CD47 is a ubiquitously expressed innate immune checkpoint that promotes evasion of tumors from immune surveillance. Given both ... associated antigen, yet anti-GPC3 therapies have achieved only minimal clinical progress. ... GPC3/CD47 biAb is highly efficacious against dual antigen-expressing tumor cells both in vitro and in vivo (A) GPC3/CD47 biAb ... R1: binding response of the GPC3/CD47 biAb to the immobilized GPC3. R2: binding response of CD47 to the GPC3/CD47 biAb. (B) The ...

CD47), partial (Active). It is produced in Mammalian cell. High purity. Good price. ... CD 47; CD47; CD47 antigen (Rh-related antigen; integrin-associated signal transducer); CD47 antigen; CD47 glycoprotein; CD47 ... Recombinant Human Leukocyte surface antigen CD47 (CD47), partial (Active). Recombinant Human Leukocyte surface antigen CD47 ( ... Recombinant Human Leukocyte surface antigen CD47 (CD47), partial,Biotinylated ( Mammalian cell-CSB-MP004940HUj8-B ) ...

Antigens, CD45. Leukocyte Common Antigens. Antigens, CD46. Membrane Cofactor Protein. Antigens, CD47. CD47 Antigen. ... Antigens, CD98 Heavy Chain. Fusion Regulatory Protein 1, Heavy Chain. Antigens, CD98 Light Chains. Fusion Regulatory Protein 1 ... Antigen Peptide Transporter-1. ATP-Binding Cassette Sub-Family B Member 2. ... Antigen Peptide Transporter-2. ATP-Binding Cassette, Sub-Family B, Member 3. ...

CD47 was first identified as a tumor antigen on human ovarian cancer in the 1980s. Since then, CD47 has been found to be ... "Entrez Gene: CD47 CD47 molecule". Sick E, Jeanne A, Schneider C, Dedieu S, Takeda K, Martiny L (December 2012). "CD47 update: a ... is elevated in CD47-null endothelial cells and a human T cell line lacking CD47. Activation of CD47 with TSP-1 in wild-type ... 1994). "Rh-related antigen CD47 is the signal-transducer integrin-associated protein". J. Biol. Chem. 269 (3): 1567-70. doi: ...

Motivated by reports of upregulation of CD47 on both normal and cancerous stem cells [1: Jaiswal et al., 2009] and also by ... in part because self cells express CD47 as a ligand for signal regulatory protein SIRPalpha, which inhibits phagocytosis. ... Antigens, Differentiation / genetics * Antigens, Differentiation / immunology* * CD47 Antigen / genetics * CD47 Antigen / ... One common human polymorph of SIRPalpha is studied and binds more strongly to human-CD47 than to mouse-CD47 (K(d) approximately ...

... upregulated antigen presentation machinery, recruited and presented antigen to T cells and resisted the effects of ... CAR macrophages (CAR-Ms) demonstrated antigen-specific phagocytosis and tumor clearance in vitro. In two solid tumor xenograft ... Primary macrophages engineered to express chimeric antigen receptors have anti-tumor activity in humanized mice. ... Chimeric antigen receptor (CAR) T cell therapy has shown promise in hematologic malignancies, but its application to solid ...

B7-H1 Antigen / biosynthesis * B7-H1 Antigen / genetics * CD47 Antigen / biosynthesis * CD47 Antigen / genetics ... we identified a subpopulation of M1 macrophages present in periodontally affected tissues which expressed high levels of CD47, ...

CD47/2937] conjugated to Biotin. Validated in IHC, Protein Array and tested in Human. Immunogen corresponding to recombinant ... Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol. ... Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Biotin Anti-CD47 antibody [CD47/2937] (ab271823) ... Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Biotin Anti-CD47 antibody [CD47/2937] (ab271823) ...

EVs released by Jurkat cells were captured with anti-CD47-MNPs and stained for CD63 antigen. Volumetric control was used to ... b) Log2 total RPM values are plotted for the indicated tRNAs from CD47+ EVs (blue bars) and uncaptured CD47− EVs. (c) Log2 RPM ... b) 27 miRNAs were upregulated, and 5 hsa-miRNA are enriched only in CD47+ EVs. (c) A comparison of CD47+ and CD63+ EVs shows ... Characterization of Jurkat T cell EV fractions and CD47 expression. (a,b) EVs were extracted from wild type (a) and CD47- ...

MeSH Terms: Angiotensin II/pharmacology*; CD47 Antigen; Calcium/metabolism*; Cells, Cultured; Flow Cytometry; Guanylate Cyclase ... Inhibition of sGC requires binding to cell-surface receptor CD47. Here, we show that a TSP-1 C-terminal fragment (E3CaG1) ... we show that E3CaG1 binds directly to CD47 on the surface of Jurkat T cells. Using digital imaging microscopy on live cells, we ...

Adding CD47 to Artificial Antigen-Presenting Cells May Stimulate T-Cell Responses and Improve Functionality. Artificial antigen ... As more experience is gained with the use of genetically engineered chimeric antigen receptor (CAR) T cells in patients with ... In a study reported in Clinical Cancer Research, Bruns and colleagues added CD47 to classic two-signal artificial... ... cells have been shown to stimulate antigen-specific T-cell responses, but their effect in vivo may be compromised by rapid ...

This research shows that macrophages can be effective at antigen presentation and are powerful initiators of the CD8+T cell ... Stanford Medicine News 2013 05 Anti-CD47 antibody may offer new route to successful cancer vaccination Story ... The Stanford group plans to start human clinical trials of the anti-CD47 cancer therapy in 2014. The new research provides hope ... The fact that T cells become involved in fighting cancer as a result of CD47-blocking antibody therapy could have important ...

Novel CD47: SIRPα dependent mechanism for the activation of STAT3 in antigen-presenting cell.. Toledano N; Gur-Wahnon D; Ben- ... Targeting the CD47-SIRPα signaling axis: current studies on B-cell lymphoma immunotherapy.. Zhang J; Jin S; Guo X; Qian W. J ... 3. CD47 Expression Defines Efficacy of Rituximab with CHOP in Non-Germinal Center B-cell (Non-GCB) Diffuse Large B-cell ... 1. Combination of CD47 and signal-regulatory protein-α constituting the "dont eat me signal" is a prognostic factor in diffuse ...

Exbio - Research products - Antibodies - CD and related antigens - Anti-Hu CD172ab PE ... Brooke G, Holbrook JD, Brown MH, Barclay AN: Human lymphocytes interact directly with CD47 through a novel member of the signal ... Antigen description CD172a, the signal-regulatory protein alpha (SIRP alpha), also known as SH2 domain-containing phosphatase ... Its extracellular ligand is CD47. CD172a serves as a substrate of activated receptor tyrosine kinases and upon phosphorylation ...

CD47, a cell surface protein, has been id... , Find, read and cite all the research you need on Tech Science Press ... Several preclinical studies have investigated the efficacy of chimeric antigen receptor (CAR) T-cells targeting CD47 in ... The role of CD47 in TME regulation and immune evasion. CD47 act as a high-affinity signaling receptor for the secreted matrix ... CD47 and Immunotherapy. CD47 is an overexpressed protein on many cancer cells that plays a critical role in regulating immune ...

Wildtype (WT) or CD47 knockout (CD47 KO) C57B6/J-background animals were exposed to 50 microg of MWCNT or saline control via ... Evaluation of performance characteristics of hepatitis B e antigen serologic assaysExternal. Mixson-Hayden T, Purdy MA, Ganova- ... Lung and plasma NOx were reduced in the WT + MWCNT group by 47% and 32%, respectively, while the CD47 KO groups were unchanged ... It is unclear exactly how TSP-1 exerts effects on vascular function, but we hypothesized that the TSP-1 receptor CD47 may ...

... targeting an ovarian tumor-associated antigen (OA3/CD47), was shown to enhance the association of liposomes with OVCAR-3 cells ...

... engulf them and subsequently present antigens to acquire immunity against those invaders. Cancer cells overexpress CD47 to hide ... CD47 sends a do-not-eat-me signal, thereby protecting tumor cells from phagocytosis by macrophages. Cancers and cancer stem ... Its a soluble ligand dimerized with an Fc region that targets a protein called CD47, which is expressed on the surface of ... CELG) recently announced a very early-stage antibody program that targets CD47. We believe Trillium is ahead of Celgene on this ...

CD47_Antigen,modify,22-AUG-08,(null),(null) C17531,Insulin-Like_Growth_Factor-1_Receptor,modify,22-AUG-08,(null),(null) C2989, ... Antigen,modify,22-AUG-08,(null),(null) C17404,CD72_Antigen,modify,22-AUG-08,(null),(null) C75336,FBN1_Gene,create,22-AUG-08,( ... Antigen,modify,22-AUG-08,(null),(null) C17402,CD31_Antigen,modify,22-AUG-08,(null),(null) C3262,Neoplasm,modify,22-AUG-08,(null ... Antigen,modify,22-AUG-08,(null),(null) C75015,Rieger_Syndrome_Type_1,create,22-AUG-08,(null),(null) C75014,BTK_wt_Allele,create ...

Antigens, CD47 CD47 Antigens IAP-50 Antigen Integrin-Associated Protein p50 Thrombospondin-1 Receptor CD47 Registry Number. 0. ... 2018; see ANTIGENS, CD47 2006-2017; CD47 ANTIGEN was indexed under ANTIGENS, CD 2005; and under CARRIER PROTEINS 1993-2004. ... CD47 Antigen Preferred Term Term UI T251608. LexicalTag NON. ThesaurusID NLM (2006). ... CD47 Antigen Preferred Concept UI. M0221607. Registry Number. 0. Scope Note. A ubiquitously expressed membrane glycoprotein. It ...

7751 Developing therapies that inhibit antigens, such as CD123, CLL-1, CD44, CD96 and CD47,81787526 or kinases, such as c-Kit ... CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells. Cell. 2009; ... van Rhenen A, van Dongen GA, Kelder A, Rombouts EJ, Feller N, Moshaver B. The novel AML stem cell associated antigen CLL-1 aids ...

CD47 Antigen Entry term(s). Antigen, CD47 Antigen, IAP-50 Antigens, CD47 CD47 Antigens CD47, Thrombospondin-1 Receptor IAP 50 ... Antigen, CD47. Antigen, IAP-50. Antigens, CD47. CD47 Antigens. CD47, Thrombospondin-1 Receptor. IAP 50 Antigen. IAP-50 Antigen ... 2018; see ANTIGENS, CD47 2006-2017; CD47 ANTIGEN was indexed under ANTIGENS, CD 2005; and under CARRIER PROTEINS 1993-2004. ... antígeno CD47. Entry term(s). antígeno IAP-50 antígenos CD47 proteína p50 asociada a integrinas receptor CD47 de trombospondina ...

Antigens, CD47 CD47 Antigens IAP-50 Antigen Integrin-Associated Protein p50 Thrombospondin-1 Receptor CD47 Registry Number. 0. ... 2018; see ANTIGENS, CD47 2006-2017; CD47 ANTIGEN was indexed under ANTIGENS, CD 2005; and under CARRIER PROTEINS 1993-2004. ... CD47 Antigen. Tree Number(s). D09.400.430.890.014. D12.776.395.550.014. D12.776.543.550.147. Unique ID. D051928. RDF Unique ... CD47 Antigen Preferred Term Term UI T251608. LexicalTag NON. ThesaurusID NLM (2006). ...

Lymphocyte antigen CD47 Current Synonym true false 1232476016 CD47 - Cluster of differentiation antigen 47 Current Synonym true ... Lymphocyte antigen CD47 (substance). Code System Preferred Concept Name. Lymphocyte antigen CD47 (substance). ...

... and CD47- erythrocytes. These results represent a substantial increase in resolution with respect to previous single-cell RNA- ... where Mhi is the level of antigen h in cell i before normalization. After this process, antigen levels are well approximated by ... Single-Cell Transcriptomic Analysis of mIHC Images via Antigen Mapping. Kiya W. Govek, Emma C. Troisi, Steven Woodhouse, Pablo ... where khi represents the observed number of ADT UMIs for antigen h in cell i, and the mixing parameter bh represents the ...

After expansion of hESC-MSCs and hESC-MSC-Fbs, cells were trypsinized and stained with specific markers for CD29, CD47, CD73, ... ITGB1 is a cell adhesion molecule appearing on platelets, as the common Beta subunit of the very late activation antigen (VLA ... CD29 complexes with one of nine integrin alpha subunits to form the very late antigen (VLA) subfamily of adhesion molecules. ... HPL-MSC, human placenta-derived mesenchymal stem cell; CD, cluster of differentiation; HLA-DR, human leukocyte antigen-DR ...

The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Proc. Natl. Acad. ... APCs = antigen presenting cells. (C) Combined data was subjected to SPADE clustering (100 clusters) and represented as a ... Study of Cell Antigens and Intracellular DNA by Identification of Element-Containing Labels and Metallointercalators Using ... For instance, the protein tyrosine phosphatase, receptor type C (CD45) has been proposed as a candidate antigen for live-cell ...

Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection. This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular ...

Antigens, CD45. Leukocyte Common Antigens. Antigens, CD46. Membrane Cofactor Protein. Antigens, CD47. CD47 Antigen. ... Antigens, CD98 Heavy Chain. Fusion Regulatory Protein 1, Heavy Chain. Antigens, CD98 Light Chains. Fusion Regulatory Protein 1 ... Antigen Peptide Transporter-1. ATP-Binding Cassette Sub-Family B Member 2. ... Antigen Peptide Transporter-2. ATP-Binding Cassette, Sub-Family B, Member 3. ...