DNA glycosylase - Wikipedia
This entry represents various uracil-DNA glycosylases and related DNA glycosylases (EC), such as uracil-DNA glycosylase, ... and single-strand selective monofunctional uracil-DNA glycosylase (SMUG1). Uracil DNA glycosylases remove uracil from DNA, ... Uracil-DNA glycosylases are DNA repair enzymes that excise uracil residues from DNA by cleaving the N-glycosydic bond, ... Lindahl, T. (1986). "DNA Glycosylases in DNA Repair". Mechanisms of DNA Damage and Repair. 38: 335-340. doi:10.1007/978-1-4615- ...
Heat-labile Cod Uracil-DNA Glycosylase, recombinant Sigma-Aldrich
... is a DNA repair enzyme. Eliminates carry-over contamination in PCR. Order from Sigma-Aldrich. ... Heat-labile Cod Uracil-DNA Glycosylase (Triton-free) ... Uracil-DNA glycosylases are DNA repair enzymes that participate ... Uracil-DNA glycosylases?Structural and functional perspectives on an essential family of DNA repair enzymes ... Uracil DNA Glycosylase, also known as UNGor UDG, is an enzyme that hydrolyses the N-glycosylic bond between the deoxyribose ...
Phage phi29 protein p56 prevents viral DNA replication impairment caused by uracil excision activity of uracil-DNA glycosylase
... inhibition is likely a defense mechanism developed by phage phi29 to prevent the action of UDG if uracilation occurs in DNA ... Protein p56 encoded by the Bacillus subtilis phage phi29 inhibits host uracil-DNA glycosylase (UDG) activity. In previous ... Phage phi29 protein p56 prevents viral DNA replication impairment caused by uracil excision activity of uracil-DNA glycosylase ... we analyzed the ability of phi29 DNA polymerase to insert dUMP into DNA. Primer extension analysis showed that viral DNA ...
Role of XRCC1 in the coordination and stimulation of oxidative DNA damage repair initiated by the DNA glycosylase hOGG1
XRCC1 participates in DNA single strand break and base excision repair (BER) to preserve genetic stability in mammalian cells. ... Role of XRCC1 in the coordination and stimulation of oxidative DNA damage repair initiated by the DNA glycosylase hOGG1 J Biol ... to 3-fold stimulation of the DNA glycosylase activity of hOGG1. XRCC1 stimulates the formation of the hOGG1 Schiff-base DNA ... Here, we report that XRCC1 interacts physically and functionally with hOGG1, the human DNA glycosylase that initiates the ...
Uracil-DNA glycosylase (Pasteurella multocida subsp. multocida str. Pm70) | Protein Target - PubChem
Substrate-specific binding of 8-oxoguanine DNA glycosylase 1 (OGG1) reprograms mucosal adaptations to chronic airway injury |...
Substrate-specific binding of 8-oxoguanine DNA glycosylase 1 (OGG1) reprograms mucosal adaptations to chronic airway injury. * ... Its cognate repair protein, 8-oxoguanine DNA glycosylase 1 (OGG1), reads oxidative substrates and participates in ... Its cognate repair protein, 8-oxoguanine DNA glycosylase 1 (OGG1), reads oxidative substrates and participates in ... Its cognate repair protein, 8-oxoguanine DNA glycosylase 1 (OGG1), reads oxidative substrates and participates in ...
Construction and phenotypic characterization of Mycobacterium smegmatis mutants deficient in the MutY DNA glycosylase
... of MutY in combination with the Fpg/Nei family of DNA glycosylases in mycobacteria to understand whether these DNA glycosylases ... DNA glycosylases leads to mispaired bases during replication which are subsequently repaired by the MutY DNA glycosylase. ... Taken together these data indicate that the mycobacterial MutY DNA glycosylase has antimutator properties and possibly has a ... lesions which are subsequently repaired by the Fpg/Nei family of DNA glycosylases of the base excision repair (BER) pathway. ...
N-methylpurine DNA glycosylase and OGG1 DNA repair activities: opposite associations with lung cancer risk.
... ... To examine whether inter-individual variations in DNA repair activity of N-methylpurine DNA glycosylase (MPG) are associated ... results opposite that of 8-oxoguanine DNA glycosylase (OGG1) DNA repair enzyme activity. For lung cancer associated with one ... Only a minority of smokers develop lung cancer, possibly due to genetic predisposition, including DNA repair deficiencies. ...
Thermo labile UDG (Uracil DNA Glycosylase) - APS LABS
The enzyme is inactive on RNA and native, uracil-free DNA. Since Uracil-DNA Glycosylase (UNG), thermo labile has no metal ion ... The enzyme is inactive on RNA and native, uracil-free DNA. Since Uracil-DNA Glycosylase (UNG), thermo labile has no metal ion ... Uracil-DNA Glycosylase (UNG), Thermo labile is a recombinant protein in E. coli, from Artic Cod. The enzyme hydrolyzes uracil ... Uracil-DNA Glycosylase (UNG), Thermo labile is a recombinant protein in E. coli, from Artic Cod. The enzyme hydrolyzes uracil ...
RecName: Full=Methyl-CpG-binding domain protein 4; AltName: Full=Methy - Protein - NCBI
Mismatch-specific DNA N-glycosylase. gi,50400819,sp,O95243.1,MBD4_HUMAN ... Mismatch-specific DNA N-glycosylase. UniProtKB/Swiss-Prot: O95243.1 ... Structural basis for thymine glycosylase activity on T:O6-methylG mismatch by methyl-CpG binding domain protein 4: Implications ...
Uracil-DNA glycosylase acts by substrate autocatalysis. | Profiles RNS
Recombinant OGG1 (8-oxoguanine DNA glycosylase),Human,AF - Biofargo
... also known as 8-oxoguanine glycosylase, is the pr ... This protein is a DNA glycosylase enzyme involved in base ... OGG1, also known as 8-oxoguanine glycosylase, is the primary enzyme responsible for the excision of 7,8-dihydro-8-oxoguanine (8 ... Additionally, OGG1 has a beta lyase activity that nicks DNA 3 to the lesion. ...
Human MPG(N-Methylpurine DNA Glycosylase) ELISA Kit - LipidX
Human MPG(N-Methylpurine DNA Glycosylase) ELISA Kit Human MPG(N-Methylpurine DNA Glycosylase) ELISA Kit. To Order Contact us: ... Description: A sandwich ELISA kit for detection of N-Methylpurine DNA Glycosylase from Human in samples from blood, serum, ... Description: A sandwich quantitative ELISA assay kit for detection of Human Uracil DNA Glycosylase (UNG) in samples from tissue ... Description: A sandwich quantitative ELISA assay kit for detection of Human Uracil DNA Glycosylase (UNG) in samples from tissue ...
Uracil DNA Glycosylase (UDG/UNG), 1 U/μL-Yeasen
Uracil DNA Glycosylase (UDG/UNG), 1 U/μL provided by Yeasen is in the form of a single enzyme, which is active in most PCR ... UDG (uracil DNA glycosylase) can catalyze the hydrolysis of the N-glycosidic link between the uracil base and the sugar- ... Uracil DNA Glycosylase (UDG/UNG), 1 U/μL. 100 μL. 500 μL. 10 mL. ... Figure 1．UDG enzyme (0.025 U) fully digested 360 ng of 200 bp dU -DNA ...
Planteome: Term Details for 'DNA N-glycosylase activity' (GO:0019104)
Parents of DNA N-glycosylase activity (GO:0019104) subject. relation. object. DNA N-glycosylase activity is_a hydrolase ... Children of DNA N-glycosylase activity (GO:0019104) subject. relation. object. mismatch base pair DNA N-glycosylase activity ( ... oxidized base lesion DNA N-glycosylase activity (GO:0000702) is_a DNA N-glycosylase activity ... DNA N-glycosylase activity. Ontology. molecular_function. Synonyms. DNA glycosylase activity, endonuclease VIII activity. ...
Strandwise translocation of a DNA glycosylase on undamaged DNA. | NECAT
Strandwise translocation of a DNA glycosylase on undamaged DNA.. Strandwise translocation of a DNA glycosylase on undamaged DNA ... Crystallization, DNA, DNA Repair, DNA-Formamidopyrimidine Glycosylase, Escherichia coli, Geobacillus stearothermophilus, Models ... Here, we report the observation of strandwise translocation of 8-oxoguanine DNA glycosylase, MutM, along undamaged DNA. In ... Considerable interest surrounds the question of how DNA glycosylases translocate efficiently along DNA while maintaining their ...
3-Biotin-GTP | NEB
Our high quality reagents are available for every workflow, including popular DNA assembly methods such as NEBuilder® HiFi DNA ... Whether you are performing your first cloning experiment or constructing multi-fragment DNA assemblies, NEB® has the solution ... Uracil-DNA Glycosylase (UDG) Submit Restocking Order. Ineligible item added to cart. Based on your Freezer Program type, you ...
Nature Communications
Structure of the human 3-methyladenine DNA glycosylase gene and localization close to the 16p telomere. - MRC Weatherall...
We now report that one of these genes encodes 3-methyladenine DNA glycosylase, an enzyme important in the repair of DNA after ... Interestingly, in contrast to the alpha-globin genes, expression of the 3-methyladenine DNA glycosylase gene is not influenced ... globin gene expression lies equidistant between the promoters of the alpha-globin genes and the 3-methyladenine DNA glycosylase ... Amino Acid Sequence, Base Sequence, Cell Line, Chromosome Mapping, Chromosomes, Human, Pair 16, DNA Glycosylases, DNA Repair, ...
Affinity purification and comparative analysis of two distinct human uracil-DNA glycosylases - Fingerprint - Rowan...
Substrate recognition by a family of uracil-DNA glycosylases: UNG, MUG, and TDG<...
The glycosylases studied here include Escherichia coli uracil-DNA glycosylase (UNG), E. coli mismatch uracil-DNA glycosylase ( ... The glycosylases studied here include Escherichia coli uracil-DNA glycosylase (UNG), E. coli mismatch uracil-DNA glycosylase ( ... The glycosylases studied here include Escherichia coli uracil-DNA glycosylase (UNG), E. coli mismatch uracil-DNA glycosylase ( ... The glycosylases studied here include Escherichia coli uracil-DNA glycosylase (UNG), E. coli mismatch uracil-DNA glycosylase ( ...
Linking active DNA demethylation by Thymine DNA Glycosylase with epigenetic regulation of gene expression - edoc
Linking active DNA demethylation by Thymine DNA Glycosylase with epigenetic regulation of gene expression. 2014, Doctoral ... Linking active DNA demethylation by Thymine DNA Glycosylase with epigenetic regulation of gene expression ... The Thymine DNA Glycosylase (TDG) was described to excise the deamination products of cytosine (C) and 5-methylcytosine (5-mC ... The underlying molecular mechanisms are not clear, but a role for DNA repair proteins has been implicated in this context, the ...
DSpace at KOASAS: Covalent binding of uracil DNA glycosylase UdgX to abasic DNA upon uracil excision
Uracil DNA glycosylases (UDGs) are important DNA repair enzymes that excise uracil from DNA, yielding an abasic site. Recently ... Covalent binding of uracil DNA glycosylase UdgX to abasic DNA upon uracil excision. ... The structure of UdgX from Mycobacterium smegmatis in complex with DNA shows an overall similarity to that of family 4 UDGs ... UdgX, an unconventional UDG with extremely tight binding to DNA containing uracil, was discovered. ...
Mutationl analysis of the damage-recognition and catalytic mechanism of human SMUG1 DNA glycosylase<...
Single-strand selective monofunctional uracil-DNA glycosylase (SMUG1), previously thought to be a backup enzyme for uracil-DNA ... "Single-strand selective monofunctional uracil-DNA glycosylase (SMUG1), previously thought to be a backup enzyme for uracil-DNA ... Single-strand selective monofunctional uracil-DNA glycosylase (SMUG1), previously thought to be a backup enzyme for uracil-DNA ... Single-strand selective monofunctional uracil-DNA glycosylase (SMUG1), previously thought to be a backup enzyme for uracil-DNA ...
A mutant of uracil DNA glycosylase that distinguishes between cytosine and 5-methylcytosine. - Department of Oncology
Uracil DNA glycosylase (UDG) efficiently removes uracil from DNA in a reaction in which the base is flipped into the enzymes ... We demonstrate that a mutant of uracil DNA glycosylase (N123D:L191A) distinguishes between cytosine and methylcytosine. ... Uracil DNA glycosylase (UDG) efficiently removes uracil from DNA in a reaction in which the base is flipped into the enzymes ... A mutant of uracil DNA glycosylase that distinguishes between cytosine and 5-methylcytosine. ...
MedlinePlus: Genes: M
Backbone dynamics of DNA containing 8-oxoguanine: Importance for substrate recognition by base excision repair glycosylases<...
Backbone dynamics of DNA containing 8-oxoguanine: Importance for substrate recognition by base excision repair glycosylases. ... Backbone dynamics of DNA containing 8-oxoguanine: Importance for substrate recognition by base excision repair glycosylases. / ... Backbone dynamics of DNA containing 8-oxoguanine : Importance for substrate recognition by base excision repair glycosylases. ... keywords = "AMBER, Glycosylase, Nucleotide flipping, Oxidative DNA damage",. author = "Dodson, {M. L.} and Lloyd, {R. Stephen ...
Structural Role of Uracil DNA Glycosylase for the Recognition of Uracil in DNA Duplexes. Clues from Atomistic Simulations
Structural Role of Uracil DNA Glycosylase for the Recognition of Uracil in DNA Duplexes. Clues from Atomistic Simulations. ... Structural Role of Uracil DNA Glycosylase for the Recognition of Uracil in DNA Duplexes. Clues from Atomistic Simulations / ... In the first stage of the base excision repair pathway the enzyme uracil DNA glycosylase (UNG) recognizes and excises uracil (U ... In the first stage of the base excision repair pathway the enzyme uracil DNA glycosylase (UNG) recognizes and excises uracil (U ...
RCSB PDB - 1NNJ: Crystal structure Complex between the Lactococcus lactis Fpg and an abasic site containing DNA
Crystal structure Complex between the Lactococcus lactis Fpg and an abasic site containing DNA ... Formamidopyrimidine-DNA glycosylase. C [auth A]. 271. Lactococcus lactis. Mutation(s): 1 Gene Names: mutM. EC: 3.2.2.23 (PDB ... Fpg is a DNA glycosylase that recognizes and excises the mutagenic 8-oxoguanine (8-oxoG) and the potentially lethal ... Fpg is a DNA glycosylase that recognizes and excises the mutagenic 8-oxoguanine (8-oxoG) and the potentially lethal ...