Cytochrome P-450 CYP1A1
- CYP1A1
Summary Report | CureHunter
This enzyme, encoded by CYP1A1 gene, can be measured by using ethoxyresorufin as a substrate for the ethoxyresorufin O- ... A liver microsomal cytochrome P-450 monooxygenase capable of biotransforming xenobiotics such as polycyclic hydrocarbons and ... CYP1A1; EROD; 7-Ethoxyresorufin O-Deethylase; CYP 1A1; CYP1A1 Protein; Cytochrome P450 IA1; Ethoxyresorufin Dealkylase; ... Cytochromes: 1553*Cytochrome P-450 Enzyme System: 3623*Aryl Hydrocarbon Hydroxylases: 16*Cytochrome P-450 CYP1A1: 1575*estrogen ...
Tissue-specific effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the activity of 5'-deiodinases I and II in rats
Cytochrome P-450 CYP1A1 / metabolism * Dose-Response Relationship, Drug * Iodide Peroxidase / metabolism* ...
Benzo(c)fluorene - Wikipedia
The type of cytochrome P 450 involved is thought to be CYP1A1. The biotransformation is depicted in the image below. First ... benzo[c]fluorene (1) is transformed into trans-3,4-dihydrodiol (2). This substance is transformed by CYP1A1 into the highly ... In general PAH carcinogenesis involves activation by the enzyme P-450 to diol epoxide metabolites with an epoxide ring in the ...
NIOSHTIC-2 Search Results - Full View
When both CYP1A1 and GSTT1 were considered, the greatest decrease was found among exposed mothers with the CYP1A1 AA-GSTT1 ... cytochrome P-450 CYP1A1; environmental exposure; genes; genetic predisposition to disease; gestational age; glutathione ... When stratified by the maternal CYP1A1 genotype, the estimated decrease was 0.54 (SE, 0.12) week for the AA group, which was ... CYP1A1 and GSTT1. This report includes 542 (302 nonexposed, 240 benzene-exposed) nonsmoking and nondrinking mothers of ...
Acne and Genetics | SpringerLink
the downloadable PDF
CYP1A1, the primary cytochrome P-450 isoenzyme that biologically activates benzo (a) pyrene, may be induced by other substances ... CYP1A1 inducible persons might be at greater risk for the effects of Susceptibility PAHs. Persons with a high degree of CYP1A1 ... CYP1A1, the primary cytochrome P-450 isoenzyme that biologically activates benzo (a) pyrene, may be induced by other substances ... The ability of CYP1A1 to biologically activate PAHs may be heritable and thus point to genetically susceptible populations at ...
Biblio | College of Agricultural Sciences
Frontiers | Gynura procumbens: An Overview of the Biological Activities
Ghofur, A., Hamid, I. S., and Listyorini, D. (2015). Anti-carcinogenic activity of Gynura procumbens extract through cytochrome ... Hamid, I. S., Meiyanto, E., and Widyarini, S. (2009). CYP1A1 and GSTμ expression of hepatocytes induced by 7,12-dimethylbenz(a) ... The treatment with ethanolic extract caused a significant reduction in expression and activity of cytochrome P-450 enzymes such ... Antioxidant properties of Gynura procumbens extracts and their inhibitory effects on two major human recombinant cytochrome ...
Biotransformation of Coumarin by Rodent and Human Cytochromes P-450: Metabolic Basis of Tissue-Selective Toxicity in Olfactory...
Furthermore, of 13 human cytochrome P-450s (P-450s) examined, five (CYP1A1, CYP1A2, CYP2B6, CYP2E1, and CYP3A4) were active in ... cytochrome P-450. b5. cytochromeb5. SF9. Spodoptera frugiperda. IgG. immunoglobulin G. GSH. reduced glutathione. o-HPA. o- ... Biotransformation of Coumarin by Rodent and Human Cytochromes P-450: Metabolic Basis of Tissue-Selective Toxicity in Olfactory ... Biotransformation of Coumarin by Rodent and Human Cytochromes P-450: Metabolic Basis of Tissue-Selective Toxicity in Olfactory ...
Coelho, N. R.<...
Estrogen and aryl hydrocarbon receptor expression and crosstalk in human Ishikawa endometrial cancer cells. - Texas A&M...
Search Results (14) | Profiles RNS
Dioxins. Medical search
... cytochrome P4501A1 (Cyp1a1). The HIF1alpha.ARNT complex binds to "hypoxia responsive enhancers" and activates the transcription ... CYP1A1 is primarily expressed in the liver, lung, and extrahepatic tissues such as the gut, skin, and immune cells. It is ... Overall, CYP1A1 is a critical enzyme in the metabolism of a wide range of compounds, and its activity can have significant ... Cytochrome P-450 CYP1A1 is an enzyme that plays a crucial role in the metabolism of various endogenous and exogenous compounds ...
Aroclor 1254 as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: Effects on enzyme induction and immunotoxicity - Fingerprint
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Cytochrome P-450 CYP1A1 10% * Cytochrome P-450 Enzyme System 3% * Enzyme Induction 78% ...
Ateneo abocado a responder amenazas y oportunidades del sector pecuario - Resultados de investigación
- Universidad...
Handali, S., Klarman, M., Gaspard, A. N., Dong, X. F., LaBorde, R., Noh, J., Lee, Y. M., Rodriguez, S., Gonzalez, A. E., H.Garcia, H., Gilman, R. H., Tsang, V. C. W. & Wilkins, P. P., abr. 2010, En: Clinical and Vaccine Immunology. 17, 4, p. 631-637 7 p.. Producción científica: Contribución a una revista › Artículo › revisión exhaustiva ...
Dong-Young Ryu - Citation Index - NCSU Libraries
Ateneo abocado a responder amenazas y oportunidades del sector pecuario - Resultados de investigación
- Universidad...
Arroyo, G., Rodriguez, S., Lescano, A. G., Alroy, K. A., Bustos, J. A., Santivañez, S., Pretell, E. J., Garcia, H. H., Gilman, R. H., Gonzalez, A. E., Tsang, V. C. W., Gonzalez, I., Saavedra, H., Martinez, M., Alvarado, M., Verastegui, M., Zimic, M., Mayta, H., Guerra, C., Castillo, Y., y 13 otrosCastro, Y., Lopez, M. T., Gavidia, C. M., Gomez, L., Moyano, L. M., Gamboa, R., Muro, C., Vilchez, P., Nash, T. E., Mahanty, S., Noh, J., Handali, S. & Friedland, J., 15 ene. 2018, En: Clinical Infectious Diseases. 66, 2, p. 282-288 7 p.. Producción científica: Contribución a una revista › Artículo › revisión exhaustiva ...
Human Cytochrome P450 Liability Studies of |i|trans|/i|-Dihydronarciclasine: A Readily Available, Potent, and Selective Cancer...
Compound 5 also demonstrated no inhibition of the related human cytochromes CYP19 and CYP1A1. This study elevates the status of ... Human Cytochrome P450 Liability Studies of trans-Dihydronarciclasine: A Readily Available, Potent, and Selective Cancer Cell ... The cytochrome P45O activities of the naturally occurring Amaryllidaceae alkaloid narciclasine (3), isolated from Narcissus ...
Over-expression of AhR (aryl hydrocarbon receptor) induces neural differentiation of Neuro2a cells: neurotoxicology study |...
CYP1A1, a typical XRE-regulated gene, mRNA was induced without the application of ligand to the culture medium. N2a-Rα cells ... Suppression of CYP1A1 mRNA expression by si-AhR. These graphs demonstrate the repression of AhR and CYP1A1 mRNA expression by ... Jones PB, Durrin LK, Galeazzi DR, Whitlock JP: Control of cytochrome P1-450 gene expression: analysis of a dioxin-responsive ... "CYP1A1"). Scramble siRNA did not exhibit any effect on the mRNA expressions of AhR and CYP1A1 compared with Mock. The results ...
KAKEN - Researchers | TOKUNAGA Shohji (50227584)
Short- and long-term biochemical effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin in female Long-Evans rat<...
Maternal cigarette smoking, metabolic gene polymorphisms, and preterm delivery: New insights on G × E interactions and...
Taken together, maternal smoking significantly increased the risk of PTD among women with high-risk CYP1A1 and GSTT1 genotypes ... Cytochrome P-450 CYP1A1 Medicine & Life Sciences 79% * Mothers Medicine & Life Sciences 64% ... Taken together, maternal smoking significantly increased the risk of PTD among women with high-risk CYP1A1 and GSTT1 genotypes ... Taken together, maternal smoking significantly increased the risk of PTD among women with high-risk CYP1A1 and GSTT1 genotypes ...
2,3,7,8-tetrachlorodibenzo-P-dioxin induces cytochrome P450IA1 enzyme activity by activating transcription of the corresponding...
We have reviewed the transcriptional regulation of the CYP1A1 gene, which encodes the cytochrome P450IA1 enzyme. TCDD induces ... N2 - We have reviewed the transcriptional regulation of the CYP1A1 gene, which encodes the cytochrome P450IA1 enzyme. TCDD ... AB - We have reviewed the transcriptional regulation of the CYP1A1 gene, which encodes the cytochrome P450IA1 enzyme. TCDD ... abstract = "We have reviewed the transcriptional regulation of the CYP1A1 gene, which encodes the cytochrome P450IA1 enzyme. ...
Investigating the inhibition of cytochrome P450 isoform 1A1 by açai berry (Euterpe oleracea) extracts using a bioassay guided...
Acai Berry, CYP1A1. Subjects. Cytochrome P-450 $x Inhibitors. Enzyme inhibitors. Acai palm. ... Investigating the inhibition of cytochrome P450 isoform 1A1 by açai berry (Euterpe oleracea) extracts using a bioassay guided ... Utilizing an activity guided fractionation scheme, acai berry extracts were assayed in CYP1A1 and CYP1A2 enzyme reactions to ... Investigating the inhibition of cytochrome P450 isoform 1A1 by açai berry (Euterpe oleracea) extracts using a bioassay guided ...
Pharmacogenetics
Cytochrome P-450 CYP1B1 | Profiles RNS
"Cytochrome P-450 CYP1B1" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... A cytochrome P450 aryl hydrocarbon hydroxylase that has specificity for ESTROGENS which it converts into 4-hydroxy estrogens. ... This graph shows the total number of publications written about "Cytochrome P-450 CYP1B1" by people in this website by year, ... Below are the most recent publications written about "Cytochrome P-450 CYP1B1" by people in Profiles. ...
Minoru Shimoda<...
Objective-To evaluate the inhibitory potency of ketoconazole (KTZ) on the metabolic activities of isozymes of cytochrome P-450 ... Furthermore, no influence of KTZ on the pharmacokinetics of CYP1A1/2, CYP2C21, and CYP2D15 substrates are likely. In clinical ... In vitro characterization of the inhibitory effects of ketoconazole on metabolic activities of cytochrome P-450 in canine ... Effect of oral administration of clinically relevant doses of dexamethasone on regulation of cytochrome P450 subfamilies in ...
The murine Cyp1a1 gene is expressed in a restricted spatial and temporal pattern during embryonic development. - Immunology
These novel data suggest that the Cyp1a1 protein may play a role in murine development and that regulation of the Cyp1a1 gene ... By comparison, constitutive CYP1A1 promoter activity in the embryo was identical in the presence of either the high or low ... Using established transgenic mouse lines where 8.5 kb of the rat CYP1A1 promoter is cloned upstream of the lacZ reporter gene ( ... In contrast to the absence of constitutive Cyp1a1 and lacZ transgene expression in tissues of the adult mouse, a constitutive ...
MESH TREE NUMBER CHANGES - 2015 MeSH
E4.502.250.180 Cytochrome P-450 CYP1A1 D8.244.453.40.555 D8.244.453.40.332 Cytochrome P-450 CYP1A2 D8.244.453.40.777 D8.244. ... D12.776.422.220.453.300 Cytochrome P-450 CYP3A D8.244.453.40.986 D8.244.453.400 D8.811.682.690.708.170.40.888 D8.811.682.690. ... Replaced for 2014 by Cytochrome P-450 CYP4A) Amacrine Cells A8.663.358.50 A8.675.358.50 A8.663.650.850.500 A8.675.650.850.500 ... 453.40.443 D12.776.422.220.453.40.555 D12.776.422.220.453.40.443 Cytochrome P-450 CYP2B1 D8.244.453.40.888 D8.244.453.40.550 ...
MESH TREE NUMBER CHANGES - 2015 MeSH
E4.502.250.180 Cytochrome P-450 CYP1A1 D8.244.453.40.555 D8.244.453.40.332 Cytochrome P-450 CYP1A2 D8.244.453.40.777 D8.244. ... D12.776.422.220.453.300 Cytochrome P-450 CYP3A D8.244.453.40.986 D8.244.453.400 D8.811.682.690.708.170.40.888 D8.811.682.690. ... Replaced for 2014 by Cytochrome P-450 CYP4A) Amacrine Cells A8.663.358.50 A8.675.358.50 A8.663.650.850.500 A8.675.650.850.500 ... 453.40.443 D12.776.422.220.453.40.555 D12.776.422.220.453.40.443 Cytochrome P-450 CYP2B1 D8.244.453.40.888 D8.244.453.40.550 ...