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*  Activin type 2 receptors - Wikipedia
There are two activin type two receptors: ACVR2A and ACVR2B. Despite the large amount of processes that these ligands regulate ... inhibin/activin betaA and betaB and the activin type II and inhibin beta-glycan receptors in the developing human testis". ... which recruits and trans-phosphorylates a type I receptor. The type I receptor recruits a receptor regulated SMAD (R-SMAD) ... "Regulation of muscle growth by multiple ligands signaling through activin type II receptors". Proc. Natl. Acad. Sci. U.S.A. 102 ...
  https://en.wikipedia.org/wiki/Activin_type_2_receptors
*  Activin RIA/ALK-2/Activin Receptor Type 1 Antibody (NBP1-33500): Novus Biologicals
Rabbit Polyclonal Anti-Activin RIA/ALK-2/Activin Receptor Type 1 Antibody. Validated: WB, IHC, IHC-Fr. Tested Reactivity: Mouse ... resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which ... and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a ... Green: Activin A Receptor type I protein stained by Activin A Receptor type I antibody ...read more ...
  https://www.novusbio.com/products/activin-ria-alk-2-activin-receptor-type-1-antibody_nbp1-33500
*  ACVR2B - Wikipedia
Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which ... and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a ... "Truncated activin type II receptors inhibit bioactivity by the formation of heteromeric complexes with activin type I. ... "Truncated activin type II receptors inhibit bioactivity by the formation of heteromeric complexes with activin type I. ...
  https://en.wikipedia.org/wiki/ACVR2B
*  ACVR2A - Wikipedia
"Truncated activin type II receptors inhibit bioactivity by the formation of heteromeric complexes with activin type I. ... and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a ... resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively ... "Truncated activin type II receptors inhibit bioactivity by the formation of heteromeric complexes with activin type I. ...
  https://en.wikipedia.org/wiki/ACVR2A
*  Morphogenic | definition of morphogenic by Medical dictionary
Key words: Pulmonary arterial hypertension, bone morphogenic protein receptor type 2, activin-like kinase type 1, endoglin. ... but also modulates the ratio of expression of two proteins, osteoprotegerin (OPG) and RANKL, that are crucial in pathogenesis ... or the development undergone by individuals who attain the type to which the majority of the individuals of the species ... 2. The ability of a molecule or group of molecules (particularly macromolecules) to assume a certain shape. ...
  http://medical-dictionary.thefreedictionary.com/morphogenic
*  ACVR1 | Cancer Genetics Web
... resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which ... activin binding - activin receptor activity, type I - activin receptor complex - activin receptor signaling pathway - acute ... and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a ... and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding ...
  http://www.cancerindex.org/geneweb/ACVR1.htm
*  KAKEN - Research Projects | Molecular mechanisms of FSH secretion induced by novel (KAKENHI-PROJECT-03454391)
To understand the molecular mechanism of activin action, we have cloned the rat type II activin receptor from a rat ovary cDNA ... The results that the granulosa cells contained two predominant rat type II activin receptor mRNA transcripts (6.0 and 3.0 ... Cloning and sequencing of a rat type II activin receptor.' FEBS letters. 312. 53-56 (1992). *. Description. 「研究成果報告書概要(和文)」より ... Rat granulosa cell / FSH receptor / Activin / Activin receptor / インヒビン / ゴナドトロピン / レセプタ- / 卵巣 / 下垂体. ...
  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03454391/
*  Plus it
Activin type 2 receptor restoration in MSI-H colon cancer suppresses growth and enhances migration with activin. ... Altered surfactant homeostasis and alveolar type II cell morphology in mice lacking Surfactant protein D. Proc Natl Acad Sci ... macrophage receptor with collagenous structure) [158], and that the uptake of both types of fibres activates the NLPR3 ... Asbestos is classified into two main families, the serpentines and the amphiboles. The serpentines consist of one type, ...
  http://err.ersjournals.com/content/24/135/115
*  SYNJ2BP Gene - GeneCards | SYJ2B Protein | SYJ2B Antibody
Synaptojanin 2 Binding Protein, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The ... GO annotations related to this gene include protein C-terminus binding and type II activin receptor binding. An important ... Regulates endocytosis of activin type 2 receptor kinases through the Ral/RALBP1-dependent pathway and may be involved in ... Regulates endocytosis of activin type 2 receptor kinases through the Ral/RALBP1-dependent pathway and may be involved in ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=SYNJ2BP
*  Plus it
Coding loci for profiles exhibited in left column: Activin type II receptor (ACTRII, GI 178049); in center column: SEC63 (GI ... Liu F., Shao L. E., Yu J. Truncated activin type II receptor inhibits erythroid differentiation in K562 cells. J. Cell. Biochem ... including the activin type II receptor (ACTRII) gene (5) . In this report, we describe the results of mutational screening of ... Known FSMs have been described in TGFβ type II receptor (TGFBR2), IGF2 receptor (IGF2R), BCL2-associated X protein (BAX), hMSH3 ...
  http://cancerres.aacrjournals.org/content/62/13/3641
*  Three-finger protein - Wikipedia
"Three-finger toxin fold for the extracellular ligand-binding domain of the type II activin receptor serine kinase". Nature ... Ploug, Michael; Ellis, Vincent (1994-08-01). "Structure-function relationships in the receptor for urokinase-type plasminogen ... such as the activin type 2 receptor; and bone morphogenetic protein receptor, type IA. Other LU domain proteins are small ... Other receptors with LU domains include members of the transforming growth factor beta receptor (TGF-beta) superfamily, ...
  https://en.wikipedia.org/wiki/Three-finger_protein
*  InACTIVatINg cancer cachexia | Disease Models & Mechanisms
... transmembrane receptors [such as activin receptor type IIB (ActRIIB), TGFβ receptor type II] and intracellular signal ... 2005). Regulation of muscle growth by multiple ligands signaling through activin type II receptors. Proc. Natl. Acad. Sci. USA ... The authors found that, depending on the type of tumor, the levels of two ligands of ActRIIB - myostatin or activin (or both ... TGFβ signaling is initiated when an extracellular ligand binds its type II receptor dimer, which in turn leads to the ...
  http://dmm.biologists.org/content/4/3/283
*  ACVR1B Gene - GeneCards | ACV1B Protein | ACV1B Antibody
Activin A Receptor Type 1B, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The ... Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II ... Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 ... Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=ACVR1B
*  Interaction between alk1 and blood flow in the development of arteriovenous malformations | Development
... which can be facilitated by type III receptors, stimulates the type II receptor to phosphorylate the type I receptor, which ... a type III accessory receptor; HHT2 is caused by mutations in the gene encoding activin receptor like kinase 1 (ALK1 or ACVRL1 ... ligand dimers bind to a complex of two type II and two type I receptors, each of which is a transmembrane serine/threonine ... 2002). Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors. EMBO J. 21, 1743-1753. ...
  http://dev.biologists.org/content/138/8/1573
*  Heterozygous disruption of activin receptor-like kinase 1 is associated with increased arterial pressure in mice | Disease...
... whereas BMP-10 binds activin receptor type IIA, activin receptor type IIB or the BMP receptor type II with comparable affinity ... TGF-β1 and TGF-β3 bind the TGF receptor type II (Pardali and Ten Dijke, 2012). BMP-9 binds preferentially to activin receptor ... The activin receptor-like kinase 1 (ALK-1) is a type I cell-surface receptor for the transforming growth factor-β (TGF-β) ... Activin receptor-like kinase 1 (ALK-1) is one of the type I membrane receptors for some of the members of the transforming ...
  http://dmm.biologists.org/content/8/11/1427?utm_source=DMM&utm_campaign=Nobel2017
*  Alk2/ACVR1 and Alk3/BMPR1A Provide Essential Function for Bone Morphogenetic Protein-Induced Retinal AngiogenesisHighlights |...
activin receptor-like kinase. BMP. bone morphogenetic protein. BMPR1. BMP type 1 receptor. BMPR2. BMP type 2 receptor. BRE. BMP ... Overexpression of a dominant negative type II bone morphogenetic protein receptor inhibits the growth of human breast cancer ... activin type 1 receptor A), and ALK3/BMPR1A by immunostaining in retinas (Figure 1D through 1G and data not shown). BMPR2 ... Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4. J Biol Chem. 1994;269:16985-16988 ...
  http://atvb.ahajournals.org/content/37/4/657
*  Peptides | RealPeptide
ACE-031 is an activin type 2 receptor, which is a myostatin inhibitor. ACE-031 is a protein that was designed to bind to ... A peptide is a chemical compound containing two or more amino acids(amino acid polymers) that are coupled by a Peptides Bond . ... The use of Hexarelin will quickly lead to peptide receptor desensitization which doesn't make it ideal for long term use but ... GHRP-6 is the first generation GHRP and bodybuilders use it for two reasons - the first is the elevation of Growth Homone and ...
  https://realpeptide.com/peptides
*  ACVRL1 - Wikipedia
"Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors". ... "Entrez Gene: ACVRL1 activin A receptor type II-like 1". Olivieri C, Mira E, Delù G, Pagella F, Zambelli A, Malvezzi L, ... It is also known as activin receptor-like kinase 1, or ALK1. This gene encodes a type I cell-surface receptor for the TGF-beta ... "Mutations in the activin receptor-like kinase 1 gene in hereditary haemorrhagic telangiectasia type 2". Nature Genetics. 13 (2 ...
  https://en.wikipedia.org/wiki/ACVRL1
*  ACVRL1 Gene - GeneCards | ACVL1 Protein | ACVL1 Antibody
Activin A Receptor Like Type 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The ... activin A receptor,type II-like 1,homolog to ORW2 *ACVRL1. UniProtKB/Swiss-Prot CatalyticActivity: ATP + [receptor-protein] = ... forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors ... forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=ACVRL1
*  Frontiers | Bone Morphogenetic Protein 9 Protects against Neonatal Hyperoxia-Induced Impairment of Alveolarization and...
BMP receptor type 2 (BMPR2) receptor complex, may be a novel therapeutic option for BPD. Therefore, we investigated the ... BMP receptor type 2 (BMPR2) receptor complex, may be a novel therapeutic option for BPD. Therefore, we investigated the ... In addition, differential mRNA expression of BMP9 and its receptor complex: ALK1, BMPR2 and Endoglin, and of the ALK1 ... Expression of the BMP9 receptor complex and TMEM100 was studied in human endothelial and epithelial cell cultures and the ...
  https://www.frontiersin.org/articles/10.3389/fphys.2017.00486/full
*  ACVR1 polyclonal antibody - (PAB3474) - Products - Abnova
... resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which ... and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a ... TGF-B superfamily receptor type I,activin A receptor, type II-like kinase 2,activin A type I receptor,hydroxyalkyl-protein ... and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding ...
  http://www.abnova.com/products/products_detail.asp?catalog_id=PAB3474
*  Primary pulmonary hypertension - The Clinical Advisor
... receptor. Mutations in activin-receptor like kinase 1 (ALK-1) and endoglin receptor have also been associated with heritable ... Treatment for two types of hypertension. *FDA approves Opsumit for pulmonary hypertension ... In heritable type (HPAH) - there is a family history of disease. In most cases (up to 70%), there is a mutation of BMPR2 (bone ... Endothelin receptor antagonists - LFTs to be monitored monthly.. D. Long-term management.. MEDICAL MANAGEMENT. Calcium channel ...
  http://www.clinicaladvisor.com/hospital-medicine/primary-pulmonary-hypertension/article/602707/
*  TGF beta receptor 1 - Wikipedia
Transforming growth factor beta receptor I (activin A receptor type II-like kinase, 53kDa) is a membrane-bound receptor protein ... "Determination of type I receptor specificity by the type II receptors for TGF-beta or activin". Science. 262 (5135): 900-2. doi ... beta receptor I (activin A receptor type II-like kinase, 53kDa)". Razani B, Zhang XL, Bitzer M, von Gersdorff G, Böttinger EP, ... "Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs". Molecular ...
  https://en.wikipedia.org/wiki/TGF_beta_receptor_1
*  Louanne Hudgins | Stanford Medicine Profiles
Most cases are caused by mutations in the endoglin gene on chromosome 9 (HHT type 1) or the activin receptor-like kinase 1 gene ... Two of the most significant factors influencing uptake of NIPT were a higher reported education level (p=0.015) and a higher ... Fibroblast Growth Factor Receptor 2 and Its Role in Caudal Appendage and Craniosynostosis JOURNAL OF CRANIOFACIAL SURGERY ... We report on two unrelated females with typical manifestations of TSC, horseshoe kidney, and an identical variant c.5138G>A in ...
  https://med.stanford.edu/profiles/louanne-hudgins
*  Melanie Manning | Stanford Medicine Profiles
Most cases are caused by mutations in the endoglin gene on chromosome 9 (HHT type 1) or the activin receptor-like kinase 1 gene ... Children meeting either of these two criteria, along with randomly-selected controls, advanced to Tier II which began with a ... was examined.Recessive pathogenic variants in CYP1B1 were identified in two PCG pedigrees, three cases with CG and ASD, and two ... Two patients underwent bilateral corneal transplantation; another two were scheduled for possible unilateral transplant. ...
  https://med.stanford.edu/profiles/melanie-manning