Animal Health Report. Strain description. SOCS1 (Suppressor of cytokine signaling 1) is a one of the signal transduction ... Copyright(c) Laboratory Animal Resource Bank at NIBIOHN, Japan ([email protected]). All Rights Reserved. Last update: $Date:: ... Faculty of Medicine, Osaka University) produced congenic mice derived from two types of gene background, BALB/c and C57BL/6J ... Laboratory Animal Resource Bank,. National Institutes of Biomedical Innovation, Health and Nutrition ...
Animals * Body Weight / genetics * Disease / genetics* * Epistasis, Genetic* * Mice * Mice, Congenic * Mice, Inbred C57BL ...
... genes in the congenic DR.,i ,lyp,/i, rat line with 2 Mb of BB DP DNA introgressed onto the DR genetic background. All (100% ... The DR.lyp (BBDR.BBDP-(D4Rhw17-SS99306861) (D4Rhw11-D4Rhw10)/Rhw) congenic rat line was derived from animals with two ... lyp congenic rat line is kept in sister-brother breeding and produces Mendelian proportions of the (25%), (50%), and (25%) ... Overall, Lr8, a gene unassociated with the Gimap family but also within the 2 Mb of DP DNA in the congenic rat line, expressed ...
"Caliper sells animal models subsidiary to Taconic Farms for $11 million". Drug Discovery News. Retrieved 13 December 2009. v t ... 1994 - Contracted with National Institute for Allergy and Infectious Disease to maintain a repository of inbred, congenic, and ... "Taconic Biosciences , Lab Animal Buyers Guide". Guide.labanimal.com. Retrieved 2017-05-22. "Nancy J. Sandy Appointed Chief ... Taconic Biosciences is a breeder and supplier of laboratory animals operating in over 50 countries. The current CEO is Nancy J ...
IC:BMDC recipient animals were almost completely protected from tumor engraftment, while all control animals developed ... In an early congenic mouse melanoma model [95], the OVA-expressing B16F10 cell line MO-4 was used. Bone marrow-derived DCs ( ... Lastly, using C57Bl.6 β2M−/−, transporter associated with antigen-processing 1 (TAP1)−/−, MHC-II−/− and FcγRγ−/− animals, the ... Landsteiner, K.; Jacobs, J. Studies on the Sensitization of Animals with Simple Chemical Compounds. J. Exp. Med. 1935, 61, 643- ...
Other strains are congenic through targeted mutations and transfer of transgenes (e.g., backcrossed for 10 or more generations ... applies to the animal, to animals, including the animal that is used/misued/abused in the institutional setting of biomedical ... The British Society of Animal Science addresses the issue of animal pain, stating that "The cost to animals can be defined as ... To ask whether animals can suffer seems naive, given that the IACUC review presupposes that animals do suffer and that such ...
Animals. Male Fmr1 KO and WT mice were bred from congenic C57BL/6J stock obtained from The Jackson Laboratory (Bar Harbor, ME ... In slices from animals aged 6-12 months, there was a clear difference between KO and WT mice in the response to TBS. As was ... In slices from animals , 12 months of age, the reduction in LTP in KO slices was present throughout the post-TBS recording ... Input-output curves were generated for SC-evoked fEPSPs in one slice from each animal. The results are shown in Figure 8A. ...
These mice were backcrossed for 10 generations to C57BL/6J mice to generate the congenic line, C57BL/6J-Bcar3tm1Lern. Further, ... Animals were maintained at Boston University Medical Center (Boston, MA) in accordance with IACUC regulations. ... since other animal models of cataract characterized by fiber breakdown do not necessarily undergo capsular rupture, it would ... the lenses from knockout animals were partially opaque, irregular structures that appeared to have lost a portion of their ...
Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 ... METHODS: In the present study, a novel congenic rat model of DP4 deficiency on a "DP4-high" DA rat genetic background was ... Phenotyping of congenic dipeptidyl peptidase 4 (DP4) deficient Dark Agouti (DA) rats suggests involvement of DP4 in neuro-, ... CONCLUSIONS: While this animal model confirms a critical role of DP4 in GLP-1-dependent glucose regulation, genetically induced ...
All mice used were on a mixed C57BL/6 background (non-congenic). Genotyping was outsourced to Transnetyx. Animal use was ... 5. The behavioral analyses of Nav1.1cKO animals show a clear loss of motor coordination, and mutant animals differ ... 5. The behavioral analyses of Nav1.1cKO animals show a clear loss of motor coordination, and mutant animals differ ... at the moment of animal fall (I) and the day 3 average (J). Each dot represents one animal. Box and whisker plots represent ...
Studies in animals infected experimentally with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of ... Studies in animals infected experimentally with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of ... and are congenic on the C57BL/6 background. Non-transgenic C57BL/6 mice were used as controls in some experiments. All ... protocols were approved by the Institutional Animal Care and Use Committee of the University of Iowa. The 2019n-CoV/USA-WA1/ ...
Our results also indicate the importance of animal models in mapping of disease genes. Congenic mapping will allow further ... For the (BB × BN)F2 data (28,29), animals with a maximal arthritis score (MAS) ,33 were compared, using a χ2 test for linkage, ... Genome scans using families or animal cohorts of small size (Tables 2 and 3) may increase the chance of type 1 error owing to ... For rodents, P values were calculated by a χ2 test of heterogeneity between affected and unaffected animals or, if unaffected ...
Passenger mutations affect experiments using transgenic animals models called congenic mice, whose modified genetic material ... they found that Casp11 mutations likely contributed to these animals resistance to shock. In some labs, animals carried ... Specifically, 129 strain congenic mice on a Black 6 background that have been backcrossed for 10 generations have more than a ... According to an analysis published today (July 7) in Immunity, passenger mutations are widespread in these animal models and ...
The Prkdc scid mutation was identified by Mel Bosma of the Fox Chase Cancer Center in a C.B-17 congenic mouse population. This ... The CIEA NOG mouse® was developed by Mamoru Ito of the Central Institute for Experimental Animals (CIEA) in Japan. ... Please note that shipments may contain animals with a larger weight variation. What our customers say: ...
Several drugs have been tested in animal models to prevent the pulmonary toxicity of bleomycin, but have not led to a useful ... In this report, we describe the construction and hemodynamic characterization of a congenic strain of SHR (SHR-Lx) that carries ... Animal studies suggest that cocaine not only blocks norepinephrine reuptake peripherally but also inhibits the baroreceptors, ... Wild-type animals had completely normal cardiac electrophysiology. In contrast, FHC mice demonstrated (a) electrocardiographic ...
... in all animals) or radiotelemetry (in select groups) at baseline and during salt loading. In the congenic strains in which a ... In the congenic strains in which both SS1a and SS1b were introgressed from SBN/y onto the genomic background of SBH/y, the ... Congenic strains confirm the presence of salt-sensitivity QTLs on chromosome 1 in the Sabra rat model of hypertension ... Congenic strains confirm the presence of salt-sensitivity QTLs on chromosome 1 in the Sabra rat model of hypertension. ...
... transferred iNKT cells into congenic mice and analysed the TCRVb usage of cells found in various tissues of recipient animals ... Animal experimentation: All animal experiments were approved by the Francis Crick Institutes and the Kings College Londons ... All animal experiments were approved by the Francis Crick Institute and the Kings College Londons Animal Welfare and Ethical ... CD1d-KO (on C57BL/6 background), WT C57BL/6, congenic CD45.1 WT C57BL/6 and Nur77GFP mice were bred under specific pathogen- ...
de Morais SMF, Chow SYM, and Wells PG (1992a) Biotransformation and toxicity of acetaminophen in congenic RHA rats with or ... Currently, there are ∼20 distinct UGTs known in both humans and rats, the best characterized animal species. These can be ... The Gunn rat provides a useful animal model to investigate the relative contribution of UGT1 isoforms in total glucuronidating ... It should be clear that advances from both basic and clinical research involving animals and humans have provided critical ...
... which makes fine-mapping them by use of a conventional congenic approach impractical. In this study, we demonstrate that it is ... Animals, Chromosome Mapping, Diabetes Mellitus, Type 1, Genetic Predisposition to Disease, Mice, Mice, Inbred NOD ... Mapping by genetic interaction: high-resolution congenic mapping of the type 1 diabetes loci Idd10 and Idd18 in the NOD mouse. ... Mapping by genetic interaction: high-resolution congenic mapping of the type 1 diabetes loci Idd10 and Idd18 in the NOD mouse. ...
ABR thresholds were determined in the left and right ears in turn in most animals. The animal was re-oriented between ... 2013) and the present study comes from a recent characterisation of a new congenic mouse model of the minimum human 22q11.2DS ... In the absence of animal-by-animal controls for hearing loss, it remains unclear whether elevation of Drd2 expression in ... taken from only a few animals (or an unspecified number of animals). Given that 60% of Df1/+ mice have hearing loss in one or ...
... and uses five times the number of animals for breeding. The Inotiv speed congenic program can shorten the generational window ... Inotiv also offers an animal production component to the Inotiv speed congenic program. Your colonies can be maintained in ... The Inotiv speed congenic program can shorten the generational window by reducing your breeding time by as much as 50% using as ... Animal models of disease provide you with a foreshortened generational window into disease progression. A major advantage for ...
Genes; Hearing-loss; Noise-induced-hearing-loss; Noise-frequencies; Laboratory-animals; Animals; Animal-studies; Age-factors; ... The congenic B6.CAST-+Ahl male mice had significantly less TTS immediately post-exposure than C57BL/6J males or females but not ... 114 (1997) 83] developed a congenic B6.CAST-+Ahl mouse which carries the wild-type allele from Mus musculus castaneus at the ... the animals underwent cardiac perfusion to fix their cochleae. The isolated cochleae were embedded in plastic and dissected ...
Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 ... Examination of OLETF-derived non-insulin-dependent diabetes mellitus QTL by construction of a series of congenic rats.. Kose H ... Institute for Animal Experimentation in 1998. Afterwards, maintained by sib mating.. ...
Recently, Johnson has developed two relevant congenic mouse strains. In the congenic C57BL/6J strain, the Ahl locus has been ... Laboratory-animals; Animals; Molecular-structure; Genetics; Genetic-factors ... This presentation will compare ABR results in the two congenic strains as well as compare the present data with the previous ... The present study was designed to test these congenic strains for their vulnerability to noise-induced hearing loss. Mouse ...
ANIMALS, CONGENIC. ANIMALES CONGENICOS. ANIMAIS CONGÊNICOS. ANTICIPATION, GENETIC. ANTICIPACION GENETICA. ANTECIPAÇÃO GENÉTICA ...
ANIMALS, CONGENIC. ANIMALES CONGENICOS. ANQUILOSE DENTAL. TOOTH ANKYLOSIS. ANQUILOSIS DEL DIENTE. ANTAGONISTAS DE LEUCOTRIENOS ...
ANIMALS, CONGENIC. ANIMAIS CONGÊNICOS. ANQUILOSIS DEL DIENTE. TOOTH ANKYLOSIS. ANQUILOSE DENTAL. ANTAGONISTAS DE LEUCOTRIENO. ...
ANIMALS, CONGENIC. ANIMALES CONGENICOS. ANIMAIS CONGÊNICOS. ANTICIPATION, GENETIC. ANTICIPACION GENETICA. ANTECIPAÇÃO GENÉTICA ...
ANIMALS, CONGENIC. ANIMALES CONGENICOS. ANIMAIS CONGÊNICOS. ANTICIPATION, GENETIC. ANTICIPACION GENETICA. ANTECIPAÇÃO GENÉTICA ...