*  Department of Health | Japanese encephalitis virus infection case definition - V1.1
This document contains the case definitions for Japanese encephalitis virus infection which is nationally notifiable within Australia. This definition should be used to determine whether a case should be notified.
  https://www.health.gov.au/internet/main/publishing.nsf/Content/cda-surveil-nndss-casedefs-cd_je.htm
*  The American Journal of Tropical Medicine and Hygiene | Ecological Studies of Japanese Encephalitis Virus in Hokkaido:...
Abstract Outbreaks of abortion and stillbirth caused by Japanese encephalitis virus were observed in swine populations in Hokkaido in 1984 and 1985. Two strains of Japanese encephalitis virus were isolated from aborted fetuses in different outbreaks, and the antigenic types of the strains found to be different from Nakayama and JaGAr-01. The outbreak of 1985 was in early June, the interepidemic period of Japanese encephalitis in northern temperate zones. A seroepidemiological survey carried out from 1984 to 1986 in 14 districts showed high rates of Japanese encephalitis antibody in swine sera in two districts. A more detailed 3-year survey showed that pig farms positive for Japanese encephalitis antibody were detected at the same sites in Hiroshima near Sapporo as negative farms. These data suggest that Japanese encephalitis virus is maintained in a distinct ...
  http://www.ajtmh.org/content/journals/10.4269/ajtmh.1988.38.420
*  Definisi dari Japanese encephalitis virus Menurut Istilah Kedokteran | Definisi dari Kata Indonesia dan Asing
Definisi dari Japanese encephalitis virus - Kata yang anda cari adalah istilah asing di ilmu Kedokteran. Definisi menurut kamus ekabahasa resmi Bahasa Indonesia definisi dari Japanese encephalitis virus adalah sebagai berikut. Definisi Japanese encephalitis virus Menurut Istilah Kedokteran virus ensefalitis Jepang Itulah definisi dari Japanese encephalitis virus, untuk mencari istilah dan definisi yang lain dapat […]
  http://edefinisi.com/definisi-japanese-encephalitis-virus-kedokteran-kamus-bahasa-kbbi.html
*  The host microRNA miR-301a blocks the IRF1-mediated neuronal innate immune response to Japanese encephalitis virus infection |...
Effective recognition of viral components and the subsequent stimulation of the production of type I interferons (IFNs) is crucial for the induction of host antiviral immunity. The failure of the host to efficiently produce type I IFNs in response to infection by the Japanese encephalitis virus (JEV) is linked with an increased probability for the disease to become lethal. JEV is a neurotropic virus of the Flaviviridae family that causes encephalitis in humans. JEV infection is regulated by several host factors, including microRNAs, which are conserved noncoding RNAs that participate in various physiological and pathological processes. We showed that the JEV-induced expression of miR-301a led to inhibition of the production of type I IFN by reducing the abundances of the transcription factor IFN regulatory factor 1 (IRF1) and the signaling protein suppressor of cytokine signaling 5 (SOCS5). Mechanistically, induction of miR-301a expression ...
  http://stke.sciencemag.org/content/10/466/eaaf5185
*  Ixiaro (Japanese Encephalitis Virus Vaccine, Inactivated, Adsorbed) FDA Approval History - Drugs.com
FDA application and approval History for Ixiaro (Japanese Encephalitis Virus Vaccine, Inactivated, Adsorbed) supplied by Intercell AG
  https://www.drugs.com/history/ixiaro.html
*  Seroepidemiology of Japanese Encephalitis Virus Infection in Hualien, Taiwan - Full Text View - ClinicalTrials.gov
According to CDC Taiwan epidemiology data, Hualien county had 6 confirmed JEV infection patients in 2009 witch was the highest county in Taiwan. Since mass vaccination was arranged since 45 years ago in Taiwan, most of the JEV infection was happened on the elderly, possible due to aging and immune compromised. However, from Mennonite Christian Hospital and CDC records, most of the confirmed JEV patients in Hualien county were aboriginal people. The youngest patient in 2009 is around 30-year-old who lived in the mountain side aboriginal village. Whether aboriginal people are at more risk for JEV infection or Genotype I JEV was appeared in Hualien with more virulent, resistent to vaccine protection is unknown.. In order to understand the risk of JEV infection and environmental (mosquito, swine) surveillance, we had arranged a small cohort study in 2 villages. The 2 villages are located at middle Hualien with direct distance around 20 KM between each other. Both villages had several pig farms and ...
  https://clinicaltrials.gov/ct2/show/NCT01163123?cond=%22Encephalitis%2C+Japanese%22&rank=11
*  Viruses | Free Full-Text | A Japanese Encephalitis Virus Vaccine Inducing Antibodies Strongly Enhancing In Vitro Infection Is...
The Japanese encephalitis virus (JEV) is responsible for zoonotic severe viral encephalitis transmitted by Culex mosquitoes. Although birds are reservoirs, pigs play a role as amplifying hosts, and are affected in particular through reproductive failure. Here, we show that a lentiviral JEV vector, expressing JEV prM and E proteins (TRIP/JEV.prME), but not JEV infection induces strong antibody-dependent enhancement (ADE) activities for infection of macrophages. Such antibodies strongly promoted infection via Fc receptors. ADE was found at both neutralizing and non-neutralizing serum dilutions. Nevertheless, in vivo JEV challenge of pigs demonstrated comparable protection induced by the TRIP/JEV.prME vaccine or heterologous JEV infection. Thus, either ADE antibodies cause no harm in the presence of neutralizing antibodies or may even have protective effects in vivo in pigs. Additionally, we found that both pre-infected and vaccinated pigs were not fully ...
  http://www.mdpi.com/1999-4915/9/5/124
*  Safety and Efficacy Study of Intravenous Immunoglobulin to Treat Japanese Encephalitis - Full Text View - ClinicalTrials.gov
Japanese encephalitis is caused by a viral infection of the brain transmitted by the bite of an infected mosquito. Patients with Japanese encephalitis can rapidly develop worsening conscious level and seizures. Around a third will die from the infection and half of survivors have serious long-term neurological disability. The majority of those affected are children. There are many causes of viral encephalitis, however Japanese encephalitis virus is the most common cause worldwide with over 60,000 cases annually. It occurs over much of Asia and the geographical range is expanding. There is no specific treatment for Japanese encephalitis virus, although several have been trialed. In this study we examined the effect of a new treatment, called intravenous immunoglobulin, on children with Japanese encephalitis in Nepal. Prior studies have suggested intravenous immunoglobulin may ...
  https://clinicaltrials.gov/ct2/show/NCT01856205?cond=Encephalitis&rank=17
*  Figure 1 - Japanese Encephalitis Virus in Meningitis Patients, Japan - Volume 11, Number 3-March 2005 - Emerging Infectious...
Cerebrospinal fluid specimens from 57 patients diagnosed with meningitis were tested for Japanese encephalitis virus. Total RNA was extracted from the specimens and amplified. Two products had highest homology with Nakayama strain and 2 with Ishikawa strain. Results suggest that Japanese encephalitis virus causes some aseptic meningitis in Japan.
  https://wwwnc.cdc.gov/eid/article/11/3/04-0285-f1
*  Japanese encephalitis virus vaccine, inactivated (Subcutaneous route) - Loyola University Health...
It is important that you receive 3 doses of the vaccine. If there is not enough time for you to get all 3 doses, you may get 2 doses of the vaccine. However, 2 doses of the vaccine will not protect you as well as 3 doses. It is important that you receive all 3 doses of the vaccine at least 10 days before you plan on traveling out of the country. There is a chance of side effects that do not show up right away, and, if they do occur, they may need medical attention. In addition, the 10 days will give your body time to produce antibodies against the Japanese encephalitis virus. Dosing- The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you ...
  http://loyolauniversity.adam.com/content.aspx?productId=47&pid=47&gid=600813
*  Japanese encephalitis virus E-D3 monoclonal antibody, clone 4j65 - (MAB8907) - Products - Abnova
Mouse monoclonal antibody raised against partial recombinant Japanese encephalitis virus E-D3. Recombinant protein corresponding to amino acids 291-402 of Japanese encephalitis virus E-D3. (MAB8907) - Products - Abnova
  http://www.abnova.com/products/products_detail.asp?catalog_id=MAB8907
*  CiNii 論文 - Japanese Encephalitis Virus Infection in Vero Cells:The Involvement of...
Japanese Encephalitis Virus Infection in Vero Cells:The Involvement of Intracellular Acidic Vesicles in the Early Phase of Viral Infection Was Observed with the Treatment of a Specific Vacuolar Type H^+-ATPase Inhibitor, Bafilomycin A1 ...
  http://ci.nii.ac.jp/naid/10004897252
*  Insights into the immunopathogenesis during Japanese encephalitis virus infection
Ommega International Journals, Open access journals, Scientific journals, International journals, Peer review journals, Ommega journals,Impact factor, Ommega pubmed, NLM ID,Journal of Anesthesia and Surgery, International Journal of Cancer and Oncology, Journal of Heart and Cardiology, Journal of Diabetes and Obesity, Journal of Environment and Health Science, International Journal of Food and Nutritional Science, Journal of Nanotechnology and Materials Science, International Journal of Neurology and Brain Disorders, Journal of Pharmacy and Pharmaceutics, Journal of Gynecology and Neonatal Biology, Journal of Addiction and Dependence, Journal of Marine Biology and Aquaculture, Journal of Dentistry and Oral Care, Journal of Gastrointestinal Disorders and Liver function, Journal of Dermatology and Skin Biology, Journal of Bioinformatics and Proteomics Review, Journal of Immunology and Serum Biology, Journal of Stem Celll and Regenerative Biology, International Journal of Hematology and Therapy, Letters to
  https://www.ommegaonline.org/article-details/article/1257
*  Genotype V Japanese Encephalitis Virus Is Emerging
Author Summary Japanese encephalitis virus (JEV) is a mosquito-borne virus that causes Japanese encephalitis (JE) with significant morbidity and mortality. Five genotypes (genotype I-V) have been identified based on the nucleotide sequence of viral envelope (E) gene of JEV. To date, the only known strain of genotype V is Muar strain, isolated from patient in Malaya in 1952. Since then, no genotype V JEV has been detected in the world. In this study, the JEV strain, XZ0934, was isolated from mosquito samples collected in China in 2009. The full-length genome sequences of the XZ0934 strain was determined and founded to be the second strain of genotype V JEV based on the phylogenetic analysis using the complete genome and structural gene sequences. This suggests that genotype V JEV is re-emerging after 57 years (1952-2009). Therefore, increased surveillance and more effective diagnosis for cases of JE caused by genotype V JEV are needed.
  http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0001231&imageURI=info:doi/10.1371/journal.pntd.0001231.t004
*  Japanese Encephalitis - Travel Clinics of America
What is Japanese encephalitis?. Japanese encephalitis is a mosquito-borne viral infection that can affect the brain and nervous system. The disease occurs most commonly in Asia, including Japan, China, India, and Southeast Asia. Encephalitis means inflammation of the brain, which can cause headache, fever, vomiting, and abnormal brain function.. How is Japanese encephalitis spread?. The virus is transmitted to humans by the bite of an infected mosquito. These mosquitoes first acquire the virus from infected pigs and wild birds. The disease is not transmitted person-to-person.. What are the symptoms of Japanese encephalitis?. Most individuals who are infected have no symptoms. Individuals with mild disease have fever and headache, while more serious infections include stiff neck, lethargy, tremors, and confusion. The disease can be serious and has a 30% fatality rate and a 30% rate of serious ...
  http://www.travelclinicsofamerica.com/diseases/japaneseencephalitis/
*  The American Journal of Tropical Medicine and Hygiene | Short report: genetic heterogeneity of Japanese encephalitis virus...
We determined the full-length genome sequence of Japanese encephalitis virus (JEV) K94P05 isolated in Korea. Sequence analysis showed that the 10,963-nucleotide-long RNA genome of K94P05 was 13 or 14 nucleotides shorter than the genome of other JEV isolates because of a deletion in the 3' noncoding region of K94P05. Compared with sequences of other JEV isolates, the full-length nucleotide sequence showed 89.0-89.6% homology, and the deduced amino acid sequence showed between 96.4-97.3% homology. A region of approximately 60 nucleotides immediately downstream of the open reading frame stop codon of K94P05 showed high sequence variability as compared with other JEV isolates. K94P05 formed a distinct group within a phylogenetic tree established with the full-length genome sequences. Cross-neutralization studies showed that polyclonal antibodies to Korean isolates were 3 times better at neutralizing the Korean isolates than antibodies to Nakayama-NIH. These findings suggest ...
  http://www.ajtmh.org/content/journals/10.4269/ajtmh.2001.65.388
*  Learn More About Japanese Encephalitis, A Virus Spread By Mosquitoes - Kabayan.Me
Here is an overview about a virus spread by mosquitos, the Japanese Encephalitis which allegedly took the lives of 9 Filipino this 2017.. Nowadays, diseases caused by virus-carrying mosquitoes such as dengue and malaria are only some of the most common and fatal diseases not only in the Philippines but also in different countries all around the world.. Japanese encephalitis is a virus spread by mosquitoes and related to dengue, yellow fever, and West Nile Viruses. It is a brain infection caused by mosquito-borne Japanese Encephalitis Virus (JEV), which is most prevalent in East Asia, South Asia, and Southeast Asia.. The first case of Japanese encephalitis was recorded in Japan during 1871. The symptoms of JEV such as fever, headache, vomiting, confusion, and difficulty in moving occurs 5 to 15 days after the bitten by an infected mosquito.. JEV is now ...
  https://www.kabayan.me/learn-japanese-encephalitis-virus-spread-mosquitoes/
*  Figure 2 - Change in Japanese Encephalitis Virus Distribution,Thailand - Volume 14, Number 11-November 2008 - Emerging...
Japanese encephalitis virus (JEV) genotypes in Thailand were studied in pigs and mosquitoes collected near houses of confirmed human JEV cases in 2003-2005. Twelve JEV strains isolated belonged to genotype I, which shows a switch from genotype III incidence that started during the 1980s.
  https://wwwnc.cdc.gov/eid/article/14/11/08-0542-f2
*  PLOS Neglected Tropical Diseases: Phylogeography of Japanese Encephalitis Virus: Genotype Is Associated with Climate
Author Summary Although Japanese encephalitis virus (JEV) is a major cause of death and disability throughout tropical and temperate Asia, little is known about the evolution, geographical distribution and epidemiology of the five JEV genotypes (genetically distinct groups). To address this gap in our knowledge, we performed a genetic-based geographical analysis using the largest JEV sequence dataset assembled to date, including 487 viral sequences sampled from 12 countries over 75 years. We showed that both the newly and previously dominant genotypes of JEV are associated with temperate climates and are maintained throughout the cold winter months in northern Asia, likely by hibernating mosquitoes (survive throughout the winter), vertical transmission in mosquitoes (female to offspring), cold-blooded vertebrates and/or bats.
  http://journals.plos.org/plosntds/article/figure?id=10.1371/journal.pntd.0002411.g004
*  Japanese Encephalitis Virus JEV Realtime PCR
Japanese Encephalitis Virus JEV , FR057 real time PCR kit for detection in different samples: nasal swabs, plasma, serum, stool, nasopharnygeal swabs, respiratory tract samples.
  http://genekam.de/realtime-pcr-kits/Japanese-Encephalitis-Virus-JEV
*  Japanese Encephalitis Virus Vaccine (Intramuscular Route) Precautions - Mayo Clinic
Portions of this document last updated: March 01, 2017. Copyright © 2017 Truven Health Analytics Inc. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.. ...
  https://www.mayoclinic.org/drugs-supplements/japanese-encephalitis-virus-vaccine-inactivated-adsorbed-intramuscular-route/precautions/DRG-20072758
*  EPO - T 1588/10 (Detection Japanese encephalitis viruses/ROCHE) of 8.10.2013
Summary of Facts and Submissions. I. The appeal lies from the decision of the examining division to refuse the European patent application no. 04 724 275.5, published as International patent application WO 2004/092412 (hereinafter 'the application').. II. The sole claim request before the examining division was filed on 2 September 2009 and consisted of sixteen claims. Claim 1 of this request read as follows:. '1. A kit for the detection of a nucleic acid of a member of the Japanese encephalitis virus serogroup, comprising:. a) a first oligonucleotide that hybridizes to a nucleic acid of SEQ ID NO: 1 or a complement thereof;. b) a second oligonucleotide that hybridizes to a nucleic acid of SEQ ID NO: 9 or a complement thereof; and. c) a detectably-labeled third oligonucleotide that hybridizes to a nucleic acid of SEQ ID NO: 16, or the complement thereof.'. Claims 2 to 16 were directed to preferred embodiments of claim 1.. III. In its decision, the examining division ...
  http://www.epo.org/law-practice/case-law-appeals/recent/t101588eu1.html
*  Japanese Encephalitis Virus is a Double Whammy for the Brain
A new study from the National Brain Research Center at Manesar, Haryana, has found that the Japanese encephalitis virus or 'brain fever' virus damages the brain in two ways, often
  http://www.medindia.net/news/Japanese-Encephalitis-Virus-is-a-Double-Whammy-for-the-Brain-39084-1.htm
*  What is Japanese Encephalitis?
Japanese encephalitis (JE) is a dangerous form of brain inflammation caused by the Japanese encephalitis virus, which is common in Asia and the West Pacific territories. The JE virus is a flavivirus, which brings it into the same family as the dengue virus. The life cycle of the virus is completed in two hosts, the mosquito and another vertebrate, whether man, pig or wading bird. The bites of culex mosquitoes transmit the virus, mainly by C. tritaeniorhynchus.
  https://www.news-medical.net/health/What-is-Japanese-Encephalitis.aspx
*  Japanese Encephalitis - Pipeline Review, H2 2017
... Summary Global Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Japanese Encephalitis - Market research report and industry analysis - 11262640
  https://www.marketresearch.com/Global-Markets-Direct-v3480/Japanese-Encephalitis-Pipeline-Review-H2-11262640/