rs78378222 polymorphism in the 3'-untranslated region of TP53 contributes to development of age-associated cataracts by...
... untranslated regions (3′-UTR) of target gene mRNAs and, thus, regulate translational interference or degradation of mRNAs (8). ... untranslated region (3‑UTR) mRNA transcripts, and the variants within or nearby ʻseed sequences may compromise or enhance ... untranslated region of TP53 contributes to development of age-associated cataracts by modifying microRNA-125b-induced apoptosis ... untranslated region of TP53 contributes to development of age-associated cataracts by modifying microRNA-125b-induced apoptosis ...
The 3'-untranslated region of the HLA-G gene in relation to pre-eclampsia: revisited<...
... untranslated region of the HLA-G gene in relation to pre-eclampsia: revisited. HLA. 2010;75(3):253-261. doi: 10.1111/j.1399- ... untranslated region of the HLA-G gene in relation to pre-eclampsia : revisited. I: HLA. 2010 ; Bind 75, Nr. 3. s. 253-261. ... untranslated region of the HLA-G gene in relation to pre-eclampsia: revisited. / Larsen, M. H.; Hylenius, S.; Nybo Andersen, A ... untranslated region (3′-UTR) (exon 8) of the HLA-G gene might be associated with severe pre-eclampsia, especially in primiparas ...
Progressive lengthening of 3′ untranslated regions of mRNAs by alternative polyadenylation during mouse embryonic development<...
... untranslated regions of mRNAs by alternative polyadenylation during mouse embryonic development. Zhe Ji, Ju Youn Lee, Zhenhua ... untranslated regions of mRNAs by alternative polyadenylation during mouse embryonic development. / Ji, Zhe; Lee, Ju Youn; Pan, ... untranslated regions of mRNAs by alternative polyadenylation during mouse embryonic development. Proceedings of the National ... untranslated regions of mRNAs by alternative polyadenylation during mouse embryonic development. In: Proceedings of the ...
Untranslated region - Wikipedia
Regulatory Activity Coding region Five prime untranslated region History of RNA biology MiRNA Three prime untranslated region ... Although they are called untranslated regions, and do not form the protein-coding region of the gene, uORFs located within the ... The untranslated regions of mRNA became a subject of study as early as the late 1970s, after the first mRNA molecule was fully ... The untranslated region is seen in prokaryotes and eukaryotes, although the length and composition may vary. In prokaryotes, ...
Selection of a subset of mRNAs from combinatorial 3' untranslated region libraries using neuronal RNA-binding protein Hel-N1.
... untranslated region libraries using neuronal RNA-binding protein Hel-N1. Proc Natl Acad Sci U S A, 91(23), 11207-11211. https ... untranslated region libraries using neuronal RNA-binding protein Hel-N1." Proc Natl Acad Sci U S A, vol. 91, no. 23, Nov. 1994 ... untranslated region libraries using neuronal RNA-binding protein Hel-N1." Proc Natl Acad Sci U S A 91, no. 23 (November 8, 1994 ... untranslated region libraries using neuronal RNA-binding protein Hel-N1. Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):11207-11. ...
A high affinity binding site for the polypyrimidine tract binding protein (PTB) is located in the 5'-untranslated region...
Singh, I.S.; He, J.R.; Calderwood, S. 2002: A high affinity HSF-1 binding site in the 5'-untranslated region of the murine ... Saifudeen, Z.; Desnick, R.J.; Ehrlich, M. 1995: A mutation in the 5' untranslated region of the human alpha-galactosidase ... untranslated region of the insulin mRNA (ins-PRS) is inhibited by rapamycin Molecular and Cellular Biochemistry 260(1-2): 85-90 ... A high affinity binding site for the polypyrimidine tract binding protein (PTB) is located in the 5'-untranslated region ...
3' Untranslated Regions | Department of Molecular Biology
Maerker M, Getwan M, Dowdle M, McSheene J, Gonzalez V, Pelliccia J, Hamilton D, Yartseva V, Vejnar C, Tingler M, Minegishi K, Vick P, Giraldez A, Hamada H, Burdine R, Sheets M, Blum M, Schweickert A. Bicc1 and Dicer regulate left-right patterning through post-transcriptional control of the Nodal inhibitor Dand5. Nat Commun. 2021;12(1):5482. PMCID: ...
RNA, Untranslated - 3' Untranslated Regions | CU Experts | CU Boulder
Untranslated Regions PubMed MeSh Term *Overview. Overview. subject area of * 3 UTRs take a long shot in the brain Journal ... Escherichia coli DbpA is a 3 5 RNA helicase. Journal Article * Genome-wide analysis of Musashi-2 targets reveals novel ... Alternative CHRNB4 3-UTRs Mediate the Allelic Effects of SNP rs1948 on Gene Expression Journal Article ... Distinct role of long 3 UTR BDNF mRNA in spine morphology and synaptic plasticity in hippocampal neurons Journal Article ...
MicroRNA-370 controls the expression of microRNA-122 and Cpt1alpha and affects lipid metabolism
Figure 2 - Recombinant Coxsackievirus A2 and Deaths of Children, Hong Kong, 2012 - Volume 19, Number 8-August 2013 - Emerging...
The effect of the length of the 3'-untranslated region on expression in plants. | College of Agricultural Sciences
... untranslated region on expression in plants.. The effect of the length of the 3-untranslated region on expression in plants.. ... untranslated region (UTR) on expression of luciferase mRNA was examined in transiently transfected carrot protoplasts. The ... These data suggest that the length of the 3-UTR plays an important role in determining the extent to which a poly(A) tail can ... For poly(A)- mRNA, there was a consistent increase in expression when the length of the 3-UTR was increased from 4 to 104 ...
Discovery of physiological and cancer-related regulators of 3' UTR processing with KAPAC
Untranslated regions (3 UTRs) length is regulated in relation to cellular state. To uncover key regulators of poly(A) site use ... Untranslated regions (3 UTRs) length is regulated in relation to cellular state. To uncover key regulators of poly(A) site use ... Discovery of physiological and cancer-related regulators of 3 UTR processing with KAPAC Genome Biol. 2018 Mar 28;19(1):44. doi ... 10.1186/s13059-018-1415-3. Authors Andreas J Gruber 1 , Ralf Schmidt 1 , Souvik Ghosh 1 , Georges Martin 1 , Andreas R Gruber 1 ...
Plus it
... untranslated region. D, Southern blot analysis of ES cell DNA after DraI digestion using the probe indicated in C. vn, Mutated ... untranslated region of the VGLUT1 mRNA leads to a downregulation of VGLUT1Venus expression. This is not the case after Cre- ... untranslated region (vn/vn) were generated by homologous recombination in embryonic stem cells as described in Materials and ... The diameter of the region of interest (ROI) was chosen as the full-width at half-maximum, which ranged between 4 and 6 pixels ...
A cis-acting element in the 3'-untranslated region of human TNF-α mRNA renders splicing dependent on the activation of protein...
... untranslated region of human TNF-α mRNA renders splicing dependent on the activation of protein kinase PKR. In: Genes and ... untranslated region of human TNF-α mRNA renders splicing dependent on the activation of protein kinase PKR. / Osman, Farhat; ... untranslated region in control of mRNA splicing and show that human TNF-α 3 UTR harbors a cis- acting element that renders ... untranslated region of human TNF-α mRNA renders splicing dependent on the activation of protein kinase PKR. Genes and ...
Sequence Analysis of the Spike Glycoprotein Nucleocapsid Gene and 3' Untranslated Region of Razi Institute H-120 & H-52 Vaccine...
Untranslated Region of Razi Institute H-120 & H-52 Vaccine Strains of Infectious Bronchitis Virus. Iran J Virol 2017; 11 (4) : ... Untranslated Region of Razi Institute H-120 & H-52 Vaccine Strains of Infectious Bronchitis Virus. مجله ویروس شناسی ایران. 1396 ... Untranslated Region of Razi Institute H-120 & H-52 Vaccine Strains of Infectious Bronchitis Virus ... Materials and Methods: This study was performed to characterize S1, N and 3UTR region of the genome of H-120 and H-52 vaccine ...
Comparison of single nucleotide polymorphisms in the 3′ untranslated region of HLA-G in placentas between spontaneous preterm...
... untranslated region (3′UTR) of human leukocyte antigen (HLA)-G in placentas between spontaneous preterm birth and preeclampsia ... UTR region of HLA-G was amplified via polymerase chain reaction. Nine SNPs were analyzed by direct Sanger sequencing. There was ... Genomic deoxyribonucleic acid was extracted from placenta tissue and the 3′ ... untranslated region of HLA-G in placentas between spontaneous preterm birth and preeclampsia. BMC Res Notes 11, 176 (2018). ...
The 3' untranslated region of a rice alpha-amylase gene functions as a sugar-dependent mRNA stability determinant...
Frontiers | Plant 3' Regulatory Regions From mRNA-Encoding Genes and Their Uses to Modulate Expression
... untranslated region, determining the fate of mRNAs in eukaryotic cells. Although a small number of 3 regulatory regions have ... untranslated region, determining the fate of mRNAs in eukaryotic cells. Although a small number of 3 regulatory regions have ... regulatory regions, such as NOS and OCS from Agrobacterium tumefaciens and 35S from cauliflower mosaic virus. In this review, ... regulatory regions, such as NOS and OCS from Agrobacterium tumefaciens and 35S from cauliflower mosaic virus. In this review, ...
MicroRNA miR-107 | Cancer Genetics Web
Untranslated Regions. *MicroRNAs. *Biomarkers, Tumor. *Chromosome 10. *Neoplasm Invasiveness. *Apoptosis. *beta Catenin ... 2018; 36(3):175-184 [PubMed] Related Publications We showed that miR-107 expression was decreased in osteosarcoma (OS) tissues ... 2018; 170(3):507-516 [PubMed] Related Publications PURPOSE: Aldehyde dehydrogenase1 (ALDH1) is widely accepted as a stem cell ... 2018; 164(3):351-355 [PubMed] Related Publications MicroRNA and methylation are important epigenetic mechanisms in the ...
Structure of the 40S-ABCE1 post-splitting complex in ribosome recycling and translation initiation | Nature Structural &...
... untranslated regions. Cell 156, 950-962 (2014). ... occurred in the region of initiator tRNA (tRNAi) and eIF1A. No ... It is to note, in ABCE1, the FeS cluster domain and NBD1 are well resolved whereas resolution in NBD2 and peripheral regions of ... Figure 3: Interactions between the 40S subunit and ABCE1 in the post-splitting state.. ... Supplementary Figure 3 Cryo-EM structure of the reconstituted 40S-ABCE1 complex and assessment of resolution.. a, Cryo-EM ...
Plus it
... untranslated region. The experiments were repeated using a nonoverlapping oligonucleotide designated AS-SIII9 (position +4 to + ... terminal region. For studies before axonogenesis, oligonucleotides were added at a concentration of 50 μm every 24 hr to ... 3. Comparison of the localization of synapsin III with that of synaptic markers in cultured hippocampal neurons. After 7 d in ... For quantification purposes cells were considered to be in stage 3 when one of the processes was at least 20 μm longer than the ...
Variation of the N-Acetyltransferase 2 Gene in a Romanian and a Kyrgyz Population | Cancer Epidemiology, Biomarkers &...
Untranslated region C 10.0 (3.8-20.5) 2.5 (1.0-5.1) 1.3 (0.6-2.7) 0 (0-0.7) 0.04 0.42 0.32 ... Untranslated region C 10.0 (3.8-20.5) 2.5 (1.0-5.1) 1.3 (0.6-2.7) 0 (0-0.7) 0.04 0.42 0.32 ... untranslated region (rs2552). Two variants (364G,A and 411A,T) turned out to be monomorphic in the IRCYL populations. No assay ... untranslated region C allele frequency. This variant was not found in the Chinese. The Kyrgyz were closer to the Chinese than ...
Spondyloepiphyseal dysplasia tarda (SEDL, MIM #313400) | European Journal of Human Genetics
... in the SEDL gene from Xp22 region. The function of the SEDL protein is not known although it is speculated that it may ... untranslated region. SEDL gene is a highly conserved gene with orthologs identified in yeast, fly and vertebrates.5 ... It is alternatively spliced involving exons 2, 4 and 6. SEDL coding region of 420 bp is split among exons 3-6. Exons 1 and 2 ... in the SEDL gene from Xp22 region. The function of the SEDL protein is not known although it is speculated that it may ...
Centre for Flow Cytometry and Microscopy - Publications - Sunnybrook Research Institute
... untranslated region regulates endogenous microRNA functions in tumorigenesis and angiogenesis. Nucleic Acids Res. 2011 Apr;39(8 ... untranslated region modulates endogenous microRNA functions. PLoS One. 2010 Oct 25;5(10):e13599. ... 2011 Mar 3;117(9):2668-80.. Shi Y, Tomic J, Wen F, Shaha S, Bahlo A, Harrison R, Dennis JW, Williams R, Gross BJ, Walker S, ... Zittermann SI, Capurro MI, Shi W, Filmus J. Soluble glypican 3 inhibits the growth of hepatocellular carcinoma in vitro and in ...
Development of a Real-Time Polymerase Chain Reaction-Based Method for the Measurement of Relative Allelic Expression and...
... untranslated region of human glycoprotein PC-1 gene stabilizes PC-1 mRNA and is associated with increased PC-1 protein content ... untranslated region; RT, reverse transcription; PCR, polymerase chain reaction; TBP, TATA box binding protein; bp, base pair(s ... untranslated region, could be associated with low transcript abundance. Subsequently, we developed a method for the measurement ... Amplification of the CYP2A13 5′-flanking region to exon 5 was carried out using primers 5′-F1 and Exon 5R (Zhang et al., 2003 ...
Antithrombin Deficiency: Practice Essentials, Background, Pathophysiology
... untranslated region. Two modes of splicing of the primary transcript are feasible at 2 sites in the first intron; the result is ... The promoter region does not have a TATA or CAAT box. A control element at the 5 flanking region is thought to be critical for ... 14] A region known as the reactive center loop (RCL) protrudes above the core of the serpin molecule and has a sequence of ... However, several cases of patients with homozygous mutations in the HBS region of the AT gene have been published and ...
Gene expression profiling of Leishmania (Leishmania) donovani: overcoming technical variation and exploiting biological...
... untranslated region element. The Journal of Biological Chemistry 277, 19511-19520.Google Scholar ... Transcription initiation and termination on Leishmania major chromosome 3. Eukaryotic Cell 3, 506-517.Google Scholar ... A common mechanism of stage-regulated gene expression in Leishmania mediated by a conserved 3′- ... Tel: +32 3 2476358. Fax: +32 3 2476359. E-mail: [email protected] ...
Peng Yao, Ph.D. | UR Medicine
... untranslated region of the VEGFA mRNA.. Yao P, Potdar AA, Ray PS, Eswarappa SM, Flagg AC, Willard B, Fox PL ... untranslated region of the VEGFA mRNA.". Peng Yao; Alka A. Potdar; Partho Sarothi Ray; Sandeepa M. Eswarappa; Andrew C. Flagg; ... Coding region polyadenylation generates a truncated tRNA synthetase that counters translation repression.. Yao P, Potdar AA, ... "Coding region polyadenylation generates a truncated tRNA synthetase that counters translation repression." ...
Vaccines | Free Full-Text | An Update on mRNA-Based Viral Vaccines
... untranslated region and use in expression active linear DNA with minimum poly(A) region. Gene 2007, 391, 130-139. [Google ... Mignone, F.; Gissi, C.; Liuni, S.; Pesole, G. Untranslated regions of mRNAs. Genome Biol. 2002, 3. [Google Scholar] [CrossRef] ... Hinnebusch, A.G.; Ivanov, I.P.; Sonenberg, N. Translational control by 5′-untranslated regions of eukaryotic mRNAs. Science ... untranslated regions (UTR) on both ends, open reading frames (ORF) encoding proteins, and a poly-A tail (Figure 1). The 5′ cap ...
MicroRNAs and the RISC | Biology | JoVE
... untranslated region; 비번역부위) 사이의 상보적 염기쌍 구성은 유전자 침묵(gene silencing; 유전자 사일런싱) 기작을 결정합니다. 광범위하거나 거의 완벽한 상보성은 mRNA의 분해를 초래하고, 제한된 ... 마이크로RNA(microRNA, 줄여서 miRNA)는 인트론(intron; 유전자의 비암호화 영역) 또는 유전자 간 영역(intergenic region; DNA의 유전자와 유전자 사이 영역)에서 전사된 짧고 조절에 관여하는 ... 분리되어서 하나는 성숙한 miRNA가 되고RISC라는 단백질군과 복합체를 형성하는데이는 RNA 유도 침묵 복합체이다이 복합체가 mRNA와 결합하는데miRNA와 mRNA의 특정 서열 사이에보완 염기 짝짓기로 이루어지고보통은 3 ...