferase ... AEP archaeal-eukaryotic primase, DNAP DNA polymerase, DPBB double-psi beta-barrel, RNAP RNA polymerase, RdRP RNA-dependent RNA ...
CATH Domain 1rtjB01
DNA can also serve as template. -!- See also EC 2.7.7.7.. 2.7.7.-. Nucleotidyltransferases. ... Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).. -!- Catalyzes DNA-template-directed extension of the 3-end of ... Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).. -!- Catalyzes RNA-template-directed extension of the 3-end of ... 3-end directed exonucleolytic cleavage of viral RNA-DNA hybrid.. -!- This is a secondary reaction to the RNA 5-end directed ...
Effective Immunoconjugate Therapy in Cancer Models Targeting a Serine Protease of Tumor Fibroblasts | Clinical Cancer Research ...
Apoptosis was determined with a terminal nucleotidyl transferase-mediated dUTP nick end labeling assay using the ApopTag ... DNA counterstaining propidium iodide). A loss of collagen type IV marker protein indicative of a disruption of the basement ... DNA counterstaining propidium iodide). A loss of collagen type IV marker protein indicative of a disruption of the basement ... fluorescence terminal nucleotidyl transferase-mediated dUTP nick end labeling assay). The inflammatory infiltrates consist ...
Synapse - Interactions between fission yeast mRNA capping enzymes and elongation factor Spt5
Kristín Edda Gylfadóttir, Author at Matís - Page 3 of 7
Thus, monitoring through DNA barcoding in the very first step of the seafood chain surveys would improve accurate species ... The enzyme contains a nucleotidyltransferase domain and a 3′-5′ exonuclease domain that is engaged in proofreading. Recombinant ... The enzyme shows low sequence identity (,30%) to the members of the type-A family of DNA polymerases, except for two yet ... Molecular Characterization of a DNA Polymerase from Thermus thermophilus MAT72 Phage vB_Tt72: A Novel Type-A Family Enzyme with ...
Kristín Edda Gylfadóttir, Author at Matís - Page 3 of 7
Thus, monitoring through DNA barcoding in the very first step of the seafood chain surveys would improve accurate species ... The enzyme contains a nucleotidyltransferase domain and a 3′-5′ exonuclease domain that is engaged in proofreading. Recombinant ... The enzyme shows low sequence identity (,30%) to the members of the type-A family of DNA polymerases, except for two yet ... Molecular Characterization of a DNA Polymerase from Thermus thermophilus MAT72 Phage vB_Tt72: A Novel Type-A Family Enzyme with ...
Jun Ninomiya-Tsuji - Citation Index - NCSU Libraries
DNA Nucleotidyltransferases / genetics; DNA Nucleotidyltransferases / metabolism; Female; Founder Effect; Fractures, Bone / ... DNA, Bacterial / genetics; DNA, Bacterial / metabolism; Intestinal Mucosa / metabolism; Intestines / microbiology; Intestines ... DNA Damage; Embryo, Mammalian / cytology; Etoposide / pharmacology; Fibroblasts / cytology; Fibroblasts / drug effects; ...
DeCS
98; see DNA POLYMERASES 1977-97, for DNA POLYMERASE see DNA NUCLEOTIDYLTRANSFERASES 1973-76, see DNA NUCLEOTIDYLTRANSFERASE ... DNA Dependent DNA Polymerases DNA Directed DNA Polymerase DNA Polymerase DNA Polymerase, DNA-Directed DNA Polymerases DNA ... DNA-directed DNA polymerase Entry term(s):. DNA Dependent DNA Polymerases. DNA Directed DNA Polymerase. DNA Polymerase. DNA ... DNA-Dependent DNA Polymerases Polymerase, DNA Polymerase, DNA-Directed DNA Polymerases, DNA Polymerases, DNA-Dependent DNA ...
RNA Polymerase III | Profiles RNS
Nucleotidyltransferases [D08.811.913.696.445]. *RNA Nucleotidyltransferases [D08.811.913.696.445.735]. *DNA-Directed RNA ... A DNA-dependent RNA polymerase present in bacterial, plant, and animal cells. It functions in the nucleoplasmic structure where ... it transcribes DNA into RNA. It has specific requirements for cations and salt and has shown an intermediate sensitivity to ...
SMED30004407
DNA-directed DNA polymerase, family B, exonuclease domain. PFAM. PF03104. DNA_pol_B_exo1. coord: 5..51. e-value: 3.3E-5. score ... nucleotidyltransferase activity. Vocabulary: Planarian Anatomy Term. Definition. PLANA:0000420. parapharyngeal region. PLANA: ... DNA/RNA polymerases. coord: 141..550. IPR006172. DNA-directed DNA polymerase, family B. PRINTS. PR00106. DNAPOLB. coord: 172.. ... BLAST of DNA polymerase vs. Ensembl Yeast Match: POL3 (Catalytic subunit of DNA polymerase delta; required for chromosomal DNA ...
Genes | Free Full-Text | Impacts of the Type I Toxin-Antitoxin System, SprG1/SprF1, on Staphylococcus aureus Gene Expression
Polbase - Reference: DNA polymerase activities in differentiating mouse neuroblastoma N-18 cells.
DNA polymerase activities in differentiating mouse neuroblastoma N-18 cells. ... The activities of two DNA polymerases (DNA nucleotidyltransferases) ... The activities of two DNA polymerases (DNA ... With activated calf thymus DNA as template, only DNA polymerase-alpha activity was stimulated in the presence of added ... inhibition was observed for DNA polymerase-beta under similar conditions. DNA polymerase-alpha activity was reduced 50-70% in N ...
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Jane Jackman | Department of Chemistry and Biochemistry
List of specific genes
SCO7361 putative DNA-binding protein. 8173887:8175416 forward MW:54367 0270. SCO7711 putative two component system sensor ... SCO4355 putative nucleotidyltransferase 4769703:4770476 forward MW:28165 0829. SCO5402 putative Asp-rich hydrophilic protein ... SCO1180 putative DNA polymerase III beta chain 1243639:1244799 forward MW:41579 0495. SCO2691 hypothetical protein 2935475: ... SCO0174 putative DNA-binding protein 164023:164994 reverse MW:34148 0635. SCO1270 putative pyruvate dehydrogenase alpha subunit ...