Reversible hemostatic properties of sulfabetaine/quaternary ammonium modified hyperbranched polyglycerol • Weinhart Group •...
A library of hyperbranched polyglycerols (HPGs) functionalized with different mole fractions of zwitterionic sulfabetaine and cationic quaternary ammonium ligands was synthesized and characterized. A post-polymerization method was employed that utilized double bond moieties on the dendritic HPG for the coupling of thiol-terminated ligands via UV initiated thiol-ene "click" chemistry. The proportions of different ligands were precisely controlled by varying the ligand concentration during the irradiation process. The effect of the polymer library on hemostasis was investigated using whole human blood. It was found that polymer with ≥40% of alkenes converted to positive charges and the remainder to sulfabetaines caused hemagglutination at ≥1 mg/mL, without causing red blood cell lysis. The quaternary ammonium groups can interact with the negative charged sites on the membranes of erythrocytes, which provides the bioadhesion. The zwitterionic sulfabetaine evidently provides a hydration layer to ...http://www.bcp.fu-berlin.de/en/chemie/chemie/forschung/OrgChem/weinhart/publications/pub019/index.html
Effect of ω-3 Fatty Acids and Simvastatin on Hemostatic Risk Factors and Postprandial Hyperlipemia in Patients With Combined...
Epidemiological, clinical, and experimental studies have shown that dyslipidemia associated with insulin resistance and hypertension also may include a procoagulant state with activation of the coagulation system and inhibition of the fibrinolytic activities.11 24 25 In the early prospective epidemiological studies, it was shown that FVIIc, fibrinogen, PAI-1a, and tPAag may represent independent risk factors for development of CHD.11 24 25 In a recent study of patients with combined hyperlipemia, we have confirmed that FVIIag and FVIIc are correlated with the triglyceride-rich lipoproteins, particularly with the concentration of intermediate density lipoproteins (IDL) TAGs.21 TFPIa showed a significant correlation with the concentration of LDL, a lipoprotein fraction also associated with increased risk for CHD.. In human plasma, 80% of TFPI is bound to lipoproteins, especially LDL, whereas 10% to 20% circulates in a free form.26 A positive correlation between the total plasma TFPI activity and ...http://atvb.ahajournals.org/content/20/1/259
PK Hemostasis dr. Bastiana SpPK
KULIAH Hemostasis Dr. Bastiana Bermawi, SpPK Hemostasis DEFINISI: mekanisme tubuh untuk mencegah /menghentikan perdarahan HEMOSTASIS: Mencegah keluarnya darah dari pembuluh darah yang utuh. Menghentikan perdarahan dari pembuluh darah yang terluka LOGO Hemostasis Formation of a clot LOGO HEMOSTASIS TROMBOSIT LOGO Proses yang terjadi setelah luka Reaksi dari pembuluh darah Pembentukan sumbat platelet Proses pembekuan darah Fibrinolysis 5 LOGO Proses Hemostasis LUKA PADA PEMBULUH DARAH Pembuluh darah Trombosit Aktivasi trombosit Vasokonstriksi pengurangan aliran darah pada daerah yang luka adhesi &aggregasi sumbat trombosit (blm stabil) Faktor Pembekuan darah Aktivasi faktor pembekuan pembentukan fibrin ( sumbat trombosit sdh stabil) LOGO Vasokonstriksi lokal Spasme lokal otot polos (symp. reflex) Dapat di 'maintained' oleh platelet vasokonstriktor LOGO Pembentukan Agregat platelet Pembuluh ...http://slidegur.com/doc/102894/pk-hemostasis-dr.-bastiana-sppk
Hemostasis - AMA Manual of Style
Thrombosis may be regarded as an accident of nature that has not had time to adapt through the lengthy process of evolution to the advances of modern medicine, which allow patients to survive the hemostatic challenge of major surgery and trauma but leave them vulnerable to venous thrombosis. R. W. Colman et al(p3) …each milliliter of blood contains enough clotting material to clot all the fibrinogen in the body in 10 to 15 s. R. I. Handin(p340) Hemostasis consists of platelet plug formation (primary hemostasis) and blood coagulation (secondary hemostasis, coagulation, clotting). Hemostasis and its control involve complex interactions of more thanhttp://www.amamanualofstyle.com/view/10.1093/jama/9780195176339.001.0001/med-9780195176339-div1-165?rskey=MsD2ud&result=2&q=
Coagulation/Hemostasis Analyzer Market by Product (Automated, POC), Consumables (Reagents, Standards), Test Type (APTT,...
The global coagulation analyzers market is estimated to grow at a lower CAGR in developed countries; however, it is expected to witness high growth in emerging countries such as China, India, and Brazil in the next five years. Growth in the coagulation analyzers market is driven by factors such as increasing adoption of automated hemostasis instruments by diagnostics laboratories, development of high-throughput hemostasis analyzers, developments in high-sensitivity point-of-care coagulation analyzers, and introduction of technologically advanced hemostasis instruments. However, slow adoption of advanced hemostasis instruments in emerging economies and high cost of hemostasis analyzers are restraining the growth of this market.. In this report, the global coagulation analyzers market has been segmented based on the type of product (clinical laboratory analyzers, point of care testing analyzers) end users (diagnostic ...http://www.gosreports.com/coagulationhemostasis-analyzer-market/
Large Amounts of Vascular Endothelial Growth Factor at the Site of Hemostatic Plug Formation In Vivo | Arteriosclerosis,...
There is evidence from recent studies that VEGF is stored in human megakaryocytes and is released from platelets on stimulation with thrombin.14 15 These studies were performed under in vitro conditions in the absence of important determinants of in vivo clotting such as the vessel wall, blood flow, and clotting proteases. Thus, it is uncertain if their in vitro observations are of relevance for the in vivo circumstances. The technique applied in our study covers many mechanisms relevant for hemostatic plug formation in vivo. It is performed directly on human subjects and takes into account the interaction between blood cells, endothelium, and various plasma proteins under physiological flow conditions. Thus, we believe that the experimental approach applied in this study is appropriate for investigating the mechanisms important for plug formation under conditions close to the in vivo circumstances.. The principal finding of our study was that much higher concentrations of VEGF are detectable in ...http://atvb.ahajournals.org/content/19/7/1757
Haemostatic mechanisms - circulation, Biology
Biology Assignment Help, Haemostatic mechanisms - circulation, Normal 0 false false false EN-IN X-NONE X-NONE MicrosoftInternetExplorer4http://www.expertsmind.com/questions/haemostatic-mechanisms-circulation-30128043.aspx
Hemostasis, Surgical Bleeding, and Transfusion - ppt video online download
Hemostasis Complex process that prevents blood loss from disrupted intravascular space. Major physiologic events: Primary hemostasis Vascular constriction Platelet plug formation Secondary hemostasis Fibrin Formation Fibrinolysishttp://slideplayer.com/slide/3382639/
Hemostasis (video) | Khan Academy
Hemostasis is the process which stops bleeding after an injury. Blood vessels are repaired by the creation of a platelet plug during primary hemostasis, and the platelet plug is further reinforced by the conversion of fibrin to fibrinogen during secondary hemostasis.https://www.khanacademy.org/science/health-and-medicine/advanced-hematologic-system/bleeding-and-impaired-hemostasis/v/introduction-to-hemostasis
A refined model of the genomic basis for phenotypic variation in vertebrate hemostasis | BMC Evolutionary Biology | Full Text
The current understanding of the biochemical processes of hemostasis was contributed by extensive studies in the context of human disease (e.g., [4-6]) and few other model systems (e.g. ). It is now established that hemostasis results from the action of an intricate network of molecules , which increased in complexity throughout vertebrate evolution, over the last 450 million years . This complexity has been linked to the evolution of closed and highly pressurized circulatory systems and appearance of novel organs such as lungs, and subsequent need to respond to trauma in a vessel wall more rapidly. Moreover, the refinement of the hemostasis in mammals has been proposed to result from overlaps with the inflammation pathway  and the complement pathway . This tight relationship between inflammation, complement, and coagulation was confirmed by recent work at the genomic level [11, 12], and has shaped our understanding of the repertoire and ...https://bmcevolbiol.biomedcentral.com/articles/10.1186/s12862-015-0409-y
What does haemostasis mean?
Definition of haemostasis in the Definitions.net dictionary. Meaning of haemostasis. What does haemostasis mean? Information and translations of haemostasis in the most comprehensive dictionary definitions resource on the web.http://www.definitions.net/definition/haemostasis
Haemostasis and Thrombosis. | Annals of Internal Medicine | American College of Physicians
The past decade has seen an explosion in knowledge of hemostasis and thrombosis, with major advances made in the understanding of basic mechanisms of platelet behavior, blood coagulation and fibrinolysis, and of the role of endothelium and other components of the blood vessel walls in the process of hemostasis and thrombosis. As a result, there have been numerous new journals and monographs published on the subject, and it has become virtually impossible to keep abreast with the advances.. Haemostasis and Thrombosis is a comprehensive book that will bring both the general physician and the experts up to date. The contributors ...http://annals.org/aim/article-abstract/695598/haemostasis-thrombosis
Advances in Thrombosis and Hemostasis | Circulation Research
Hemostasis, the arrest of bleeding, requires a finely tuned balance between clot formation and clot degradation. Platelets provide the first line of defense when vascular integrity is compromised. They home to the site of injury where they adhere to the damaged vessel wall, become activated and aggregate to form a platelet plug.. The second line of defense involves the strengthening and stabilization of the platelet plug by fibrin strands, which tie the platelet aggregates together and render the hemostatic plug resistant to degradation. Fibrin strand formation is the culmination of the coagulation pathway, which is initiated by tissue factor exposed to the blood when the vessel is injured. Thus, the connective tissue surrounding blood vessels, the adventitia, is rich in tissue factor. Damage to the outside of the vessel disrupts this hemostatic envelope and triggers a series of connected reactions that culminate in a burst of thrombin generation. Through limited proteolysis, thrombin ...http://circres.ahajournals.org/content/118/9/1337.full
Femoral Compression Hemostasis Device(Manual Type) - Fervid Medical Technology Co.Ltd - ecplaza.net
Femoral compression hemostasis device(Manual type) Femoral compression hemostasis device (Manual type) is used to assist hemostasis of the femoral artery after transradial procedure. compression plate provides precise compression. Manual controlled...https://www.ecplaza.net/products/femoral-compression-hemostasis-devicemanual-type_4251403
Stago's Global Haemostasis Solution Provides Premium Service | SelectScience
Diagnostica Stago has announced today its Global Haemostasis Solution, a UK based haemostasis hotline comprising of application support, after sales care and training services. The company, which is dedicated to the field of haemostasis, has designed the solution to ensure that customers are provided with reliable, efficient instruments and reagents, all backed up by a dedicated support team.http://www.selectscience.net/industry-news/stagos-global-haemostasis-solution-provides-premium-service/?artID=23429
Orthoclot - Absorbable Polysaccharide Surgical Haemostat - Orthopaedic Product News
OrthoClot Polysaccharide Haemostatic System Administrator (PHS) is a natural plant-based haemostatic system composed of Absorbable Modified Polymer (AMP). OrthoClot is intended as an absorbable haemostatic system to control bleeding during orthopaedic surgery including Spinal Surgery, Bone Tumour Resection, and Complete Knee Replacement Surgery etc.. Total AMP absorption occurs rapidly within several days and is dependent on the amount of material applied and the site of use. AMP particles are degraded by histamines, including amylase and glucoamylase in the human body.. The OrthoClot product is delivered to the sterile field in a double barrier, sterile pouch. The AMP particles are then delivered to the surgical site with a Standard (100mm or 200mm) polypropylene applicator which requires no mixing or preparation whatsoever.. OrthoClot PHS is CE marked and registered in major international markets. OrthoClot is non-pyrogenic and latex-free.. UK Distributor:. ...http://www.opnews.com/2010/09/orthoclot-absorbable-polysaccharide-surgical-haemostat/4409
Thrombosis & Hemostasis] Bleeding Disorders
Bleeding disorders can be subdivided into three categories, including: Primary hemostasis disordersSecondary hemostasis disordersFibrinolysis disordershttp://forum.tomhsiung.com/board-of-pharmacy-specialties-and-pharmacy-practice/hematology-and-oncology-pharmacy/1002-bleeding-disorders.html?s=0946a5158ef4587f57e5813cfb24118e
Thrombosis & Hemostasis] Bleeding Disorders
Bleeding disorders can be subdivided into three categories, including: Primary hemostasis disordersSecondary hemostasis disordersFibrinolysis disordershttp://forum.tomhsiung.com/board-of-pharmacy-specialties-and-pharmacy-practice/hematology-and-oncology-pharmacy/1002-bleeding-disorders.html?s=63319314acacc9f3d5689ddda82d0ff0
Publications of Faculty of Medicine:Abstract of EFFECT OF ACUTE AND CHRONIC STRESS ON THE HEMOSTATIC BALANCE AND THE ROLE OF...
Abstract of Paper: EFFECT OF ACUTE AND CHRONIC STRESS ON THE HEMOSTATIC BALANCE AND THE ROLE OF RENIN-ANGIOTENSIN SYSTEM , Author: Ahmed I. Agamy MD, Awad M. BI-Abd MD and Thanaa H. Belal MD , Year: 1999 , Faculty of Medicine, Benha Universityhttp://bu.edu.eg/medicine_publications/259/abstract
Reviews and Notes: Blood: Hemostasis, Transfusion, and Alternatives in the Perioperative Period | Annals of Internal Medicine |...
Detailed summaries of hemostatic mechanisms, both humoral and cellular; of methods and interpretations for assessment of hemostasis and blood loss; of transfusion and alternative therapies; and of particular problems, such as those seen with hematologic diseases, cardiac surgery, peridelivery states, and organ transplantation. Well documented; indexed in detail ...http://annals.org/aim/article/709163/reviews-notes-blood-hemostasis-transfusion-alternatives-perioperative-period
Hemostasis Market Global Briefing 2017 Including: Cell Counters, Coagulators, Fully Automated Analyzers And SemiAutomated...
From BioPortfolio: The global hemostasis market was estimated to be around $2.6 billion as of 2016. The global hemostasis made up around 4% of the overall invitro diagnostics mark...https://www.bioportfolio.com/news/article/3261337/Hemostasis-Market-Global-Briefing-2017-Including-Cell-Counters-Coagulators-Fully-Automated-Analyzers.html
Hemostasis Testing: Leading Suppliers Strategic Profiles
This 165-page report presents the clinical significance and market needs for major hemostasis laboratory tests, as well as extensive listings of companies developing or marketing innovative coagulation technologies and products. The report also includes strategic assessments of current and emerging suppliers of hemostasis diagnostic products, including marketing tactics, technological know-how, new products in R&D, collaborative arrangements and business strategies. Contains 165 pages and 19 ...https://www.bigmarketresearch.com/hemostasis-testing-leading-suppliers-strategic-profiles-market
Patent US7674260 - Emergency hemostasis device utilizing energy - Google Patents
A method and system for achieving hemostasis (the stoppage of bleeding) is described. RF (radio frequency) energy is used to ablate the surface of tissue to stop bleeding. The depth of destruction of the tissue can be controlled so as to desiccate and coagulate the tissue. In one implementation, an electrode carrier including bipolar electrodes is applied to the tissue, and RF energy transmitted through the bipolar electrodes to ablate the tissue. A layer of desiccated tissue can be created as well as coagulation of the tissue to achieve hemostasis.http://www.google.co.uk/patents/US7674260
Patent US7674260 - Emergency hemostasis device utilizing energy - Google Patents
A method and system for achieving hemostasis (the stoppage of bleeding) is described. RF (radio frequency) energy is used to ablate the surface of tissue to stop bleeding. The depth of destruction of the tissue can be controlled so as to desiccate and coagulate the tissue. In one implementation, an electrode carrier including bipolar electrodes is applied to the tissue, and RF energy transmitted through the bipolar electrodes to ablate the tissue. A layer of desiccated tissue can be created as well as coagulation of the tissue to achieve hemostasis.http://www.google.com.au/patents/US7674260
Effect of Aspirin on Hemostatic and Vascular Function After Live Fire Fighting - Full Text View - ClinicalTrials.gov
short-term fire fighting activity will result in: a) a reduction in arterial function (reduced endothelial function, increased augmentation index and an attenuated arterial stiffness response); b) a disruption in hemostasis that is characterized by an increase in platelet number and function, an increased coagulatory potential and altered fibrinolytic potential; and c) an elevation in procoagulatory cytokines, systemic inflammation, monokine chemoattractant protein, and matrix metalloproteinases ...https://clinicaltrials.gov/ct2/show/NCT01276691