Aprotinin - Wikipedia
Nordic became distributor of aprotinin in 2012. Aprotinin is a monomeric (single-chain) globular polypeptide derived from ... aprotinin may increase the risk of death. On October 29, 2006 the Food and Drug Administration issued a warning that aprotinin ... 30,000 of whom received aprotinin and the rest other anti-fibrinolytics. The study concluded aprotinin carried greater risks. ... Small amounts of aprotinin can be added to tubes of drawn blood to enable laboratory measurement of certain rapidly degraded ...
Aprotinin-related mortality risk
Aprotinin is currently approved for preventing perioperative blood loss and cutting the need for transfusions during pump- ... Cite this: Aprotinin-related mortality risk puts brakes on randomized surgery trial - Medscape - Oct 25, 2007. ... BART had been designed to determine whether aprotinin would be better than either epsilon-aminocaproic acid or tranexamic acid ... The announcement closely follows the publication of a massive meta-analysis of randomized trials suggesting that aprotinin does ...
TRASYLOL® (aprotinin injection)
Re-exposure to aprotinin: Administration of aprotinin, especially to patients who have received aprotinin in the past, requires ... Trasylol® (aprotinin injection), C284H432N84O79S7, is a natural proteinase inhibitor obtained from bovine lung. Aprotinin ( ... Aprotinin is slowly degraded by lysosomal enzymes. The physiological renal handling of aprotinin is similar to that of other ... Hypersensitivity to aprotinin.. Administration of Trasylol® to patients with a known or suspected previous aprotinin exposure ...
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Aprotinin Inhibits SARS-CoV-2 Replication - PubMed
Aprotinin Inhibits SARS-CoV-2 Replication Denisa Bojkova 1 , Marco Bechtel 1 , Katie-May McLaughlin 2 , Jake E McGreig 2 , ... In conclusion, therapeutic aprotinin concentrations exert anti-SARS-CoV-2 activity. An approved aprotinin aerosol may have ... Hence, aprotinin may compensate for downregulated host cell proteases during later virus replication cycles. Aprotinin ... Aprotinin Inhibits SARS-CoV-2 Replication Denisa Bojkova et al. Cells. 2020. . ...
Aprotinin decreases blood loss and blood product utilization in patients undergoing thoracoabdominal aneurysmectomy
Pugh, S.C.; Wielogorski, A.K. 1995: A comparison of the effects of tranexamic acid and low-dose aprotinin on blood loss and ... Taggart, D.P.; Djapardy, V.; Naik, M.; Davies, A. 2003: A randomized trial of aprotinin (Trasylol) on blood loss, blood product ... Janssens, M.; Joris, J.; David, J.L.; Lemaire, R.; Lamy, M. 1994: High-dose aprotinin reduces blood loss in patients undergoing ... Murkin, J.M.; Shannon, N.A.; Bourne, R.B.; Rorabeck, C.H.; Cruickshank, M.; Wyile, G. 1995: Aprotinin decreases blood loss in ...
Vitellogenin Analysis and the use of Aprotinin in Ecotoxicology - Smithers
Home Resources Vitellogenin Analysis and the use of Aprotinin in Ecotoxicology Vitellogenin Analysis and the use of Aprotinin ... These data indicate that addition of aprotinin to fathead minnow plasma as a means to stabilize VTG for analysis should be re- ... Results were inconclusive - with VTG levels being unaffected by the presence or absence of aprotinin in the majority of samples ... Tracey Goodband, Senior Manager of Ecotoxicology from Smithers in Harrogate, and her team looked at the impact of aprotinin on ...
Aprotinin: Uses, Interactions, Mechanism of Action | DrugBank Online
Aprotinin is a serine protease inhibitor used to reduce the risk for perioperative blood loss and the need for blood ... Aprotinin. DrugBank Accession Number. DB06692. Background. Aprotinin is a protein-based drug that is also known as bovine ... Aprotinin is slowly degraded by lysosomal enzymes.. Route of elimination. Following a single IV dose of radiolabelled aprotinin ... Aprotinin may increase the neuromuscular blocking activities of Aclidinium.. Albutrepenonacog alfa. Aprotinin may increase the ...
INHIBITION OF MICROAGGREGATION BY APROTININ IN ACD-BLOOD | Anesthesiology | American Society of Anesthesiologists
INHIBITION OF MICROAGGREGATION BY APROTININ IN ACD-BLOOD H. Harke, M.D.; H. Harke, M.D. ... H. Harke, S. Rahman, M. Gennrich; INHIBITION OF MICROAGGREGATION BY APROTININ IN ACD-BLOOD. Anesthesiology 1980; 53:S161 doi: ... Aprotinin Decreases Blood Loss and Homologous Transfusions in Patients Undergoing Major Orthopedic Surgery Anesthesiology ( ... THE EFFECT OF APROTININ-ACD-BLOOD ON PULMONARY FUNCTION Anesthesiology (September 1980) ...
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Transfusion Requirements in Liver Transplantation: Overview, History and Background, Bleeding During Liver Transplantation
These include aprotinin, epsilon amino caproic acid (epsilon-ACA), and tranexamic acid. [53] Recently, aprotinin has incited ... Aprotinin. Aprotinin is a serine protease inhibitor that prevents the lysis of fibrinogen by inhibiting plasmin, kallikrein, ... However, other studies have not reported a benefit with aprotinin use. Therefore, the precise role of aprotinin remains ... A comparison of aprotinin and lysine analogues in high-risk cardiac surgery. N Engl J Med. 2008 May 29. 358(22):2319-31. [QxMD ...
Aprotinin - information til sundhedsfaglige - Medicin.dk
Polypeptidet aprotinin, som udvindes af bovint lungevæv, hæmmer relativt uspecifikt en række enzymer, herunder enzymer fra ... Aprotinin blev taget af markedet i 2007 på grund af mistanke om protrombotisk virkning, men efter revurdering af de ... Polypeptidet aprotinin, som udvindes af bovint lungevæv, hæmmer relativt uspecifikt en række enzymer, herunder enzymer fra ... Aprotinin skal administreres intravenøst. Polypeptidet kan, især ved gentagne ekspositioner, udløse allergiske/anafylaktiske ...
Polyclonal Antibody to Aprotinin (AP) - danabio
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Abstract | Prospective, Randomized, comparative study between aprotinin and tranexamic acid in cardiac surgery | Journal of...
... of aprotinin over 30 minutes, then infusion of 500 000 KIU/hr throughout the operation and 2 000 000 aprotinin KIU) were added ... Use of aprotinin should be useful for cases at high risk for bleeding such as redo surgery. It should be used cautiously in ... The effects of aprotinin and TA were monitored by ACT, PT, INR, aPTT, platelets, fibrinogen, D-dimer, troponin I, blood losses ... Conclusion: Aprotinin decreases fibrinolysis, blood losses, and need for blood products transfusion in comparison to TA during ...
Aprotinin: effect on bleeding during and after surgery - Teachers of EBHC
Aprotinin: effect on bleeding during and after surgery. < Back to search results * Format Audio, Texts ... Aprotinin works. The shocking bit is that, long after strong evidence had accumulated showing that the drug substantially ... A shocking analysis published in 2005 focused on controlled trials of a drug called aprotinin to reduce bleeding during and ... Between 1987 and 2002, the proportion of relevant previous reports cited in successive reports of aprotinin trials fell from a ...
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Inhibition of tryptase TL2 from human T4(+) lymphocytes and inhibition of HIV-1 replication in H9 cells by recombinant...
In contrast to native aprotinin, the recombinant variant [Arg(15), Phe(17), Glu(52)]aprotinin with a reactive-site sequence ... The [Leu(15), Phe(17), Glu(52)]aprotinin showed a significant retardation of syncytium formation over a period of 5 days in a 1 ... Recombinant variants of the Kunitz-type serine proteinase inhibitor aprotinin were investigated for their ability to inhibit ... aprotinin variant with hydrophobic subsites was the most potent inhibitor of the binding of gp120 to tryptase TL2 (68%). Our ...
Removal of aprotinin from low-dose aprotinin/tranexamic acid antifibrinolytic therapy increases transfusion requirements in...
Vonk, ABA, Meesters, MI, Schats, J, Romijn, JWA, Jansen, EK & Boer, C 2011, Removal of aprotinin from low-dose aprotinin/ ... Removal of aprotinin from low-dose aprotinin/tranexamic acid antifibrinolytic therapy increases transfusion requirements in ... Removal of aprotinin from low-dose aprotinin/tranexamic acid antifibrinolytic therapy increases transfusion requirements in ... Removal of aprotinin from low-dose aprotinin/tranexamic acid antifibrinolytic therapy increases transfusion requirements in ...
Safety of Perioperative Aprotinin Administration During Isolated Coronary Artery Bypass Graft Surgery: Insights From the ART ...
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Frontiers | Inflammation and Oxidative Stress in the Context of Extracorporeal Cardiac and Pulmonary Support
Effects of Aprotinin or Tranexamic Acid on Proteolytic/Cytokine Profiles in Infants After Cardiac Surgery. Ann Thorac Surg ( ... Aprotinin and Methylprednisolone Equally Blunt Cardiopulmonary Bypass-Induced Inflammation in Humans. J Thorac Cardiovasc Surg ... Aprotinin and the Systemic Inflammatory Response After Cardiopulmonary Bypass. Ann Thorac Surg (2001) 71(2):745-54. doi: ... Judging the Safety of Aprotinin. New Engl J Med (2006) 355(21):2261-2. doi: 10.1056/NEJMc066520 ...
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Alternative perioperative anticoagulation monitoring during cardiopulmonary bypass in aprotinin-treated patients. J ...