Amyloid precursor protein (APP) as well as β- and γ-secretases are the principal players involved in amyloid-β (Aβ) production ... Generation of amyloid-β peptide is at the beginning of a cascade that leads to Alzheimers disease. ... This process is mediated by activity-regulated association of ADAM10 with the clathrin adaptor protein 2 (AP2) complex. ... Furthermore, ADAM10 interaction with synapse-associated protein 97 (SAP97) is necessary for LTD-induced ADAM10 trafficking and ...