Biochemical and functional characterization of a novel neuron-glia adhesion molecule that is involved in neuronal migration. |...
... is a novel neural cell adhesion molecule that mediates neuron-astrocyte interaction in vitro. In situ AMOG is expressed in the ... Adhesion molecule on glia (AMOG) is a novel neural cell adhesion molecule that mediates neuron-astrocyte interaction in vitro. ... family of neural cell adhesion molecules but expresses another carbohydrate epitope that is shared with the adhesion molecules ... Degeneration of neural cells in the central nervous system of mice deficient in the gene for the adhesion molecule on Glia, the ...
Membrane Proteins - Cell Adhesion Molecules, Neuronal | CU Experts | CU Boulder
Membrane Proteins - Cell Adhesion Molecules, Neuronal PubMed MeSh Term *Overview. Overview. subject area of * A novel mode of ... Membrane Proteins - Cell Adhesion Molecules PubMed MeSh Term narrower concept * Membrane Proteins - Contactins PubMed MeSh Term ... FAK deficiency in cells contributing to the basal lamina results in cortical abnormalities resembling congenital muscular ... Massive loss of Cajal-Retzius cells does not disrupt neocortical layer order Journal Article ...
Genetic predictors of weight loss and weight regain after intensive lifestyle modification, metformin treatment, or standard...
Molecular genetics of neuronal recognition in Drosophila: Evolution and function of immunoglobulin superfamily cell adhesion...
Evolution and function of immunoglobulin superfamily cell adhesion molecules. G. Grenningloh, A. J. Bieber, E. J. Rehm, P. M. ... Evolution and function of immunoglobulin superfamily cell adhesion molecules. Together they form a unique fingerprint. ... Dive into the research topics of Molecular genetics of neuronal recognition in Drosophila: ... Molecular genetics of neuronal recognition in Drosophila: ...
NRCAM - Wikipedia
Neuronal cell adhesion molecule is a protein that in humans is encoded by the NRCAM gene. Cell adhesion molecules (CAMs) are ... NRCAM neuronal cell adhesion molecule". Marui T, Funatogawa I, Koishi S, et al. (2008). "Association of the neuronal cell ... This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III ... Grumet M (1997). "Nr-CAM: a cell adhesion molecule with ligand and receptor functions". Cell Tissue Res. 290 (2): 423-8. doi: ...
In Vitro Modeling of the Bipolar Disorder and Schizophrenia Using Patient-Derived Induced Pluripotent Stem Cells with Copy...
Cell Adhesion Molecules, Neuronal / genetics * Cell Culture Techniques / methods* * Cells, Cultured * DNA Copy Number ... 2 iPS Cell-Based Drug Discovery, Drug Research Division, Sumitomo Dainippon Pharma. Co., Ltd, Osaka, Osaka 554-0022, Japan. ... Additionally, we analyzed isogenic PCDH15- or RELN-deleted cells. The dendrite and synapse phenotypes of isogenic neurons were ... In Vitro Modeling of the Bipolar Disorder and Schizophrenia Using Patient-Derived Induced Pluripotent Stem Cells with Copy ...
Frontiers | Intramuscular Delivery of Gene Therapy for Targeting the Nervous System
This is particularly enticing for neuronal conditions, as the nervous system is renowned for its intransigence to therapeutic ... For successful transgene expression, viruses administered into muscle must undergo a series of processes, including host cell ... This is particularly enticing for neuronal conditions, as the nervous system is renowned for its intransigence to therapeutic ... For successful transgene expression, viruses administered into muscle must undergo a series of processes, including host cell ...
Proteomes | Free Full-Text | The Proteome of the Murine Presynaptic Active Zone
... of presynaptic proteins with their targets and opens novel insights into the functional role of these proteins in neuronal ... proteins involved in intracellular and extracellular signaling and a large variety of adhesion molecules, were identified. ... and the GPI-anchored neural cell adhesion molecule, neurotrimin [72]. The cell adhesion molecules, SynCAM 2/3, engaged in homo ... a neuronal cell adhesion molecule implicated in axogenesis and myelination. Biol. Cell 2002, 94, 327-334. [Google Scholar] [ ...
Hepatocellular Adenoma (Hepatic Adenoma): Practice Essentials, Background, Pathophysiology
... are also known as hepatic adenomas or liver cell adenomas. They are rare, benign tumors of presumable epithelial origin and ... Diagnostic use of cytokeratins, CD34, and neuronal cell adhesion molecule staining in focal nodular hyperplasia and hepatic ... Liver cell adenoma: a multicenter analysis of risk factors for rupture and malignancy. Ann Surg Oncol. 2009 Mar. 16(3):640-8. [ ... 19] Tumor cell analysis showed biallelic inactivation of HNFα. Micro/small HNF1α-inactivated HCAs have also been incidental ...
Regeneration of Aplysia Bag Cell Neurons is Synergistically Enhanced by Substrate-Bound Hemolymph Proteins and Laminin |...
We have investigated Aplysia hemolymph as a source of endogenous factors to promote regeneration of bag cell neurons. We ... An Aplysia cell adhesion molecule associated with site-directed actin filament assembly in neuronal growth cones. J. Cell Sci. ... Neuronal transcriptome of Aplysia: neuronal compartments and circuitry. Cell 127, 1453-1467 (2006). ... it would not be surprising if endogenous lectins could function as neuronal adhesion molecules. Lectins from Aplysia hemolymph ...
A Pilot Study Assessing the Potential Role of non-CD133 Colorectal Cancer Stem Cells as Biomarkers
Involved in neuronal extension, embryonic hemopoiesis, embryonic angiogenesis. -Cell adhesion molecule. -Associated with ... Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein mediating epithelium-specific intercellular adhesion ... Involved in cell growth, differentiation, migration and death. CD44. CD44. -Cell surface glycoprotein involved in cell adhesion ... Epithelial cell adhesion molecule expression (CD326) in cancer: a short review. Cancer Treat Rev. 2012;38:68-75 ...
Kang Shen's Profile | Stanford Profiles
An Extracellular Adhesion Molecule Complex Patterns Dendritic Branching and Morphogenesis CELL Dong, X., Liu, O. W., Howell, A ... Extracellular adhesion molecules and their neuronal receptors guide the growth and branching of axons and dendrites. Growth ... While several cell-adhesion and secreted molecules promote the assembly of synapses, the contribution of signals that ... Functional dissection of SYG-1 and SYG-2, cell adhesion molecules required for selective synaptogenesis in C-elegans MOLECULAR ...
Alphabetical Browse | Britannica
Gerald Maurice Edelman: …1975 he discovered substances called cell adhesion molecules (CAMs), which "glue" cells together to ... His work led to the construction of a general theory of brain development and function called neuronal… ... Root hairs also begin to develop as simple extensions of protodermal cells near the root apex. They greatly increase the ... cambium, in plants, layer of actively dividing cells between xylem (wood) and phloem (bast) tissues that is responsible for the ...
Contactin Associates with Sodium Channel Nav1.3 in Native Tissues and Increases Channel Density at the Cell Surface | Journal...
A soluble form of the F3 neuronal cell adhesion molecule promotes neurite outgrowth. J Cell Biol 117: 877-887. ... However, factors that regulate delivery of Nav1.3 to the cell surface are not known. Contactin/F3, a cell adhesion molecule, ... Contactin enhances Nav1.3 at the cell surface in transfected HEK 293 cells. HEK-Nav1.3 cells or HEK-Nav1.3 cells transfected ... of cell extracts prepared from control HEK 293 cells transfected with Ctn-GFP, HEK-Nav1.3 cells, or HEK-Nav1.3 cells ...
Corey S. Goodman - Publications
Pathway recognition by neuronal growth cones: genetic analysis of neural cell adhesion molecules in Drosophila. Current Opinion ... The role of cell interactions and cell lineage in the determination of neuronal precursor cells. Developmental Biology. 111: ... Genetic analysis reveals multiple roles for a cell adhesion molecule during the generation of neuronal specificity. Cold Spring ... Connectin: a homophilic cell adhesion molecule expressed on a subset of muscles and the motoneurons that innervate them in ...
L1CAM Mouse Monoclonal Antibody [Clone ID: OTI1A8] - TA501437 | OriGene
This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and ... Recombinant protein of human L1 cell adhesion molecule (L1CAM), transcript variant 1, 20 µg ... Transient overexpression lysate of L1 cell adhesion molecule (L1CAM), transcript variant 1 ... Full length human recombinant protein of human L1CAM (NP_000416) produced in HEK293T cell.. ...
Gene Report for G00006395 - Genes2Cognition Neuroscience Research Programme
Intermediate Progenitors in Adult Hippocampal Neurogenesis: Tbr2 Expression and Coordinate Regulation of Neuronal Output |...
DCX and polysialylated neural cell adhesion molecule (PSA-NCAM) were used to determine whether Tbr2 colocalizes with markers of ... most Tbr2+ cells were present as single cells or pairs of cells. The frequency of clusters larger than four cells was low in ... S-U, Some Tbr2-GFP+ cells colocalized with NeuN, which is expressed in all neuronal nuclei. Generally, Tbr2-GFP+/NeuN+ cells ... D-F, Cells expressing Tbr2-GFP had diverse morphologies, some with tangentially oriented cell bodies typical of type-2 cells (D ...
Characterization of Different Microbubbles in Assisting Focused Ultrasound-Induced Blood-Brain Barrier Opening | Scientific...
Evans blue, dynamic contrast-enhanced (DCE) MRI and small-animal ultrasound imaging were used as surrogates to allow molecule- ... and junctional adhesion molecules to support specialized endothelial cells, forming the tight junction to prevent molecules ... The BBB allows for the controlled transport of necessary peptides and proteins to maintain proper neuronal function, even under ... Evans blue, dynamic contrast-enhanced (DCE) MRI and small-animal ultrasound imaging were used as surrogates to allow molecule- ...
Molecular Characterization of Cryptically Circulating Rabies Virus from Ferret Badgers, Taiwan - Volume 20, Number 5-May 2014 -...
Evidence is strong that the muscular form of the nicotinic acetylcholine receptor, the neuronal cell adhesion molecule, and the ... The increased pathogenicity is caused by increased virus spread in vivo and faster internalization of the virus into cells (36 ... G is responsible for cell attachment and fusion and is the main viral protein responsible for the induction of neutralization ... internalization of the virus into cells after N194K substitution might suggest that this region has some role in host cell ...
BBB seminar: George Uhl | The Department of Biomedicine | UiB
"Cell adhesion" molecules, the brain and brain disorders: examples from addiction studies ... molecules are often misunderstood, since different CAMs play differential roles in: a) the way in which adjacent neuronal/glial ... between neurons are established and modulated in ways that depend substantially on their expression of cell adhesion molecules ...
BUV737 Mouse Anti-Human CD49a
... of the integrin family of cell adhesion molecules. CD49a associates with the integrin β1 subunit (CD29) to form the α1/β1 ... neuronal cells and smooth muscle cells. CD49a has been reported to play a role in cell attachment during the development of ... neuronal cells and smooth muscle cells. CD49a has been reported to play a role in cell attachment during the development of ... of the integrin family of cell adhesion molecules. CD49a associates with the integrin β1 subunit (CD29) to form the α1/β1 ...
Polysialic acid, a glycan with highly restricted expression, is found on human and murine leukocytes and modulates immune...
... typically found attached to the protein scaffold neural cell adhesion molecule (NCAM). PolySia is best known for its proposed ... role in modulating neuronal development. Its presence and potential functions outside the nervous systems are essentially ... Profiling surface glycans and glycoprotein expression of human embryonic stem cells. *Human Stem Cell Training at UC Berkeley ... Herein we show the expression of polySia on hematopoietic progenitor cells, and demonstrate a role for this glycan in immune ...
SMART: CUB domain annotation
Neuropilin (A5 antigen), a calcium-independent cell adhesion molecule that functions during the formation of certain neuronal ... complement subcomponents Cls/Clr and the neuronal recognition molecule A5. Most of them are known to be involved in ... cell signalling, fertilisation, haemostasis, inflammation, neurotransmission, receptor-mediated endocytosis, and tumour ...
Frontiers | A Disintegrin and Metalloprotease 17 in the Cardiovascular and Central Nervous Systems
ADAM17 is a metalloprotease and disintegrin that lodges in the plasmatic membrane of several cell types and is able to cleave a ... wide variety of cell surface proteins. It is somatically expressed in mammalian organisms and its proteolytic action influences ... ADAM17 is a metalloprotease and disintegrin that lodges in the plasmatic membrane of several cell types and is able to cleave a ... wide variety of cell surface proteins. It is somatically expressed in mammalian organisms and its proteolytic action influences ...
Intracellular Adhesion Molecule 3 monoclonal antibody Flow Cytometry, Immunohistochemistry, Western, Immunofluorescence,...
Mouse monoclonal Intracellular Adhesion Molecule 3 monoclonal antibody. 100% Bioguaranteed ... Activation of cells bearing LFA-1. Mapping of the ICAM-5 (telencephalin) gene, a neuronal member of the ICAM family, to a ... Intercellular adhesion molecule 5 (ICAM-5, telencephalin) is a cell adhesion molecule expressed on neurons in the most rostral ... and mediates adhesive interactions of leukocyte cell surface adhesion molecules in inflammatory and immune response. LFA-1 ...
Caspr regulates the processing of contactin and inhibits its binding to neurofascin | Journal of Cell Biology | Rockefeller...
Three cell adhesion molecules are present at the axoglial junctions that form between the axon and myelinating glia on either ... F3/contactin, a neuronal cell adhesion molecule implicated in axogenesis and myelination. Biol. Cell. ... F3/contactin, a neuronal cell adhesion molecule implicated in axogenesis and myelination. Biol. Cell. ... An oligodendrocyte cell adhesion molecule at the site of assembly of the paranodal axo-glial junction. J. Cell Biol. ...
The Emerging Portrait of Glial Cell Line-derived Neurotrophic Factor Family Receptor Alpha (GFRα) in Cancers
Neural cell adhesion molecule (NCAM) is a homophilic binding glycoprotein playing critical roles in cell-cell adhesion, neurite ... GDNF and GFRα1 promote formation of neuronal synapses by ligand-induced cell adhesion. Nature neuroscience. 2007;10:293-300 ... The Neural Cell Adhesion Molecule NCAM Is an Alternative Signaling Receptor for GDNF Family Ligands. Cell. 2003;1130-879 ... Regarding cell adhesion molecules, GDNF can induce the association of membrane-bound GFRα from non-same cells (trans-homophilic ...
Kallmann Syndrome and Idiopathic Hypogonadotropic Hypogonadism: Practice Essentials, Pathophysiology, Etiology
The KAL1 gene (present on band Xp22.3) encodes anosmin-1, a putative neural cell adhesion molecule that is essential for the ... In these patients, GnRH deficiency and anosmia are believed to be secondary to abnormalities of neuronal migration during ... Mutations of the KAL1 gene, which encodes a putative neural cell adhesion molecule (anosmin), have been described in several ... 13] Also of note, heterozygous missense mutations of the NSMF (NMDA receptor synaptonuclear signaling and neuronal migration ...